SIMILAR PATTERNS OF AMINO ACIDS FOR 2XZ5_E_ACHE1210

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 ILE A  62
TYR A 309
VAL A 189
TYR A 265
 None
 1.35A 2xz5D-1ayeA:
undetectable
2xz5E-1ayeA:
0.0		 2xz5D-1ayeA:
20.70
2xz5E-1ayeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ILE A 417
TYR A 665
VAL A 545
TYR A 621
 None
 1.37A 2xz5D-1dtdA:
undetectable
2xz5E-1dtdA:
undetectable		 2xz5D-1dtdA:
21.59
2xz5E-1dtdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.17A 2xz5D-1f4hA:
0.0
2xz5E-1f4hA:
0.0		 2xz5D-1f4hA:
11.67
2xz5E-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 414
TYR A 270
VAL A 397
CYH A 404
 None
 1.29A 2xz5D-1ig8A:
0.0
2xz5E-1ig8A:
0.0		 2xz5D-1ig8A:
21.68
2xz5E-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo SICP

(Salmonella
enterica) 		PF05932
(CesT) 		4 ILE A  63
TYR A  84
TRP A  64
VAL A  58
 None
 1.26A 2xz5D-1jyoA:
undetectable
2xz5E-1jyoA:
undetectable		 2xz5D-1jyoA:
20.47
2xz5E-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 152
TYR A  21
VAL A  25
TYR A 147
 None
 1.33A 2xz5D-1k4qA:
undetectable
2xz5E-1k4qA:
undetectable		 2xz5D-1k4qA:
19.39
2xz5E-1k4qA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqy PEPTIDE DEFORMYLASE
2

(Geobacillus
stearothermophilus) 		PF01327
(Pep_deformylase) 		4 ILE A 149
VAL A 121
TYR A 124
CYH A 102
 BB2  A 401 ( 4.9A)
None
None
None
 1.34A 2xz5D-1lqyA:
undetectable
2xz5E-1lqyA:
undetectable		 2xz5D-1lqyA:
22.22
2xz5E-1lqyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 ILE A 322
VAL A 334
TYR A 311
CYH A 308
 None
 1.19A 2xz5D-1m7jA:
undetectable
2xz5E-1m7jA:
undetectable		 2xz5D-1m7jA:
20.08
2xz5E-1m7jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 296
TYR A 281
VAL A 329
TYR A 294
 None
 1.35A 2xz5D-1n7rA:
0.0
2xz5E-1n7rA:
undetectable		 2xz5D-1n7rA:
15.12
2xz5E-1n7rA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.23A 2xz5D-1pvgA:
undetectable
2xz5E-1pvgA:
undetectable		 2xz5D-1pvgA:
20.81
2xz5E-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc6 EVH1 DOMAIN FROM
ENA/VASP-LIKE
PROTEIN

(Mus musculus) 		PF00568
(WH1) 		4 ILE A1036
TYR A1088
VAL A1060
TYR A1063
 None
 1.20A 2xz5D-1qc6A:
undetectable
2xz5E-1qc6A:
undetectable		 2xz5D-1qc6A:
20.47
2xz5E-1qc6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 431
TYR A 428
VAL A 434
TYR A 406
 None
 1.25A 2xz5D-1r8wA:
undetectable
2xz5E-1r8wA:
undetectable		 2xz5D-1r8wA:
14.66
2xz5E-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 298
TYR A 417
VAL A 595
TYR A 406
 None
 1.34A 2xz5D-1rw9A:
undetectable
2xz5E-1rw9A:
undetectable		 2xz5D-1rw9A:
13.61
2xz5E-1rw9A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ILE A 248
TYR A 388
TRP A 253
VAL A 252
 None
 1.28A 2xz5D-1rzvA:
undetectable
2xz5E-1rzvA:
undetectable		 2xz5D-1rzvA:
18.24
2xz5E-1rzvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 TYR A 186
VAL A 213
TYR A 184
TYR A 159
 None
 1.22A 2xz5D-1s58A:
undetectable
2xz5E-1s58A:
undetectable		 2xz5D-1s58A:
16.70
2xz5E-1s58A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC

(Escherichia
coli) 		PF04127
(DFP) 		4 ILE A 272
VAL A 324
TYR A 400
TYR A 323
 None
 1.29A 2xz5D-1u7wA:
undetectable
2xz5E-1u7wA:
undetectable		 2xz5D-1u7wA:
20.42
2xz5E-1u7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf1 RNA-BINDING PROTEIN
RALY

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  32
TYR A  69
VAL A  79
TYR A  52
 None
 1.30A 2xz5D-1wf1A:
undetectable
2xz5E-1wf1A:
undetectable		 2xz5D-1wf1A:
16.44
2xz5E-1wf1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 ILE A  66
TYR A 505
VAL A  36
CYH A  43
 None
 0.98A 2xz5D-1xrsA:
undetectable
2xz5E-1xrsA:
undetectable		 2xz5D-1xrsA:
17.69
2xz5E-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 191
VAL A 112
TYR A 103
TYR A 196
 None
 1.23A 2xz5D-1yq2A:
undetectable
2xz5E-1yq2A:
undetectable		 2xz5D-1yq2A:
12.56
2xz5E-1yq2A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 4 ILE A 129
TYR A  71
VAL A 149
TYR A 154
 None
 1.31A 2xz5D-1zs3A:
undetectable
2xz5E-1zs3A:
undetectable		 2xz5D-1zs3A:
20.09
2xz5E-1zs3A:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN

(Bulinus
truncatus) 		PF02931
(Neur_chan_LBD) 		4 TYR A  88
TRP A 142
TYR A 184
TYR A 191
 None
CXS  A1204 (-3.6A)
CXS  A1204 (-4.6A)
CXS  A1204 (-4.7A)
 0.55A 2xz5D-2bj0A:
24.7
2xz5E-2bj0A:
24.6		 2xz5D-2bj0A:
31.30
2xz5E-2bj0A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		4 ILE A 133
TYR A 140
TYR A  50
TYR A  54
 None
 1.26A 2xz5D-2bqxA:
undetectable
2xz5E-2bqxA:
undetectable		 2xz5D-2bqxA:
23.77
2xz5E-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		4 ILE A  31
VAL A  33
TYR A  54
CYH A  52
 None
 1.01A 2xz5D-2bsxA:
undetectable
2xz5E-2bsxA:
undetectable		 2xz5D-2bsxA:
22.22
2xz5E-2bsxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 ILE A 300
TYR A 337
VAL A 323
CYH A 375
 None
 1.35A 2xz5D-2c2gA:
undetectable
2xz5E-2c2gA:
undetectable		 2xz5D-2c2gA:
17.28
2xz5E-2c2gA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 539
TYR A 721
VAL A 534
TYR A  50
 None
 1.00A 2xz5D-2d5lA:
undetectable
2xz5E-2d5lA:
undetectable		 2xz5D-2d5lA:
14.80
2xz5E-2d5lA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyu FORMAMIDASE

(Helicobacter
pylori) 		PF00795
(CN_hydrolase) 		4 ILE A  56
VAL A 100
TYR A  88
CYH A  92
 None
 1.33A 2xz5D-2dyuA:
undetectable
2xz5E-2dyuA:
undetectable		 2xz5D-2dyuA:
19.29
2xz5E-2dyuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ILE A  13
TYR A 111
VAL A  10
TYR A  75
 None
 1.23A 2xz5D-2gk3A:
undetectable
2xz5E-2gk3A:
undetectable		 2xz5D-2gk3A:
20.61
2xz5E-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmn METALLO-BETA-LACTAMA
SE

(Bradyrhizobium
diazoefficiens) 		PF00753
(Lactamase_B) 		4 ILE A  55
TYR A 246
TYR A  58
TYR A  49
 None
 1.36A 2xz5D-2gmnA:
undetectable
2xz5E-2gmnA:
undetectable		 2xz5D-2gmnA:
22.02
2xz5E-2gmnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A1865
TRP A1868
VAL A1873
CYH A1959
 None
 1.28A 2xz5D-2h03A:
undetectable
2xz5E-2h03A:
undetectable		 2xz5D-2h03A:
21.80
2xz5E-2h03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 164
TYR A  24
VAL A  28
TYR A 159
 None
 1.34A 2xz5D-2hqmA:
undetectable
2xz5E-2hqmA:
undetectable		 2xz5D-2hqmA:
16.88
2xz5E-2hqmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ILE A 281
TYR A 254
TYR A 250
CYH A 270
 None
 1.31A 2xz5D-2i9uA:
undetectable
2xz5E-2i9uA:
undetectable		 2xz5D-2i9uA:
19.68
2xz5E-2i9uA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.23A 2xz5D-2j3hA:
undetectable
2xz5E-2j3hA:
undetectable		 2xz5D-2j3hA:
21.11
2xz5E-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		4 ILE A 181
TYR A 132
TYR A 145
TYR A 143
 None
 1.35A 2xz5D-2myiA:
undetectable
2xz5E-2myiA:
undetectable		 2xz5D-2myiA:
18.96
2xz5E-2myiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		4 ILE A 123
VAL A   9
CYH A  34
TYR A  12
 None
 1.37A 2xz5D-2o42A:
undetectable
2xz5E-2o42A:
undetectable		 2xz5D-2o42A:
21.86
2xz5E-2o42A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 631
VAL A 626
TYR A 628
TYR A 987
 None
 1.34A 2xz5D-2qf7A:
undetectable
2xz5E-2qf7A:
undetectable		 2xz5D-2qf7A:
10.06
2xz5E-2qf7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 TYR A 384
VAL A 128
TYR A 380
TYR A 182
 None
 1.34A 2xz5D-2vdaA:
undetectable
2xz5E-2vdaA:
undetectable		 2xz5D-2vdaA:
13.15
2xz5E-2vdaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		4 ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.29A 2xz5D-2xh6A:
undetectable
2xz5E-2xh6A:
undetectable		 2xz5D-2xh6A:
20.25
2xz5E-2xh6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		4 ILE A 130
TYR A 102
TYR A  82
TYR A  18
 None
 1.27A 2xz5D-2xtqA:
undetectable
2xz5E-2xtqA:
undetectable		 2xz5D-2xtqA:
21.58
2xz5E-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE X 414
TYR X 270
VAL X 397
CYH X 404
 None
 1.30A 2xz5D-3b8aX:
undetectable
2xz5E-3b8aX:
undetectable		 2xz5D-3b8aX:
20.05
2xz5E-3b8aX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		4 ILE A 214
TYR A 384
TYR A 380
TYR A 182
 None
 1.34A 2xz5D-3bxzA:
undetectable
2xz5E-3bxzA:
undetectable		 2xz5D-3bxzA:
17.87
2xz5E-3bxzA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 654
TYR A 584
TYR A 686
CYH A 687
 None
 1.14A 2xz5D-3cwgA:
undetectable
2xz5E-3cwgA:
undetectable		 2xz5D-3cwgA:
19.09
2xz5E-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 155
TYR A 137
VAL A  70
TYR A  36
 None
 1.09A 2xz5D-3dkhA:
2.1
2xz5E-3dkhA:
2.1		 2xz5D-3dkhA:
17.27
2xz5E-3dkhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 ILE O 296
TRP O 315
VAL O 313
CYH O 158
 None
 1.24A 2xz5D-3e6aO:
undetectable
2xz5E-3e6aO:
undetectable		 2xz5D-3e6aO:
21.02
2xz5E-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evi PHOSDUCIN-LIKE
PROTEIN 2

(Homo sapiens) 		PF02114
(Phosducin) 		4 ILE A  95
TYR A 167
VAL A 101
CYH A 152
 None
 1.32A 2xz5D-3eviA:
undetectable
2xz5E-3eviA:
undetectable		 2xz5D-3eviA:
18.43
2xz5E-3eviA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 ILE A  92
TYR A  85
VAL A 109
TYR A 274
 None
 1.32A 2xz5D-3ff1A:
undetectable
2xz5E-3ff1A:
undetectable		 2xz5D-3ff1A:
19.13
2xz5E-3ff1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 ILE A 526
TYR A 428
VAL A 435
TYR A 440
 None
 1.36A 2xz5D-3gecA:
undetectable
2xz5E-3gecA:
undetectable		 2xz5D-3gecA:
20.39
2xz5E-3gecA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 674
TYR A 648
VAL A 645
TYR A 555
 None
 1.21A 2xz5D-3gm8A:
undetectable
2xz5E-3gm8A:
undetectable		 2xz5D-3gm8A:
15.37
2xz5E-3gm8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 654
VAL A 649
TYR A 651
TYR A1013
 None
 1.34A 2xz5D-3ho8A:
undetectable
2xz5E-3ho8A:
undetectable		 2xz5D-3ho8A:
11.96
2xz5E-3ho8A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 ILE W 178
TYR W  81
VAL W  58
TYR W  44
 None
 1.29A 2xz5D-3iylW:
undetectable
2xz5E-3iylW:
undetectable		 2xz5D-3iylW:
10.25
2xz5E-3iylW:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 ILE A 643
TYR A 502
VAL A 602
CYH A 599
 None
 1.19A 2xz5D-3j97A:
undetectable
2xz5E-3j97A:
undetectable		 2xz5D-3j97A:
14.13
2xz5E-3j97A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE B 224
TYR B 248
TRP B 226
VAL B 190
 None
 1.28A 2xz5D-3jcmB:
undetectable
2xz5E-3jcmB:
undetectable		 2xz5D-3jcmB:
19.19
2xz5E-3jcmB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.15A 2xz5D-3juxA:
undetectable
2xz5E-3juxA:
undetectable		 2xz5D-3juxA:
13.39
2xz5E-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 413
TYR A 269
VAL A 396
CYH A 403
 None
 1.26A 2xz5D-3o80A:
undetectable
2xz5E-3o80A:
undetectable		 2xz5D-3o80A:
18.52
2xz5E-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 158
VAL A  50
TYR A 135
CYH A  57
 None
 1.14A 2xz5D-3pfeA:
undetectable
2xz5E-3pfeA:
undetectable		 2xz5D-3pfeA:
18.22
2xz5E-3pfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.78A 2xz5D-3pl1A:
undetectable
2xz5E-3pl1A:
undetectable		 2xz5D-3pl1A:
21.37
2xz5E-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.27A 2xz5D-3psfA:
undetectable
2xz5E-3psfA:
undetectable		 2xz5D-3psfA:
13.15
2xz5E-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.37A 2xz5D-3psiA:
undetectable
2xz5E-3psiA:
undetectable		 2xz5D-3psiA:
10.74
2xz5E-3psiA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 ILE A  67
TRP A  69
VAL A  85
TYR A  56
 None
 1.26A 2xz5D-3pxjA:
undetectable
2xz5E-3pxjA:
undetectable		 2xz5D-3pxjA:
21.76
2xz5E-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		4 ILE A 419
TYR A 305
VAL A 423
TYR A 325
 None
 1.25A 2xz5D-3qk9A:
undetectable
2xz5E-3qk9A:
undetectable		 2xz5D-3qk9A:
21.31
2xz5E-3qk9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		4 ILE A 113
TYR A  77
VAL A  87
TYR A  61
 None
 1.35A 2xz5D-3qvmA:
undetectable
2xz5E-3qvmA:
undetectable		 2xz5D-3qvmA:
22.18
2xz5E-3qvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 TYR A 242
TRP A  67
VAL A  87
TYR A  75
 None
 1.32A 2xz5D-3rkxA:
undetectable
2xz5E-3rkxA:
undetectable		 2xz5D-3rkxA:
20.14
2xz5E-3rkxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ILE A 749
TYR A 658
VAL A 681
TYR A 533
 None
 1.19A 2xz5D-3s29A:
undetectable
2xz5E-3s29A:
undetectable		 2xz5D-3s29A:
12.27
2xz5E-3s29A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 ILE A  86
VAL A  88
TYR A  38
CYH A  35
 None
 1.33A 2xz5D-3stgA:
undetectable
2xz5E-3stgA:
undetectable		 2xz5D-3stgA:
22.83
2xz5E-3stgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 ILE A 340
TYR A  69
VAL A 222
TYR A  80
 None
 1.25A 2xz5D-3vbeA:
undetectable
2xz5E-3vbeA:
undetectable		 2xz5D-3vbeA:
20.93
2xz5E-3vbeA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdh ACETYLCHOLINE
BINDING PROTEIN

(Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 TYR A  89
TRP A 143
TYR A 185
TYR A 192
 None
XRS  A 301 (-3.6A)
XRS  A 301 ( 4.1A)
XRS  A 301 (-3.8A)
 0.59A 2xz5D-3zdhA:
25.1
2xz5E-3zdhA:
25.2		 2xz5D-3zdhA:
35.32
2xz5E-3zdhA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5d CAPITELLA TELETA
ACHBP

(Capitella
teleta) 		PF02931
(Neur_chan_LBD) 		4 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.49A 2xz5D-4b5dA:
22.1
2xz5E-4b5dA:
22.1		 2xz5D-4b5dA:
29.88
2xz5E-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 ILE A 243
TYR A 247
CYH A 298
TYR A 300
 None
 1.22A 2xz5D-4bg2A:
undetectable
2xz5E-4bg2A:
undetectable		 2xz5D-4bg2A:
19.70
2xz5E-4bg2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.28A 2xz5D-4g59C:
undetectable
2xz5E-4g59C:
undetectable		 2xz5D-4g59C:
20.36
2xz5E-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		4 ILE A 161
TYR A 179
VAL A 205
TYR A 211
 None
 1.19A 2xz5D-4gdfA:
undetectable
2xz5E-4gdfA:
undetectable		 2xz5D-4gdfA:
17.45
2xz5E-4gdfA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.21A 2xz5D-4gfhA:
undetectable
2xz5E-4gfhA:
undetectable		 2xz5D-4gfhA:
10.54
2xz5E-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.13A 2xz5D-4gvlA:
undetectable
2xz5E-4gvlA:
undetectable		 2xz5D-4gvlA:
16.59
2xz5E-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.20A 2xz5D-4gx0A:
undetectable
2xz5E-4gx0A:
undetectable		 2xz5D-4gx0A:
16.79
2xz5E-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 ILE A 123
VAL A 185
TYR A  96
TYR A 110
 None
 1.27A 2xz5D-4ifaA:
undetectable
2xz5E-4ifaA:
undetectable		 2xz5D-4ifaA:
19.82
2xz5E-4ifaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE

(Leishmania
infantum) 		PF00155
(Aminotran_1_2) 		4 ILE A 239
VAL A 219
CYH A 202
TYR A 192
 None
 1.32A 2xz5D-4ix8A:
undetectable
2xz5E-4ix8A:
undetectable		 2xz5D-4ix8A:
19.63
2xz5E-4ix8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 418
TYR B 320
TRP B 355
VAL B 351
 None
 1.34A 2xz5D-4l37B:
undetectable
2xz5E-4l37B:
undetectable		 2xz5D-4l37B:
14.59
2xz5E-4l37B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		4 ILE A 108
VAL A  81
TYR A 136
TYR A 156
 None
 1.27A 2xz5D-4p5hA:
undetectable
2xz5E-4p5hA:
undetectable		 2xz5D-4p5hA:
20.68
2xz5E-4p5hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		4 ILE A  56
TYR A  60
VAL A  33
TYR A 330
 None
 1.15A 2xz5D-4qhxA:
undetectable
2xz5E-4qhxA:
undetectable		 2xz5D-4qhxA:
19.53
2xz5E-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 TYR H 623
VAL H 618
TYR H 620
TYR H 979
 None
 1.32A 2xz5D-4qslH:
undetectable
2xz5E-4qslH:
undetectable		 2xz5D-4qslH:
11.06
2xz5E-4qslH:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		4 ILE A  23
TYR A 201
VAL A 176
TYR A 183
 ILE  A  23 ( 0.7A)
TYR  A 201 ( 1.3A)
VAL  A 176 (-0.6A)
TYR  A 183 ( 1.3A)
 1.31A 2xz5D-4rhyA:
undetectable
2xz5E-4rhyA:
undetectable		 2xz5D-4rhyA:
21.70
2xz5E-4rhyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 ILE A 250
VAL A 311
TYR A 245
TYR A 242
 None
 1.28A 2xz5D-4w8xA:
undetectable
2xz5E-4w8xA:
undetectable		 2xz5D-4w8xA:
20.61
2xz5E-4w8xA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ILE A 265
VAL A 332
TYR A 327
TYR A 406
 None
 1.35A 2xz5D-4y67A:
undetectable
2xz5E-4y67A:
undetectable		 2xz5D-4y67A:
19.63
2xz5E-4y67A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 ILE A 274
TYR A 454
VAL A 366
TYR A 207
 None
 1.31A 2xz5D-4ylrA:
undetectable
2xz5E-4ylrA:
undetectable		 2xz5D-4ylrA:
19.12
2xz5E-4ylrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ILE A 380
TYR A 168
CYH A 251
TYR A 347
 None
 1.27A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ILE A 380
VAL A 346
CYH A 251
TYR A 347
 None
 1.32A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A 122
TRP A 178
TYR A 219
TYR A 226
 EPJ  A 300 (-4.6A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
 0.68A 2xz5D-5fjvA:
22.8
2xz5E-5fjvA:
22.7		 2xz5D-5fjvA:
31.39
2xz5E-5fjvA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i20 UNCHARACTERIZED
PROTEIN

(Starkeya
novella) 		PF00892
(EamA) 		4 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.27A 2xz5D-5i20A:
undetectable
2xz5E-5i20A:
undetectable		 2xz5D-5i20A:
19.67
2xz5E-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 436
TYR A 433
VAL A 439
TYR A 411
 None
 1.34A 2xz5D-5i2gA:
undetectable
2xz5E-5i2gA:
undetectable		 2xz5D-5i2gA:
13.94
2xz5E-5i2gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 ILE A 755
TYR A 656
CYH A 659
TYR A 661
 None
 1.14A 2xz5D-5kd5A:
undetectable
2xz5E-5kd5A:
undetectable		 2xz5D-5kd5A:
17.56
2xz5E-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 TYR A 100
TRP A 156
TYR A 197
TYR A 204
 NCT  A 402 (-4.8A)
NCT  A 402 (-3.9A)
NCT  A 402 ( 4.9A)
NCT  A 402 (-3.8A)
 0.70A 2xz5D-5kxiA:
24.5
2xz5E-5kxiA:
24.4		 2xz5D-5kxiA:
19.00
2xz5E-5kxiA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE B 691
TYR B 370
VAL B 750
TYR B 431
 None
 1.34A 2xz5D-5kyuB:
undetectable
2xz5E-5kyuB:
undetectable		 2xz5D-5kyuB:
14.32
2xz5E-5kyuB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 ILE A 238
VAL A 229
TYR A 194
CYH A 191
 None
 1.25A 2xz5D-5lmcA:
undetectable
2xz5E-5lmcA:
undetectable		 2xz5D-5lmcA:
19.22
2xz5E-5lmcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04

(Pseudomonas
aeruginosa;
Lama glama) 		no annotation
no annotation 		4 ILE A  55
TYR C  59
VAL A  90
TYR C  52
 None
 1.24A 2xz5D-5mp2A:
undetectable
2xz5E-5mp2A:
undetectable		 2xz5D-5mp2A:
undetectable
2xz5E-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		4 ILE O 418
TYR O 423
TYR O 591
TYR O 376
 None
 1.26A 2xz5D-5n5zO:
undetectable
2xz5E-5n5zO:
undetectable		 2xz5D-5n5zO:
16.06
2xz5E-5n5zO:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.13A 2xz5D-5tf2A:
undetectable
2xz5E-5tf2A:
undetectable		 2xz5D-5tf2A:
17.97
2xz5E-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A  71
TYR A  52
TRP A  40
TYR A  97
 None
 1.36A 2xz5D-5thhA:
undetectable
2xz5E-5thhA:
undetectable		 2xz5D-5thhA:
21.45
2xz5E-5thhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 ILE A 921
VAL A 923
TYR A 904
CYH A 901
 None
 1.30A 2xz5D-5xgjA:
undetectable
2xz5E-5xgjA:
undetectable		 2xz5D-5xgjA:
undetectable
2xz5E-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 ILE A 404
TYR A 249
VAL A 388
CYH A 409
 None
 1.06A 2xz5D-5xwbA:
undetectable
2xz5E-5xwbA:
undetectable		 2xz5D-5xwbA:
18.38
2xz5E-5xwbA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 ILE A 134
TYR A   4
VAL A   8
TYR A 129
 None
 1.31A 2xz5D-6b4oA:
undetectable
2xz5E-6b4oA:
undetectable		 2xz5D-6b4oA:
19.29
2xz5E-6b4oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 4 ILE A  69
TYR A  98
VAL A 133
TYR A  92
 None
 1.08A 2xz5D-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable		 2xz5D-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		no annotation 4 ILE A 282
TYR A 137
VAL A 176
TYR A 150
 None
 1.37A 2xz5D-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable		 2xz5D-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable