SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y4N_B_PACB503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		4 SER A  78
GLY A 324
GLY A  49
LYS A  51
 SO4  A 940 (-2.7A)
PLP  A 342 (-4.0A)
None
PLP  A 342 ( 1.3A)
 1.39A 2y4nB-1f2dA:
1.0		 2y4nB-1f2dA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		4 SER A 478
GLY A 486
GLY A 337
LYS A 335
 None
 1.32A 2y4nB-1rh1A:
undetectable		 2y4nB-1rh1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 SER A 165
GLY A 176
GLY A 225
LYS A 224
 None
 1.37A 2y4nB-1zl6A:
0.1		 2y4nB-1zl6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 SER A 105
GLY A 156
GLY A 136
LYS A 132
 None
 1.17A 2y4nB-2eceA:
0.0		 2y4nB-2eceA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 SER A 354
GLY A 362
GLY A 165
LYS A 166
 None
 1.35A 2y4nB-2i0zA:
undetectable		 2y4nB-2i0zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		4 SER A 176
GLY A   7
GLY A  13
LYS A  14
 A2R  A 401 ( 4.7A)
A2R  A 401 ( 4.1A)
None
None
 1.36A 2y4nB-2pk3A:
3.8		 2y4nB-2pk3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 SER A 965
GLY A 603
GLY A 450
LYS A 446
 None
 0.97A 2y4nB-2q1fA:
undetectable		 2y4nB-2q1fA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		4 SER A 201
GLY A 197
GLY A 222
LYS A 223
 None
SO4  A1242 (-3.4A)
SO4  A1242 (-3.6A)
None
 1.33A 2y4nB-2x30A:
3.4		 2y4nB-2x30A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		4 SER A 259
GLY A  25
GLY A 265
LYS A 266
 None
None
None
PO4  A 304 (-2.9A)
 1.01A 2y4nB-3e0fA:
0.1		 2y4nB-3e0fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f67 PUTATIVE
DIENELACTONE
HYDROLASE

(Klebsiella
pneumoniae) 		PF01738
(DLH) 		4 SER A 154
GLY A 122
GLY A 144
LYS A 145
 None
 1.30A 2y4nB-3f67A:
2.5		 2y4nB-3f67A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 SER A 206
GLY A 215
GLY A 197
LYS A 196
 None
 0.98A 2y4nB-3m1tA:
undetectable		 2y4nB-3m1tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		no annotation
PF02136
(NTF2) 		4 SER A 328
GLY B  89
GLY B 120
LYS B 129
 PEG  B1004 ( 4.4A)
None
None
NA  B 456 (-3.8A)
 1.28A 2y4nB-3nv0A:
undetectable		 2y4nB-3nv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 SER A 505
GLY A 346
GLY A 382
LYS A 450
 None
 1.38A 2y4nB-3pf2A:
undetectable		 2y4nB-3pf2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Bacillus
subtilis) 		PF01884
(PcrB) 		4 SER A  40
GLY A 187
GLY A 208
LYS A  12
 None
 1.36A 2y4nB-3vzxA:
3.5		 2y4nB-3vzxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		4 SER A  84
GLY A 214
GLY A 504
LYS A 506
 None
 1.48A 2y4nB-4n4kA:
undetectable		 2y4nB-4n4kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 SER A  65
GLY A 561
GLY A 622
LYS A 635
 None
 1.04A 2y4nB-4zgvA:
undetectable		 2y4nB-4zgvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 SER A 166
GLY A 177
GLY A 226
LYS A 225
 None
 1.10A 2y4nB-4zktA:
undetectable		 2y4nB-4zktA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 SER B 560
GLY B 488
GLY B  44
LYS B  42
 None
 1.18A 2y4nB-5cwwB:
undetectable		 2y4nB-5cwwB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 SER A 741
GLY A 683
GLY A 687
LYS A 689
 None
 1.49A 2y4nB-5hlbA:
undetectable		 2y4nB-5hlbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		4 SER A 111
GLY A 139
GLY A 145
LYS A 146
 None
 1.03A 2y4nB-5ht0A:
undetectable		 2y4nB-5ht0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 322
GLY A 282
GLY A 278
LYS A 264
 None
 1.25A 2y4nB-5i2tA:
undetectable		 2y4nB-5i2tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 SER A 347
GLY A 248
GLY A 492
LYS A 491
 None
None
None
LMR  A 601 ( 2.6A)
 0.92A 2y4nB-5l2rA:
2.3		 2y4nB-5l2rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 SER A 149
GLY A  46
GLY A  41
LYS A  40
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.2A)
 0.97A 2y4nB-5m10A:
undetectable		 2y4nB-5m10A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 SER A 343
GLY A  85
GLY A 279
LYS A 280
 None
 1.23A 2y4nB-5mjuA:
undetectable		 2y4nB-5mjuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nur ABC TRANSPORTER
PERMEASE

(Klebsiella
pneumoniae) 		no annotation 4 SER D 120
GLY D  76
GLY D  81
LYS D  80
 None
 1.45A 2y4nB-5nurD:
undetectable		 2y4nB-5nurD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 SER A 366
GLY A 361
GLY A 173
LYS A 172
 None
 1.47A 2y4nB-5oe5A:
16.5		 2y4nB-5oe5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 SER A  51
GLY A 371
GLY A 305
LYS A 306
 None
 1.24A 2y4nB-5u03A:
3.1		 2y4nB-5u03A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 SER A 144
GLY A 346
GLY A 331
LYS A 330
 None
CA  A 402 ( 4.4A)
None
None
 1.41A 2y4nB-5vf4A:
undetectable		 2y4nB-5vf4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		4 SER A  50
GLY A 237
GLY A 260
LYS A 261
 None
 1.47A 2y4nB-5viuA:
3.6		 2y4nB-5viuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 SER A1885
GLY A1807
GLY A1898
LYS A1897
 None
 1.03A 2y4nB-5y29A:
1.2		 2y4nB-5y29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 4 SER B 214
GLY B 275
GLY B 260
LYS B 259
 None
 1.38A 2y4nB-5zc2B:
undetectable		 2y4nB-5zc2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 SER A 557
GLY A 633
GLY A 635
LYS A 636
 None
 1.28A 2y4nB-6f2tA:
undetectable		 2y4nB-6f2tA:
undetectable