SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y00_B_Y00B601_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6c | TOBACCO RINGSPOTVIRUS CAPSID PROTEIN (Tobaccoringspot virus) |
PF03391(Nepo_coat)PF03688(Nepo_coat_C)PF03689(Nepo_coat_N) | 3 | VAL A 430ASN A 373TRP A 439 | None | 1.11A | 2y00B-1a6cA:undetectable | 2y00B-1a6cA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8m | HUMAN RHINOVIRUS 16COAT PROTEIN (Rhinovirus A) |
PF00073(Rhv) | 3 | VAL 2 208ASN 2 218TRP 2 219 | None | 1.11A | 2y00B-1c8m2:undetectable | 2y00B-1c8m2:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ex0 | COAGULATION FACTORXIII A CHAIN (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 3 | VAL A 266ASN A 376TRP A 375 | None | 1.00A | 2y00B-1ex0A:undetectable | 2y00B-1ex0A:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzv | GLUCOSE-6-PHOSPHATEISOMERASE (Sus scrofa) |
PF00342(PGI) | 3 | VAL A 97ASN A 507TRP A 512 | None | 0.75A | 2y00B-1gzvA:undetectable | 2y00B-1gzvA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 3 | VAL A 288ASN A 241TRP A 273 | None | 1.13A | 2y00B-1h3gA:undetectable | 2y00B-1h3gA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kob | TWITCHIN (Aplysiacalifornica) |
PF00069(Pkinase) | 3 | VAL A 42ASN A 112TRP A 34 | None | 1.10A | 2y00B-1kobA:undetectable | 2y00B-1kobA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7g | GDP-D-MANNOSE-4,6-DEHYDRATASE (Arabidopsisthaliana) |
PF16363(GDP_Man_Dehyd) | 3 | VAL A 119ASN A 214TRP A 255 | GDR A 801 (-4.3A)GDR A 801 ( 3.1A)None | 1.11A | 2y00B-1n7gA:undetectable | 2y00B-1n7gA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 3 | VAL A 145ASN A 558TRP A 563 | None | 0.89A | 2y00B-1q50A:undetectable | 2y00B-1q50A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sr4 | CYTOLETHALDISTENDING TOXINPROTEIN B ([Haemophilus]ducreyi) |
PF03372(Exo_endo_phos) | 3 | VAL B 118ASN B 33TRP B 32 | None | 0.66A | 2y00B-1sr4B:undetectable | 2y00B-1sr4B:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t66 | IMMUNOGLOBULIN HEAVYCHAIN (Mus musculus) |
no annotation | 3 | VAL H 81ASN H 35TRP H 47 | None | 1.12A | 2y00B-1t66H:undetectable | 2y00B-1t66H:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl2 | ARGININOSUCCINATESYNTHASE (Thermotogamaritima) |
PF00764(Arginosuc_synth) | 3 | VAL A 343ASN A 78TRP A 289 | None | 1.09A | 2y00B-1vl2A:undetectable | 2y00B-1vl2A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4j | SULFATASE MODIFYINGFACTOR 2 (Homo sapiens) |
PF03781(FGE-sulfatase) | 3 | VAL A 271ASN A 186TRP A 187 | None | 1.12A | 2y00B-1y4jA:undetectable | 2y00B-1y4jA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9g | EXO-INULINASE (Aspergillusawamori) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | VAL A 259ASN A 304TRP A 305 | None | 1.08A | 2y00B-1y9gA:undetectable | 2y00B-1y9gA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxn | GLUCOSE-6-PHOSPHATEISOMERASE (Mus musculus) |
PF00342(PGI) | 3 | VAL A 98ASN A 508TRP A 513 | None | 0.81A | 2y00B-2cxnA:undetectable | 2y00B-2cxnA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1n | CYTOLETHALDISTENDING TOXINSUBUNIT B (Escherichiacoli) |
PF03372(Exo_endo_phos) | 3 | VAL A 96ASN A 11TRP A 10 | None | 0.89A | 2y00B-2f1nA:undetectable | 2y00B-2f1nA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjx | BETA-HEXOSAMINIDASEALPHA CHAIN (Homo sapiens) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 3 | VAL A 512ASN A 196TRP A 24 | None | 1.04A | 2y00B-2gjxA:undetectable | 2y00B-2gjxA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk1 | BETA-HEXOSAMINIDASESUBUNIT ALPHA (Homo sapiens) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2)no annotation | 3 | VAL I 512ASN I 196TRP A 24 | None | 1.11A | 2y00B-2gk1I:undetectable | 2y00B-2gk1I:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htb | PUTATIVE ENZYMERELATED TO ALDOSE1-EPIMERASE (Salmonellaenterica) |
PF01263(Aldose_epim) | 3 | VAL A 169ASN A 243TRP A 242 | None | 0.84A | 2y00B-2htbA:undetectable | 2y00B-2htbA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mgy | TRANSLOCATOR PROTEIN (Mus musculus) |
PF03073(TspO_MBR) | 3 | VAL A 115ASN A 151TRP A 155 | NonePKA A 201 ( 4.1A)None | 0.95A | 2y00B-2mgyA:undetectable | 2y00B-2mgyA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psf | RENILLA-LUCIFERIN2-MONOOXYGENASE (Renillareniformis) |
PF00561(Abhydrolase_1) | 3 | VAL A 175ASN A 53TRP A 121 | None | 1.07A | 2y00B-2psfA:undetectable | 2y00B-2psfA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w68 | SIALIDASE (Vibrio cholerae) |
PF09264(Sial-lect-inser) | 3 | VAL A 102ASN A 110TRP A 193 | None | 1.10A | 2y00B-2w68A:undetectable | 2y00B-2w68A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wae | PENICILLIN-BINDINGPROTEIN 2B (Streptococcuspneumoniae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 3 | VAL A 237ASN A 74TRP A 221 | None | 1.03A | 2y00B-2waeA:undetectable | 2y00B-2waeA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk8 | CAI-1 AUTOINDUCERSYNTHASE (Vibrio cholerae) |
PF00155(Aminotran_1_2) | 3 | VAL A 171ASN A 112TRP A 109 | NonePLP A 600 ( 4.7A)None | 1.05A | 2y00B-2wk8A:undetectable | 2y00B-2wk8A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xpi | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT CUT9 (Schizosaccharomycespombe) |
PF12895(ANAPC3)PF13181(TPR_8)PF13424(TPR_12) | 3 | VAL A 317ASN A 280TRP A 252 | None | 1.02A | 2y00B-2xpiA:undetectable | 2y00B-2xpiA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 3 | VAL A 156ASN A 226TRP A 224 | None | 0.99A | 2y00B-2xvgA:undetectable | 2y00B-2xvgA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzw | ABC TRANSPORTER,SOLUTE-BINDINGPROTEIN (Thermusthermophilus) |
PF03480(DctP) | 3 | VAL A 47ASN A 291TRP A 295 | None | 1.12A | 2y00B-2zzwA:undetectable | 2y00B-2zzwA:24.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiv | BETA-GLUCOSIDASE (Secale cereale) |
PF00232(Glyco_hydro_1) | 3 | VAL A 99ASN A 185TRP A 186 | None | 0.90A | 2y00B-3aivA:undetectable | 2y00B-3aivA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4w | UNCHARACTERIZEDPROTEIN BB4693 (Bordetellabronchiseptica) |
PF04909(Amidohydro_2) | 3 | VAL A 133ASN A 190TRP A 193 | None | 1.02A | 2y00B-3k4wA:undetectable | 2y00B-3k4wA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmm | UNCHARACTERIZEDPROTEIN (Corynebacteriumdiphtheriae) |
PF04326(AlbA_2)PF13749(HATPase_c_4) | 3 | VAL A 115ASN A 77TRP A 164 | None | 0.89A | 2y00B-3lmmA:undetectable | 2y00B-3lmmA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmm | UNCHARACTERIZEDPROTEIN (Corynebacteriumdiphtheriae) |
PF04326(AlbA_2)PF13749(HATPase_c_4) | 3 | VAL A 134ASN A 77TRP A 164 | None | 0.95A | 2y00B-3lmmA:undetectable | 2y00B-3lmmA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os7 | GALACTOSEMUTAROTASE-LIKEPROTEIN (Clostridiumacetobutylicum) |
PF01263(Aldose_epim) | 3 | VAL A 189ASN A 289TRP A 288 | NoneNoneTLA A 401 (-4.4A) | 1.10A | 2y00B-3os7A:undetectable | 2y00B-3os7A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdi | NITROGENASE MOFECOFACTORBIOSYNTHESIS PROTEINNIFE (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | VAL A 175ASN A 246TRP A 269 | None | 0.95A | 2y00B-3pdiA:undetectable | 2y00B-3pdiA:21.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pds | FUSION PROTEINBETA-2 ADRENERGICRECEPTOR/LYSOZYME (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | VAL A 114ASN A 312TRP A 313 | ERC A1201 (-3.8A)ERC A1201 (-3.0A)ERC A1201 (-4.4A) | 1.00A | 2y00B-3pdsA:38.3 | 2y00B-3pdsA:42.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pds | FUSION PROTEINBETA-2 ADRENERGICRECEPTOR/LYSOZYME (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | VAL A 117ASN A 312TRP A 313 | NoneERC A1201 (-3.0A)ERC A1201 (-4.4A) | 0.59A | 2y00B-3pdsA:38.3 | 2y00B-3pdsA:42.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q88 | GLUCOSE-6-PHOSPHATEISOMERASE (Francisellatularensis) |
PF00342(PGI) | 3 | VAL A 86ASN A 494TRP A 499 | None | 0.89A | 2y00B-3q88A:undetectable | 2y00B-3q88A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rfr | PMOB (Methylocystissp. M) |
PF04744(Monooxygenase_B) | 3 | VAL A 277ASN A 44TRP A 45 | None | 1.04A | 2y00B-3rfrA:undetectable | 2y00B-3rfrA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sun | DNA POLYMERASE (Escherichiavirus RB69) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | VAL A 825ASN A 217TRP A 216 | None | 0.97A | 2y00B-3sunA:undetectable | 2y00B-3sunA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdp | FORMATE/NITRITETRANSPORTER (Clostridioidesdifficile) |
PF01226(Form_Nir_trans) | 3 | VAL A 171ASN A 86TRP A 108 | None | 1.12A | 2y00B-3tdpA:undetectable | 2y00B-3tdpA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttl | POLYAMINE TRANSPORTPROTEIN (Pseudomonasaeruginosa) |
PF13416(SBP_bac_8) | 3 | VAL A 119ASN A 269TRP A 271 | None | 1.14A | 2y00B-3ttlA:undetectable | 2y00B-3ttlA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx8 | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Corynebacteriumglutamicum) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | VAL A 286ASN A 178TRP A 320 | NonePO4 A 401 ( 4.8A)None | 1.11A | 2y00B-3tx8A:undetectable | 2y00B-3tx8A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1t | DMMA HALOALKANEDEHALOGENASE (unidentified) |
PF00561(Abhydrolase_1) | 3 | VAL A 204ASN A 78TRP A 145 | None CL A 350 (-4.4A) CL A 350 (-4.7A) | 1.06A | 2y00B-3u1tA:undetectable | 2y00B-3u1tA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubu | AGGLUCETIN SUBUNITBETA-2 (Deinagkistrodonacutus) |
PF00059(Lectin_C) | 3 | VAL B 121ASN B 107TRP B 109 | None | 1.03A | 2y00B-3ubuB:undetectable | 2y00B-3ubuB:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujh | GLUCOSE-6-PHOSPHATEISOMERASE (Toxoplasmagondii) |
PF00342(PGI) | 3 | VAL A 95ASN A 508TRP A 513 | None | 0.81A | 2y00B-3ujhA:undetectable | 2y00B-3ujhA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8u | TRANSFERRINBINDING-PROTEIN B (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 3 | VAL A 152ASN A 50TRP A 51 | None | 0.75A | 2y00B-3v8uA:undetectable | 2y00B-3v8uA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vva | ALTERNATIVE OXIDASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF01786(AOX) | 3 | VAL A 157ASN A 289TRP A 151 | None | 1.11A | 2y00B-3vvaA:undetectable | 2y00B-3vvaA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wib | HALOALKANEDEHALOGENASE (Agrobacteriumfabrum) |
PF00561(Abhydrolase_1) | 3 | VAL A 164ASN A 43TRP A 109 | NoneNHE A 401 (-3.8A)NHE A 401 (-4.1A) | 1.08A | 2y00B-3wibA:undetectable | 2y00B-3wibA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1b | LACCASE (Lentinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | VAL A 488ASN A 104TRP A 506 | None | 1.14A | 2y00B-3x1bA:undetectable | 2y00B-3x1bA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdr | ALCOHOLDEHYDROGENASE DOMAINOF THE BIFUNCTIONALACETALDEHYDEDEHYDROGENASE (Parageobacillusthermoglucosidasius) |
PF00465(Fe-ADH) | 3 | VAL A 613ASN A 723TRP A 462 | None | 0.78A | 2y00B-3zdrA:undetectable | 2y00B-3zdrA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bok | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03663(Glyco_hydro_76) | 3 | VAL A 369ASN A 49TRP A 53 | None | 0.99A | 2y00B-4bokA:undetectable | 2y00B-4bokA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4brz | HALOALKANEDEHALOGENASE (Rhodobacteraceae) |
PF00561(Abhydrolase_1) | 3 | VAL A 162ASN A 36TRP A 107 | None CL A1293 (-4.4A) CL A1293 (-4.7A) | 1.04A | 2y00B-4brzA:undetectable | 2y00B-4brzA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1o | BETA-XYLOSIDASE (Parageobacillusthermoglucosidasius) |
PF03512(Glyco_hydro_52) | 3 | VAL A 142ASN A 380TRP A 382 | None | 1.13A | 2y00B-4c1oA:undetectable | 2y00B-4c1oA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4em6 | GLUCOSE-6-PHOSPHATEISOMERASE (Brucellamelitensis) |
no annotation | 3 | VAL D 95ASN D 502TRP D 507 | None | 0.84A | 2y00B-4em6D:undetectable | 2y00B-4em6D:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbo | PSEUDOMONASFLUORESCENSAGGLUTININ (Pseudomonasfluorescens) |
no annotation | 3 | VAL A 100ASN A 8TRP A 10 | None | 0.88A | 2y00B-4fboA:undetectable | 2y00B-4fboA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fff | LEVANFRUCTOTRANSFERASE (Paenarthrobacterureafaciens) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | VAL A 329ASN A 320TRP A 322 | None | 0.99A | 2y00B-4fffA:undetectable | 2y00B-4fffA:21.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 3 | VAL A 117ASN A 284TRP A 285 | CAU A 500 (-4.2A)CAU A 500 (-3.3A)None | 0.65A | 2y00B-4gbrA:39.0 | 2y00B-4gbrA:58.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hb4 | EXPORTIN-1 (Saccharomycescerevisiae) |
PF03810(IBN_N)PF08389(Xpo1)PF08767(CRM1_C) | 3 | VAL C 709ASN C 673TRP C 676 | None | 1.02A | 2y00B-4hb4C:undetectable | 2y00B-4hb4C:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jg5 | PUTATIVE CELLADHESION PROTEIN (Parabacteroidesdistasonis) |
PF06321(P_gingi_FimA) | 3 | VAL A 192ASN A 55TRP A 365 | None | 0.99A | 2y00B-4jg5A:undetectable | 2y00B-4jg5A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2x | POLYKETIDEOXYGENASE/HYDROXYLASE (Streptomycesrimosus) |
PF01494(FAD_binding_3) | 3 | VAL A 388ASN A 310TRP A 313 | None | 0.99A | 2y00B-4k2xA:undetectable | 2y00B-4k2xA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 3 | VAL A 393ASN A 314TRP A 317 | None | 0.90A | 2y00B-4k5rA:undetectable | 2y00B-4k5rA:19.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lde | LYSOZYME, BETA-2ADRENERGIC RECEPTOR (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | VAL A1114ASN A1312TRP A1313 | P0G A1401 (-3.7A)P0G A1401 (-2.9A)1WV A1403 ( 4.3A) | 1.08A | 2y00B-4ldeA:32.8 | 2y00B-4ldeA:42.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lde | LYSOZYME, BETA-2ADRENERGIC RECEPTOR (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | VAL A1117ASN A1312TRP A1313 | P0G A1401 ( 4.4A)P0G A1401 (-2.9A)1WV A1403 ( 4.3A) | 0.97A | 2y00B-4ldeA:32.8 | 2y00B-4ldeA:42.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ngu | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Desulfovibrioalaskensis) |
PF03480(DctP) | 3 | VAL A 154ASN A 40TRP A 202 | NoneDAL A 403 (-4.2A)DAL A 403 (-4.1A) | 1.10A | 2y00B-4nguA:undetectable | 2y00B-4nguA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmy | ABC-TYPE TRANSPORTSYSTEM,EXTRACELLULARSOLUTE-BINDINGPROTEIN (Clostridioidesdifficile) |
PF09084(NMT1) | 3 | VAL A 84ASN A 15TRP A 12 | NoneVIB A 401 (-3.3A)VIB A 401 (-3.6A) | 1.10A | 2y00B-4nmyA:undetectable | 2y00B-4nmyA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4or2 | SOLUBLE CYTOCHROMEB562, METABOTROPICGLUTAMATE RECEPTOR 1 (Escherichiacoli;Homo sapiens) |
PF00003(7tm_3)PF07361(Cytochrom_B562) | 3 | VAL A 721ASN A 760TRP A 798 | NoneFM9 A1901 (-3.9A)None | 1.04A | 2y00B-4or2A:16.9 | 2y00B-4or2A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbo | C-REACTIVE PROTEIN (Danio rerio) |
PF00354(Pentaxin) | 3 | VAL A 134ASN A 63TRP A 65 | None | 1.11A | 2y00B-4pboA:undetectable | 2y00B-4pboA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwo | DSBA (Corynebacteriumdiphtheriae) |
PF13462(Thioredoxin_4) | 3 | VAL A 252ASN A 155TRP A 154 | None | 1.06A | 2y00B-4pwoA:undetectable | 2y00B-4pwoA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfh | GLUCOSE-6-PHOSPHATEISOMERASE (Trypanosomacruzi) |
PF00342(PGI) | 3 | VAL A 147ASN A 561TRP A 566 | None | 0.74A | 2y00B-4qfhA:undetectable | 2y00B-4qfhA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzc | FV M6P-1 LIGHT CHAIN (Oryctolaguscuniculus) |
no annotation | 3 | VAL H 77ASN H 35TRP H 47 | None | 1.13A | 2y00B-4rzcH:undetectable | 2y00B-4rzcH:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tnw | AVERMECTIN-SENSITIVEGLUTAMATE-GATEDCHLORIDE CHANNELGLUCL ALPHA (Caenorhabditiselegans) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 3 | VAL A 228ASN A 331TRP A 335 | None | 0.95A | 2y00B-4tnwA:3.4 | 2y00B-4tnwA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uri | CHITINASE-RELATEDAGGLUTININ (Robiniapseudoacacia) |
PF00704(Glyco_hydro_18) | 3 | VAL A 267ASN A 324TRP A 325 | None | 0.95A | 2y00B-4uriA:undetectable | 2y00B-4uriA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wdr | HALOALKANEDEHALOGENASE (Sphingobiumjaponicum) |
PF00561(Abhydrolase_1) | 3 | VAL A 163ASN A 38TRP A 109 | None CL A 301 (-4.2A) CL A 301 (-4.7A) | 1.03A | 2y00B-4wdrA:undetectable | 2y00B-4wdrA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 3 | VAL A 102ASN A 511TRP A 516 | None | 0.83A | 2y00B-4wmjA:undetectable | 2y00B-4wmjA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfk | PUTATIVE BRANCHEDCHAIN AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Brucella ovis) |
PF13458(Peripla_BP_6) | 3 | VAL A 288ASN A 235TRP A 240 | NoneNoneACT A 500 ( 4.0A) | 0.84A | 2y00B-4xfkA:undetectable | 2y00B-4xfkA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhp | PARM HYBRID FUSIONPROTEIN (Bacillusthuringiensis) |
no annotation | 3 | VAL A 770ASN A 363TRP A 359 | None | 0.89A | 2y00B-4xhpA:undetectable | 2y00B-4xhpA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c4q | BROMODOMAIN (Leishmaniadonovani) |
PF00439(Bromodomain) | 3 | VAL A 47ASN A 87TRP A 93 | NoneBMF A 201 (-2.8A)BMF A 201 (-3.5A) | 1.03A | 2y00B-5c4qA:undetectable | 2y00B-5c4qA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz7 | POLYKETIDEBIOSYNTHESIS PROTEINPKSE (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 3 | VAL A 149ASN A 153TRP A 248 | None | 1.12A | 2y00B-5dz7A:undetectable | 2y00B-5dz7A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esr | HALOALKANEDEHALOGENASE (Caulobactervibrioides) |
PF00561(Abhydrolase_1) | 3 | VAL A 102ASN A 227TRP A 231 | None | 0.85A | 2y00B-5esrA:undetectable | 2y00B-5esrA:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f8u | BETA-1 ADRENERGICRECEPTOR (Meleagrisgallopavo) |
no annotation | 3 | VAL B 122ASN B 329TRP B 330 | P32 B 400 (-3.5A)P32 B 400 (-2.9A)None | 1.07A | 2y00B-5f8uB:39.8 | 2y00B-5f8uB:99.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f8u | BETA-1 ADRENERGICRECEPTOR (Meleagrisgallopavo) |
no annotation | 3 | VAL B 125ASN B 329TRP B 330 | P32 B 400 ( 4.7A)P32 B 400 (-2.9A)None | 0.53A | 2y00B-5f8uB:39.8 | 2y00B-5f8uB:99.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flz | TUBULIN GAMMA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 3 | VAL C 397ASN C 186TRP C 105 | None | 1.07A | 2y00B-5flzC:undetectable | 2y00B-5flzC:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 3 | VAL A 612ASN A 390TRP A 392 | None | 0.50A | 2y00B-5l46A:undetectable | 2y00B-5l46A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m77 | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03422(CBM_6)PF03663(Glyco_hydro_76) | 3 | VAL A 369ASN A 49TRP A 53 | NoneEDO A 602 (-3.9A)EDO A 602 ( 4.7A) | 1.00A | 2y00B-5m77A:undetectable | 2y00B-5m77A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 3 | VAL A 333ASN A 250TRP A 249 | None | 0.84A | 2y00B-5m8tA:undetectable | 2y00B-5m8tA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npu | ANC27 (syntheticconstruct) |
no annotation | 3 | VAL A 535ASN A 487TRP A 488 | None | 1.05A | 2y00B-5npuA:undetectable | 2y00B-5npuA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8f | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITBETA-3,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNITALPHA-5,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-5 (Homo sapiens) |
no annotation | 3 | VAL A 241ASN A 410TRP A 414 | None | 1.00A | 2y00B-5o8fA:3.1 | 2y00B-5o8fA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osb | PROTON-GATED IONCHANNEL,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1 (Gloeobacterviolaceus;Mus musculus) |
no annotation | 3 | VAL A 237ASN A 407TRP A 411 | None | 1.03A | 2y00B-5osbA:4.3 | 2y00B-5osbA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uzh | NAFOA.00085.B (Naegleriafowleri) |
PF16363(GDP_Man_Dehyd) | 3 | VAL A 123ASN A 217TRP A 258 | GDP A 401 (-4.1A)GDP A 401 ( 3.4A)None | 1.10A | 2y00B-5uzhA:undetectable | 2y00B-5uzhA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0t | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 3 | VAL A 138ASN A 119TRP A 116 | None | 0.87A | 2y00B-5v0tA:undetectable | 2y00B-5v0tA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wa0 | PUTATIVE SULFITEOXIDASE (Sinorhizobiummeliloti) |
no annotation | 3 | VAL A 124ASN A 130TRP A 150 | None | 0.72A | 2y00B-5wa0A:undetectable | 2y00B-5wa0A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wze | AMINOPEPTIDASE P (Pseudomonasaeruginosa) |
no annotation | 3 | VAL A 318ASN A 311TRP A 310 | None | 1.05A | 2y00B-5wzeA:undetectable | 2y00B-5wzeA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yy8 | INFLUENZA VIRUSNS1A-BINDING PROTEIN (Homo sapiens) |
no annotation | 3 | VAL A 233ASN A 277TRP A 319 | None | 1.06A | 2y00B-5yy8A:undetectable | 2y00B-5yy8A:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z06 | BDI_3064 PROTEIN (Parabacteroidesdistasonis) |
no annotation | 3 | VAL A 410ASN A 481TRP A 480 | NoneGOL A 805 (-3.7A)None | 0.69A | 2y00B-5z06A:undetectable | 2y00B-5z06A:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brd | RIFAMPINMONOOXYGENASE (Streptomycesvenezuelae) |
no annotation | 3 | VAL A 377ASN A 299TRP A 302 | None | 0.89A | 2y00B-6brdA:undetectable | 2y00B-6brdA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btm | ALTERNATIVE COMPLEXIII SUBUNIT F (Flavobacteriumjohnsoniae) |
no annotation | 3 | VAL F 176ASN F 104TRP F 107 | None | 1.13A | 2y00B-6btmF:3.1 | 2y00B-6btmF:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7s | PUTATIVE RIFAMPINMONOOXYGENASE (Nocardiafarcinica) |
no annotation | 3 | VAL A 376ASN A 298TRP A 301 | None | 1.01A | 2y00B-6c7sA:undetectable | 2y00B-6c7sA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1 (Homo sapiens) |
no annotation | 3 | VAL B 238ASN B 337TRP B 341 | None | 0.98A | 2y00B-6d6uB:4.4 | 2y00B-6d6uB:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITGAMMA-2,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT GAMMA-2 (Homo sapiens) |
no annotation | 3 | VAL E 248ASN E 347TRP E 351 | None | 0.83A | 2y00B-6d6uE:3.4 | 2y00B-6d6uE:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6egt | GLYCOPROTEIN (Rift Valleyfeverphlebovirus) |
no annotation | 3 | VAL A 803ASN A 812TRP A 791 | None | 0.66A | 2y00B-6egtA:undetectable | 2y00B-6egtA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 3 | VAL A 128ASN A 136TRP A 219 | None | 1.06A | 2y00B-6eksA:undetectable | 2y00B-6eksA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gpl | GDP-MANNOSE 4,6DEHYDRATASE (Homo sapiens) |
no annotation | 3 | VAL B 114ASN B 208TRP B 249 | F7E B 402 (-4.1A)F7E B 402 ( 3.1A)None | 1.08A | 2y00B-6gplB:undetectable | 2y00B-6gplB:undetectable |