SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y01_B_Y00B601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 VAL A  43
VAL A  50
ASN A  48
TRP A 113
 None
 1.32A 2y01B-1dr6A:
undetectable		 2y01B-1dr6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		4 VAL A 157
VAL A 288
ASN A 289
TRP A 151
 None
 1.36A 2y01B-3vvaA:
1.5		 2y01B-3vvaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  32
VAL H  37
ASN H  35
TRP H  47
 None
 1.40A 2y01B-4idjH:
undetectable		 2y01B-4idjH:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 VAL B 122
VAL B 326
ASN B 329
TRP B 330
 P32  B 400 (-3.5A)
None
P32  B 400 (-2.9A)
None
 1.16A 2y01B-5f8uB:
39.6		 2y01B-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 VAL B 125
VAL B 326
ASN B 329
TRP B 330
 P32  B 400 ( 4.7A)
None
P32  B 400 (-2.9A)
None
 0.44A 2y01B-5f8uB:
39.6		 2y01B-5f8uB:
99.37