SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y5M_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 VAL A 304
TRP A 313
VAL A 249
TRP A 305
 None
 1.39A 2y5mA-1clxA:
undetectable
2y5mB-1clxA:
undetectable		 2y5mA-1clxA:
8.70
2y5mB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		4 VAL A 551
TRP A 560
VAL A 500
TRP A 552
 None
XYP  A1609 ( 4.0A)
None
XYP  A1609 ( 4.1A)
 1.36A 2y5mA-1us2A:
undetectable
2y5mB-1us2A:
undetectable		 2y5mA-1us2A:
3.14
2y5mB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		4 VAL A  23
TRP A 300
VAL A 298
TRP A 292
 None
XYP  A 402 (-4.1A)
None
XYP  A 401 (-4.2A)
 1.36A 2y5mA-3w25A:
undetectable
2y5mB-3w25A:
undetectable		 2y5mA-3w25A:
3.79
2y5mB-3w25A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 4 VAL A 288
TRP A 297
VAL A 252
TRP A 289
 None
CBI  A 404 (-4.2A)
None
CBI  A 404 (-4.0A)
 1.41A 2y5mA-5xzuA:
undetectable
2y5mB-5xzuA:
undetectable		 2y5mA-5xzuA:
undetectable
2y5mB-5xzuA:
undetectable