SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y6R_C_CTCC1385_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 ASP M  65
PHE M  54
HIS M  56
GLY M  53
GLY M 468
 None
None
ZN  M 923 (-3.2A)
GOL  M 933 ( 4.5A)
None
 1.34A 2y6rC-1dwaM:
undetectable		 2y6rC-1dwaM:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN B 692
ARG A 137
SER B 564
PRO B 759
GLY B 700
 PCD  B1920 (-3.4A)
None
PCD  B1920 (-4.0A)
None
None
 1.12A 2y6rC-1ffvB:
undetectable		 2y6rC-1ffvB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A  59
ARG A  63
MET A 247
HIS A 225
GLY A  87
 None
 1.48A 2y6rC-1pvdA:
1.3		 2y6rC-1pvdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ARG A 325
MET A 338
GLY A 432
SER A 284
GLY A 161
 None
 1.47A 2y6rC-1r8wA:
undetectable		 2y6rC-1r8wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 ASN A 150
HIS A 272
GLY A 163
SER A 165
GLY A 263
 NAP  A 800 (-4.4A)
None
None
None
None
 0.77A 2y6rC-1vljA:
1.5		 2y6rC-1vljA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ASP A 573
PHE A 350
GLY A 349
PRO A 544
GLY A 542
 None
 1.43A 2y6rC-1z68A:
undetectable		 2y6rC-1z68A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
 None
 1.27A 2y6rC-2dw4A:
13.7		 2y6rC-2dw4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 ARG A 130
PHE A 291
HIS A 287
GLY A 288
GLY A 192
 DFP  A1189 (-2.8A)
None
DFP  A1189 (-3.8A)
None
None
 1.44A 2y6rC-2gzsA:
undetectable		 2y6rC-2gzsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ASP A 778
ARG A 782
GLY A 852
SER A 850
MET A 875
 None
 1.50A 2y6rC-2ogvA:
undetectable		 2y6rC-2ogvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 ASP A 174
ASN A 101
PHE A 127
GLY A  99
GLY A 131
 None
ACT  A 286 (-3.2A)
CL  A 290 ( 4.7A)
None
None
 1.35A 2y6rC-2p10A:
undetectable		 2y6rC-2p10A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A  59
ARG A  63
MET A 247
HIS A 225
GLY A  87
 None
 1.44A 2y6rC-2vk4A:
undetectable		 2y6rC-2vk4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.50A 2y6rC-2wzfA:
undetectable		 2y6rC-2wzfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.47A 2y6rC-2wzgA:
undetectable		 2y6rC-2wzgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		5 ASP A 145
ASN A 262
GLY A  69
SER A 287
PRO A 284
 None
 1.32A 2y6rC-3cx3A:
3.1		 2y6rC-3cx3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		5 GLN A 604
GLY A 440
SER A 454
PRO A 690
GLY A 693
 None
 1.33A 2y6rC-3fbyA:
undetectable		 2y6rC-3fbyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ASP A 335
PHE A  10
GLY A   8
GLY A 359
MET A 574
 None
 1.46A 2y6rC-3gf7A:
undetectable		 2y6rC-3gf7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00694
(Aconitase_C) 		5 ASP A 156
GLY A 166
SER A   1
GLY A 103
MET A  85
 None
EDO  A1301 (-3.5A)
None
None
None
 1.17A 2y6rC-3h5jA:
undetectable		 2y6rC-3h5jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 ASN A 261
HIS A 224
GLY A 155
PRO A 252
GLY A 255
 None
 1.43A 2y6rC-3io0A:
undetectable		 2y6rC-3io0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 ASP A 291
ASN A 172
HIS A 224
GLY A 195
GLY A 248
 None
None
ACT  A 605 (-3.8A)
None
None
 1.36A 2y6rC-3lv4A:
undetectable		 2y6rC-3lv4A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		6 ASN A 190
GLN A 192
HIS A 234
SER A 238
PRO A 318
GLY A 323
 FAD  A 401 ( 4.5A)
FAD  A 401 (-3.4A)
SO4  A   1 ( 4.6A)
None
FAD  A 401 (-4.4A)
FAD  A 401 (-3.4A)
 1.45A 2y6rC-3p9uA:
56.4		 2y6rC-3p9uA:
94.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		7 ASP A  61
ASN A 190
ARG A 213
PHE A 224
SER A 238
PRO A 318
GLY A 321
 None
FAD  A 401 ( 4.5A)
SO4  A   1 (-4.5A)
None
None
FAD  A 401 (-4.4A)
None
 1.50A 2y6rC-3p9uA:
56.4		 2y6rC-3p9uA:
94.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		11 ASP A  61
ASN A 190
GLN A 192
ARG A 213
MET A 215
HIS A 234
GLY A 236
SER A 238
PRO A 318
GLY A 321
MET A 375
 None
FAD  A 401 ( 4.5A)
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
None
SO4  A   1 ( 4.6A)
None
None
FAD  A 401 (-4.4A)
None
None
 0.84A 2y6rC-3p9uA:
56.4		 2y6rC-3p9uA:
94.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 ARG A 119
MET A 123
PHE A 202
SER A 199
GLY A   9
 None
 1.49A 2y6rC-3qatA:
undetectable		 2y6rC-3qatA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 MET A  80
HIS A  76
GLY A  77
SER A 129
GLY A 310
 None
 1.22A 2y6rC-3qj3A:
undetectable		 2y6rC-3qj3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		5 ASP A 126
ASN A  62
GLN A  64
HIS A 239
GLY A  99
 SO4  A   1 (-2.8A)
None
None
None
None
 1.44A 2y6rC-3rm5A:
undetectable		 2y6rC-3rm5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ARG A 272
HIS A 298
GLY A 292
PRO A 266
GLY A 269
 None
 1.43A 2y6rC-3u3xA:
3.9		 2y6rC-3u3xA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		5 ASN A 436
PHE A 475
HIS A 582
GLY A 430
MET A 442
 None
 1.46A 2y6rC-3vsvA:
undetectable		 2y6rC-3vsvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 358
GLN A 410
PHE A 516
GLY A 411
GLY A 407
 ZN  A1001 (-2.1A)
None
None
None
None
 1.45A 2y6rC-4b56A:
undetectable		 2y6rC-4b56A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.39A 2y6rC-4ci8A:
undetectable		 2y6rC-4ci8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE

(Bacillus
anthracis) 		no annotation 5 ASN B 215
GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 1.26A 2y6rC-4fetB:
undetectable		 2y6rC-4fetB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.41A 2y6rC-4iaoA:
3.6		 2y6rC-4iaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mec HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		5 GLN A 145
PHE A 167
GLY A 144
GLY A 161
MET A  51
 None
 1.50A 2y6rC-4mecA:
undetectable		 2y6rC-4mecA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		5 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.48A 2y6rC-4mlgA:
undetectable		 2y6rC-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2c SHIGA TOXIN 2E,
SUBUNIT B
NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION

(Escherichia
coli;
Lama glama) 		PF02258
(SLT_beta)
PF07686
(V-set) 		5 ASN B  31
GLY B  61
SER G  53
GLY G  26
MET G  34
 None
 1.35A 2y6rC-4p2cB:
undetectable		 2y6rC-4p2cB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		PF06722
(DUF1205) 		5 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.37A 2y6rC-4rihA:
3.1		 2y6rC-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 ASP A 306
HIS A  31
GLY A 177
SER A 182
GLY A 309
 None
 1.24A 2y6rC-5cslA:
undetectable		 2y6rC-5cslA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 ASP A 328
PHE A 202
HIS A 192
GLY A 201
SER A 150
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.6A)
 1.33A 2y6rC-5eefA:
undetectable		 2y6rC-5eefA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 5 PHE B 583
HIS B 573
GLY B 582
SER B 531
GLY B 713
 None
 1.36A 2y6rC-5efnB:
undetectable		 2y6rC-5efnB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		5 ASP A 353
GLN A 288
GLY A  61
SER A  55
GLY A 355
 None
 1.15A 2y6rC-5ghfA:
undetectable		 2y6rC-5ghfA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
 None
 1.36A 2y6rC-5l3dA:
13.2		 2y6rC-5l3dA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 ASP A  41
HIS A 108
GLY A 160
SER A 178
GLY A 151
 None
 1.34A 2y6rC-5ot4A:
undetectable		 2y6rC-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 5 ASP B 252
ASN B  58
ARG B 261
GLY B  55
GLY B 221
 None
GSH  B 302 ( 2.9A)
None
EDO  B 306 ( 3.0A)
None
 1.47A 2y6rC-5uuoB:
undetectable		 2y6rC-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 5 ASP B 252
ASN B  58
ARG B 261
GLY B  59
GLY B 221
 None
GSH  B 302 ( 2.9A)
None
None
None
 1.16A 2y6rC-5uuoB:
undetectable		 2y6rC-5uuoB:
undetectable