SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y5M_E_DVAE6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebp EPO RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 ALA A 123
VAL A 196
TRP A 212
TRP A 142
 None
 1.49A 2y5mE-1ebpA:
undetectable
2y5mF-1ebpA:
undetectable		 2y5mE-1ebpA:
6.94
2y5mF-1ebpA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 ALA A 176
VAL A 171
TRP A 188
TRP A 174
 None
 1.33A 2y5mE-4pxnA:
undetectable
2y5mF-4pxnA:
undetectable		 2y5mE-4pxnA:
2.60
2y5mF-4pxnA:
2.60