SIMILAR PATTERNS OF AMINO ACIDS FOR 2Y00_A_Y00A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN
4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 LEU B  56
VAL B  57
ASP B 126
SER A  97
PHE A 103
 None
 1.11A 2y00A-1bouB:
undetectable		 2y00A-1bouB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.45A 2y00A-1f8rA:
undetectable		 2y00A-1f8rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ASP A 749
VAL A 750
SER A 668
ASN A 634
ASN A 609
 None
 1.48A 2y00A-1h17A:
undetectable		 2y00A-1h17A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.49A 2y00A-1kwmA:
undetectable		 2y00A-1kwmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 300
VAL A 296
TRP A   3
ASP A  18
PHE A 179
 None
 1.48A 2y00A-1ml4A:
undetectable		 2y00A-1ml4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.48A 2y00A-1nsaA:
undetectable		 2y00A-1nsaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 VAL A 145
TRP A 189
VAL A 110
SER A 124
ASN A 131
 None
 1.46A 2y00A-1wkrA:
undetectable		 2y00A-1wkrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		5 LEU A  91
VAL A  92
SER A 108
SER A 110
ASN A 127
 None
None
MN  A 301 ( 2.0A)
HEM  A 396 (-2.6A)
None
 1.45A 2y00A-2ciyA:
undetectable		 2y00A-2ciyA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		5 LEU A  19
ASP A  70
VAL A  34
SER A 231
ASN A 128
 None
 1.42A 2y00A-2dqwA:
undetectable		 2y00A-2dqwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		5 VAL A 147
ASP A  70
VAL A  34
SER A 231
ASN A 128
 None
 1.39A 2y00A-2dqwA:
undetectable		 2y00A-2dqwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H  34
SER H  30
SER H  55
PHE H  24
ASN H  78
 None
 1.37A 2y00A-2f5aH:
undetectable		 2y00A-2f5aH:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 154
VAL A 152
ASP A 231
SER A 264
ASN A 138
 None
None
PLP  A1265 (-2.8A)
PLP  A1265 (-3.1A)
PLP  A1265 (-4.2A)
 1.38A 2y00A-2jg2A:
undetectable		 2y00A-2jg2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 249
VAL A 252
ASP A 199
PHE A 182
TYR A 235
 None
 1.48A 2y00A-2qygA:
undetectable		 2y00A-2qygA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1396
VAL G1372
VAL G1605
PHE G1311
ASN G1306
 None
 1.18A 2y00A-2uv8G:
undetectable		 2y00A-2uv8G:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 301
VAL A  50
ASP A  97
VAL A 129
TYR A 155
 None
 1.48A 2y00A-2wuaA:
undetectable		 2y00A-2wuaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		5 LEU A 310
VAL A 311
SER A 243
ASN A 182
TYR A 218
 None
None
PLP  A1400 ( 2.9A)
PLP  A1400 (-3.3A)
None
 1.46A 2y00A-2x5dA:
undetectable		 2y00A-2x5dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
no annotation 		5 LEU C  43
VAL C  39
VAL A 733
PHE A 703
ASN A 663
 None
 1.19A 2y00A-2yevC:
undetectable		 2y00A-2yevC:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.44A 2y00A-2zc0A:
undetectable		 2y00A-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 5 LEU A 191
VAL A 193
TRP A 214
VAL A 125
TYR A 241
 None
 1.49A 2y00A-3cjiA:
undetectable		 2y00A-3cjiA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 ASP A 309
VAL A 311
SER A 212
ASN A 189
TYR A 286
 None
None
None
None
FAD  A 600 ( 4.5A)
 1.17A 2y00A-3e1tA:
undetectable		 2y00A-3e1tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh6 MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALF

(Escherichia
coli) 		PF00528
(BPD_transp_1)
PF14785
(MalF_P2) 		5 LEU F 302
VAL F 301
VAL F 375
PHE F 287
ASN F 437
 None
 1.45A 2y00A-3fh6F:
undetectable		 2y00A-3fh6F:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 LEU A   9
VAL A  12
SER A  64
ASN A  66
TYR A  38
 None
 1.44A 2y00A-3ivrA:
undetectable		 2y00A-3ivrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 LEU A 330
VAL A 289
SER A 445
PHE A 157
ASN A 156
 None
None
None
None
NAP  A 482 (-3.3A)
 1.47A 2y00A-3jz4A:
undetectable		 2y00A-3jz4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.35A 2y00A-3kveA:
undetectable		 2y00A-3kveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 LEU A 428
VAL A 427
SER A   2
SER A   3
TYR A 266
 None
 1.24A 2y00A-3lovA:
undetectable		 2y00A-3lovA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		5 VAL A  84
VAL A  60
SER A  19
ASN A 295
ASN A  67
 None
None
None
None
AP5  A 346 (-3.4A)
 1.40A 2y00A-3otxA:
undetectable		 2y00A-3otxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.06A 2y00A-3pblA:
32.6		 2y00A-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 LEU A  89
ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.95A 2y00A-3pblA:
32.6		 2y00A-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 LEU A  89
ASP A 110
VAL A 111
SER A 196
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.71A 2y00A-3pblA:
32.6		 2y00A-3pblA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A  87
VAL A 111
SER A 196
PHE A 345
PHE A 346
TYR A 373
 None
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.29A 2y00A-3pblA:
32.6		 2y00A-3pblA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 TRP A 109
ASP A 113
SER A 204
SER A 207
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.0A)
None
 1.31A 2y00A-3pdsA:
38.6		 2y00A-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
ASP A 113
VAL A 114
SER A 203
SER A 207
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.51A 2y00A-3pdsA:
38.6		 2y00A-3pdsA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 117
SER A 207
PHE A 289
ASN A 312
TYR A 316
 None
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
 1.34A 2y00A-3pdsA:
38.6		 2y00A-3pdsA:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		5 LEU A 357
VAL A 425
PHE A 345
ASN A  86
ASN A 349
 None
 1.46A 2y00A-3pdxA:
undetectable		 2y00A-3pdxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 VAL A1529
ASP A1570
VAL A1571
ASN A1583
TYR A1588
 None
 1.43A 2y00A-3rytA:
undetectable		 2y00A-3rytA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		5 LEU A 144
TRP A 102
ASP A  38
PHE A  55
TYR A 126
 None
 1.34A 2y00A-3simA:
undetectable		 2y00A-3simA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		5 LEU A 199
VAL A 198
ASP A 257
SER A 251
PHE A 246
 None
 1.41A 2y00A-3t2nA:
undetectable		 2y00A-3t2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A  25
VAL A 293
ASP A  84
VAL A  85
ASN A  55
 None
None
BGC  A 776 (-2.8A)
None
BGC  A 776 ( 4.2A)
 1.42A 2y00A-3u4aA:
undetectable		 2y00A-3u4aA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 LEU B 241
VAL B 237
ASP B 168
VAL B 169
TYR B 266
 None
 1.47A 2y00A-3vsjB:
undetectable		 2y00A-3vsjB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		5 LEU A  99
VAL A 102
TRP A  93
PHE A  54
PHE A  10
 None
 1.37A 2y00A-3wibA:
undetectable		 2y00A-3wibA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 VAL B  96
VAL B 526
ASN B 504
ASN B 491
TYR B 486
 None
 1.33A 2y00A-3x17B:
undetectable		 2y00A-3x17B:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
ASP A 113
VAL A 114
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.64A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
ASP A 113
VAL A 114
SER A 203
PHE A 261
PHE A 262
ASN A 284
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
 1.40A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
ASP A 113
VAL A 114
SER A 203
PHE A 261
PHE A 262
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.74A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
ASP A 113
VAL A 114
SER A 203
SER A 207
PHE A 261
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 0.76A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 261
PHE A 262
ASN A 265
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-4.6A)
 0.66A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 1.49A 2y00A-4gbrA:
39.3		 2y00A-4gbrA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 LEU A  57
VAL A  53
VAL A 332
SER A 349
PHE A 339
 None
 1.49A 2y00A-4i3hA:
3.1		 2y00A-4i3hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 LEU A 467
SER A 266
SER A 323
ASN A 345
ASN A 341
 None
 1.50A 2y00A-4iaoA:
undetectable		 2y00A-4iaoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.62A 2y00A-4ib4A:
27.8		 2y00A-4ib4A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iin 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE (FABG)

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		5 LEU A  46
VAL A  42
PHE A  62
PHE A  70
ASN A  35
 None
None
None
None
NAD  A 301 (-3.6A)
 1.41A 2y00A-4iinA:
undetectable		 2y00A-4iinA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A1113
SER A1204
SER A1207
ASN A1312
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-2.9A)
None
 1.23A 2y00A-4ldeA:
33.1		 2y00A-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
ASP A1113
VAL A1114
SER A1203
PHE A1290
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
None
 1.34A 2y00A-4ldeA:
33.1		 2y00A-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
ASP A1113
VAL A1114
SER A1203
SER A1207
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.72A 2y00A-4ldeA:
33.1		 2y00A-4ldeA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 LEU A 120
VAL A 118
ASP A 205
VAL A 207
SER A 236
 None
 1.42A 2y00A-4my5A:
undetectable		 2y00A-4my5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 VAL A 272
TRP A 116
VAL A 145
ASN A 184
TYR A 194
 None
None
None
None
MLI  A 302 (-4.1A)
 1.20A 2y00A-4otkA:
undetectable		 2y00A-4otkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 LEU A 305
VAL A 217
SER C  79
SER C  80
ASN A 390
 None
 1.49A 2y00A-4owtA:
undetectable		 2y00A-4owtA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 LEU A 158
VAL A 146
ASP A 166
ASN A 201
TYR A 204
 None
 1.41A 2y00A-4qjyA:
undetectable		 2y00A-4qjyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 417
VAL A 543
VAL A 467
PHE A 532
PHE A 594
 None
 1.45A 2y00A-4tptA:
2.0		 2y00A-4tptA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A  28
VAL A  29
SER A 375
SER A 332
ASN A  94
 None
 1.49A 2y00A-4tx8A:
undetectable		 2y00A-4tx8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		5 VAL A 312
VAL A  75
PHE A 116
ASN A 160
TYR A 336
 None
 1.39A 2y00A-4zv3A:
undetectable		 2y00A-4zv3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 LEU A 663
PHE A 221
ASN A 204
ASN A 708
TYR A 747
 None
 1.17A 2y00A-5c9iA:
undetectable		 2y00A-5c9iA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		5 LEU A1478
VAL A1547
SER A1232
SER A1218
ASN A1214
 None
 1.42A 2y00A-5f3yA:
undetectable		 2y00A-5f3yA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 12 LEU B 101
VAL B 102
TRP B 117
ASP B 121
VAL B 122
SER B 211
SER B 215
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 None
None
P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.65A 2y00A-5f8uB:
40.0		 2y00A-5f8uB:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 LEU B 101
VAL B 125
PHE B 306
ASN B 310
ASN B 329
 None
P32  B 400 ( 4.7A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
 1.43A 2y00A-5f8uB:
40.0		 2y00A-5f8uB:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		5 ASP B  53
VAL B  52
SER B  48
SER B  43
TYR B  55
 None
 1.39A 2y00A-5g52B:
undetectable		 2y00A-5g52B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 LEU A 107
VAL A 108
ASP A  86
VAL A  87
TYR A 144
 None
 1.32A 2y00A-5ktkA:
undetectable		 2y00A-5ktkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		5 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.27A 2y00A-5lltA:
undetectable		 2y00A-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 LEU A 110
VAL A 106
SER A 948
SER A 947
ASN A 144
 None
 1.46A 2y00A-5lrbA:
undetectable		 2y00A-5lrbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 LEU A  64
ASP A 142
VAL A 141
SER A 182
TYR A  34
 None
 1.45A 2y00A-5nsqA:
undetectable		 2y00A-5nsqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.40A 2y00A-5ts5A:
undetectable		 2y00A-5ts5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.79A 2y00A-5v54A:
28.8		 2y00A-5v54A:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.05A 2y00A-5wivA:
29.9		 2y00A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.16A 2y00A-5wivA:
29.9		 2y00A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 200
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.76A 2y00A-5wivA:
29.9		 2y00A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A  92
ASP A 115
SER A 196
PHE A 410
PHE A 411
 PEG  A1218 ( 4.6A)
AQD  A1201 (-3.3A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.08A 2y00A-5wivA:
29.9		 2y00A-5wivA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A  92
ASP A 115
SER A 200
PHE A 410
PHE A 411
 PEG  A1218 ( 4.6A)
AQD  A1201 (-3.3A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.22A 2y00A-5wivA:
29.9		 2y00A-5wivA:
32.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 5 LEU A  37
VAL A  64
VAL A 114
SER A 122
ASN A 303
 None
 1.36A 2y00A-5ysbA:
undetectable		 2y00A-5ysbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.68A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
SER A 219
PHE A 327
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
 1.10A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.48A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.79A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 7 LEU A  94
ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.88A 2y00A-6cm4A:
30.5		 2y00A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
 1.09A 2y00A-6g79S:
28.3		 2y00A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.84A 2y00A-6g79S:
28.3		 2y00A-6g79S:
14.22