SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7H_C_SAMC530

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 5 ILE A 105
ALA A 188
THR A 191
GLY A 193
THR A 184
 None
 1.07A 2y7hC-1am2A:
undetectable		 2y7hC-1am2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpr DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 THR A 420
ALA A 503
GLY A 482
LEU A 507
PRO A 396
 None
 0.92A 2y7hC-1bprA:
undetectable		 2y7hC-1bprA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 ALA A 143
THR A  10
GLY A  10
LEU A  85
ASN A   9
 None
 1.00A 2y7hC-1esoA:
undetectable		 2y7hC-1esoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		5 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
 None
None
None
None
HC1  A 580 (-3.5A)
 1.05A 2y7hC-1fehA:
undetectable		 2y7hC-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 ALA A  47
GLY A  51
ASN A 105
PRO A 107
PHE A 146
 NEA  A 500 (-3.1A)
None
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.98A 2y7hC-1g38A:
16.1		 2y7hC-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		6 THR A  23
ALA A  47
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 (-3.1A)
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.84A 2y7hC-1g38A:
16.1		 2y7hC-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ILE A 213
GLY A  87
GLY A 103
ASN A 217
PRO A  84
 None
 0.99A 2y7hC-1g8wA:
undetectable		 2y7hC-1g8wA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 577
GLY A 569
THR A 570
GLY A 571
LEU A 584
 None
 1.01A 2y7hC-1itzA:
undetectable		 2y7hC-1itzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		6 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hC-1izeA:
undetectable		 2y7hC-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 GLY A 298
LEU A 325
ASN A 339
THR A 314
PHE A 343
 None
 1.07A 2y7hC-1j93A:
undetectable		 2y7hC-1j93A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpt M-PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 ALA A 151
THR A 220
GLY A 178
LEU A 111
PRO A 168
 None
 0.85A 2y7hC-1mptA:
undetectable		 2y7hC-1mptA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvh LEUKEMIA INHIBITORY
FACTOR

(Homo sapiens) 		PF01291
(LIF_OSM) 		5 THR B 145
GLY B  91
THR B  92
GLY B 147
LEU B  30
 None
 1.01A 2y7hC-1pvhB:
undetectable		 2y7hC-1pvhB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		5 THR A 105
ALA A  97
GLY A 101
GLY A  72
LEU A 234
 None
 1.07A 2y7hC-1qaxA:
undetectable		 2y7hC-1qaxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		6 ALA A 371
GLY A 373
GLY A 396
THR A 321
THR A 335
PHE A 387
 None
SO4  A 475 ( 3.7A)
SO4  A 475 (-3.3A)
None
None
None
 1.20A 2y7hC-1svdA:
undetectable		 2y7hC-1svdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 THR A 646
ILE A 604
ALA A 627
THR A 563
GLY A 560
 None
 1.07A 2y7hC-1u1hA:
undetectable		 2y7hC-1u1hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		6 THR A  30
GLY A  59
THR A  60
GLY A  61
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 1.03A 2y7hC-1wy7A:
13.0		 2y7hC-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		6 THR A  30
THR A  60
GLY A  61
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 1.13A 2y7hC-1wy7A:
13.0		 2y7hC-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 ALA A 204
GLY A 105
THR A 101
THR A  84
PHE A 213
 None
 0.93A 2y7hC-2a6vA:
undetectable		 2y7hC-2a6vA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ALA A  15
GLY A 317
THR A 316
GLY A 291
LEU A  71
THR A  22
 None
None
None
FAD  A 601 (-3.2A)
None
None
 1.26A 2y7hC-2bc0A:
undetectable		 2y7hC-2bc0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 THR A 178
ILE A 187
GLY A 229
THR A  70
LEU A  73
 None
None
None
LYS  A 601 (-3.5A)
None
 1.03A 2y7hC-2cdqA:
undetectable		 2y7hC-2cdqA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 6 THR B 232
ILE B 236
ALA B 265
GLY B 271
LEU B 278
PRO B 245
 None
 1.49A 2y7hC-2d4aB:
4.4		 2y7hC-2d4aB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		7 THR A  98
ALA A 126
GLY A 128
THR A 129
LEU A 182
PRO A 198
PHE A 226
 SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
 0.91A 2y7hC-2f8lA:
23.4		 2y7hC-2f8lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ALA A 103
GLY A 110
GLY A 124
LEU A 380
ASN A 106
 None
 1.06A 2y7hC-2gepA:
undetectable		 2y7hC-2gepA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 ILE A 115
ALA A  71
GLY A 118
LEU A 327
PHE A 320
 None
 1.07A 2y7hC-2i4cA:
undetectable		 2y7hC-2i4cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 ILE A 269
ALA A 235
GLY A 274
GLY A 276
LEU A 238
 None
 0.96A 2y7hC-2iceA:
undetectable		 2y7hC-2iceA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA A 442
GLY A 445
GLY A  59
LEU A 424
PRO A 467
 None
 0.97A 2y7hC-2ifyA:
2.6		 2y7hC-2ifyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 410
GLY A 384
LEU A  64
PRO A 379
THR A  46
 None
 1.05A 2y7hC-2iikA:
undetectable		 2y7hC-2iikA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ALA A  97
GLY A  81
LEU A 128
ASN A  78
PHE A  99
 None
 0.97A 2y7hC-2iujA:
undetectable		 2y7hC-2iujA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 121
ILE A 125
GLY A 296
LEU A 276
ASN A 143
 None
 1.01A 2y7hC-2jifA:
undetectable		 2y7hC-2jifA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 ALA A 149
THR A  11
GLY A  14
LEU A  97
ASN A   8
 None
 0.99A 2y7hC-2k4wA:
undetectable		 2y7hC-2k4wA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvz PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Geobacillus
kaustophilus) 		PF00160
(Pro_isomerase) 		6 THR A  64
ALA A  90
GLY A  97
THR A  70
LEU A 111
PHE A 102
 None
 1.34A 2y7hC-2mvzA:
undetectable		 2y7hC-2mvzA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		9 ILE A 159
ALA A 178
GLY A 180
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.71A 2y7hC-2okcA:
38.8		 2y7hC-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR A 154
ALA A 178
THR A 181
GLY A 182
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.5A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 1.06A 2y7hC-2okcA:
38.8		 2y7hC-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		9 THR A 154
ILE A 159
ALA A 178
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.74A 2y7hC-2okcA:
38.8		 2y7hC-2okcA:
37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		5 ALA A 231
GLY A 233
GLY A 123
LEU A 205
THR A 153
 None
 1.04A 2y7hC-2pifA:
undetectable		 2y7hC-2pifA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A 105
ALA A 163
GLY A 135
THR A 136
GLY A 140
 None
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
None
 1.06A 2y7hC-2pnzA:
undetectable		 2y7hC-2pnzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ILE A 347
ALA A 255
GLY A 340
THR A 341
GLY A 344
THR A 402
 None
 1.47A 2y7hC-2qo3A:
undetectable		 2y7hC-2qo3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 THR A 118
GLY A 142
GLY A 145
LEU A 262
THR A 240
 CA  A 621 (-4.8A)
None
CA  A 621 ( 4.1A)
None
None
 1.07A 2y7hC-2quaA:
undetectable		 2y7hC-2quaA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 ILE A 268
GLY A 440
THR A 439
ASN A 270
PRO A 443
 None
 1.04A 2y7hC-2r9hA:
undetectable		 2y7hC-2r9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ILE A 263
ALA A 154
GLY A 125
GLY A 157
THR A  39
 None
 1.07A 2y7hC-2x24A:
undetectable		 2y7hC-2x24A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 ILE B 159
ALA B 175
THR B 249
LEU B 250
ASN B 266
PRO B 268
THR B 275
PHE B 292
 None
 1.46A 2y7hC-2y7cB:
53.5		 2y7hC-2y7cB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR B 151
ALA B 175
THR B 178
GLY B 180
THR B 249
LEU B 250
PRO B 267
PHE B 292
 None
 1.49A 2y7hC-2y7cB:
53.5		 2y7hC-2y7cB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		12 THR B 151
ILE B 156
ALA B 175
GLY B 177
THR B 178
GLY B 180
THR B 249
LEU B 250
ASN B 266
PRO B 268
THR B 275
PHE B 292
 None
 0.30A 2y7hC-2y7cB:
53.5		 2y7hC-2y7cB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 THR A 183
ILE A 227
LEU A 291
ASN A 218
PHE A  87
 None
 1.08A 2y7hC-2zc0A:
2.1		 2y7hC-2zc0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ILE A 196
ALA A 220
GLY A 231
LEU A 358
PRO A 222
 None
 0.98A 2y7hC-3a1iA:
undetectable		 2y7hC-3a1iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 GLY A 180
LEU A 128
ASN A 185
PRO A 139
PHE A 102
 None
 1.07A 2y7hC-3aivA:
undetectable		 2y7hC-3aivA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 ALA A 484
GLY A 486
THR A 472
LEU A 473
ASN A 398
PRO A 401
 None
 1.43A 2y7hC-3b9eA:
undetectable		 2y7hC-3b9eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ILE A 440
ALA A 291
GLY A 439
LEU A 637
PRO A 287
 None
None
None
None
GOL  A3002 (-4.0A)
 1.08A 2y7hC-3cttA:
undetectable		 2y7hC-3cttA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 THR A 130
ILE A 128
ALA A  98
GLY A  96
THR A  62
 None
 1.00A 2y7hC-3dahA:
undetectable		 2y7hC-3dahA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A 966
THR A 929
GLY A 931
LEU A 949
PHE A 937
 None
 1.01A 2y7hC-3eh1A:
undetectable		 2y7hC-3eh1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 ILE A 199
GLY A 176
GLY A 196
LEU A 158
PHE A 185
 None
5RP  A 501 (-3.7A)
5RP  A 501 (-3.6A)
None
None
 1.01A 2y7hC-3exsA:
undetectable		 2y7hC-3exsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9h SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		PF10291
(muHD) 		6 ILE A 739
GLY A 834
GLY A 830
THR A 857
ASN A 823
THR A 838
 None
 1.41A 2y7hC-3g9hA:
undetectable		 2y7hC-3g9hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 THR A 385
GLY A 337
LEU A 268
PRO A 327
THR A 264
 None
 0.96A 2y7hC-3gcwA:
undetectable		 2y7hC-3gcwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hC-3hvyA:
undetectable		 2y7hC-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA B 465
GLY B 468
GLY B  73
LEU B 447
PRO B 502
 None
 1.01A 2y7hC-3igzB:
2.3		 2y7hC-3igzB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hC-3j4sA:
2.2		 2y7hC-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1
PRE-MRNA-PROCESSING
FACTOR 17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		5 ALA g  66
GLY d  61
THR d  60
PRO g  65
THR d  97
 None
 1.06A 2y7hC-3jb9g:
undetectable		 2y7hC-3jb9g:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		6 THR A 289
ILE A 285
GLY A  91
THR A 246
GLY A 300
THR A 100
 None
None
None
None
AHZ  A 500 (-3.5A)
None
 1.45A 2y7hC-3jskA:
undetectable		 2y7hC-3jskA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 228
ALA A 251
GLY A 253
GLY A 256
ASN A 335
PRO A 337
 None
 0.79A 2y7hC-3khkA:
25.4		 2y7hC-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 228
ALA A 251
GLY A 255
ASN A 335
PRO A 337
 None
 0.82A 2y7hC-3khkA:
25.4		 2y7hC-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 THR A 339
ILE A 341
GLY A 723
THR A 752
LEU A 753
 None
 1.06A 2y7hC-3la4A:
undetectable		 2y7hC-3la4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
GLY A 231
THR A 285
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 0.91A 2y7hC-3lkdA:
24.8		 2y7hC-3lkdA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 201
GLY A 233
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 1.19A 2y7hC-3lkdA:
24.8		 2y7hC-3lkdA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 THR A  63
ALA A  34
THR A  15
GLY A  13
PHE A  82
 None
 0.94A 2y7hC-3pk0A:
5.0		 2y7hC-3pk0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ILE B 283
ALA B 249
GLY B 288
GLY B 290
LEU B 252
 None
 0.92A 2y7hC-3prxB:
undetectable		 2y7hC-3prxB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 GLY A 168
LEU A 116
ASN A 173
PRO A 127
PHE A  88
 None
 1.03A 2y7hC-3ptkA:
undetectable		 2y7hC-3ptkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		6 ALA A 174
GLY A 205
THR A 243
GLY A 242
LEU A  95
PHE A  62
 None
 1.46A 2y7hC-3pvcA:
8.3		 2y7hC-3pvcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 ALA A 329
GLY A 331
GLY A 333
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 1.16A 2y7hC-3s1sA:
18.7		 2y7hC-3s1sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ILE A 124
GLY A  52
GLY A  82
LEU A  10
PRO A  78
PHE A 332
 None
 1.36A 2y7hC-3u4aA:
undetectable		 2y7hC-3u4aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		9 THR A 201
ALA A 225
GLY A 227
THR A 228
GLY A 230
LEU A 290
ASN A 309
PRO A 311
PHE A 337
 None
 0.66A 2y7hC-3ufbA:
29.2		 2y7hC-3ufbA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
ALA A 225
THR A 228
GLY A 229
ASN A 309
PRO A 311
PHE A 337
 None
 0.98A 2y7hC-3ufbA:
29.2		 2y7hC-3ufbA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 THR B 263
ILE B 252
GLY B 256
THR B 314
ASN B 308
 None
 1.05A 2y7hC-3ufxB:
undetectable		 2y7hC-3ufxB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A  73
GLY A 101
THR A 383
LEU A 384
PHE A 520
 None
 1.06A 2y7hC-3v9eA:
undetectable		 2y7hC-3v9eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		5 ILE A  61
GLY A 299
GLY A 337
LEU A 201
PHE A 169
 None
ADN  A 401 ( 3.8A)
None
None
ADN  A 401 (-3.7A)
 1.07A 2y7hC-3vasA:
4.4		 2y7hC-3vasA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		5 THR A 212
ILE A  64
GLY A  79
PRO A 224
THR A  87
 None
 1.07A 2y7hC-3vaxA:
2.8		 2y7hC-3vaxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vlb XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE A

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		5 THR B  39
ALA B  70
GLY B 203
THR B 204
PHE B  21
 None
 1.00A 2y7hC-3vlbB:
undetectable		 2y7hC-3vlbB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 THR A 915
GLY A1002
GLY A1007
LEU A 393
THR A 392
 None
 1.05A 2y7hC-3w9iA:
3.1		 2y7hC-3w9iA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtb PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 THR A  33
ALA A 115
GLY A  63
GLY A  67
THR A 155
 None
 1.06A 2y7hC-3wtbA:
5.5		 2y7hC-3wtbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica) 		PF07228
(SpoIIE) 		6 ILE A  40
ALA A  84
GLY A  37
GLY A  39
LEU A  65
PHE A  69
 None
None
None
MN  A1194 (-4.2A)
None
None
 1.48A 2y7hC-3zt9A:
undetectable		 2y7hC-3zt9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE C 390
GLY C 365
LEU C  31
PRO C 360
THR C  13
 None
 0.97A 2y7hC-4b3iC:
undetectable		 2y7hC-4b3iC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 944
GLY A 949
GLY A 924
LEU A 971
ASN A 946
 None
 0.92A 2y7hC-4cu8A:
undetectable		 2y7hC-4cu8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		5 ILE A 180
ALA A 166
GLY A   5
GLY A 169
PRO A 163
 None
 1.02A 2y7hC-4g9bA:
undetectable		 2y7hC-4g9bA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  65
GLY A  68
LEU A 113
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.92A 2y7hC-4gc5A:
10.4		 2y7hC-4gc5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  52
THR A  53
GLY A  55
ASN A 116
PRO A 118
 None
 0.75A 2y7hC-4jxjA:
8.8		 2y7hC-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 THR A  30
GLY A 328
THR A 329
GLY A 361
LEU A 242
 None
PLP  A 500 (-3.4A)
PLP  A 500 (-3.1A)
PLP  A 500 (-3.7A)
None
 1.04A 2y7hC-4k6nA:
undetectable		 2y7hC-4k6nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 ILE A  24
GLY A 197
THR A 196
THR A  78
LEU A  82
 None
 1.06A 2y7hC-4m0dA:
undetectable		 2y7hC-4m0dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A 369
ALA A 499
THR A 438
LEU A 473
PHE A 501
 None
 1.08A 2y7hC-4o1oA:
2.4		 2y7hC-4o1oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		6 ALA B 212
GLY B 238
THR B 235
GLY B 234
THR B 245
PHE B 209
 None
 1.44A 2y7hC-4o9uB:
undetectable		 2y7hC-4o9uB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE B 371
ALA B 502
THR B 440
LEU B 475
PHE B 504
 ACP  B 801 (-4.2A)
None
ACP  B 801 (-4.1A)
None
None
 1.07A 2y7hC-4oavB:
undetectable		 2y7hC-4oavB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ILE A 336
ALA A 325
GLY A 327
THR A 328
GLY A 333
THR A 381
 None
None
None
GOL  A 903 ( 3.7A)
None
None
 1.23A 2y7hC-4oqjA:
undetectable		 2y7hC-4oqjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 THR B 385
GLY B 337
LEU B 268
PRO B 327
THR B 264
 None
 0.97A 2y7hC-4ov6B:
undetectable		 2y7hC-4ov6B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		5 ILE A 240
ALA A 281
GLY A 278
THR A  40
PHE A 132
 None
 1.04A 2y7hC-4pm4A:
undetectable		 2y7hC-4pm4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 THR A 176
ILE A 274
ALA A  57
GLY A  43
THR A 227
 None
 0.94A 2y7hC-4pneA:
9.9		 2y7hC-4pneA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ILE A  38
GLY A 287
THR A 288
GLY A 317
THR A 193
 None
 0.74A 2y7hC-4q3oA:
undetectable		 2y7hC-4q3oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 THR A 326
ILE A 289
ALA A 360
GLY A 363
PRO A 320
 None
 1.07A 2y7hC-4r27A:
undetectable		 2y7hC-4r27A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 THR A 583
ILE A 581
GLY A 439
THR A 440
LEU A 477
 BEF  A1732 (-4.2A)
None
MG  A1731 ( 4.6A)
None
None
 0.97A 2y7hC-4umvA:
undetectable		 2y7hC-4umvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wid RHUL123

(Macacine
betaherpesvirus
3) 		PF07340
(Herpes_IE1) 		6 ILE A 119
ALA A 230
GLY A 233
GLY A 235
LEU A 298
PHE A 130
 None
None
None
TRS  A 401 ( 4.7A)
None
None
 1.34A 2y7hC-4widA:
2.3		 2y7hC-4widA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 ILE A  76
ALA A  94
GLY A 101
THR A 100
LEU A 162
 None
None
GDP  A 401 (-3.3A)
GDP  A 401 (-3.4A)
None
 1.06A 2y7hC-4xcqA:
undetectable		 2y7hC-4xcqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 THR A 869
GLY A 906
THR A 907
THR A 982
ASN A1018
PRO A1020
 None
 0.78A 2y7hC-4xqkA:
21.1		 2y7hC-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 THR A 869
THR A 907
GLY A 908
THR A 982
ASN A1018
PRO A1020
 None
 1.20A 2y7hC-4xqkA:
21.1		 2y7hC-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bui STAPHYLOKINASE

(Staphylococcus
phage 42D.m) 		PF02821
(Staphylokinase) 		3 TYR C  44
GLU C  46
ASN C 122
 None
 0.96A 2y7hC-1buiC:
undetectable		 2y7hC-1buiC:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 166
GLU A 162
ASN A  10
 None
 0.97A 2y7hC-1cpnA:
0.0		 2y7hC-1cpnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND

(Homo sapiens) 		PF00229
(TNF) 		3 TYR B 213
GLU B 173
ASN B 140
 None
 1.02A 2y7hC-1d4vB:
undetectable		 2y7hC-1d4vB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		3 TYR A 218
GLU A 322
ASN A 465
 None
None
PO4  A 600 (-3.1A)
 0.74A 2y7hC-1f0iA:
0.9		 2y7hC-1f0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkf NK CELL ACTIVATING
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 TYR A  24
GLU A  32
ASN A  99
 None
 1.01A 2y7hC-1hkfA:
undetectable		 2y7hC-1hkfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 TYR A1552
GLU A1557
ASN A1559
 None
 1.03A 2y7hC-1iahA:
0.0		 2y7hC-1iahA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TYR A 540
GLU A 147
ASN A 150
 None
 1.02A 2y7hC-1ksiA:
0.0		 2y7hC-1ksiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 TYR A1102
GLU A1105
ASN A1119
 None
 1.00A 2y7hC-1mskA:
0.0		 2y7hC-1mskA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 TYR E 248
GLU E 213
ASN E 182
 None
 0.98A 2y7hC-1nfiE:
undetectable		 2y7hC-1nfiE:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		3 TYR A 112
GLU A 272
ASN A 346
 None
 1.04A 2y7hC-1s6rA:
0.0		 2y7hC-1s6rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 TYR A 200
GLU A 139
ASN A  94
 None
 0.86A 2y7hC-1vjzA:
0.0		 2y7hC-1vjzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 TYR A 331
GLU A 249
ASN A 163
 None
 0.90A 2y7hC-1zl6A:
undetectable		 2y7hC-1zl6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		3 TYR A 230
GLU A 160
ASN A 165
 None
 0.90A 2y7hC-2bs9A:
undetectable		 2y7hC-2bs9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 643
GLU A 564
ASN A 361
 None
 0.96A 2y7hC-2d5lA:
undetectable		 2y7hC-2d5lA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9m ZINC FINGER
CCCH-TYPE DOMAIN
CONTAINING PROTEIN
7A

(Homo sapiens) 		PF00642
(zf-CCCH) 		3 TYR A 893
GLU A 932
ASN A 927
 None
 0.95A 2y7hC-2d9mA:
undetectable		 2y7hC-2d9mA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 TYR A  80
GLU A 224
ASN A 165
 None
None
EPE  A 501 ( 4.2A)
 1.02A 2y7hC-2douA:
2.4		 2y7hC-2douA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 TYR A 204
GLU A 173
ASN A 177
 None
 0.97A 2y7hC-2gzsA:
undetectable		 2y7hC-2gzsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 TYR A 362
GLU A 292
ASN A 287
 None
 1.02A 2y7hC-2incA:
0.7		 2y7hC-2incA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		3 TYR A 212
GLU A 189
ASN A 283
 None
 1.02A 2y7hC-2iuyA:
undetectable		 2y7hC-2iuyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		3 TYR C 144
GLU C 102
ASN C 104
 None
 1.02A 2y7hC-2nraC:
undetectable		 2y7hC-2nraC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		3 TYR A 198
GLU A  39
ASN A  20
 None
 0.92A 2y7hC-2v25A:
undetectable		 2y7hC-2v25A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		3 TYR A 216
GLU A 317
ASN A 459
 None
 0.76A 2y7hC-2ze4A:
undetectable		 2y7hC-2ze4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajv PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aeropyrum
pernix) 		PF01974
(tRNA_int_endo) 		3 TYR A  89
GLU A  51
ASN A  35
 None
 0.96A 2y7hC-3ajvA:
undetectable		 2y7hC-3ajvA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 TYR A 306
GLU A 331
ASN A 366
 None
 1.01A 2y7hC-3bu7A:
undetectable		 2y7hC-3bu7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 TYR A 241
GLU A  25
ASN A 206
 None
None
DCS  A 372 ( 4.7A)
 0.96A 2y7hC-3e6eA:
undetectable		 2y7hC-3e6eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 TYR A 668
GLU A 671
ASN A 689
 None
UNX  A 902 ( 4.4A)
None
 0.97A 2y7hC-3hzjA:
undetectable		 2y7hC-3hzjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 TYR A  62
GLU A 353
ASN A 397
 None
 1.02A 2y7hC-3ic9A:
2.5		 2y7hC-3ic9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 TYR A 419
GLU A 393
ASN A 162
 None
NAD  A 505 (-2.9A)
NAD  A 505 ( 4.8A)
 1.04A 2y7hC-3iwkA:
undetectable		 2y7hC-3iwkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		3 TYR A 416
GLU A 390
ASN A 157
 None
 1.04A 2y7hC-3k2wA:
undetectable		 2y7hC-3k2wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 107
GLU A 467
ASN A 473
 EDO  A  14 (-3.7A)
EDO  A  14 (-3.2A)
None
 0.91A 2y7hC-3kezA:
undetectable		 2y7hC-3kezA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 112
GLU A 497
ASN A 503
 1PE  A   5 (-3.6A)
1PE  A   5 (-2.6A)
None
 0.80A 2y7hC-3lewA:
undetectable		 2y7hC-3lewA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		3 TYR A 307
GLU A 276
ASN A 270
 None
None
NAG  A3001 (-2.2A)
 0.75A 2y7hC-3lrkA:
undetectable		 2y7hC-3lrkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 112
GLU A 485
ASN A 491
 GOL  A  10 (-3.4A)
GOL  A  10 (-2.5A)
None
 1.03A 2y7hC-3mcxA:
undetectable		 2y7hC-3mcxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		3 TYR A 181
GLU A 117
ASN A  25
 None
 0.91A 2y7hC-3o7oA:
undetectable		 2y7hC-3o7oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 TYR A 261
GLU A 293
ASN A 245
 None
 1.01A 2y7hC-3phfA:
1.0		 2y7hC-3phfA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		3 TYR A 231
GLU A 169
ASN A 134
 None
 0.86A 2y7hC-3pzuA:
undetectable		 2y7hC-3pzuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		3 TYR A 393
GLU A 368
ASN A 141
 None
 0.94A 2y7hC-3rhdA:
3.3		 2y7hC-3rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		3 TYR A 160
GLU A  92
ASN A 279
 None
 1.02A 2y7hC-3s6bA:
undetectable		 2y7hC-3s6bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 116
GLU A 486
ASN A 492
 None
 0.88A 2y7hC-3snxA:
undetectable		 2y7hC-3snxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 216
GLU A 266
ASN A 291
 None
MG  A 391 (-2.6A)
None
 1.01A 2y7hC-3stpA:
undetectable		 2y7hC-3stpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		3 TYR A 226
GLU A 205
ASN A 136
 None
 1.00A 2y7hC-3tevA:
undetectable		 2y7hC-3tevA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 TYR B 186
GLU B 188
ASN B 116
 None
 1.01A 2y7hC-3u0jB:
undetectable		 2y7hC-3u0jB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 TYR A 230
GLU A 172
ASN A 184
 None
CA0  A 602 (-3.3A)
None
 0.97A 2y7hC-3vexA:
1.9		 2y7hC-3vexA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh7 CP32M

(-) 		no annotation 3 TYR B 638
GLU B 634
ASN B 624
 None
 0.91A 2y7hC-3vh7B:
undetectable		 2y7hC-3vh7B:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 373
GLU A 308
ASN A 315
 None
 0.97A 2y7hC-3vw5A:
undetectable		 2y7hC-3vw5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win 17 KD HEMAGGLUTININ
COMPONENT
HA3

(Clostridium
botulinum;
Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF03505
(Clenterotox) 		3 TYR C  24
GLU C 144
ASN E 546
 None
 0.99A 2y7hC-3winC:
undetectable		 2y7hC-3winC:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 389
GLU A 326
ASN A 333
 None
 1.00A 2y7hC-3wkhA:
undetectable		 2y7hC-3wkhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		3 TYR A 243
GLU A 178
ASN A  82
 GOL  A 409 (-4.6A)
BGC  A 414 (-3.9A)
BGC  A 412 (-3.1A)
 0.96A 2y7hC-3wq1A:
undetectable		 2y7hC-3wq1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		3 TYR A  66
GLU A 102
ASN A  12
 None
MG  A1253 ( 4.9A)
None
 0.97A 2y7hC-3zdbA:
undetectable		 2y7hC-3zdbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 249
GLU A 170
ASN A 223
 None
 0.75A 2y7hC-4as3A:
undetectable		 2y7hC-4as3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi5 TRIOSEPHOSPHATE
ISOMERASE

(Giardia
intestinalis) 		PF00121
(TIM) 		3 TYR A 169
GLU A 130
ASN A 138
 None
 0.85A 2y7hC-4bi5A:
undetectable		 2y7hC-4bi5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		3 TYR A 239
GLU A 236
ASN A 260
 None
 1.00A 2y7hC-4bmrA:
undetectable		 2y7hC-4bmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE

(Alicyclobacillus
acidocaldarius) 		no annotation 3 TYR A 203
GLU A 151
ASN A  97
 MVL  A 400 (-3.8A)
MVL  A 400 (-2.6A)
BMA  A 401 (-3.2A)
 0.95A 2y7hC-4cd8A:
undetectable		 2y7hC-4cd8A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 TYR A  75
GLU A  48
ASN A 369
 None
 1.00A 2y7hC-4eclA:
undetectable		 2y7hC-4eclA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 TYR B  57
GLU B 434
ASN B 101
 None
 0.97A 2y7hC-4fhnB:
2.1		 2y7hC-4fhnB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 TYR A 174
GLU A  89
ASN A  36
 None
 0.91A 2y7hC-4g9iA:
undetectable		 2y7hC-4g9iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 TYR A1013
GLU A 545
ASN A 931
 None
 0.88A 2y7hC-4gzuA:
undetectable		 2y7hC-4gzuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 150
GLU A  77
ASN A  75
 None
 0.88A 2y7hC-4l37A:
undetectable		 2y7hC-4l37A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5h VVTL1

(Vitis vinifera) 		PF00314
(Thaumatin) 		3 TYR A 197
GLU A 107
ASN A  65
 None
 0.72A 2y7hC-4l5hA:
undetectable		 2y7hC-4l5hA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 3 TYR C 149
GLU C 156
ASN C  90
 0FX  C 301 (-4.0A)
None
None
 0.99A 2y7hC-4nv1C:
undetectable		 2y7hC-4nv1C:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		3 TYR A 386
GLU A 360
ASN A 132
 None
 1.03A 2y7hC-4ohtA:
undetectable		 2y7hC-4ohtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 TYR A  47
GLU A  79
ASN A 180
 EAX  A 401 (-4.1A)
EAX  A 401 (-3.0A)
None
 0.97A 2y7hC-4pddA:
undetectable		 2y7hC-4pddA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 643
GLU A 564
ASN A 340
 None
 0.98A 2y7hC-4q1vA:
undetectable		 2y7hC-4q1vA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 TYR B 384
GLU B 335
ASN B 236
 None
 1.03A 2y7hC-4r3zB:
undetectable		 2y7hC-4r3zB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		3 TYR B  47
GLU B 257
ASN B 259
 None
 0.89A 2y7hC-4s1iB:
undetectable		 2y7hC-4s1iB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		3 TYR A 221
GLU A 107
ASN A 243
 None
 1.02A 2y7hC-4tzoA:
undetectable		 2y7hC-4tzoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 3 TYR B  53
GLU B  49
ASN B  80
 None
 0.98A 2y7hC-4w5uB:
undetectable		 2y7hC-4w5uB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		3 TYR A  27
GLU A  29
ASN A 176
 None
None
EDO  A 301 (-4.3A)
 1.02A 2y7hC-4w79A:
undetectable		 2y7hC-4w79A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 TYR A 205
GLU A 142
ASN A 107
 None
 0.77A 2y7hC-4xzbA:
undetectable		 2y7hC-4xzbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N) 		3 TYR A 151
GLU A 158
ASN A  92
 None
 0.93A 2y7hC-4yfvA:
undetectable		 2y7hC-4yfvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A  53
GLU A 413
ASN A 319
 LGC  A 602 ( 4.5A)
LGC  A 602 (-2.9A)
None
 0.96A 2y7hC-4ynuA:
undetectable		 2y7hC-4ynuA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 376
GLU A 312
ASN A 319
 None
 0.98A 2y7hC-4z4lA:
undetectable		 2y7hC-4z4lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 TYR A 222
GLU A 106
ASN A 474
 None
 1.00A 2y7hC-4zktA:
1.5		 2y7hC-4zktA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 TYR A 332
GLU A 250
ASN A 164
 None
 0.88A 2y7hC-4zktA:
1.5		 2y7hC-4zktA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		3 TYR A 408
GLU A 382
ASN A 149
 None
NAD  A 501 (-3.0A)
NAD  A 501 (-3.1A)
 0.97A 2y7hC-4zz7A:
undetectable		 2y7hC-4zz7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 TYR A 511
GLU A 447
ASN A 392
 None
 0.84A 2y7hC-5dmyA:
undetectable		 2y7hC-5dmyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		3 TYR A 299
GLU A 313
ASN A 237
 None
 1.01A 2y7hC-5dztA:
undetectable		 2y7hC-5dztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 TYR A 391
GLU A 401
ASN A 405
 None
 0.83A 2y7hC-5e9jA:
9.4		 2y7hC-5e9jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 TYR A 257
GLU A 188
ASN A 152
 EDO  A 614 (-4.1A)
CA  A 643 (-2.5A)
None
 0.88A 2y7hC-5ecuA:
undetectable		 2y7hC-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		3 TYR A 207
GLU A 369
ASN A 387
 None
 0.73A 2y7hC-5ejjA:
undetectable		 2y7hC-5ejjA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 TYR A 261
GLU A 192
ASN A 156
 None
 0.87A 2y7hC-5fipA:
undetectable		 2y7hC-5fipA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		3 TYR A 987
GLU A 493
ASN A 470
 None
 0.95A 2y7hC-5fswA:
3.3		 2y7hC-5fswA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 316
GLU A 172
ASN A 186
 None
 0.88A 2y7hC-5jboA:
undetectable		 2y7hC-5jboA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 TYR A 415
GLU A 716
ASN A 693
 None
 1.01A 2y7hC-5jouA:
undetectable		 2y7hC-5jouA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 TYR A1789
GLU A1743
ASN A1517
 None
 1.00A 2y7hC-5m5pA:
undetectable		 2y7hC-5m5pA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		3 TYR O 102
GLU C 367
ASN C 294
 None
 0.92A 2y7hC-5mdxO:
undetectable		 2y7hC-5mdxO:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA
COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF01602
(Adaptin_N)
PF01217
(Clat_adaptor_s) 		3 TYR A 114
GLU B 115
ASN B 118
 None
 0.93A 2y7hC-5mu7A:
undetectable		 2y7hC-5mu7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 3 TYR A 700
GLU A 704
ASN A 740
 None
 1.00A 2y7hC-5nfhA:
1.9		 2y7hC-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 3 TYR A 128
GLU A 133
ASN A  79
 GOL  A 412 ( 3.9A)
GOL  A 410 ( 4.9A)
None
 1.01A 2y7hC-5obwA:
undetectable		 2y7hC-5obwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 3 TYR A 258
GLU A 196
ASN A 159
 EDO  A 411 (-4.0A)
EDO  A 411 ( 4.1A)
None
 1.01A 2y7hC-5wh8A:
undetectable		 2y7hC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		3 TYR A 110
GLU A 120
ASN A 125
 None
 0.94A 2y7hC-5x62A:
7.9		 2y7hC-5x62A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 213
GLU A  28
ASN A 240
 None
 0.99A 2y7hC-5xmgA:
undetectable		 2y7hC-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 3 TYR B 195
GLU B 143
ASN B  89
 BMA  B 401 (-4.5A)
BMA  B 401 (-2.6A)
BMA  B 402 (-3.0A)
 0.96A 2y7hC-5yllB:
undetectable		 2y7hC-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhg OUTER CAPSID PROTEIN
VP8*

(Rotavirus C) 		no annotation 3 TYR A 153
GLU A  50
ASN A  66
 None
 1.00A 2y7hC-5zhgA:
undetectable		 2y7hC-5zhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		no annotation
no annotation 		3 TYR A 424
GLU A 419
ASN B 982
 None
 0.79A 2y7hC-6btmA:
undetectable		 2y7hC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 TYR A 809
GLU A 513
ASN A 827
 MGD  A 903 (-4.1A)
None
MGD  A 903 (-2.2A)
 0.97A 2y7hC-6czaA:
undetectable		 2y7hC-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME RNA HELICASE
MTR4

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 TYR H 163
GLU M 577
ASN M 580
 None
 1.00A 2y7hC-6d6qH:
undetectable		 2y7hC-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 3 TYR A 748
GLU A 659
ASN A 652
 None
 0.95A 2y7hC-6d6yA:
2.9		 2y7hC-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 3 TYR O  49
GLU O 582
ASN O 575
 None
 1.00A 2y7hC-6eu2O:
2.3		 2y7hC-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 3 TYR l 170
GLU l 190
ASN l 118
 None
 0.99A 2y7hC-6fail:
2.1		 2y7hC-6fail:
undetectable