SIMILAR PATTERNS OF AMINO ACIDS FOR 2XZ5_E_ACHE1211

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		4 ILE A 109
SER A  57
TYR A  62
TYR A  11
 None
 1.43A 2xz5D-1awbA:
0.0
2xz5E-1awbA:
0.0		 2xz5D-1awbA:
21.22
2xz5E-1awbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		4 GLN A 110
ILE A  95
TYR A 108
TYR A  97
 None
 1.26A 2xz5D-1eqcA:
0.0
2xz5E-1eqcA:
0.0		 2xz5D-1eqcA:
18.53
2xz5E-1eqcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 272
SER A 295
TYR A 187
TYR A 299
 None
None
PPE  A 413 (-4.4A)
None
 1.09A 2xz5D-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5D-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		4 GLN A  35
ILE A  20
TYR A  29
CYH A  18
 None
 1.38A 2xz5D-1iomA:
0.0
2xz5E-1iomA:
0.0		 2xz5D-1iomA:
18.16
2xz5E-1iomA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 ILE A  68
SER A  85
TYR A  89
TRP A 118
 None
 0.91A 2xz5D-1jznA:
0.0
2xz5E-1jznA:
0.0		 2xz5D-1jznA:
19.00
2xz5E-1jznA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		4 ILE D 386
TYR D 351
TRP D 390
TYR D 347
 None
 1.42A 2xz5D-1mtyD:
0.0
2xz5E-1mtyD:
0.0		 2xz5D-1mtyD:
16.63
2xz5E-1mtyD:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 GLN A  15
ILE A  20
TYR A 136
CYH A 114
 None
 1.25A 2xz5D-1tk1A:
0.0
2xz5E-1tk1A:
0.0		 2xz5D-1tk1A:
20.65
2xz5E-1tk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 GLN A  15
ILE A  20
TYR A 136
CYH A 114
 None
 1.29A 2xz5D-1tklA:
0.0
2xz5E-1tklA:
0.0		 2xz5D-1tklA:
18.48
2xz5E-1tklA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3d FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A

(Homo sapiens) 		PF00041
(fn3) 		4 GLN A  74
ILE A  77
TYR A  68
CYH A  67
 None
 1.38A 2xz5D-1x3dA:
0.0
2xz5E-1x3dA:
0.0		 2xz5D-1x3dA:
20.00
2xz5E-1x3dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynz PIN3P

(Saccharomyces
cerevisiae) 		PF00018
(SH3_1) 		4 GLN A  13
ILE A  47
TRP A  36
TYR A  52
 None
 1.29A 2xz5D-1ynzA:
undetectable
2xz5E-1ynzA:
undetectable		 2xz5D-1ynzA:
14.06
2xz5E-1ynzA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 ILE A1109
SER A1057
TYR A1062
TYR A1011
 None
 1.43A 2xz5D-2bjiA:
undetectable
2xz5E-2bjiA:
undetectable		 2xz5D-2bjiA:
19.16
2xz5E-2bjiA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ILE A 383
SER A 411
TRP A 402
TYR A 394
 None
 1.01A 2xz5D-2bmfA:
undetectable
2xz5E-2bmfA:
undetectable		 2xz5D-2bmfA:
19.80
2xz5E-2bmfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF03480
(DctP) 		4 GLN A 261
SER A 255
TYR A 260
TYR A  24
 None
 1.43A 2xz5D-2hpgA:
undetectable
2xz5E-2hpgA:
undetectable		 2xz5D-2hpgA:
19.09
2xz5E-2hpgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 250
SER A 255
TYR A 261
CYH A 441
 None
MGD  A1986 (-4.6A)
None
None
 1.39A 2xz5D-2ivfA:
undetectable
2xz5E-2ivfA:
undetectable		 2xz5D-2ivfA:
12.53
2xz5E-2ivfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 GLN B 351
ILE B  41
SER B 352
TRP A 104
 None
 1.13A 2xz5D-2ivfB:
undetectable
2xz5E-2ivfB:
undetectable		 2xz5D-2ivfB:
21.02
2xz5E-2ivfB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 GLN A1900
ILE A1743
SER A1469
TYR A1439
 None
 1.41A 2xz5D-2ix8A:
undetectable
2xz5E-2ix8A:
undetectable		 2xz5D-2ix8A:
11.20
2xz5E-2ix8A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ILE A 383
SER A 411
TRP A 402
TYR A 394
 None
 0.90A 2xz5D-2jlsA:
undetectable
2xz5E-2jlsA:
undetectable		 2xz5D-2jlsA:
19.69
2xz5E-2jlsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okv PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 1

(Homo sapiens) 		PF02580
(Tyr_Deacylase) 		4 GLN A  19
ILE A 135
SER A  21
CYH A  28
 None
None
None
MG  A1201 (-4.1A)
 1.42A 2xz5D-2okvA:
undetectable
2xz5E-2okvA:
undetectable		 2xz5D-2okvA:
19.56
2xz5E-2okvA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A 272
SER A 245
TYR A 188
TYR A 242
 None
 1.04A 2xz5D-2q3rA:
undetectable
2xz5E-2q3rA:
undetectable		 2xz5D-2q3rA:
19.89
2xz5E-2q3rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 GLN A 252
ILE A 432
SER A 256
TYR A 478
 None
 1.18A 2xz5D-2rfoA:
undetectable
2xz5E-2rfoA:
undetectable		 2xz5D-2rfoA:
16.64
2xz5E-2rfoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8o FLAVIVIRIN PROTEASE
NS3

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 ILE A 384
SER A 412
TRP A 403
TYR A 395
 None
 0.99A 2xz5D-2v8oA:
undetectable
2xz5E-2v8oA:
undetectable		 2xz5D-2v8oA:
21.94
2xz5E-2v8oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 GLN A 220
ILE A 214
SER A 221
CYH A 184
 None
 1.37A 2xz5D-2vj5A:
undetectable
2xz5E-2vj5A:
undetectable		 2xz5D-2vj5A:
22.58
2xz5E-2vj5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 GLN A 220
ILE A 214
TYR A 185
CYH A 184
 None
 1.36A 2xz5D-2vj5A:
undetectable
2xz5E-2vj5A:
undetectable		 2xz5D-2vj5A:
22.58
2xz5E-2vj5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 ILE A 217
SER A 168
TYR A  91
TYR A 214
 None
 1.33A 2xz5D-2vtcA:
undetectable
2xz5E-2vtcA:
undetectable		 2xz5D-2vtcA:
17.97
2xz5E-2vtcA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w47 LIPOLYTIC ENZYME,
G-D-S-L

(Ruminiclostridium
thermocellum) 		PF16990
(CBM_35) 		4 GLN A   8
ILE A  14
SER A  29
TYR A  31
 None
 1.36A 2xz5D-2w47A:
undetectable
2xz5E-2w47A:
undetectable		 2xz5D-2w47A:
19.82
2xz5E-2w47A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 ILE A 383
SER A 411
TRP A 402
TYR A 394
 None
 0.93A 2xz5D-2whxA:
undetectable
2xz5E-2whxA:
undetectable		 2xz5D-2whxA:
16.83
2xz5E-2whxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		4 ILE A 384
SER A 412
TRP A 403
TYR A 395
 None
 0.99A 2xz5D-2wv9A:
undetectable
2xz5E-2wv9A:
undetectable		 2xz5D-2wv9A:
17.42
2xz5E-2wv9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 GLN A 570
ILE A 683
SER A 568
TYR A 540
 None
 1.26A 2xz5D-2yiaA:
undetectable
2xz5E-2yiaA:
undetectable		 2xz5D-2yiaA:
13.62
2xz5E-2yiaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 GLN D 570
ILE D 683
SER D 568
TYR D 540
 None
 1.28A 2xz5D-2yibD:
undetectable
2xz5E-2yibD:
undetectable		 2xz5D-2yibD:
15.81
2xz5E-2yibD:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 GLN A 362
ILE A  52
TRP A  51
TYR A 382
 None
 1.16A 2xz5D-2zblA:
undetectable
2xz5E-2zblA:
undetectable		 2xz5D-2zblA:
18.00
2xz5E-2zblA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLN A 493
ILE A 596
TYR A 500
TYR A 484
 None
 1.38A 2xz5D-3a24A:
undetectable
2xz5E-3a24A:
undetectable		 2xz5D-3a24A:
16.07
2xz5E-3a24A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLN A 523
ILE A 596
TYR A 484
TYR A 500
 None
 1.38A 2xz5D-3a24A:
undetectable
2xz5E-3a24A:
undetectable		 2xz5D-3a24A:
16.07
2xz5E-3a24A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 GLN A 255
SER A 204
TYR A 269
TYR A 212
 CBI  A 459 ( 4.6A)
None
None
None
 1.41A 2xz5D-3axxA:
undetectable
2xz5E-3axxA:
undetectable		 2xz5D-3axxA:
18.92
2xz5E-3axxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 GLN A 178
ILE A 147
TYR A 124
TRP A 119
 None
 1.15A 2xz5D-3b8oA:
undetectable
2xz5E-3b8oA:
undetectable		 2xz5D-3b8oA:
19.34
2xz5E-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 GLN B 275
ILE B 239
SER B 274
TYR B 231
 None
 0.92A 2xz5D-3bg0B:
undetectable
2xz5E-3bg0B:
undetectable		 2xz5D-3bg0B:
20.32
2xz5E-3bg0B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		4 GLN A 214
SER A 215
TYR A 210
CYH A 420
 None
 1.34A 2xz5D-3bg2A:
undetectable
2xz5E-3bg2A:
undetectable		 2xz5D-3bg2A:
20.27
2xz5E-3bg2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLN X  37
ILE X  21
SER X  11
TYR X  15
 None
None
None
FE  X 326 (-4.3A)
 1.35A 2xz5D-3e13X:
undetectable
2xz5E-3e13X:
undetectable		 2xz5D-3e13X:
20.30
2xz5E-3e13X:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLN X 185
ILE X 108
TYR X 146
TYR X 203
 None
None
FE  X 326 (-4.3A)
FE  X 326 (-4.1A)
 1.28A 2xz5D-3e13X:
undetectable
2xz5E-3e13X:
undetectable		 2xz5D-3e13X:
20.30
2xz5E-3e13X:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		4 ILE A 181
SER A 311
TYR A 202
TYR A 187
 None
 1.38A 2xz5D-3e79A:
undetectable
2xz5E-3e79A:
undetectable		 2xz5D-3e79A:
21.43
2xz5E-3e79A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLN A 150
ILE A 128
TYR A 145
CYH A 143
 None
 1.41A 2xz5D-3eoeA:
undetectable
2xz5E-3eoeA:
undetectable		 2xz5D-3eoeA:
17.95
2xz5E-3eoeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 GLN X 103
ILE X 107
SER X 279
TYR X 104
 None
 1.32A 2xz5D-3fmxX:
undetectable
2xz5E-3fmxX:
undetectable		 2xz5D-3fmxX:
18.75
2xz5E-3fmxX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 122
SER A 337
TYR A 344
CYH A 145
 GOL  A 402 (-4.2A)
None
None
None
 1.23A 2xz5D-3fn4A:
undetectable
2xz5E-3fn4A:
undetectable		 2xz5D-3fn4A:
19.51
2xz5E-3fn4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h08 RNH (RIBONUCLEASE H)

(Chlorobaculum
tepidum) 		PF00075
(RNase_H) 		4 ILE A 108
SER A  69
TYR A  73
TRP A 105
 None
MG  A 501 (-3.4A)
None
None
 1.14A 2xz5D-3h08A:
undetectable
2xz5E-3h08A:
undetectable		 2xz5D-3h08A:
18.35
2xz5E-3h08A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 GLN A  15
ILE A  18
TYR A  39
CYH A  35
 None
 1.28A 2xz5D-3hamA:
undetectable
2xz5E-3hamA:
undetectable		 2xz5D-3hamA:
20.33
2xz5E-3hamA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 ILE A 863
TYR A 858
TYR A 737
CYH A 733
 None
 1.28A 2xz5D-3ihyA:
undetectable
2xz5E-3ihyA:
undetectable		 2xz5D-3ihyA:
17.00
2xz5E-3ihyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 4 ILE H 125
SER H 157
TYR H 151
CYH H 164
 None
 1.29A 2xz5D-3j97H:
undetectable
2xz5E-3j97H:
undetectable		 2xz5D-3j97H:
21.23
2xz5E-3j97H:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 GLN A1276
ILE A1240
SER A1275
TYR A1232
 None
 0.85A 2xz5D-3jroA:
undetectable
2xz5E-3jroA:
undetectable		 2xz5D-3jroA:
14.38
2xz5E-3jroA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		4 GLN A 126
ILE A  85
TYR A 127
CYH A  39
 None
 1.43A 2xz5D-3ko7A:
undetectable
2xz5E-3ko7A:
undetectable		 2xz5D-3ko7A:
20.61
2xz5E-3ko7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ILE A 205
TYR A 138
TRP A 204
CYH A 299
 None
 1.30A 2xz5D-3mn8A:
undetectable
2xz5E-3mn8A:
undetectable		 2xz5D-3mn8A:
18.62
2xz5E-3mn8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLN A  60
ILE A 147
TYR A  64
TYR A  38
 None
 1.40A 2xz5D-3n0qA:
undetectable
2xz5E-3n0qA:
undetectable		 2xz5D-3n0qA:
19.04
2xz5E-3n0qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 GLN A 254
ILE A 283
TRP A 322
CYH A 276
 None
 1.02A 2xz5D-3nowA:
undetectable
2xz5E-3nowA:
undetectable		 2xz5D-3nowA:
13.27
2xz5E-3nowA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 GLN A  89
ILE A 209
TRP A 219
CYH A 228
 None
 1.28A 2xz5D-3oftA:
undetectable
2xz5E-3oftA:
undetectable		 2xz5D-3oftA:
18.78
2xz5E-3oftA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 ILE A 214
SER A 192
TYR A 166
TYR A 217
 None
None
PHE  A 400 (-3.8A)
PHE  A 400 (-4.8A)
 1.29A 2xz5D-3td9A:
undetectable
2xz5E-3td9A:
undetectable		 2xz5D-3td9A:
19.89
2xz5E-3td9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr4 INORGANIC
PYROPHOSPHATASE

(Coxiella
burnetii) 		PF00719
(Pyrophosphatase) 		4 ILE A 133
TYR A 140
TYR A  50
CYH A  52
 None
 0.86A 2xz5D-3tr4A:
undetectable
2xz5E-3tr4A:
undetectable		 2xz5D-3tr4A:
25.00
2xz5E-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 GLN A 255
SER A 204
TYR A 269
TYR A 212
 None
 1.42A 2xz5D-3w6mA:
undetectable
2xz5E-3w6mA:
undetectable		 2xz5D-3w6mA:
18.80
2xz5E-3w6mA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC

(Escherichia
coli) 		PF01551
(Peptidase_M23) 		4 GLN A 395
SER A 399
TYR A 401
TRP A 320
 None
 1.36A 2xz5D-4bh5A:
undetectable
2xz5E-4bh5A:
undetectable		 2xz5D-4bh5A:
21.62
2xz5E-4bh5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		4 ILE A 451
SER A 164
TYR A  51
TYR A 455
 None
 1.41A 2xz5D-4ci7A:
undetectable
2xz5E-4ci7A:
undetectable		 2xz5D-4ci7A:
19.33
2xz5E-4ci7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 GLN A 224
ILE A 233
SER A 266
TYR A 273
 None
 1.38A 2xz5D-4dwsA:
undetectable
2xz5E-4dwsA:
undetectable		 2xz5D-4dwsA:
18.86
2xz5E-4dwsA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 GLN A 224
ILE A 233
TYR A 273
CYH A 204
 None
 1.31A 2xz5D-4dwsA:
undetectable
2xz5E-4dwsA:
undetectable		 2xz5D-4dwsA:
18.86
2xz5E-4dwsA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 GLN A 257
ILE A 150
TYR A 266
CYH A 273
 None
 1.43A 2xz5D-4efcA:
undetectable
2xz5E-4efcA:
undetectable		 2xz5D-4efcA:
17.08
2xz5E-4efcA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 GLN A 703
ILE A 618
TYR A 690
CYH A 628
 None
 1.38A 2xz5D-4i1pA:
undetectable
2xz5E-4i1pA:
undetectable		 2xz5D-4i1pA:
20.35
2xz5E-4i1pA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 GLN B 388
ILE B 439
TYR B 613
TYR B 413
 None
 1.13A 2xz5D-4iglB:
undetectable
2xz5E-4iglB:
undetectable		 2xz5D-4iglB:
16.62
2xz5E-4iglB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLN A 371
ILE A 325
SER A 368
TYR A 364
 None
 1.18A 2xz5D-4irnA:
undetectable
2xz5E-4irnA:
undetectable		 2xz5D-4irnA:
19.74
2xz5E-4irnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		4 GLN A 207
ILE A 193
SER A 203
TYR A 200
 None
 1.29A 2xz5D-4iuyA:
undetectable
2xz5E-4iuyA:
undetectable		 2xz5D-4iuyA:
20.73
2xz5E-4iuyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 GLN A   3
ILE A  87
TRP A  53
TYR A  10
 BAM  A 202 (-2.9A)
BAM  A 202 (-4.2A)
BAM  A 202 ( 4.3A)
None
 1.36A 2xz5D-4izxA:
undetectable
2xz5E-4izxA:
undetectable		 2xz5D-4izxA:
19.91
2xz5E-4izxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 326
SER A 355
TYR A 339
CYH A 318
 None
 1.32A 2xz5D-4j3bA:
1.8
2xz5E-4j3bA:
1.5		 2xz5D-4j3bA:
12.83
2xz5E-4j3bA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 GLN B 132
ILE B  59
SER B 128
TYR B 125
 None
 1.39A 2xz5D-4nfuB:
undetectable
2xz5E-4nfuB:
undetectable		 2xz5D-4nfuB:
16.36
2xz5E-4nfuB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLN A1890
ILE A1939
TYR A2114
TYR A1913
 None
 1.08A 2xz5D-4o9xA:
undetectable
2xz5E-4o9xA:
undetectable		 2xz5D-4o9xA:
7.18
2xz5E-4o9xA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 GLN A 151
ILE A 130
SER A  52
TYR A  63
 None
 1.23A 2xz5D-4onoA:
undetectable
2xz5E-4onoA:
undetectable		 2xz5D-4onoA:
19.42
2xz5E-4onoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLN A 177
ILE A  69
TYR A 343
TYR A  71
 None
 1.28A 2xz5D-4ovkA:
undetectable
2xz5E-4ovkA:
undetectable		 2xz5D-4ovkA:
24.18
2xz5E-4ovkA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 ILE A 225
SER A 216
TYR A 280
TYR A 219
 None
 1.42A 2xz5D-4pbqA:
undetectable
2xz5E-4pbqA:
undetectable		 2xz5D-4pbqA:
18.63
2xz5E-4pbqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		4 GLN A  49
ILE A  90
SER A  48
CYH A  94
 None
None
7PE  A 502 ( 4.5A)
None
 1.35A 2xz5D-4r5oA:
undetectable
2xz5E-4r5oA:
undetectable		 2xz5D-4r5oA:
18.33
2xz5E-4r5oA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		4 GLN A 245
ILE A 227
SER A 126
TYR A 221
 None
 1.33A 2xz5D-4tznA:
undetectable
2xz5E-4tznA:
undetectable		 2xz5D-4tznA:
21.79
2xz5E-4tznA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v10 MYOMESIN-1

(Mus musculus) 		PF07679
(I-set) 		4 ILE A 168
SER A 144
TYR A 205
CYH A 190
 None
 1.21A 2xz5D-4v10A:
undetectable
2xz5E-4v10A:
undetectable		 2xz5D-4v10A:
19.42
2xz5E-4v10A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 GLN A 101
ILE A 104
SER A  99
TYR A  82
 None
 1.13A 2xz5D-4v20A:
undetectable
2xz5E-4v20A:
undetectable		 2xz5D-4v20A:
19.50
2xz5E-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 GLN A 178
ILE A 147
TYR A 124
TRP A 119
 None
 1.19A 2xz5D-4wl1A:
undetectable
2xz5E-4wl1A:
undetectable		 2xz5D-4wl1A:
20.11
2xz5E-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF04084
(ORC2)
PF07034
(ORC3_N) 		4 GLN B 477
ILE C 606
SER C 310
TYR C 307
 None
 1.11A 2xz5D-4xgcB:
undetectable
2xz5E-4xgcB:
undetectable		 2xz5D-4xgcB:
20.68
2xz5E-4xgcB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		4 GLN A 315
ILE A 243
TYR A 318
CYH A 255
 None
 1.34A 2xz5D-4yraA:
undetectable
2xz5E-4yraA:
undetectable		 2xz5D-4yraA:
22.09
2xz5E-4yraA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 GLN A1190
SER A1182
TYR A1163
CYH A1217
 None
 1.20A 2xz5D-5amqA:
undetectable
2xz5E-5amqA:
undetectable		 2xz5D-5amqA:
6.82
2xz5E-5amqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP1
VP0

(Enterovirus A;
Enterovirus A) 		PF00073
(Rhv)
PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 GLN A 189
ILE B  30
SER A 191
TYR B  33
 None
 1.31A 2xz5D-5c8cA:
undetectable
2xz5E-5c8cA:
undetectable		 2xz5D-5c8cA:
21.09
2xz5E-5c8cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 ILE A 254
SER A 321
TYR A 261
CYH A 326
 None
 1.41A 2xz5D-5c9eA:
undetectable
2xz5E-5c9eA:
undetectable		 2xz5D-5c9eA:
21.96
2xz5E-5c9eA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ILE A 380
SER A 249
TYR A 168
TYR A 347
 None
 1.35A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 GLN A 149
ILE A 697
SER A 150
TYR A 703
 None
 0.96A 2xz5D-5d0fA:
undetectable
2xz5E-5d0fA:
undetectable		 2xz5D-5d0fA:
8.67
2xz5E-5d0fA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 GLN A 519
ILE A 270
SER A 516
TYR A 492
 None
 1.26A 2xz5D-5fnoA:
undetectable
2xz5E-5fnoA:
undetectable		 2xz5D-5fnoA:
19.34
2xz5E-5fnoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLN A  89
ILE A 126
TYR A 120
TYR A 104
 None
 1.40A 2xz5D-5hc4A:
undetectable
2xz5E-5hc4A:
undetectable		 2xz5D-5hc4A:
21.07
2xz5E-5hc4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 GLN A 379
ILE A 414
TYR A 402
TYR A 316
 None
None
GOL  A 654 (-4.4A)
None
 1.26A 2xz5D-5jvkA:
undetectable
2xz5E-5jvkA:
undetectable		 2xz5D-5jvkA:
18.30
2xz5E-5jvkA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 GLN B 388
ILE B 438
TYR B 612
TYR B 413
 None
None
None
CL  B1002 (-4.8A)
 1.10A 2xz5D-5kisB:
undetectable
2xz5E-5kisB:
undetectable		 2xz5D-5kisB:
13.80
2xz5E-5kisB:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 ILE K 165
SER K  76
TYR K 173
CYH K 175
 None
 1.13A 2xz5D-5mm7K:
undetectable
2xz5E-5mm7K:
undetectable		 2xz5D-5mm7K:
undetectable
2xz5E-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 4 GLN A  95
ILE A 282
SER A  91
TYR A 252
 None
 1.35A 2xz5D-5olcA:
undetectable
2xz5E-5olcA:
undetectable		 2xz5D-5olcA:
undetectable
2xz5E-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom MITOCHONDRIAL
ASSEMBLY OF
RIBOSOMAL LARGE
SUBUNIT PROTEIN 1
MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN

(Homo sapiens;
Homo sapiens) 		PF00276
(Ribosomal_L23)
PF00467
(KOW)
PF17136
(ribosomal_L24) 		4 GLN v  19
ILE u 112
TYR v  31
CYH u 110
 None
 1.41A 2xz5D-5oomv:
undetectable
2xz5E-5oomv:
undetectable		 2xz5D-5oomv:
15.00
2xz5E-5oomv:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A  71
TYR A  52
TRP A  40
TYR A  97
 None
 1.36A 2xz5D-5thhA:
undetectable
2xz5E-5thhA:
undetectable		 2xz5D-5thhA:
21.45
2xz5E-5thhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ILE A 121
SER A 117
TYR A 271
TYR A 111
 None
 1.23A 2xz5D-5ukiA:
undetectable
2xz5E-5ukiA:
undetectable		 2xz5D-5ukiA:
undetectable
2xz5E-5ukiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF13927
(Ig_3) 		4 GLN C 109
ILE C  68
SER C 121
TYR C 108
 None
 1.34A 2xz5D-5vxzC:
undetectable
2xz5E-5vxzC:
undetectable		 2xz5D-5vxzC:
19.82
2xz5E-5vxzC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x45 PROTEASE 2A

(Rhinovirus C) 		no annotation 4 GLN A  90
ILE A 119
TYR A  84
CYH A 100
 None
 1.37A 2xz5D-5x45A:
undetectable
2xz5E-5x45A:
undetectable		 2xz5D-5x45A:
undetectable
2xz5E-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 GLN B 230
ILE B 530
SER B 229
TRP B 265
 None
 1.42A 2xz5D-5y2zB:
undetectable
2xz5E-5y2zB:
undetectable		 2xz5D-5y2zB:
undetectable
2xz5E-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y39 RAGULATOR COMPLEX
PROTEIN LAMTOR1
RAGULATOR COMPLEX
PROTEIN LAMTOR5

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLN A 130
ILE A 124
SER A 133
CYH E 148
 None
 1.31A 2xz5D-5y39A:
undetectable
2xz5E-5y39A:
undetectable		 2xz5D-5y39A:
undetectable
2xz5E-5y39A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 4 GLN C 182
ILE C  17
TYR C  47
TYR C  55
 None
 1.35A 2xz5D-6c4mC:
undetectable
2xz5E-6c4mC:
undetectable		 2xz5D-6c4mC:
undetectable
2xz5E-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 GLN A 540
ILE A 529
TYR A 549
TYR A 527
 None
 1.14A 2xz5D-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable		 2xz5D-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 4 GLN A 128
ILE A 155
TYR A 138
CYH A 152
 None
 1.33A 2xz5D-6dllA:
undetectable
2xz5E-6dllA:
undetectable		 2xz5D-6dllA:
undetectable
2xz5E-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 4 ILE A 559
TYR A 584
TYR A 520
CYH A 513
 None
 1.42A 2xz5D-6fmqA:
undetectable
2xz5E-6fmqA:
undetectable		 2xz5D-6fmqA:
undetectable
2xz5E-6fmqA:
undetectable