SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y6R_D_CTCD1385

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASP A 653
PHE A  16
HIS A 203
GLY A  17
MET A  50
 None
 1.46A 2y6rD-1tmoA:
0.2		 2y6rD-1tmoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ASP A 778
ARG A 782
GLY A 852
SER A 850
MET A 875
 None
 1.49A 2y6rD-2ogvA:
0.0		 2y6rD-2ogvA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		9 ASP A  61
GLN A 192
ARG A 213
MET A 215
HIS A 234
GLY A 236
SER A 238
PRO A 318
MET A 375
 None
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
None
SO4  A   1 ( 4.6A)
None
None
FAD  A 401 (-4.4A)
None
 0.80A 2y6rD-3p9uA:
56.7		 2y6rD-3p9uA:
94.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 ASP A 328
PHE A 202
HIS A 192
GLY A 201
SER A 150
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.6A)
 1.35A 2y6rD-5eefA:
0.0		 2y6rD-5eefA:
21.11