SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y5M_A_DVAA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 VAL A 204
TRP A 211
TRP A 130
TRP A 136
 None
 1.36A 2y5mA-2vowA:
undetectable
2y5mB-2vowA:
undetectable		 2y5mA-2vowA:
3.65
2y5mB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 ALA A 205
VAL A 224
TRP A 246
TRP A 207
 None
None
None
EDO  A 490 (-3.5A)
 1.39A 2y5mA-3b9tA:
undetectable
2y5mB-3b9tA:
undetectable		 2y5mA-3b9tA:
3.02
2y5mB-3b9tA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 317
VAL A 315
TRP A  23
TRP A 339
 None
 1.40A 2y5mA-4e4uA:
undetectable
2y5mB-4e4uA:
undetectable		 2y5mA-4e4uA:
4.02
2y5mB-4e4uA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 ALA A 176
VAL A 171
TRP A 188
TRP A 174
 None
 1.43A 2y5mA-4pxnA:
undetectable
2y5mB-4pxnA:
undetectable		 2y5mA-4pxnA:
2.60
2y5mB-4pxnA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 ALA A 103
VAL A 105
TRP A 407
TRP A  66
 None
 1.40A 2y5mA-5xd0A:
undetectable
2y5mB-5xd0A:
undetectable		 2y5mA-5xd0A:
2.49
2y5mB-5xd0A:
2.49