SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y00_B_Y00B601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN
4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 LEU B  56
VAL B  57
ASP B 126
SER A  97
PHE A 103
 None
 1.12A 2y00B-1bouB:
undetectable		 2y00B-1bouB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.42A 2y00B-1f8rA:
undetectable		 2y00B-1f8rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.49A 2y00B-1kwmA:
undetectable		 2y00B-1kwmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 300
VAL A 296
TRP A   3
ASP A  18
PHE A 179
 None
 1.50A 2y00B-1ml4A:
undetectable		 2y00B-1ml4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.48A 2y00B-1nsaA:
undetectable		 2y00B-1nsaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 LEU A 313
THR A 186
ASP A 189
SER A  97
ASN A  69
 None
NAP  A1800 (-4.7A)
FE  A 900 ( 2.5A)
NAP  A1800 (-2.6A)
NAP  A1800 (-4.2A)
 1.23A 2y00B-1o2dA:
undetectable		 2y00B-1o2dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 LEU A 280
TRP A  38
ASP A  53
SER A  16
TYR A 198
 None
 1.41A 2y00B-1pcaA:
undetectable		 2y00B-1pcaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 THR A  46
ASP A  11
VAL A  37
SER A 128
PHE A 165
 None
CA  A2001 (-3.1A)
None
None
GOL  A3005 ( 4.5A)
 1.44A 2y00B-1q8fA:
undetectable		 2y00B-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 VAL A 145
TRP A 189
VAL A 110
SER A 124
ASN A 131
 None
 1.43A 2y00B-1wkrA:
undetectable		 2y00B-1wkrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		5 VAL A 227
THR A 208
VAL A 160
PHE A 275
ASN A 274
 None
 1.32A 2y00B-1yw6A:
undetectable		 2y00B-1yw6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arh HYPOTHETICAL PROTEIN
AQ_1966

(Aquifex
aeolicus) 		PF06557
(DUF1122) 		5 LEU A  24
VAL A  25
VAL A  99
PHE A  77
PHE A  78
 None
 1.29A 2y00B-2arhA:
undetectable		 2y00B-2arhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 LEU A  62
VAL A  61
THR A 252
SER A 235
ASN A 183
 None
None
None
None
ZN  A1550 ( 2.6A)
 1.43A 2y00B-2bibA:
undetectable		 2y00B-2bibA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		5 LEU 2  42
VAL 2 159
THR 2  34
SER 2  98
PHE 2  94
 None
 1.47A 2y00B-2bpa2:
undetectable		 2y00B-2bpa2:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 LEU A 445
TRP A 465
THR A 457
ASP A 463
TYR A 198
 None
None
None
None
FMT  A1802 (-3.1A)
 1.34A 2y00B-2c4mA:
undetectable		 2y00B-2c4mA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		5 VAL A 338
THR A  34
ASP A  18
VAL A  17
TYR A 313
 None
 1.16A 2y00B-2j1nA:
undetectable		 2y00B-2j1nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		5 LEU A  99
VAL A  46
SER A 208
PHE A 169
ASN A 170
 None
 1.41A 2y00B-2vhqA:
undetectable		 2y00B-2vhqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 301
VAL A  50
ASP A  97
VAL A 129
TYR A 155
 None
 1.47A 2y00B-2wuaA:
undetectable		 2y00B-2wuaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		5 LEU A 310
VAL A 311
SER A 243
ASN A 182
TYR A 218
 None
None
PLP  A1400 ( 2.9A)
PLP  A1400 (-3.3A)
None
 1.49A 2y00B-2x5dA:
undetectable		 2y00B-2x5dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 TRP A  40
THR A  44
SER A 123
SER A 119
PHE A 490
 None
None
None
None
3ES  A1611 (-4.7A)
 1.37A 2y00B-2xydA:
undetectable		 2y00B-2xydA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
no annotation 		5 LEU C  43
VAL C  39
VAL A 733
PHE A 703
ASN A 663
 None
 1.20A 2y00B-2yevC:
undetectable		 2y00B-2yevC:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 LEU A  52
VAL A  48
TRP A 411
ASN A 113
TYR A 416
 None
 1.31A 2y00B-2yheA:
undetectable		 2y00B-2yheA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bij UNCHARACTERIZED
PROTEIN GSU0716

(Geobacter
sulfurreducens) 		PF00656
(Peptidase_C14) 		5 LEU A  11
THR A 102
VAL A  88
PHE A 182
TYR A  19
 None
 1.41A 2y00B-3bijA:
undetectable		 2y00B-3bijA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 482
ASP A 379
VAL A 380
PHE A  55
ASN A  83
 None
None
FAD  A 612 ( 3.8A)
None
None
 1.48A 2y00B-3eyaA:
undetectable		 2y00B-3eyaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyf PROTEIN BVU-3222

(Bacteroides
vulgatus) 		PF14059
(DUF4251) 		5 LEU A  68
VAL A  67
THR A 166
SER A 172
TYR A 141
 None
 1.44A 2y00B-3fyfA:
undetectable		 2y00B-3fyfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.36A 2y00B-3kveA:
undetectable		 2y00B-3kveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 LEU A 428
VAL A 427
SER A   2
SER A   3
TYR A 266
 None
 1.21A 2y00B-3lovA:
undetectable		 2y00B-3lovA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A

(Homo sapiens) 		PF01351
(RNase_HII) 		5 LEU A 100
THR A 120
ASP A 119
SER A 156
TYR A 111
 None
 1.36A 2y00B-3p56A:
undetectable		 2y00B-3p56A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.09A 2y00B-3pblA:
32.3		 2y00B-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 LEU A  89
ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.93A 2y00B-3pblA:
32.3		 2y00B-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 LEU A  89
ASP A 110
VAL A 111
SER A 196
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.72A 2y00B-3pblA:
32.3		 2y00B-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A  87
VAL A 111
SER A 196
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.38A 2y00B-3pblA:
32.3		 2y00B-3pblA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
PHE A 289
PHE A 290
ASN A 293
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
 0.56A 2y00B-3pdsA:
38.3		 2y00B-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
PHE A 289
PHE A 290
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
None
 1.41A 2y00B-3pdsA:
38.3		 2y00B-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		5 LEU A 144
TRP A 102
ASP A  38
PHE A  55
TYR A 126
 None
 1.30A 2y00B-3simA:
undetectable		 2y00B-3simA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		5 LEU A 199
VAL A 198
ASP A 257
SER A 251
PHE A 246
 None
 1.45A 2y00B-3t2nA:
undetectable		 2y00B-3t2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 LEU B 241
VAL B 237
ASP B 168
VAL B 169
TYR B 266
 None
 1.48A 2y00B-3vsjB:
undetectable		 2y00B-3vsjB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wge THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00085
(Thioredoxin) 		5 LEU A 286
TRP A 227
VAL A 245
PHE A 268
ASN A 257
 None
 1.38A 2y00B-3wgeA:
undetectable		 2y00B-3wgeA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		5 LEU A  99
VAL A 102
TRP A  93
PHE A  54
PHE A  10
 None
 1.33A 2y00B-3wibA:
undetectable		 2y00B-3wibA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 1.48A 2y00B-4gbrA:
39.0		 2y00B-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
PHE A 261
PHE A 262
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
 1.32A 2y00B-4gbrA:
39.0		 2y00B-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
PHE A 261
PHE A 262
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 0.70A 2y00B-4gbrA:
39.0		 2y00B-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
PHE A 261
PHE A 262
ASN A 265
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-4.6A)
 0.63A 2y00B-4gbrA:
39.0		 2y00B-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1) 		PF16451
(Spike_NTD) 		5 LEU A 155
VAL A 140
THR A 224
VAL A 229
PHE A 104
 None
 1.41A 2y00B-4h14A:
undetectable		 2y00B-4h14A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 LEU A  57
VAL A  53
VAL A 332
SER A 349
PHE A 339
 None
 1.49A 2y00B-4i3hA:
undetectable		 2y00B-4i3hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 LEU A 166
VAL A 114
THR A 237
PHE A 480
ASN A 479
 None
None
NAD  A 601 (-4.2A)
None
None
 1.36A 2y00B-4i8qA:
undetectable		 2y00B-4i8qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.67A 2y00B-4ib4A:
27.9		 2y00B-4ib4A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A

(Homo sapiens) 		PF00059
(Lectin_C) 		5 VAL A 154
TRP A 137
THR A  98
ASP A  97
PHE A  70
 None
None
None
NAG  A 201 ( 3.7A)
None
 1.44A 2y00B-4iopA:
undetectable		 2y00B-4iopA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
PHE A1290
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.9A)
None
 1.36A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
SER A1207
PHE A1289
PHE A1290
ASN A1293
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
None
 0.75A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1117
SER A1207
PHE A1289
PHE A1290
ASN A1293
 P0G  A1401 ( 4.4A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
 1.35A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqc TCPB

(Brucella
melitensis) 		PF13676
(TIR_2) 		5 LEU A 169
THR A 197
SER A 223
PHE A 183
PHE A 184
 None
 1.39A 2y00B-4lqcA:
undetectable		 2y00B-4lqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 THR A 163
SER A 170
PHE A 140
PHE A 134
TYR A 147
 None
 1.44A 2y00B-4mdpA:
undetectable		 2y00B-4mdpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 LEU A 643
VAL A 656
THR A 499
SER A 395
PHE A 402
 None
 1.48A 2y00B-4mmhA:
undetectable		 2y00B-4mmhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myw ENVELOPE
GLYCOPROTEIN D

(Human
alphaherpesvirus
2) 		PF01537
(Herpes_glycop_D) 		5 VAL A 212
THR A  96
VAL A 168
SER A  75
TYR A 100
 None
 1.40A 2y00B-4mywA:
undetectable		 2y00B-4mywA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 VAL A 272
TRP A 116
VAL A 145
ASN A 184
TYR A 194
 None
None
None
None
MLI  A 302 (-4.1A)
 1.19A 2y00B-4otkA:
undetectable		 2y00B-4otkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 LEU A 305
VAL A 217
SER C  79
SER C  80
ASN A 390
 None
 1.44A 2y00B-4owtA:
undetectable		 2y00B-4owtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A 199
VAL A 195
TRP A  78
ASP A  81
VAL A  82
 None
 1.29A 2y00B-4rncA:
undetectable		 2y00B-4rncA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 LEU A 301
THR A 367
ASP A 390
SER A 455
TYR A 363
 None
 1.50A 2y00B-4txgA:
undetectable		 2y00B-4txgA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Paenarthrobacter
aurescens) 		PF00977
(His_biosynth) 		5 LEU A 213
VAL A 212
THR A 171
ASP A 172
VAL A 173
 None
 1.21A 2y00B-4wd0A:
undetectable		 2y00B-4wd0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		5 LEU A 456
VAL A 424
ASP A 444
SER A 180
PHE A 516
 None
 1.29A 2y00B-4xbrA:
undetectable		 2y00B-4xbrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 306
VAL A 305
THR A 224
PHE A 197
ASN A 394
 None
 1.19A 2y00B-4xvmA:
undetectable		 2y00B-4xvmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 LEU A 219
VAL A 220
SER A 358
PHE A 251
ASN A 249
 None
 1.48A 2y00B-5cg0A:
undetectable		 2y00B-5cg0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A 281
VAL A 268
SER A  17
PHE A  22
ASN A  59
 None
 1.45A 2y00B-5dxiA:
undetectable		 2y00B-5dxiA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 12 LEU B 101
VAL B 102
TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
SER B 215
PHE B 306
PHE B 307
ASN B 310
TYR B 333
 None
None
P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-4.6A)
 0.62A 2y00B-5f8uB:
39.8		 2y00B-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		5 VAL A 334
THR A  34
ASP A  18
VAL A  17
TYR A 309
 None
 1.15A 2y00B-5fvnA:
undetectable		 2y00B-5fvnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		5 ASP B  53
VAL B  52
SER B  48
SER B  43
TYR B  55
 None
 1.40A 2y00B-5g52B:
undetectable		 2y00B-5g52B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 TRP B  69
ASP B  71
VAL B  72
SER A  81
ASN B 152
 None
 1.49A 2y00B-5gj4B:
undetectable		 2y00B-5gj4B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA

(Pyrococcus
furiosus) 		PF10418
(DHODB_Fe-S_bind) 		5 LEU S  16
THR S  66
ASP S  57
SER S  61
TYR S 120
 None
 1.44A 2y00B-5jfcS:
undetectable		 2y00B-5jfcS:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 LEU A 107
VAL A 108
ASP A  86
VAL A  87
TYR A 144
 None
 1.31A 2y00B-5ktkA:
undetectable		 2y00B-5ktkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		5 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.30A 2y00B-5lltA:
undetectable		 2y00B-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		5 LEU B 924
VAL B 951
VAL B 901
SER A 148
ASN A 144
 None
 1.45A 2y00B-5lxvB:
undetectable		 2y00B-5lxvB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 LEU A 730
VAL A 729
THR A 672
SER A 708
PHE A 651
 None
 1.44A 2y00B-5m41A:
undetectable		 2y00B-5m41A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 VAL C 372
THR C 358
SER C  91
SER C  94
ASN C 382
 None
None
None
None
SCY  C  88 ( 3.5A)
 1.26A 2y00B-5mg5C:
undetectable		 2y00B-5mg5C:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 LEU A  64
ASP A 142
VAL A 141
SER A 182
TYR A  34
 None
 1.43A 2y00B-5nsqA:
undetectable		 2y00B-5nsqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.40A 2y00B-5ts5A:
undetectable		 2y00B-5ts5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.82A 2y00B-5v54A:
28.5		 2y00B-5v54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 5 TRP A 125
ASP A 129
SER A 212
PHE A 330
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
None
 1.30A 2y00B-5v54A:
28.5		 2y00B-5v54A:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.03A 2y00B-5wivA:
29.7		 2y00B-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.19A 2y00B-5wivA:
29.7		 2y00B-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 200
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.79A 2y00B-5wivA:
29.7		 2y00B-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A  92
ASP A 115
SER A 196
PHE A 410
PHE A 411
 PEG  A1218 ( 4.6A)
AQD  A1201 (-3.3A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.14A 2y00B-5wivA:
29.7		 2y00B-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A  92
ASP A 115
SER A 200
PHE A 410
PHE A 411
 PEG  A1218 ( 4.6A)
AQD  A1201 (-3.3A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.25A 2y00B-5wivA:
29.7		 2y00B-5wivA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 5 LEU A 235
VAL A 232
THR A 241
VAL A 364
ASN A 107
 None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.4A)
None
 1.36A 2y00B-5yhjA:
undetectable		 2y00B-5yhjA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 5 LEU A  37
VAL A  64
VAL A 114
SER A 122
ASN A 303
 None
 1.35A 2y00B-5ysbA:
undetectable		 2y00B-5ysbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.22A 2y00B-6bfnA:
2.0		 2y00B-6bfnA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.14A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.50A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.83A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 7 LEU A  94
ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.90A 2y00B-6cm4A:
30.6		 2y00B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
 None
 1.29A 2y00B-6criM:
undetectable		 2y00B-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 1.12A 2y00B-6g79S:
28.3		 2y00B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.82A 2y00B-6g79S:
28.3		 2y00B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		3 VAL A 430
ASN A 373
TRP A 439
 None
 1.11A 2y00B-1a6cA:
undetectable		 2y00B-1a6cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		3 VAL 2 208
ASN 2 218
TRP 2 219
 None
 1.11A 2y00B-1c8m2:
undetectable		 2y00B-1c8m2:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 VAL A 266
ASN A 376
TRP A 375
 None
 1.00A 2y00B-1ex0A:
undetectable		 2y00B-1ex0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		3 VAL A  97
ASN A 507
TRP A 512
 None
 0.75A 2y00B-1gzvA:
undetectable		 2y00B-1gzvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		3 VAL A 288
ASN A 241
TRP A 273
 None
 1.13A 2y00B-1h3gA:
undetectable		 2y00B-1h3gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		3 VAL A  42
ASN A 112
TRP A  34
 None
 1.10A 2y00B-1kobA:
undetectable		 2y00B-1kobA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		3 VAL A 119
ASN A 214
TRP A 255
 GDR  A 801 (-4.3A)
GDR  A 801 ( 3.1A)
None
 1.11A 2y00B-1n7gA:
undetectable		 2y00B-1n7gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		3 VAL A 145
ASN A 558
TRP A 563
 None
 0.89A 2y00B-1q50A:
undetectable		 2y00B-1q50A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 VAL B 118
ASN B  33
TRP B  32
 None
 0.66A 2y00B-1sr4B:
undetectable		 2y00B-1sr4B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 3 VAL H  81
ASN H  35
TRP H  47
 None
 1.12A 2y00B-1t66H:
undetectable		 2y00B-1t66H:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		3 VAL A 343
ASN A  78
TRP A 289
 None
 1.09A 2y00B-1vl2A:
undetectable		 2y00B-1vl2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		3 VAL A 271
ASN A 186
TRP A 187
 None
 1.12A 2y00B-1y4jA:
undetectable		 2y00B-1y4jA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 259
ASN A 304
TRP A 305
 None
 1.08A 2y00B-1y9gA:
undetectable		 2y00B-1y9gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		3 VAL A  98
ASN A 508
TRP A 513
 None
 0.81A 2y00B-2cxnA:
undetectable		 2y00B-2cxnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 VAL A  96
ASN A  11
TRP A  10
 None
 0.89A 2y00B-2f1nA:
undetectable		 2y00B-2f1nA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 VAL A 512
ASN A 196
TRP A  24
 None
 1.04A 2y00B-2gjxA:
undetectable		 2y00B-2gjxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		3 VAL I 512
ASN I 196
TRP A  24
 None
 1.11A 2y00B-2gk1I:
undetectable		 2y00B-2gk1I:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		3 VAL A 169
ASN A 243
TRP A 242
 None
 0.84A 2y00B-2htbA:
undetectable		 2y00B-2htbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		3 VAL A 115
ASN A 151
TRP A 155
 None
PKA  A 201 ( 4.1A)
None
 0.95A 2y00B-2mgyA:
undetectable		 2y00B-2mgyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		3 VAL A 175
ASN A  53
TRP A 121
 None
 1.07A 2y00B-2psfA:
undetectable		 2y00B-2psfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		3 VAL A 102
ASN A 110
TRP A 193
 None
 1.10A 2y00B-2w68A:
undetectable		 2y00B-2w68A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 VAL A 237
ASN A  74
TRP A 221
 None
 1.03A 2y00B-2waeA:
undetectable		 2y00B-2waeA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 VAL A 171
ASN A 112
TRP A 109
 None
PLP  A 600 ( 4.7A)
None
 1.05A 2y00B-2wk8A:
undetectable		 2y00B-2wk8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		3 VAL A 317
ASN A 280
TRP A 252
 None
 1.02A 2y00B-2xpiA:
undetectable		 2y00B-2xpiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 VAL A 156
ASN A 226
TRP A 224
 None
 0.99A 2y00B-2xvgA:
undetectable		 2y00B-2xvgA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		3 VAL A  47
ASN A 291
TRP A 295
 None
 1.12A 2y00B-2zzwA:
undetectable		 2y00B-2zzwA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 VAL A  99
ASN A 185
TRP A 186
 None
 0.90A 2y00B-3aivA:
undetectable		 2y00B-3aivA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		3 VAL A 133
ASN A 190
TRP A 193
 None
 1.02A 2y00B-3k4wA:
undetectable		 2y00B-3k4wA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 VAL A 115
ASN A  77
TRP A 164
 None
 0.89A 2y00B-3lmmA:
undetectable		 2y00B-3lmmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 VAL A 134
ASN A  77
TRP A 164
 None
 0.95A 2y00B-3lmmA:
undetectable		 2y00B-3lmmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		3 VAL A 189
ASN A 289
TRP A 288
 None
None
TLA  A 401 (-4.4A)
 1.10A 2y00B-3os7A:
undetectable		 2y00B-3os7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 VAL A 175
ASN A 246
TRP A 269
 None
 0.95A 2y00B-3pdiA:
undetectable		 2y00B-3pdiA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 VAL A 114
ASN A 312
TRP A 313
 ERC  A1201 (-3.8A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 1.00A 2y00B-3pdsA:
38.3		 2y00B-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 VAL A 117
ASN A 312
TRP A 313
 None
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 0.59A 2y00B-3pdsA:
38.3		 2y00B-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		3 VAL A  86
ASN A 494
TRP A 499
 None
 0.89A 2y00B-3q88A:
undetectable		 2y00B-3q88A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M) 		PF04744
(Monooxygenase_B) 		3 VAL A 277
ASN A  44
TRP A  45
 None
 1.04A 2y00B-3rfrA:
undetectable		 2y00B-3rfrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 825
ASN A 217
TRP A 216
 None
 0.97A 2y00B-3sunA:
undetectable		 2y00B-3sunA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		3 VAL A 171
ASN A  86
TRP A 108
 None
 1.12A 2y00B-3tdpA:
undetectable		 2y00B-3tdpA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		3 VAL A 119
ASN A 269
TRP A 271
 None
 1.14A 2y00B-3ttlA:
undetectable		 2y00B-3ttlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 VAL A 286
ASN A 178
TRP A 320
 None
PO4  A 401 ( 4.8A)
None
 1.11A 2y00B-3tx8A:
undetectable		 2y00B-3tx8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		3 VAL A 204
ASN A  78
TRP A 145
 None
CL  A 350 (-4.4A)
CL  A 350 (-4.7A)
 1.06A 2y00B-3u1tA:
undetectable		 2y00B-3u1tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
BETA-2

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 VAL B 121
ASN B 107
TRP B 109
 None
 1.03A 2y00B-3ubuB:
undetectable		 2y00B-3ubuB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		3 VAL A  95
ASN A 508
TRP A 513
 None
 0.81A 2y00B-3ujhA:
undetectable		 2y00B-3ujhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 VAL A 152
ASN A  50
TRP A  51
 None
 0.75A 2y00B-3v8uA:
undetectable		 2y00B-3v8uA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		3 VAL A 157
ASN A 289
TRP A 151
 None
 1.11A 2y00B-3vvaA:
undetectable		 2y00B-3vvaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		3 VAL A 164
ASN A  43
TRP A 109
 None
NHE  A 401 (-3.8A)
NHE  A 401 (-4.1A)
 1.08A 2y00B-3wibA:
undetectable		 2y00B-3wibA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A 488
ASN A 104
TRP A 506
 None
 1.14A 2y00B-3x1bA:
undetectable		 2y00B-3x1bA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		3 VAL A 613
ASN A 723
TRP A 462
 None
 0.78A 2y00B-3zdrA:
undetectable		 2y00B-3zdrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 VAL A 369
ASN A  49
TRP A  53
 None
 0.99A 2y00B-4bokA:
undetectable		 2y00B-4bokA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brz HALOALKANE
DEHALOGENASE

(Rhodobacteraceae) 		PF00561
(Abhydrolase_1) 		3 VAL A 162
ASN A  36
TRP A 107
 None
CL  A1293 (-4.4A)
CL  A1293 (-4.7A)
 1.04A 2y00B-4brzA:
undetectable		 2y00B-4brzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		3 VAL A 142
ASN A 380
TRP A 382
 None
 1.13A 2y00B-4c1oA:
undetectable		 2y00B-4c1oA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 3 VAL D  95
ASN D 502
TRP D 507
 None
 0.84A 2y00B-4em6D:
undetectable		 2y00B-4em6D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbo PSEUDOMONAS
FLUORESCENS
AGGLUTININ

(Pseudomonas
fluorescens) 		no annotation 3 VAL A 100
ASN A   8
TRP A  10
 None
 0.88A 2y00B-4fboA:
undetectable		 2y00B-4fboA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 329
ASN A 320
TRP A 322
 None
 0.99A 2y00B-4fffA:
undetectable		 2y00B-4fffA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		3 VAL A 117
ASN A 284
TRP A 285
 CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
None
 0.65A 2y00B-4gbrA:
39.0		 2y00B-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 VAL C 709
ASN C 673
TRP C 676
 None
 1.02A 2y00B-4hb4C:
undetectable		 2y00B-4hb4C:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg5 PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		3 VAL A 192
ASN A  55
TRP A 365
 None
 0.99A 2y00B-4jg5A:
undetectable		 2y00B-4jg5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		3 VAL A 388
ASN A 310
TRP A 313
 None
 0.99A 2y00B-4k2xA:
undetectable		 2y00B-4k2xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		3 VAL A 393
ASN A 314
TRP A 317
 None
 0.90A 2y00B-4k5rA:
undetectable		 2y00B-4k5rA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 VAL A1114
ASN A1312
TRP A1313
 P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
 1.08A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 VAL A1117
ASN A1312
TRP A1313
 P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
 0.97A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		3 VAL A 154
ASN A  40
TRP A 202
 None
DAL  A 403 (-4.2A)
DAL  A 403 (-4.1A)
 1.10A 2y00B-4nguA:
undetectable		 2y00B-4nguA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		3 VAL A  84
ASN A  15
TRP A  12
 None
VIB  A 401 (-3.3A)
VIB  A 401 (-3.6A)
 1.10A 2y00B-4nmyA:
undetectable		 2y00B-4nmyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		3 VAL A 721
ASN A 760
TRP A 798
 None
FM9  A1901 (-3.9A)
None
 1.04A 2y00B-4or2A:
16.9		 2y00B-4or2A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbo C-REACTIVE PROTEIN

(Danio rerio) 		PF00354
(Pentaxin) 		3 VAL A 134
ASN A  63
TRP A  65
 None
 1.11A 2y00B-4pboA:
undetectable		 2y00B-4pboA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwo DSBA

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		3 VAL A 252
ASN A 155
TRP A 154
 None
 1.06A 2y00B-4pwoA:
undetectable		 2y00B-4pwoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		3 VAL A 147
ASN A 561
TRP A 566
 None
 0.74A 2y00B-4qfhA:
undetectable		 2y00B-4qfhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzc FV M6P-1 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 3 VAL H  77
ASN H  35
TRP H  47
 None
 1.13A 2y00B-4rzcH:
undetectable		 2y00B-4rzcH:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 VAL A 228
ASN A 331
TRP A 335
 None
 0.95A 2y00B-4tnwA:
3.4		 2y00B-4tnwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		3 VAL A 267
ASN A 324
TRP A 325
 None
 0.95A 2y00B-4uriA:
undetectable		 2y00B-4uriA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		3 VAL A 163
ASN A  38
TRP A 109
 None
CL  A 301 (-4.2A)
CL  A 301 (-4.7A)
 1.03A 2y00B-4wdrA:
undetectable		 2y00B-4wdrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		3 VAL A 102
ASN A 511
TRP A 516
 None
 0.83A 2y00B-4wmjA:
undetectable		 2y00B-4wmjA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		3 VAL A 288
ASN A 235
TRP A 240
 None
None
ACT  A 500 ( 4.0A)
 0.84A 2y00B-4xfkA:
undetectable		 2y00B-4xfkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 VAL A 770
ASN A 363
TRP A 359
 None
 0.89A 2y00B-4xhpA:
undetectable		 2y00B-4xhpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4q BROMODOMAIN

(Leishmania
donovani) 		PF00439
(Bromodomain) 		3 VAL A  47
ASN A  87
TRP A  93
 None
BMF  A 201 (-2.8A)
BMF  A 201 (-3.5A)
 1.03A 2y00B-5c4qA:
undetectable		 2y00B-5c4qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		3 VAL A 149
ASN A 153
TRP A 248
 None
 1.12A 2y00B-5dz7A:
undetectable		 2y00B-5dz7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		3 VAL A 102
ASN A 227
TRP A 231
 None
 0.85A 2y00B-5esrA:
undetectable		 2y00B-5esrA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 3 VAL B 122
ASN B 329
TRP B 330
 P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
None
 1.07A 2y00B-5f8uB:
39.8		 2y00B-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 3 VAL B 125
ASN B 329
TRP B 330
 P32  B 400 ( 4.7A)
P32  B 400 (-2.9A)
None
 0.53A 2y00B-5f8uB:
39.8		 2y00B-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 VAL C 397
ASN C 186
TRP C 105
 None
 1.07A 2y00B-5flzC:
undetectable		 2y00B-5flzC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 VAL A 612
ASN A 390
TRP A 392
 None
 0.50A 2y00B-5l46A:
undetectable		 2y00B-5l46A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		3 VAL A 369
ASN A  49
TRP A  53
 None
EDO  A 602 (-3.9A)
EDO  A 602 ( 4.7A)
 1.00A 2y00B-5m77A:
undetectable		 2y00B-5m77A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 VAL A 333
ASN A 250
TRP A 249
 None
 0.84A 2y00B-5m8tA:
undetectable		 2y00B-5m8tA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 3 VAL A 535
ASN A 487
TRP A 488
 None
 1.05A 2y00B-5npuA:
undetectable		 2y00B-5npuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 3 VAL A 241
ASN A 410
TRP A 414
 None
 1.00A 2y00B-5o8fA:
3.1		 2y00B-5o8fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 3 VAL A 237
ASN A 407
TRP A 411
 None
 1.03A 2y00B-5osbA:
4.3		 2y00B-5osbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		3 VAL A 123
ASN A 217
TRP A 258
 GDP  A 401 (-4.1A)
GDP  A 401 ( 3.4A)
None
 1.10A 2y00B-5uzhA:
undetectable		 2y00B-5uzhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		3 VAL A 138
ASN A 119
TRP A 116
 None
 0.87A 2y00B-5v0tA:
undetectable		 2y00B-5v0tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE

(Sinorhizobium
meliloti) 		no annotation 3 VAL A 124
ASN A 130
TRP A 150
 None
 0.72A 2y00B-5wa0A:
undetectable		 2y00B-5wa0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wze AMINOPEPTIDASE P

(Pseudomonas
aeruginosa) 		no annotation 3 VAL A 318
ASN A 311
TRP A 310
 None
 1.05A 2y00B-5wzeA:
undetectable		 2y00B-5wzeA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 3 VAL A 233
ASN A 277
TRP A 319
 None
 1.06A 2y00B-5yy8A:
undetectable		 2y00B-5yy8A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 VAL A 410
ASN A 481
TRP A 480
 None
GOL  A 805 (-3.7A)
None
 0.69A 2y00B-5z06A:
undetectable		 2y00B-5z06A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 3 VAL A 377
ASN A 299
TRP A 302
 None
 0.89A 2y00B-6brdA:
undetectable		 2y00B-6brdA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 3 VAL F 176
ASN F 104
TRP F 107
 None
 1.13A 2y00B-6btmF:
3.1		 2y00B-6btmF:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 VAL A 376
ASN A 298
TRP A 301
 None
 1.01A 2y00B-6c7sA:
undetectable		 2y00B-6c7sA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 3 VAL B 238
ASN B 337
TRP B 341
 None
 0.98A 2y00B-6d6uB:
4.4		 2y00B-6d6uB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 3 VAL E 248
ASN E 347
TRP E 351
 None
 0.83A 2y00B-6d6uE:
3.4		 2y00B-6d6uE:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 3 VAL A 803
ASN A 812
TRP A 791
 None
 0.66A 2y00B-6egtA:
undetectable		 2y00B-6egtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 VAL A 128
ASN A 136
TRP A 219
 None
 1.06A 2y00B-6eksA:
undetectable		 2y00B-6eksA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 3 VAL B 114
ASN B 208
TRP B 249
 F7E  B 402 (-4.1A)
F7E  B 402 ( 3.1A)
None
 1.08A 2y00B-6gplB:
undetectable		 2y00B-6gplB:
undetectable