SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y03_A_5FWA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5f MONOCLONAL
ANTI-E-SELECTIN 7A9
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 200
ASN H 162
 None
 1.45A 2y03A-1a5fH:
undetectable		 2y03A-1a5fH:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1e CATALYTIC ANTIBODY
1E9 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.40A 2y03A-1c1eH:
undetectable		 2y03A-1c1eH:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl7 PROTEIN (IGG1
ANTIBODY 1696
(CONSTANT HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set) 		5 VAL I 170
VAL I 188
SER I 186
ASN I 203
ASN I 162
 None
 1.45A 2y03A-1cl7I:
undetectable		 2y03A-1cl7I:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cly IGG FAB (HUMAN IGG1,
KAPPA)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.44A 2y03A-1clyH:
undetectable		 2y03A-1clyH:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.42A 2y03A-1fskC:
undetectable		 2y03A-1fskC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.08A 2y03A-1gy9A:
undetectable		 2y03A-1gy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 164
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 2y03A-1h3pH:
undetectable		 2y03A-1h3pH:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.40A 2y03A-1i9iH:
undetectable		 2y03A-1i9iH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.45A 2y03A-1jnhB:
undetectable		 2y03A-1jnhB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb5 ANTIBODY DESIRE-1

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.38A 2y03A-1kb5H:
undetectable		 2y03A-1kb5H:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfa MONOCLONAL ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 176
VAL H 194
SER H 192
ASN H 209
ASN H 168
 None
 1.39A 2y03A-1kfaH:
undetectable		 2y03A-1kfaH:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL F 171
VAL F 191
SER F 189
ASN F 209
ASN F 162
 None
 1.45A 2y03A-1nfdF:
undetectable		 2y03A-1nfdF:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ngq N1G9 (IGG1-LAMBDA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.45A 2y03A-1ngqH:
undetectable		 2y03A-1ngqH:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.44A 2y03A-1pz5B:
undetectable		 2y03A-1pz5B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rur IMMUNOGLOBULIN 13G5,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.43A 2y03A-1rurH:
undetectable		 2y03A-1rurH:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f58 PROTEIN (IGG1 FAB
58.2 ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.44A 2y03A-2f58H:
undetectable		 2y03A-2f58H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.39A 2y03A-2fl5H:
undetectable		 2y03A-2fl5H:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.44A 2y03A-2g60H:
undetectable		 2y03A-2g60H:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.44A 2y03A-2w9dH:
undetectable		 2y03A-2w9dH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.44A 2y03A-2zchH:
undetectable		 2y03A-2zchH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 174
VAL D 192
SER D 190
ASN D 207
ASN D 166
 None
 1.42A 2y03A-3bquD:
undetectable		 2y03A-3bquD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.40A 2y03A-3cvhH:
undetectable		 2y03A-3cvhH:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.44A 2y03A-3g04B:
undetectable		 2y03A-3g04B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnm JAA-F11 FAB ANTIBODY
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.43A 2y03A-3gnmH:
undetectable		 2y03A-3gnmH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2c CNTO4088 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.44A 2y03A-3i2cH:
undetectable		 2y03A-3i2cH:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 2y03A-3mlxH:
undetectable		 2y03A-3mlxH:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.87A 2y03A-3pblA:
32.3		 2y03A-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.02A 2y03A-3pblA:
32.3		 2y03A-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 196
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.65A 2y03A-3pblA:
32.3		 2y03A-3pblA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 289
PHE A 290
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.0A)
None
 1.32A 2y03A-3pdsA:
38.5		 2y03A-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
SER A 207
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.38A 2y03A-3pdsA:
38.5		 2y03A-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A 117
SER A 204
SER A 207
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 1.42A 2y03A-3pdsA:
38.5		 2y03A-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 117
SER A 207
PHE A 289
ASN A 312
TYR A 316
 None
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
 1.30A 2y03A-3pdsA:
38.5		 2y03A-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sge HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.43A 2y03A-3sgeH:
undetectable		 2y03A-3sgeH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.44A 2y03A-4ag4H:
undetectable		 2y03A-4ag4H:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 171
VAL B 191
SER B 189
ASN B 209
ASN B 162
 None
 1.44A 2y03A-4edxB:
undetectable		 2y03A-4edxB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A 362
SER A  18
SER A 366
PHE A 334
ASN A 330
 None
 1.38A 2y03A-4f4cA:
undetectable		 2y03A-4f4cA:
13.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 TRP A 109
ASP A 113
VAL A 114
SER A 203
PHE A 261
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
 1.39A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 1.48A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		10 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.57A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		9 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
PHE A 261
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 0.65A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 TRP A 109
VAL A 114
PHE A 193
SER A 203
SER A 207
 None
CAU  A 500 (-3.5A)
CAU  A 500 (-4.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
 0.97A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 TRP A 109
VAL A 114
PHE A 193
SER A 207
ASN A 265
 None
CAU  A 500 (-3.5A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-3.4A)
 0.90A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 VAL A 117
PHE A 261
ASN A 265
ASN A 284
TYR A 288
 CAU  A 500 (-4.2A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 1.24A 2y03A-4gbrA:
39.4		 2y03A-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i77 LEBRIKIZUMAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 2y03A-4i77H:
undetectable		 2y03A-4i77H:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.54A 2y03A-4ib4A:
27.6		 2y03A-4ib4A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 159
VAL H 178
SER H 176
ASN H 190
ASN H 151
 None
 1.42A 2y03A-4jo2H:
undetectable		 2y03A-4jo2H:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.43A 2y03A-4jo3H:
undetectable		 2y03A-4jo3H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.45A 2y03A-4k3dH:
undetectable		 2y03A-4k3dH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.40A 2y03A-4k3eH:
undetectable		 2y03A-4k3eH:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 2y03A-4ktdH:
undetectable		 2y03A-4ktdH:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A1113
VAL A1117
SER A1204
SER A1207
ASN A1312
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-2.9A)
None
 1.25A 2y03A-4ldeA:
32.9		 2y03A-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
ASP A1113
VAL A1114
SER A1203
PHE A1289
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-2.9A)
None
 1.10A 2y03A-4ldeA:
32.9		 2y03A-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 TRP A1109
ASP A1113
VAL A1114
VAL A1117
PHE A1193
SER A1203
SER A1207
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-3.8A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.79A 2y03A-4ldeA:
32.9		 2y03A-4ldeA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 2y03A-4m5yH:
undetectable		 2y03A-4m5yH:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhh H5M9 ANTIBODY, HEAVY
CHAIN (IGG1)

(Mus musculus) 		no annotation 5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.42A 2y03A-4mhhH:
undetectable		 2y03A-4mhhH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocs CAP256-VRC26.10
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 2y03A-4ocsH:
undetectable		 2y03A-4ocsH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py8 ANTIBODY 3.1 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.35A 2y03A-4py8I:
undetectable		 2y03A-4py8I:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i HEAVY CHAIN OF
MURINE 2D5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.45A 2y03A-4q6iB:
undetectable		 2y03A-4q6iB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfe FAB HEAVY CHAIN OF
ADCC-POTENT
ANTI-HIV-1 ANTIBODY
JR4

(Macaca mulatta) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 2y03A-4rfeH:
undetectable		 2y03A-4rfeH:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.43A 2y03A-4rnrA:
undetectable		 2y03A-4rnrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs6 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 2y03A-4zs6H:
undetectable		 2y03A-4zs6H:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anm IMMUNOGLOBULIN G

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 171
VAL B 190
SER B 188
ASN B 205
ASN B 163
 None
 1.43A 2y03A-5anmB:
undetectable		 2y03A-5anmB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cck ANTIBODY 3BC315 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.39A 2y03A-5cckH:
undetectable		 2y03A-5cckH:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dur HEAVY CHAIN OF
ANTIBODY 100F4

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.40A 2y03A-5durH:
undetectable		 2y03A-5durH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ea0 HEAVY CHAIN OF
ANTIBODY 7968 FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 184
SER H 182
ASN H 199
ASN H 157
 None
 1.45A 2y03A-5ea0H:
undetectable		 2y03A-5ea0H:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoc FAB FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 167
VAL H 185
SER H 183
ASN H 200
ASN H 159
 None
 1.45A 2y03A-5eocH:
undetectable		 2y03A-5eocH:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 9 TRP B 117
ASP B 121
VAL B 122
PHE B 201
SER B 211
SER B 215
PHE B 306
ASN B 310
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-4.0A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
P32  B 400 (-4.6A)
 0.71A 2y03A-5f8uB:
39.7		 2y03A-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 7 TRP B 117
ASP B 121
VAL B 122
SER B 211
PHE B 306
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 (-4.1A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.41A 2y03A-5f8uB:
39.7		 2y03A-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 11 TRP B 117
ASP B 121
VAL B 122
VAL B 125
PHE B 201
SER B 211
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-4.0A)
P32  B 400 (-2.7A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.52A 2y03A-5f8uB:
39.7		 2y03A-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 2y03A-5fuzH:
undetectable		 2y03A-5fuzH:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 VAL A 462
VAL A 481
SER A 455
PHE A 503
ASN A 501
 None
 1.24A 2y03A-5gqfA:
undetectable		 2y03A-5gqfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8e VRC34.01 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.37A 2y03A-5i8eA:
undetectable		 2y03A-5i8eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 218
VAL H 237
SER H 235
ASN H 251
ASN H 210
 None
 1.43A 2y03A-5ihuH:
undetectable		 2y03A-5ihuH:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 5 VAL H 199
VAL H 218
SER H 216
ASN H 232
ASN H 191
 None
 1.39A 2y03A-5ijvH:
undetectable		 2y03A-5ijvH:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 216
VAL H 235
SER H 233
ASN H 249
ASN H 208
 None
 1.43A 2y03A-5iltH:
undetectable		 2y03A-5iltH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn ANTIBODY

(Mus musculus) 		no annotation 5 VAL H 166
VAL H 184
SER H 182
ASN H 199
ASN H 158
 None
 1.44A 2y03A-5ldnH:
undetectable		 2y03A-5ldnH:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 H CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 194
VAL H 213
SER H 211
ASN H 225
ASN H 186
 None
 1.45A 2y03A-5m63H:
undetectable		 2y03A-5m63H:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4g HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 184
SER H 182
ASN H 199
ASN H 157
 None
 1.45A 2y03A-5n4gH:
undetectable		 2y03A-5n4gH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3s FAB 35022 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 163
VAL D 182
SER D 180
ASN D 197
ASN D 155
 None
 1.45A 2y03A-5t3sD:
undetectable		 2y03A-5t3sD:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukp DH522.1 FAB FRAGMENT
HEAVY CHAIN

(Macaca mulatta) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 2y03A-5ukpH:
undetectable		 2y03A-5ukpH:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 168
VAL H 187
SER H 185
ASN H 202
ASN H 160
 None
 1.45A 2y03A-5uy3H:
undetectable		 2y03A-5uy3H:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.76A 2y03A-5v54A:
28.6		 2y03A-5v54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6l HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A37

(Oryctolagus
cuniculus) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.42A 2y03A-5v6lH:
undetectable		 2y03A-5v6lH:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vta FAB HEAVY CHAIN

(Mus musculus) 		no annotation 5 VAL H 166
VAL H 185
SER H 183
ASN H 200
ASN H 158
 None
 1.44A 2y03A-5vtaH:
undetectable		 2y03A-5vtaH:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5x 3C10 FAB' HEAVY
CHAIN

(Rattus
norvegicus) 		no annotation 5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
None
None
None
EDO  H 303 ( 4.1A)
 1.45A 2y03A-5w5xH:
undetectable		 2y03A-5w5xH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6g 6649 ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL H 175
VAL H 194
SER H 192
ASN H 209
ASN H 167
 None
 1.41A 2y03A-5w6gH:
undetectable		 2y03A-5w6gH:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcd VRC315 04-1D02 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 174
VAL H 193
SER H 191
ASN H 208
ASN H 166
 None
 1.43A 2y03A-5wcdH:
undetectable		 2y03A-5wcdH:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.01A 2y03A-5wivA:
29.6		 2y03A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.16A 2y03A-5wivA:
29.6		 2y03A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 200
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.83A 2y03A-5wivA:
29.6		 2y03A-5wivA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 VAL A 336
SER A 136
SER A 135
ASN A 157
TYR A 312
 ARG  A 601 ( 4.8A)
None
None
None
ARG  A 601 (-4.4A)
 1.34A 2y03A-6ao8A:
2.2		 2y03A-6ao8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.04A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 1.23A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.68A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 VAL B 163
VAL B 182
SER B 180
ASN B 194
ASN B 155
 None
 1.43A 2y03A-6cjkB:
undetectable		 2y03A-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.27A 2y03A-6cm4A:
30.5		 2y03A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.61A 2y03A-6cm4A:
30.5		 2y03A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.79A 2y03A-6g79S:
28.3		 2y03A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 TRP S 125
ASP S 129
SER S 212
PHE S 330
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
 0.98A 2y03A-6g79S:
28.3		 2y03A-6g79S:
14.22