SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y6R_B_CTCB1385

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis
virus;
Cricket
paralysis
virus;
Cricket
paralysis virus) 		PF08762
(CRPV_capsid)
no annotation
no annotation 		4 GLN A   7
MET B 185
PRO C  63
GLY B 169
 None
 0.91A 2y6rB-1b35A:
undetectable		 2y6rB-1b35A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cv8 STAPHOPAIN

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47) 		4 GLN A  18
GLY A  22
GLY A 107
MET A  70
 E64  A 176 (-3.3A)
E64  A 176 (-3.2A)
None
E64  A 176 ( 3.8A)
 0.88A 2y6rB-1cv8A:
undetectable		 2y6rB-1cv8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4o NADP(H)
TRANSHYDROGENASE

(Bos taurus) 		PF02233
(PNTB) 		4 ARG A  66
GLY A  69
PRO A  29
GLY A 105
 NAP  A 201 (-2.7A)
None
None
NAP  A 201 (-4.0A)
 0.79A 2y6rB-1d4oA:
2.7		 2y6rB-1d4oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 GLY A  12
PRO A  54
GLY A  53
MET A 116
 None
 0.79A 2y6rB-1eqwA:
undetectable		 2y6rB-1eqwA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLN A 366
GLY A 260
GLY A 600
MET A  42
 None
None
None
R03  A 800 ( 4.9A)
 0.76A 2y6rB-1h39A:
undetectable		 2y6rB-1h39A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6x AUTOINDUCER-2
PRODUCTION PROTEIN
LUXS

(Helicobacter
pylori) 		PF02664
(LuxS) 		4 PHE A  41
GLY A  83
GLY A 132
MET A 105
 None
 0.93A 2y6rB-1j6xA:
undetectable		 2y6rB-1j6xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ARG A 352
PHE A 354
PRO A 150
GLY A 325
 None
 0.89A 2y6rB-1k4qA:
11.0		 2y6rB-1k4qA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 ARG A 253
GLY A 427
PRO A  83
GLY A  81
 None
None
None
SO4  A 601 ( 3.8A)
 0.96A 2y6rB-1kzhA:
3.5		 2y6rB-1kzhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 None
TEI  A3006 (-3.6A)
None
None
 0.84A 2y6rB-1n5xA:
undetectable		 2y6rB-1n5xA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 GLN A 466
GLY A 464
GLY A 416
MET A 394
 None
 0.95A 2y6rB-1pixA:
undetectable		 2y6rB-1pixA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME
ALPHA-TYPE SUBUNIT 1
PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis;
Rhodococcus
erythropolis) 		PF00227
(Proteasome)
PF00227
(Proteasome) 		4 ARG A 218
PHE A 220
GLY A  61
GLY H  71
 None
 0.90A 2y6rB-1q5qA:
undetectable		 2y6rB-1q5qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A 111
GLY A 126
GLY A  59
MET A 295
 None
HEM  A 501 (-3.8A)
None
None
 0.93A 2y6rB-1si8A:
undetectable		 2y6rB-1si8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02233
(PNTB) 		4 ARG A  89
GLY A  92
PRO A  52
GLY A 128
 NDP  A 300 (-3.1A)
None
None
NDP  A 300 (-3.6A)
 0.95A 2y6rB-1u31A:
3.0		 2y6rB-1u31A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 ARG A  63
GLY A 394
PRO A 402
GLY A 399
 GOL  A1435 (-4.6A)
GOL  A1435 ( 4.6A)
None
None
 0.84A 2y6rB-1uz4A:
undetectable		 2y6rB-1uz4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 GLN A 234
GLY A 230
PRO A 199
GLY A 194
 None
 0.83A 2y6rB-1wkyA:
undetectable		 2y6rB-1wkyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		4 PHE A 367
GLY A 368
PRO A 318
GLY A 322
 None
 0.83A 2y6rB-1ybeA:
undetectable		 2y6rB-1ybeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		4 PHE A 150
GLY A 148
GLY A  81
MET A 120
 None
 0.74A 2y6rB-2bwmA:
undetectable		 2y6rB-2bwmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ARG A 317
GLY A  51
PRO A  83
MET A 361
 FAD  A1524 ( 4.8A)
FAD  A1524 ( 4.8A)
COM  A1525 ( 4.2A)
FAD  A1524 ( 3.6A)
 0.95A 2y6rB-2c3dA:
8.8		 2y6rB-2c3dA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 PHE A 113
PRO A  95
GLY A  93
MET A 159
 None
 0.79A 2y6rB-2cw2A:
undetectable		 2y6rB-2cw2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		4 MET A 189
PHE A 194
GLY A  29
GLY A  81
 None
 0.93A 2y6rB-2d2eA:
undetectable		 2y6rB-2d2eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
 None
 1.27A 2y6rB-2dw4A:
13.6		 2y6rB-2dw4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		4 PHE A 394
GLY A 352
GLY A 369
MET A 347
 None
 0.90A 2y6rB-2e9qA:
undetectable		 2y6rB-2e9qA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 GLN A 147
MET A 213
GLY A 175
GLY A 166
 None
 0.92A 2y6rB-2f02A:
undetectable		 2y6rB-2f02A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 MET A 426
PHE A 353
GLY A 352
GLY A 468
 None
 0.89A 2y6rB-2fj0A:
undetectable		 2y6rB-2fj0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		4 PHE A 150
GLY A 145
GLY A 213
MET A  14
 None
 0.82A 2y6rB-2vqxA:
undetectable		 2y6rB-2vqxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 348
PHE B 344
GLY B 345
GLY B 230
 None
HPA  B1780 (-3.4A)
None
None
 0.91A 2y6rB-2w55B:
undetectable		 2y6rB-2w55B:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		4 GLY A  22
PRO A  72
GLY A  64
MET A 133
 None
 0.80A 2y6rB-2wwoA:
undetectable		 2y6rB-2wwoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A  47
GLY A  48
GLY A 321
MET A 279
 None
 0.77A 2y6rB-2y24A:
undetectable		 2y6rB-2y24A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycd GLUTATHIONE
S-TRANSFERASE

(Agrobacterium
tumefaciens) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLN A 105
PRO A 102
GLY A  99
MET A 115
 None
 0.90A 2y6rB-2ycdA:
undetectable		 2y6rB-2ycdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 PHE A  76
GLY A 314
GLY A 195
MET A 280
 None
 0.89A 2y6rB-2yp1A:
undetectable		 2y6rB-2yp1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ARG A  88
PHE A  90
GLY A  91
GLY A 314
 None
 0.94A 2y6rB-2ys6A:
4.0		 2y6rB-2ys6A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 194
GLY A 244
 None
A5A  A 801 (-2.7A)
None
A5A  A 801 (-4.0A)
 0.82A 2y6rB-2ztgA:
undetectable		 2y6rB-2ztgA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 GLN A 122
PHE A 116
GLY A 117
GLY A 151
 None
 0.96A 2y6rB-2zucA:
undetectable		 2y6rB-2zucA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 195
GLY A 250
 None
A5A  A 999 (-3.0A)
None
A5A  A 999 (-3.5A)
 0.63A 2y6rB-2zzgA:
undetectable		 2y6rB-2zzgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f13 PUTATIVE NUDIX
HYDROLASE FAMILY
MEMBER

(Chromobacterium
violaceum) 		PF00293
(NUDIX) 		4 GLN A  95
GLY A  94
PRO A  27
GLY A  29
 None
 0.89A 2y6rB-3f13A:
undetectable		 2y6rB-3f13A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ARG A  65
GLY A 374
PRO A 138
GLY A 140
 None
 0.92A 2y6rB-3fedA:
undetectable		 2y6rB-3fedA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 GLN A 469
GLY A 467
GLY A 419
MET A 397
 None
 0.95A 2y6rB-3gf7A:
undetectable		 2y6rB-3gf7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		4 GLN A1051
GLY A1147
PRO A1078
GLY A1082
 None
 0.88A 2y6rB-3hx6A:
undetectable		 2y6rB-3hx6A:
26.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		4 PHE A 219
GLY A 203
PRO A 310
GLY A 308
 None
FAD  A 371 (-3.5A)
None
None
 0.94A 2y6rB-3if9A:
15.0		 2y6rB-3if9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbc NANOBODY VHH PVSP29F

(Camelus
dromedarius) 		PF07686
(V-set) 		4 MET 7  83
PHE 7  68
GLY 7  66
GLY 7  47
 None
 0.82A 2y6rB-3jbc7:
undetectable		 2y6rB-3jbc7:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLN A 330
PHE A 103
GLY A 324
GLY A  99
 None
 0.93A 2y6rB-3k5pA:
4.2		 2y6rB-3k5pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 0.82A 2y6rB-3kl0A:
undetectable		 2y6rB-3kl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		4 GLY A 226
PRO A  14
GLY A  16
MET A 322
 None
 0.92A 2y6rB-3l5aA:
undetectable		 2y6rB-3l5aA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 GLN A 209
PHE A 183
GLY A 208
GLY A 237
 None
 0.95A 2y6rB-3ojaA:
undetectable		 2y6rB-3ojaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN

(Homo sapiens) 		PF05743
(UEV) 		4 GLY A 107
PRO A  71
GLY A  57
MET A 131
 None
 0.87A 2y6rB-3p9hA:
undetectable		 2y6rB-3p9hA:
15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		7 GLN A 192
ARG A 213
MET A 215
GLY A 236
PRO A 318
GLY A 321
MET A 375
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
None
None
FAD  A 401 (-4.4A)
None
None
 0.91A 2y6rB-3p9uA:
56.7		 2y6rB-3p9uA:
94.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 GLN A 419
PHE A 423
GLY A 424
GLY A 400
 None
 0.93A 2y6rB-3pdiA:
undetectable		 2y6rB-3pdiA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		4 ARG A 119
GLY A 255
GLY A   9
MET A 134
 None
 0.90A 2y6rB-3qatA:
undetectable		 2y6rB-3qatA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 ARG M 273
PHE M 131
GLY M 129
GLY M  85
 None
 0.95A 2y6rB-3rkoM:
undetectable		 2y6rB-3rkoM:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN C 918
PHE C 914
GLY C 915
GLY C 800
 None
RMO  C1317 (-3.6A)
None
None
 0.85A 2y6rB-3sr6C:
undetectable		 2y6rB-3sr6C:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqj SUPEROXIDE DISMUTASE
[FE]

(Coxiella
burnetii) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 PHE A 107
PRO A  89
GLY A  87
MET A 154
 None
 0.89A 2y6rB-3tqjA:
undetectable		 2y6rB-3tqjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 194
GLY A 244
 None
A5A  A1001 (-3.4A)
None
A5A  A1001 (-3.7A)
 0.62A 2y6rB-3wqyA:
undetectable		 2y6rB-3wqyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 923
PHE A 919
GLY A 920
GLY A 805
 None
 0.69A 2y6rB-3zyvA:
undetectable		 2y6rB-3zyvA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 ARG A 676
GLY A 804
GLY A 580
MET A 690
 None
 0.94A 2y6rB-4ammA:
undetectable		 2y6rB-4ammA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		4 ARG A  78
PHE A  97
GLY A 116
GLY A 101
 None
None
EDO  A1201 ( 3.8A)
None
 0.87A 2y6rB-4b29A:
undetectable		 2y6rB-4b29A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 GLN A  98
PHE A 103
GLY A 102
PRO A 312
 None
 0.93A 2y6rB-4djiA:
undetectable		 2y6rB-4djiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE

(Bacillus
anthracis) 		no annotation 4 GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 0.78A 2y6rB-4fetB:
undetectable		 2y6rB-4fetB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A  19
GLY A  20
GLY A 297
MET A 254
 None
 0.76A 2y6rB-4fmvA:
undetectable		 2y6rB-4fmvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		4 GLN A 179
ARG A 370
GLY A 198
GLY A  30
 None
 0.80A 2y6rB-4iheA:
undetectable		 2y6rB-4iheA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ARG C 336
GLY C 339
PRO C 299
GLY C 375
 NAP  C 501 (-2.5A)
None
None
NAP  C 501 (-3.8A)
 0.92A 2y6rB-4j16C:
3.7		 2y6rB-4j16C:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 ARG A 621
PHE A 614
GLY A 254
GLY A 304
 None
 0.88A 2y6rB-4jc8A:
undetectable		 2y6rB-4jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 PHE A 157
GLY A 610
PRO A 245
MET A 465
 None
 0.92A 2y6rB-4jc8A:
undetectable		 2y6rB-4jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd6 ENOYL-COA
HYDRATASE/ISOMERASE

(Paraburkholderia
graminis) 		PF00378
(ECH_1) 		4 MET A 129
PHE A 112
GLY A 109
GLY A 118
 None
 0.70A 2y6rB-4kd6A:
undetectable		 2y6rB-4kd6A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 GLY A  16
PRO A  66
GLY A  58
MET A 126
 None
 0.84A 2y6rB-4l05A:
undetectable		 2y6rB-4l05A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mec HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		5 GLN A 145
PHE A 167
GLY A 144
GLY A 161
MET A  51
 None
 1.49A 2y6rB-4mecA:
undetectable		 2y6rB-4mecA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ARG B 336
GLY B 339
PRO B 299
GLY B 375
 NAP  B 500 (-2.3A)
None
None
NAP  B 500 (-3.7A)
 0.90A 2y6rB-4o9uB:
3.0		 2y6rB-4o9uB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 PHE A  39
GLY A 111
PRO A 130
GLY A 126
 None
 0.95A 2y6rB-4q3kA:
undetectable		 2y6rB-4q3kA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 PHE A  18
GLY A  19
GLY A 299
MET A 256
 None
 0.81A 2y6rB-4qawA:
undetectable		 2y6rB-4qawA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ARG A 217
GLY A 350
GLY A 101
MET A 229
 FMT  A 500 (-2.9A)
None
None
None
 0.63A 2y6rB-4qbuA:
undetectable		 2y6rB-4qbuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		4 ARG A 113
GLY A 240
GLY A   9
MET A 125
 ACT  A 301 (-3.3A)
None
None
None
 0.91A 2y6rB-4rr5A:
undetectable		 2y6rB-4rr5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 GLN A 230
PHE A 222
GLY A 226
GLY A 290
 None
None
None
GOL  A 504 (-3.2A)
 0.92A 2y6rB-4x8dA:
undetectable		 2y6rB-4x8dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 MET A 207
GLY A 210
PRO A 145
GLY A 147
 499  A 401 ( 3.7A)
499  A 401 (-3.4A)
499  A 401 (-4.2A)
499  A 401 (-3.3A)
 0.77A 2y6rB-4y85A:
undetectable		 2y6rB-4y85A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 BCT  A3006 (-3.0A)
URC  A3007 ( 3.4A)
BCT  A3006 (-3.9A)
None
 0.81A 2y6rB-4yswA:
undetectable		 2y6rB-4yswA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		4 PHE A  20
GLY A  21
GLY A 297
MET A 252
 None
 0.89A 2y6rB-5cxpA:
undetectable		 2y6rB-5cxpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ARG A1111
GLY A1103
PRO A1024
GLY A1026
 None
 0.84A 2y6rB-5ehkA:
undetectable		 2y6rB-5ehkA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 927
PHE A 923
GLY A 924
GLY A 809
 None
MOS  A3005 (-4.2A)
None
None
 0.70A 2y6rB-5epgA:
undetectable		 2y6rB-5epgA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 PHE A 298
GLY A 297
GLY A 101
MET A 288
 None
 0.71A 2y6rB-5f9aA:
undetectable		 2y6rB-5f9aA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1) 		PF09408
(Spike_rec_bind) 		4 GLN A 535
PHE A 574
GLY A 550
GLY A 557
 None
 0.78A 2y6rB-5gnbA:
undetectable		 2y6rB-5gnbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxy TYROSINE RECOMBINASE
XERA

(Thermoplasma
acidophilum) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		4 ARG A 247
PHE A 248
GLY A 244
GLY A 254
 PO4  A 302 (-3.0A)
None
None
None
 0.94A 2y6rB-5hxyA:
undetectable		 2y6rB-5hxyA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 GLN A  12
GLY A  17
PRO A  33
GLY A  30
 None
 0.94A 2y6rB-5i92A:
undetectable		 2y6rB-5i92A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Aspergillus
nidulans) 		PF00579
(tRNA-synt_1b) 		4 PHE A 306
GLY A 309
PRO A 251
GLY A 254
 None
 0.87A 2y6rB-5ihxA:
undetectable		 2y6rB-5ihxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VHH 12B

(Camelus
dromedarius) 		PF07686
(V-set) 		4 MET 7  83
PHE 7  68
GLY 7  66
GLY 7  47
 None
 0.94A 2y6rB-5ktz7:
undetectable		 2y6rB-5ktz7:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
 None
 1.36A 2y6rB-5l3dA:
3.7		 2y6rB-5l3dA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		4 GLN A1840
PHE A1927
GLY A1933
MET A1867
 None
 0.91A 2y6rB-5mptA:
2.3		 2y6rB-5mptA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nc6 PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		no annotation 4 ARG A 272
MET A 273
GLY A 185
GLY A 176
 None
 0.93A 2y6rB-5nc6A:
undetectable		 2y6rB-5nc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nek PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		no annotation 4 ARG A 272
MET A 273
GLY A 185
GLY A 176
 None
 0.88A 2y6rB-5nekA:
undetectable		 2y6rB-5nekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		4 PHE A 291
GLY A 288
PRO A 349
GLY A 338
 None
 0.89A 2y6rB-5nnoA:
2.0		 2y6rB-5nnoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 PHE L  98
GLY L  99
GLY H  60
MET H 100
 None
 0.71A 2y6rB-5u3pL:
undetectable		 2y6rB-5u3pL:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ARG A 324
PHE A 326
PRO A 133
GLY A 297
 None
 0.85A 2y6rB-5v36A:
10.9		 2y6rB-5v36A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6c HEMOLYSIN-RELATED
PROTEIN

(Vibrio cholerae) 		no annotation 4 PHE A 953
GLY A 952
PRO A 824
GLY A 822
 None
 0.93A 2y6rB-5v6cA:
undetectable		 2y6rB-5v6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 GLN A  60
PHE A 312
GLY A 313
GLY A 380
 None
CL  A 601 (-3.6A)
None
None
 0.90A 2y6rB-5vj1A:
undetectable		 2y6rB-5vj1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		4 GLN B  79
GLY B  82
GLY B 148
MET B 163
 None
 0.87A 2y6rB-5w3lB:
undetectable		 2y6rB-5w3lB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 GLN A  56
ARG A 322
GLY A 440
GLY A 289
 None
 0.83A 2y6rB-5xgvA:
27.4		 2y6rB-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 ARG A 175
GLY A 169
PRO A 238
GLY A 242
 SAM  A 601 ( 4.2A)
None
SAM  A 601 ( 4.8A)
None
 0.90A 2y6rB-5ybbA:
2.5		 2y6rB-5ybbA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 4 GLN A 300
ARG A 558
PHE A 415
GLY A 425
 None
 0.89A 2y6rB-5zibA:
2.3		 2y6rB-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 4 GLN A 300
ARG A 558
PHE A 415
GLY A 425
 None
 0.94A 2y6rB-5zicA:
undetectable		 2y6rB-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 ARG A 323
PHE A 325
PRO A 132
GLY A 296
 None
 0.87A 2y6rB-6b4oA:
4.2		 2y6rB-6b4oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		4 ARG L  54
GLY L  47
PRO K 146
GLY K 153
 None
 0.93A 2y6rB-6cfwL:
undetectable		 2y6rB-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 MET A 196
PHE A 199
GLY A 202
GLY A 225
 None
 0.95A 2y6rB-6fn1A:
undetectable		 2y6rB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 GLY F 417
PRO F 299
GLY F 301
MET F 337
 None
 0.95A 2y6rB-6g2jF:
undetectable		 2y6rB-6g2jF:
undetectable