SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y6O_A_1N1A1892_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.72A 2y6oA-1k2pA:
26.5		 2y6oA-1k2pA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.78A 2y6oA-1k9aA:
33.3		 2y6oA-1k9aA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ILE A 201
ALA A 220
LYS A 222
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.82A 2y6oA-1k9aA:
33.3		 2y6oA-1k9aA:
27.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 580
ALA A 606
LYS A 608
MET A 629
TYR A 656
GLY A 660
LEU A 731
 None
 1.15A 2y6oA-1lufA:
34.1		 2y6oA-1lufA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.61A 2y6oA-1opkA:
31.7		 2y6oA-1opkA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ILE A 211
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.70A 2y6oA-1py5A:
26.1		 2y6oA-1py5A:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.52A 2y6oA-1t46A:
33.0		 2y6oA-1t46A:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
LEU A 158
 None
 0.78A 2y6oA-1u5qA:
24.8		 2y6oA-1u5qA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.76A 2y6oA-1zltA:
21.2		 2y6oA-1zltA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LYS X  15
ALA X  37
LYS X  39
GLU X  54
MET X  58
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 None
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.82A 2y6oA-2dq7X:
32.6		 2y6oA-2dq7X:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.51A 2y6oA-2h8hA:
30.6		 2y6oA-2h8hA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 635
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.85A 2y6oA-2henA:
38.8		 2y6oA-2henA:
81.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.87A 2y6oA-2henA:
38.8		 2y6oA-2henA:
81.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 2y6oA-2hk5A:
28.1		 2y6oA-2hk5A:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
MET A 290
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.69A 2y6oA-2hz0A:
31.9		 2y6oA-2hz0A:
38.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 ILE A 428
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.85A 2y6oA-2j0jA:
34.4		 2y6oA-2j0jA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 428
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.75A 2y6oA-2jkmA:
34.6		 2y6oA-2jkmA:
41.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.67A 2y6oA-2og8A:
33.2		 2y6oA-2og8A:
43.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LYS A 625
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.02A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LYS A 625
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.08A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.62A 2y6oA-2r2pA:
37.6		 2y6oA-2r2pA:
86.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.77A 2y6oA-2r2pA:
37.6		 2y6oA-2r2pA:
86.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LYS A  80
ILE A  82
ALA A 103
LYS A 105
GLU A 124
MET A 128
TYR A 155
GLY A 159
LEU A 205
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
 1.06A 2y6oA-2v55A:
18.6		 2y6oA-2v55A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 2y6oA-2xikA:
20.4		 2y6oA-2xikA:
29.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 ILE A 627
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
TYR A 701
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.32A 2y6oA-2xyuA:
34.3		 2y6oA-2xyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LYS A 251
ALA A 273
LYS A 275
GLU A 290
MET A 294
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.96A 2y6oA-2zv7A:
27.1		 2y6oA-2zv7A:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.75A 2y6oA-3b2tA:
26.5		 2y6oA-3b2tA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 485
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 None
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 1.08A 2y6oA-3b2tA:
26.5		 2y6oA-3b2tA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 482
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
 1.00A 2y6oA-3c4fA:
31.9		 2y6oA-3c4fA:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.78A 2y6oA-3d7uA:
29.4		 2y6oA-3d7uA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A 201
ALA A 220
LYS A 222
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.82A 2y6oA-3d7uA:
29.4		 2y6oA-3d7uA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ILE A 639
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.57A 2y6oA-3dkoA:
37.6		 2y6oA-3dkoA:
75.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A 209
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.74A 2y6oA-3g2fA:
19.7		 2y6oA-3g2fA:
27.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 831
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
LEU A1029
 None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
 0.87A 2y6oA-3hngA:
31.9		 2y6oA-3hngA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 LYS A  57
ILE A  59
ALA A  80
LYS A  82
MET A 104
TYR A 131
GLY A 135
LEU A 182
 None
 0.72A 2y6oA-3iecA:
23.1		 2y6oA-3iecA:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.69A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.60A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 LYS A 639
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 1.08A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 LYS A 639
ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 1.03A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		9 LYS A 208
ILE A 210
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 None
LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.59A 2y6oA-3mdyA:
25.8		 2y6oA-3mdyA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.47A 2y6oA-3my0A:
25.4		 2y6oA-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
GLU A 130
MET A 134
TYR A 161
GLY A 165
LEU A 212
 JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.77A 2y6oA-3nuuA:
23.8		 2y6oA-3nuuA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 ILE A 557
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.82A 2y6oA-3ppzA:
29.4		 2y6oA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 ILE A 557
ALA A 576
LYS A 578
MET A 600
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.67A 2y6oA-3ppzA:
29.4		 2y6oA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  80
ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
 None
None
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
 0.80A 2y6oA-3qfvA:
18.8		 2y6oA-3qfvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
LEU A 467
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
 0.84A 2y6oA-3s95A:
20.1		 2y6oA-3s95A:
29.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
LYS A 445
ILE A 487
THR A 489
TYR A 491
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.78A 2y6oA-3sxsA:
31.9		 2y6oA-3sxsA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LYS A 421
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 None
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.55A 2y6oA-3sxsA:
31.9		 2y6oA-3sxsA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 482
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
 None
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
 0.82A 2y6oA-3tt0A:
32.4		 2y6oA-3tt0A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 482
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
 None
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.80A 2y6oA-3tt0A:
32.4		 2y6oA-3tt0A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 625
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.77A 2y6oA-3zfxA:
38.6		 2y6oA-3zfxA:
80.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ILE A 625
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.79A 2y6oA-3zfxA:
38.6		 2y6oA-3zfxA:
80.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LYS A  81
ILE A  83
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
LEU A 208
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.86A 2y6oA-4aw2A:
19.7		 2y6oA-4aw2A:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ILE A  97
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.77A 2y6oA-4aw5A:
32.4		 2y6oA-4aw5A:
76.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LYS A 244
ALA A 267
LYS A 269
GLU A 288
TYR A 320
GLY A 324
LEU A 371
 None
 0.88A 2y6oA-4c0tA:
22.5		 2y6oA-4c0tA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 ILE A 567
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.82A 2y6oA-4e93A:
34.9		 2y6oA-4e93A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.70A 2y6oA-4f4pA:
26.9		 2y6oA-4f4pA:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  64
ALA A  88
LYS A  90
GLU A 104
ILE A 132
TYR A 136
LEU A 184
 None
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
None
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.9A)
 0.62A 2y6oA-4f99A:
15.5		 2y6oA-4f99A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ILE A 327
ALA A 348
LYS A 350
GLU A 366
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 1.01A 2y6oA-4fieA:
22.6		 2y6oA-4fieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ILE A 327
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 1.01A 2y6oA-4fieA:
22.6		 2y6oA-4fieA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.66A 2y6oA-4k33A:
33.0		 2y6oA-4k33A:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 476
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
LEU A 624
 None
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
 0.76A 2y6oA-4k33A:
33.0		 2y6oA-4k33A:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  54
LYS A  56
MET A  74
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.80A 2y6oA-4lg4A:
18.7		 2y6oA-4lg4A:
27.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.89A 2y6oA-4lggA:
31.8		 2y6oA-4lggA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.66A 2y6oA-4o27B:
19.5		 2y6oA-4o27B:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.75A 2y6oA-4o38A:
21.3		 2y6oA-4o38A:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 LYS A 617
ILE A 619
ALA A 644
GLU A 663
ILE A 690
THR A 692
TYR A 694
GLY A 698
LEU A 746
SER A 756
 None
 0.97A 2y6oA-4p2kA:
37.1		 2y6oA-4p2kA:
74.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 LYS A 617
ILE A 619
ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
TYR A 694
LEU A 746
SER A 756
 None
 1.09A 2y6oA-4p2kA:
37.1		 2y6oA-4p2kA:
74.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 LYS A 617
ILE A 619
LYS A 646
GLU A 663
MET A 667
ILE A 690
TYR A 694
 None
 1.34A 2y6oA-4p2kA:
37.1		 2y6oA-4p2kA:
74.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.54A 2y6oA-4ueuA:
33.7		 2y6oA-4ueuA:
45.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.74A 2y6oA-4ueuA:
33.7		 2y6oA-4ueuA:
45.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ILE A 327
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 None
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
None
None
ATP  A 601 ( 4.6A)
 0.81A 2y6oA-4xbrA:
17.3		 2y6oA-4xbrA:
24.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 ALA B 288
LYS B 290
MET B 309
ILE B 332
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.61A 2y6oA-4xeyB:
28.0		 2y6oA-4xeyB:
31.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LYS A 406
ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.95A 2y6oA-4xi2A:
30.4		 2y6oA-4xi2A:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.68A 2y6oA-4y93A:
31.6		 2y6oA-4y93A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
ILE A 537
THR A 539
TYR A 541
GLY A 545
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.68A 2y6oA-4yffA:
26.4		 2y6oA-4yffA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
LYS A 490
GLU A 509
ILE A 537
THR A 539
TYR A 541
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
 0.60A 2y6oA-4yffA:
26.4		 2y6oA-4yffA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
ALA A 488
LYS A 490
ILE A 537
THR A 539
TYR A 541
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.56A 2y6oA-4yffA:
26.4		 2y6oA-4yffA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.78A 2y6oA-5ci7A:
23.7		 2y6oA-5ci7A:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.62A 2y6oA-5grnA:
27.0		 2y6oA-5grnA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LYS A  84
ALA A 105
ILE A 146
THR A 148
TYR A 150
GLY A 154
LEU A 215
 None
 0.50A 2y6oA-5gz8A:
19.6		 2y6oA-5gz8A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  77
MET A  99
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.44A 2y6oA-5i3oA:
22.8		 2y6oA-5i3oA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  22
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.74A 2y6oA-5j5tA:
22.3		 2y6oA-5j5tA:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 716
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 None
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.40A 2y6oA-5j9zA:
34.1		 2y6oA-5j9zA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 276
ALA A 297
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.45A 2y6oA-5kbrA:
22.5		 2y6oA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
LEU A 338
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.64A 2y6oA-5ko1A:
28.2		 2y6oA-5ko1A:
28.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 639
ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
LEU A 765
SER A 775
 6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
6P6  A1001 ( 3.7A)
 0.63A 2y6oA-5l6oA:
37.5		 2y6oA-5l6oA:
81.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
SER A1026
 None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
 0.63A 2y6oA-5lpyA:
24.1		 2y6oA-5lpyA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.70A 2y6oA-5lpzA:
23.9		 2y6oA-5lpzA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
GLY A  92
LEU A 139
 7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
None
7LV  A 401 (-4.9A)
 0.85A 2y6oA-5tvtA:
23.1		 2y6oA-5tvtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
 None
 0.76A 2y6oA-5u7qA:
19.6		 2y6oA-5u7qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LYS A  96
ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
 None
 1.02A 2y6oA-5u7qA:
19.6		 2y6oA-5u7qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 ALA A 707
LYS A 709
GLU A 725
ILE A 752
GLY A 760
LEU A 810
SER A 821
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-2.7A)
 0.80A 2y6oA-5vilA:
12.6		 2y6oA-5vilA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 ALA A  45
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.47A 2y6oA-5w5jA:
24.6		 2y6oA-5w5jA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 ALA A  49
GLU A  69
MET A  73
TYR A  98
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.64A 2y6oA-5wnmA:
28.4		 2y6oA-5wnmA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.56A 2y6oA-5wnoA:
28.5		 2y6oA-5wnoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 LYS A  64
ILE A  66
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
 None
 0.68A 2y6oA-6c9dA:
22.1		 2y6oA-6c9dA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 LYS A  64
ILE A  66
ALA A  87
LYS A  89
MET A 111
TYR A 138
LEU A 189
 None
 0.91A 2y6oA-6c9dA:
22.1		 2y6oA-6c9dA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 ALA A 211
GLU A 233
MET A 237
TYR A 264
GLY A 268
LEU A 318
SER A 328
 CJT  A 502 (-3.4A)
CJT  A 502 (-3.9A)
None
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.3A)
 1.15A 2y6oA-6f3dA:
24.8		 2y6oA-6f3dA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LYS A 728
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 None
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
ADN  A1104 ( 4.8A)
 0.77A 2y6oA-6fekA:
31.6		 2y6oA-6fekA:
13.78