SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y7H_B_SAMB530_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 ILE A 134
ALA A  47
GLY A  77
ASN A 198
LEU A 194
 None
NOV  A   1 ( 4.2A)
None
None
None
 1.03A 2y7hB-1aj6A:
undetectable		 2y7hB-1aj6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 5 ILE A 105
ALA A 188
THR A 191
GLY A 193
THR A 184
 None
 1.07A 2y7hB-1am2A:
undetectable		 2y7hB-1am2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpr DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 THR A 420
ALA A 503
GLY A 482
LEU A 507
PRO A 396
 None
 0.92A 2y7hB-1bprA:
undetectable		 2y7hB-1bprA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 ALA A 143
THR A  10
GLY A  10
LEU A  85
ASN A   9
 None
 1.01A 2y7hB-1esoA:
undetectable		 2y7hB-1esoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		5 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
 None
None
None
None
HC1  A 580 (-3.5A)
 1.04A 2y7hB-1fehA:
undetectable		 2y7hB-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 ALA A  47
GLY A  51
ASN A 105
PRO A 107
PHE A 146
 NEA  A 500 (-3.1A)
None
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.98A 2y7hB-1g38A:
18.0		 2y7hB-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		6 THR A  23
ALA A  47
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 (-3.1A)
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.84A 2y7hB-1g38A:
18.0		 2y7hB-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		6 ILE A 213
GLY A  87
GLY A 103
ASN A  75
ASN A 217
PRO A  84
 None
 1.14A 2y7hB-1g8wA:
undetectable		 2y7hB-1g8wA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 577
GLY A 569
THR A 570
GLY A 571
LEU A 584
 None
 1.00A 2y7hB-1itzA:
undetectable		 2y7hB-1itzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		6 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hB-1izeA:
undetectable		 2y7hB-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 GLY A  51
THR A  50
GLY A  38
ASN A  96
PRO A  26
 None
 1.04A 2y7hB-1js4A:
undetectable		 2y7hB-1js4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpt M-PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 ALA A 151
THR A 220
GLY A 178
LEU A 111
PRO A 168
 None
 0.86A 2y7hB-1mptA:
undetectable		 2y7hB-1mptA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvh LEUKEMIA INHIBITORY
FACTOR

(Homo sapiens) 		PF01291
(LIF_OSM) 		5 THR B 145
GLY B  91
THR B  92
GLY B 147
LEU B  30
 None
 1.01A 2y7hB-1pvhB:
undetectable		 2y7hB-1pvhB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		5 THR A 105
ALA A  97
GLY A 101
GLY A  72
LEU A 234
 None
 1.06A 2y7hB-1qaxA:
undetectable		 2y7hB-1qaxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 371
GLY A 373
GLY A 396
THR A 321
PHE A 387
 None
SO4  A 475 ( 3.7A)
SO4  A 475 (-3.3A)
None
None
 1.08A 2y7hB-1svdA:
undetectable		 2y7hB-1svdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 THR A 646
ILE A 604
ALA A 627
THR A 563
GLY A 560
 None
 1.07A 2y7hB-1u1hA:
undetectable		 2y7hB-1u1hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		6 THR A  30
GLY A  59
THR A  60
GLY A  61
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 1.03A 2y7hB-1wy7A:
11.8		 2y7hB-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		6 THR A  30
THR A  60
GLY A  61
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 1.12A 2y7hB-1wy7A:
11.8		 2y7hB-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		5 GLY A  39
GLY A  61
ASN A  31
THR A  30
ASN A 115
 None
 1.01A 2y7hB-1xjtA:
undetectable		 2y7hB-1xjtA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		5 ILE A  30
GLY A  34
GLY A  32
ASN A  17
LEU A  44
 ACY  A1225 ( 4.7A)
None
None
None
None
 1.04A 2y7hB-2cb9A:
undetectable		 2y7hB-2cb9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 THR A 178
ILE A 187
GLY A 229
THR A  70
LEU A  73
 None
None
None
LYS  A 601 (-3.5A)
None
 1.03A 2y7hB-2cdqA:
undetectable		 2y7hB-2cdqA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 6 THR B 232
ILE B 236
ALA B 265
GLY B 271
LEU B 278
PRO B 245
 None
 1.48A 2y7hB-2d4aB:
4.1		 2y7hB-2d4aB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 ILE A 313
ALA A 186
GLY A 320
THR A 321
GLY A 322
 None
 1.09A 2y7hB-2e87A:
undetectable		 2y7hB-2e87A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A 724
ALA A 732
GLY A 774
GLY A 725
ASN A 799
 None
 1.09A 2y7hB-2eaeA:
undetectable		 2y7hB-2eaeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		7 THR A  98
ALA A 126
GLY A 128
THR A 129
LEU A 182
PRO A 198
PHE A 226
 SAM  A 400 (-3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
 0.91A 2y7hB-2f8lA:
23.3		 2y7hB-2f8lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ALA A 103
GLY A 110
GLY A 124
LEU A 380
ASN A 106
 None
 1.06A 2y7hB-2gepA:
undetectable		 2y7hB-2gepA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 ILE A 115
ALA A  71
GLY A 118
LEU A 327
PHE A 320
 None
 1.07A 2y7hB-2i4cA:
undetectable		 2y7hB-2i4cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 ILE A 269
ALA A 235
GLY A 274
GLY A 276
LEU A 238
 None
 0.96A 2y7hB-2iceA:
undetectable		 2y7hB-2iceA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA A 442
GLY A 445
GLY A  59
LEU A 424
PRO A 467
 None
 0.97A 2y7hB-2ifyA:
3.0		 2y7hB-2ifyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ALA A  97
GLY A  81
LEU A 128
ASN A  78
PHE A  99
 None
 0.97A 2y7hB-2iujA:
undetectable		 2y7hB-2iujA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 121
ILE A 125
GLY A 296
LEU A 276
ASN A 143
 None
 1.02A 2y7hB-2jifA:
undetectable		 2y7hB-2jifA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 ALA A 149
THR A  11
GLY A  14
LEU A  97
ASN A   8
 None
 1.00A 2y7hB-2k4wA:
undetectable		 2y7hB-2k4wA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvz PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Geobacillus
kaustophilus) 		PF00160
(Pro_isomerase) 		6 THR A  64
ALA A  90
GLY A  97
THR A  70
LEU A 111
PHE A 102
 None
 1.34A 2y7hB-2mvzA:
undetectable		 2y7hB-2mvzA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		9 ILE A 159
ALA A 178
GLY A 180
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.71A 2y7hB-2okcA:
38.7		 2y7hB-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR A 154
ALA A 178
THR A 181
GLY A 182
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.5A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 1.06A 2y7hB-2okcA:
38.7		 2y7hB-2okcA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		9 THR A 154
ILE A 159
ALA A 178
THR A 181
GLY A 183
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
None
SAM  A 500 (-3.4A)
SAM  A 500 (-3.1A)
SAM  A 500 (-3.2A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.73A 2y7hB-2okcA:
38.7		 2y7hB-2okcA:
37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A 105
ALA A 163
GLY A 135
THR A 136
GLY A 140
 None
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
None
 1.06A 2y7hB-2pnzA:
undetectable		 2y7hB-2pnzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ILE A 347
ALA A 255
GLY A 340
THR A 341
GLY A 344
THR A 402
 None
 1.47A 2y7hB-2qo3A:
undetectable		 2y7hB-2qo3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 ILE A 268
GLY A 440
THR A 439
ASN A 270
PRO A 443
 None
 1.03A 2y7hB-2r9hA:
undetectable		 2y7hB-2r9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ILE A 263
ALA A 154
GLY A 125
GLY A 157
THR A  39
 None
 1.07A 2y7hB-2x24A:
undetectable		 2y7hB-2x24A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 ILE B 159
ALA B 175
ASN B 248
THR B 249
LEU B 250
ASN B 266
PRO B 268
PHE B 292
 None
 1.40A 2y7hB-2y7cB:
53.4		 2y7hB-2y7cB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR B 151
ALA B 175
THR B 178
GLY B 180
THR B 249
LEU B 250
PRO B 267
PHE B 292
 None
 1.49A 2y7hB-2y7cB:
53.4		 2y7hB-2y7cB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		12 THR B 151
ILE B 156
ALA B 175
GLY B 177
THR B 178
GLY B 180
ASN B 248
THR B 249
LEU B 250
ASN B 266
PRO B 268
PHE B 292
 None
 0.31A 2y7hB-2y7cB:
53.4		 2y7hB-2y7cB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 THR A 183
ILE A 227
LEU A 291
ASN A 218
PHE A  87
 None
 1.08A 2y7hB-2zc0A:
2.3		 2y7hB-2zc0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ILE A 196
ALA A 220
GLY A 231
LEU A 358
PRO A 222
 None
 0.98A 2y7hB-3a1iA:
undetectable		 2y7hB-3a1iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 GLY A 180
LEU A 128
ASN A 185
PRO A 139
PHE A 102
 None
 1.07A 2y7hB-3aivA:
undetectable		 2y7hB-3aivA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A  32
GLY A 372
THR A 371
ASN A 306
LEU A 329
 None
 1.03A 2y7hB-3awkA:
undetectable		 2y7hB-3awkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 ALA A 484
GLY A 486
THR A 472
LEU A 473
ASN A 398
PRO A 401
 None
 1.43A 2y7hB-3b9eA:
2.9		 2y7hB-3b9eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ILE A 440
ALA A 291
GLY A 439
LEU A 637
PRO A 287
 None
None
None
None
GOL  A3002 (-4.0A)
 1.08A 2y7hB-3cttA:
undetectable		 2y7hB-3cttA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 THR A 130
ILE A 128
ALA A  98
GLY A  96
THR A  62
 None
 1.00A 2y7hB-3dahA:
2.3		 2y7hB-3dahA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		5 ILE A 333
ALA A 328
GLY A 302
ASN A 385
PRO A 383
 None
None
None
GOL  A 426 (-3.4A)
None
 1.09A 2y7hB-3e2vA:
undetectable		 2y7hB-3e2vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A 966
THR A 929
GLY A 931
LEU A 949
PHE A 937
 None
 1.01A 2y7hB-3eh1A:
undetectable		 2y7hB-3eh1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 ILE A 199
GLY A 176
GLY A 196
LEU A 158
PHE A 185
 None
5RP  A 501 (-3.7A)
5RP  A 501 (-3.6A)
None
None
 1.01A 2y7hB-3exsA:
undetectable		 2y7hB-3exsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 THR A 114
GLY A  38
THR A  37
GLY A  89
LEU A  97
 None
 1.08A 2y7hB-3gg0A:
undetectable		 2y7hB-3gg0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hB-3hvyA:
undetectable		 2y7hB-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ALA B 465
GLY B 468
GLY B  73
LEU B 447
PRO B 502
 None
 1.01A 2y7hB-3igzB:
2.1		 2y7hB-3igzB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hB-3j4sA:
undetectable		 2y7hB-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 228
ALA A 251
GLY A 253
GLY A 256
ASN A 335
PRO A 337
 None
 0.78A 2y7hB-3khkA:
25.3		 2y7hB-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 228
ALA A 251
GLY A 255
ASN A 335
PRO A 337
 None
 0.81A 2y7hB-3khkA:
25.3		 2y7hB-3khkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 THR A 339
ILE A 341
GLY A 723
THR A 752
LEU A 753
 None
 1.06A 2y7hB-3la4A:
undetectable		 2y7hB-3la4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
GLY A 231
THR A 285
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 0.91A 2y7hB-3lkdA:
24.4		 2y7hB-3lkdA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 201
GLY A 233
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 1.19A 2y7hB-3lkdA:
24.4		 2y7hB-3lkdA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA A 257
GLY A 253
LEU A 386
PRO A 248
PHE A 259
 None
 1.05A 2y7hB-3n92A:
undetectable		 2y7hB-3n92A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 THR A  63
ALA A  34
THR A  15
GLY A  13
PHE A  82
 None
 0.95A 2y7hB-3pk0A:
4.9		 2y7hB-3pk0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ILE B 283
ALA B 249
GLY B 288
GLY B 290
LEU B 252
 None
 0.92A 2y7hB-3prxB:
undetectable		 2y7hB-3prxB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 GLY A 168
LEU A 116
ASN A 173
PRO A 127
PHE A  88
 None
 1.04A 2y7hB-3ptkA:
undetectable		 2y7hB-3ptkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		6 ALA A 174
GLY A 205
THR A 243
GLY A 242
LEU A  95
PHE A  62
 None
 1.46A 2y7hB-3pvcA:
8.6		 2y7hB-3pvcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		5 ILE A 309
GLY A  14
GLY A  17
ASN A  58
PRO A  80
 None
SAH  A 323 (-3.6A)
SAH  A 323 (-3.0A)
SAH  A 323 (-3.1A)
SAH  A 323 (-4.4A)
 1.00A 2y7hB-3qv2A:
5.8		 2y7hB-3qv2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 ALA A 329
GLY A 331
GLY A 333
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 1.16A 2y7hB-3s1sA:
18.0		 2y7hB-3s1sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ILE A 124
GLY A  52
GLY A  82
LEU A  10
PRO A  78
PHE A 332
 None
 1.37A 2y7hB-3u4aA:
undetectable		 2y7hB-3u4aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		10 THR A 201
ALA A 225
GLY A 227
THR A 228
GLY A 230
ASN A 288
LEU A 290
ASN A 309
PRO A 311
PHE A 337
 None
 0.73A 2y7hB-3ufbA:
28.1		 2y7hB-3ufbA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
ALA A 225
THR A 228
GLY A 229
ASN A 309
PRO A 311
PHE A 337
 None
 0.98A 2y7hB-3ufbA:
28.1		 2y7hB-3ufbA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 THR B 263
ILE B 252
GLY B 256
THR B 314
ASN B 308
 None
 1.05A 2y7hB-3ufxB:
undetectable		 2y7hB-3ufxB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A  73
GLY A 101
THR A 383
LEU A 384
PHE A 520
 None
 1.06A 2y7hB-3v9eA:
undetectable		 2y7hB-3v9eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		5 ILE A  61
GLY A 299
GLY A 337
LEU A 201
PHE A 169
 None
ADN  A 401 ( 3.8A)
None
None
ADN  A 401 (-3.7A)
 1.07A 2y7hB-3vasA:
3.9		 2y7hB-3vasA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vlb XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE A

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		5 THR B  39
ALA B  70
GLY B 203
THR B 204
PHE B  21
 None
 1.00A 2y7hB-3vlbB:
undetectable		 2y7hB-3vlbB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica) 		PF07228
(SpoIIE) 		6 ILE A  40
ALA A  84
GLY A  37
GLY A  39
LEU A  65
PHE A  69
 None
None
None
MN  A1194 (-4.2A)
None
None
 1.48A 2y7hB-3zt9A:
undetectable		 2y7hB-3zt9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 944
GLY A 949
GLY A 924
LEU A 971
ASN A 946
 None
 0.93A 2y7hB-4cu8A:
undetectable		 2y7hB-4cu8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		5 ILE A 180
ALA A 166
GLY A   5
GLY A 169
PRO A 163
 None
 1.02A 2y7hB-4g9bA:
undetectable		 2y7hB-4g9bA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  65
GLY A  68
LEU A 113
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.91A 2y7hB-4gc5A:
9.2		 2y7hB-4gc5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 GLY A 249
GLY A 454
ASN A 276
PRO A 147
PHE A 154
 NAD  A 601 (-3.5A)
None
None
NAD  A 601 ( 4.0A)
NAD  A 601 (-4.5A)
 1.09A 2y7hB-4go4A:
undetectable		 2y7hB-4go4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		6 ILE A 251
GLY A 243
GLY A 246
ASN A 152
LEU A 155
ASN A 253
 None
 1.44A 2y7hB-4h18A:
undetectable		 2y7hB-4h18A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		6 ILE A 251
GLY A 243
GLY A 247
ASN A 152
LEU A 155
ASN A 253
 None
 1.40A 2y7hB-4h18A:
undetectable		 2y7hB-4h18A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  52
THR A  53
GLY A  55
ASN A 116
PRO A 118
 None
 0.74A 2y7hB-4jxjA:
11.3		 2y7hB-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 THR A  30
GLY A 328
THR A 329
GLY A 361
LEU A 242
 None
PLP  A 500 (-3.4A)
PLP  A 500 (-3.1A)
PLP  A 500 (-3.7A)
None
 1.04A 2y7hB-4k6nA:
undetectable		 2y7hB-4k6nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 ILE A  24
GLY A 197
THR A 196
THR A  78
LEU A  82
 None
 1.06A 2y7hB-4m0dA:
undetectable		 2y7hB-4m0dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 789
ALA A 835
GLY A 784
ASN A 603
LEU A 604
 None
 0.98A 2y7hB-4ncnA:
undetectable		 2y7hB-4ncnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		6 ALA B 212
GLY B 238
THR B 235
GLY B 234
THR B 245
PHE B 209
 None
 1.45A 2y7hB-4o9uB:
undetectable		 2y7hB-4o9uB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE B 371
ALA B 502
THR B 440
LEU B 475
PHE B 504
 ACP  B 801 (-4.2A)
None
ACP  B 801 (-4.1A)
None
None
 1.08A 2y7hB-4oavB:
undetectable		 2y7hB-4oavB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		5 ILE A 240
ALA A 281
GLY A 278
THR A  40
PHE A 132
 None
 1.04A 2y7hB-4pm4A:
undetectable		 2y7hB-4pm4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 THR A 176
ILE A 274
ALA A  57
GLY A  43
THR A 227
 None
 0.95A 2y7hB-4pneA:
10.4		 2y7hB-4pneA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ILE A  38
GLY A 287
THR A 288
GLY A 317
THR A 193
 None
 0.74A 2y7hB-4q3oA:
undetectable		 2y7hB-4q3oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0k DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
thetaiotaomicron) 		PF00877
(NLPC_P60) 		5 ILE A 157
ASN A 322
THR A 319
ASN A 133
PHE A 212
 None
GOL  A 403 (-3.6A)
None
None
None
 0.92A 2y7hB-4r0kA:
undetectable		 2y7hB-4r0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 THR A 326
ILE A 289
ALA A 360
GLY A 363
PRO A 320
 None
 1.07A 2y7hB-4r27A:
undetectable		 2y7hB-4r27A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 THR A 583
ILE A 581
GLY A 439
THR A 440
LEU A 477
 BEF  A1732 (-4.2A)
None
MG  A1731 ( 4.6A)
None
None
 0.97A 2y7hB-4umvA:
undetectable		 2y7hB-4umvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		5 GLY A 101
GLY A  99
ASN A 110
THR A 109
LEU A 154
 None
 1.02A 2y7hB-4wd3A:
undetectable		 2y7hB-4wd3A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wid RHUL123

(Macacine
betaherpesvirus
3) 		PF07340
(Herpes_IE1) 		6 ILE A 119
ALA A 230
GLY A 233
GLY A 235
LEU A 298
PHE A 130
 None
None
None
TRS  A 401 ( 4.7A)
None
None
 1.34A 2y7hB-4widA:
undetectable		 2y7hB-4widA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 ILE A  76
ALA A  94
GLY A 101
THR A 100
LEU A 162
 None
None
GDP  A 401 (-3.3A)
GDP  A 401 (-3.4A)
None
 1.07A 2y7hB-4xcqA:
2.4		 2y7hB-4xcqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 THR A 869
GLY A 906
THR A 907
THR A 982
ASN A1018
PRO A1020
 None
 0.78A 2y7hB-4xqkA:
19.7		 2y7hB-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 THR A 869
THR A 907
GLY A 908
THR A 982
ASN A1018
PRO A1020
 None
 1.19A 2y7hB-4xqkA:
19.7		 2y7hB-4xqkA:
15.93