SIMILAR PATTERNS OF AMINO ACIDS FOR 2XZ5_D_ACHD1210

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.07A 2xz5C-1b25A:
0.0
2xz5D-1b25A:
0.0		 2xz5C-1b25A:
14.64
2xz5D-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.22A 2xz5C-1b25A:
0.0
2xz5D-1b25A:
0.0		 2xz5C-1b25A:
14.64
2xz5D-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4a ARGININE REPRESSOR

(Geobacillus
stearothermophilus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ILE A 106
VAL A 108
CYH A 128
CYH A 123
 None
 1.03A 2xz5C-1b4aA:
undetectable
2xz5D-1b4aA:
0.0		 2xz5C-1b4aA:
21.00
2xz5D-1b4aA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9y PROTEIN (PHOSDUCIN)

(Rattus
norvegicus) 		PF02114
(Phosducin) 		4 ILE C 136
VAL C 165
TYR C 115
CYH C 168
 None
 1.24A 2xz5C-1b9yC:
undetectable
2xz5D-1b9yC:
undetectable		 2xz5C-1b9yC:
20.00
2xz5D-1b9yC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dux ETS-DOMAIN PROTEIN
ELK-1

(Homo sapiens) 		PF00178
(Ets) 		4 ILE C  24
TYR C  57
VAL C  37
TYR C  83
 None
 1.13A 2xz5C-1duxC:
undetectable
2xz5D-1duxC:
undetectable		 2xz5C-1duxC:
20.77
2xz5D-1duxC:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.20A 2xz5C-1f4hA:
0.0
2xz5D-1f4hA:
0.0		 2xz5C-1f4hA:
11.67
2xz5D-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 414
TYR A 270
VAL A 397
CYH A 404
 None
 1.29A 2xz5C-1ig8A:
0.0
2xz5D-1ig8A:
undetectable		 2xz5C-1ig8A:
21.68
2xz5D-1ig8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo SICP

(Salmonella
enterica) 		PF05932
(CesT) 		4 ILE A  63
TYR A  84
TRP A  64
VAL A  58
 None
 1.29A 2xz5C-1jyoA:
undetectable
2xz5D-1jyoA:
undetectable		 2xz5C-1jyoA:
20.47
2xz5D-1jyoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		4 ILE A 322
VAL A 334
TYR A 311
CYH A 308
 None
 1.19A 2xz5C-1m7jA:
undetectable
2xz5D-1m7jA:
undetectable		 2xz5C-1m7jA:
20.08
2xz5D-1m7jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.25A 2xz5C-1pvgA:
undetectable
2xz5D-1pvgA:
undetectable		 2xz5C-1pvgA:
20.81
2xz5D-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5

(Mycobacterium
tuberculosis) 		PF00668
(Condensation)
PF16911
(PapA_C) 		4 ILE A 245
VAL A 240
TYR A 264
CYH A 344
 None
 1.18A 2xz5C-1q9jA:
undetectable
2xz5D-1q9jA:
undetectable		 2xz5C-1q9jA:
17.71
2xz5D-1q9jA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc6 EVH1 DOMAIN FROM
ENA/VASP-LIKE
PROTEIN

(Mus musculus) 		PF00568
(WH1) 		4 ILE A1036
TYR A1088
VAL A1060
TYR A1063
 None
 1.20A 2xz5C-1qc6A:
undetectable
2xz5D-1qc6A:
undetectable		 2xz5C-1qc6A:
20.47
2xz5D-1qc6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 431
TYR A 428
VAL A 434
TYR A 406
 None
 1.25A 2xz5C-1r8wA:
undetectable
2xz5D-1r8wA:
undetectable		 2xz5C-1r8wA:
14.66
2xz5D-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ILE A 248
TYR A 388
TRP A 253
VAL A 252
 None
 1.30A 2xz5C-1rzvA:
undetectable
2xz5D-1rzvA:
undetectable		 2xz5C-1rzvA:
18.24
2xz5D-1rzvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 TYR A 186
VAL A 213
TYR A 184
TYR A 159
 None
 1.22A 2xz5C-1s58A:
undetectable
2xz5D-1s58A:
undetectable		 2xz5C-1s58A:
16.70
2xz5D-1s58A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Haemophilus
influenzae) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 ILE A 121
TRP A 117
VAL A 231
CYH A 128
 None
 1.22A 2xz5C-1vioA:
undetectable
2xz5D-1vioA:
undetectable		 2xz5C-1vioA:
19.68
2xz5D-1vioA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 ILE A  66
TYR A 505
VAL A  36
CYH A  43
 None
 0.97A 2xz5C-1xrsA:
undetectable
2xz5D-1xrsA:
undetectable		 2xz5C-1xrsA:
17.69
2xz5D-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 191
VAL A 112
TYR A 103
TYR A 196
 None
 1.26A 2xz5C-1yq2A:
undetectable
2xz5D-1yq2A:
undetectable		 2xz5C-1yq2A:
12.56
2xz5D-1yq2A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 4 ILE A 129
TYR A  71
VAL A 149
TYR A 154
 None
 1.30A 2xz5C-1zs3A:
undetectable
2xz5D-1zs3A:
undetectable		 2xz5C-1zs3A:
20.09
2xz5D-1zs3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ILE A  72
TYR A  65
VAL A  62
CYH A  96
 None
 1.18A 2xz5C-2b24A:
undetectable
2xz5D-2b24A:
undetectable		 2xz5C-2b24A:
17.88
2xz5D-2b24A:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN

(Bulinus
truncatus) 		PF02931
(Neur_chan_LBD) 		4 TYR A  88
TRP A 142
TYR A 184
TYR A 191
 None
CXS  A1204 (-3.6A)
CXS  A1204 (-4.6A)
CXS  A1204 (-4.7A)
 0.56A 2xz5C-2bj0A:
24.6
2xz5D-2bj0A:
24.7		 2xz5C-2bj0A:
31.30
2xz5D-2bj0A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		4 ILE A 133
TYR A 140
TYR A  50
TYR A  54
 None
 1.27A 2xz5C-2bqxA:
undetectable
2xz5D-2bqxA:
undetectable		 2xz5C-2bqxA:
23.77
2xz5D-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		4 ILE A  31
VAL A  33
TYR A  54
CYH A  52
 None
 1.00A 2xz5C-2bsxA:
undetectable
2xz5D-2bsxA:
undetectable		 2xz5C-2bsxA:
22.22
2xz5D-2bsxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ILE A 429
TYR A 405
VAL A 505
CYH A 436
 None
 1.25A 2xz5C-2btvA:
undetectable
2xz5D-2btvA:
undetectable		 2xz5C-2btvA:
13.74
2xz5D-2btvA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 539
TYR A 721
VAL A 534
TYR A  50
 None
 1.03A 2xz5C-2d5lA:
undetectable
2xz5D-2d5lA:
undetectable		 2xz5C-2d5lA:
14.80
2xz5D-2d5lA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ILE A  13
TYR A 111
VAL A  10
TYR A  75
 None
 1.24A 2xz5C-2gk3A:
undetectable
2xz5D-2gk3A:
undetectable		 2xz5C-2gk3A:
20.61
2xz5D-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A1865
TRP A1868
VAL A1873
CYH A1959
 None
 1.30A 2xz5C-2h03A:
undetectable
2xz5D-2h03A:
undetectable		 2xz5C-2h03A:
21.80
2xz5D-2h03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.24A 2xz5C-2j3hA:
undetectable
2xz5D-2j3hA:
undetectable		 2xz5C-2j3hA:
21.11
2xz5D-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.26A 2xz5C-2j3hA:
undetectable
2xz5D-2j3hA:
undetectable		 2xz5C-2j3hA:
21.11
2xz5D-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2trc PHOSDUCIN

(Rattus
norvegicus) 		PF02114
(Phosducin) 		4 ILE P 136
VAL P 165
TYR P 115
CYH P 168
 None
 1.25A 2xz5C-2trcP:
undetectable
2xz5D-2trcP:
undetectable		 2xz5C-2trcP:
19.69
2xz5D-2trcP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 ILE G  65
TRP G  68
VAL G 123
CYH G 104
 SF4  G 483 (-4.7A)
None
None
SF4  G 482 (-2.4A)
 0.94A 2xz5C-2vdcG:
undetectable
2xz5D-2vdcG:
undetectable		 2xz5C-2vdcG:
18.74
2xz5D-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.22A 2xz5C-2vfkA:
undetectable
2xz5D-2vfkA:
undetectable		 2xz5C-2vfkA:
17.83
2xz5D-2vfkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		4 ILE A 132
VAL A 154
TYR A 143
CYH A 146
 None
 1.18A 2xz5C-2x8uA:
undetectable
2xz5D-2x8uA:
undetectable		 2xz5C-2x8uA:
18.14
2xz5D-2x8uA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		4 ILE A 130
TYR A 102
TYR A  82
TYR A  18
 None
 1.28A 2xz5C-2xtqA:
undetectable
2xz5D-2xtqA:
undetectable		 2xz5C-2xtqA:
21.58
2xz5D-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ILE A 132
VAL A  37
TYR A   8
CYH A  40
 None
 1.26A 2xz5C-3ab4A:
undetectable
2xz5D-3ab4A:
undetectable		 2xz5C-3ab4A:
20.87
2xz5D-3ab4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE X 414
TYR X 270
VAL X 397
CYH X 404
 None
 1.30A 2xz5C-3b8aX:
undetectable
2xz5D-3b8aX:
undetectable		 2xz5C-3b8aX:
20.05
2xz5D-3b8aX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 654
TYR A 584
TYR A 686
CYH A 687
 None
 1.13A 2xz5C-3cwgA:
2.5
2xz5D-3cwgA:
undetectable		 2xz5C-3cwgA:
19.09
2xz5D-3cwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 155
TYR A 137
VAL A  70
TYR A  36
 None
 1.10A 2xz5C-3dkhA:
2.2
2xz5D-3dkhA:
1.8		 2xz5C-3dkhA:
17.27
2xz5D-3dkhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 ILE O 296
TRP O 315
VAL O 313
CYH O 158
 None
 1.25A 2xz5C-3e6aO:
undetectable
2xz5D-3e6aO:
undetectable		 2xz5C-3e6aO:
21.02
2xz5D-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5

(Homo sapiens) 		PF00270
(DEAD) 		4 ILE A 220
VAL A 183
TYR A 190
CYH A 191
 None
 1.24A 2xz5C-3fe2A:
undetectable
2xz5D-3fe2A:
undetectable		 2xz5C-3fe2A:
20.99
2xz5D-3fe2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 674
TYR A 648
VAL A 645
TYR A 555
 None
 1.18A 2xz5C-3gm8A:
2.6
2xz5D-3gm8A:
undetectable		 2xz5C-3gm8A:
15.37
2xz5D-3gm8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE A 419
TYR A 321
TRP A 356
VAL A 352
 None
 1.27A 2xz5C-3gwjA:
undetectable
2xz5D-3gwjA:
undetectable		 2xz5C-3gwjA:
15.71
2xz5D-3gwjA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 ILE A 863
TYR A 858
TYR A 737
CYH A 733
 None
 1.30A 2xz5C-3ihyA:
undetectable
2xz5D-3ihyA:
undetectable		 2xz5C-3ihyA:
17.00
2xz5D-3ihyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 ILE W 178
TYR W  81
VAL W  58
TYR W  44
 None
 1.27A 2xz5C-3iylW:
undetectable
2xz5D-3iylW:
undetectable		 2xz5C-3iylW:
10.25
2xz5D-3iylW:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.28A 2xz5C-3j4rA:
undetectable
2xz5D-3j4rA:
undetectable		 2xz5C-3j4rA:
19.84
2xz5D-3j4rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 ILE A 643
TYR A 502
VAL A 602
CYH A 599
 None
 1.17A 2xz5C-3j97A:
undetectable
2xz5D-3j97A:
undetectable		 2xz5C-3j97A:
14.13
2xz5D-3j97A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ILE A 243
VAL A 157
TYR A 152
CYH A 154
 None
 1.14A 2xz5C-3jujA:
undetectable
2xz5D-3jujA:
undetectable		 2xz5C-3jujA:
23.47
2xz5D-3jujA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.18A 2xz5C-3juxA:
undetectable
2xz5D-3juxA:
undetectable		 2xz5C-3juxA:
13.39
2xz5D-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TRP A 147
VAL A 106
CYH A 114
CYH A 122
 None
None
ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
 1.27A 2xz5C-3m6iA:
undetectable
2xz5D-3m6iA:
undetectable		 2xz5C-3m6iA:
20.42
2xz5D-3m6iA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A  73
TYR A  77
VAL A  97
CYH A  89
 None
 1.02A 2xz5C-3o21A:
undetectable
2xz5D-3o21A:
undetectable		 2xz5C-3o21A:
20.21
2xz5D-3o21A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 413
TYR A 269
VAL A 396
CYH A 403
 None
 1.25A 2xz5C-3o80A:
undetectable
2xz5D-3o80A:
undetectable		 2xz5C-3o80A:
18.52
2xz5D-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 158
VAL A  50
TYR A 135
CYH A  57
 None
 1.13A 2xz5C-3pfeA:
undetectable
2xz5D-3pfeA:
undetectable		 2xz5C-3pfeA:
18.22
2xz5D-3pfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.78A 2xz5C-3pl1A:
undetectable
2xz5D-3pl1A:
undetectable		 2xz5C-3pl1A:
21.37
2xz5D-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.26A 2xz5C-3psfA:
undetectable
2xz5D-3psfA:
undetectable		 2xz5C-3psfA:
13.15
2xz5D-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 ILE A  67
TRP A  69
VAL A  85
TYR A  56
 None
 1.27A 2xz5C-3pxjA:
undetectable
2xz5D-3pxjA:
undetectable		 2xz5C-3pxjA:
21.76
2xz5D-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		4 ILE A 449
TYR A 438
CYH A 529
TYR A 465
 None
 1.16A 2xz5C-3q6mA:
undetectable
2xz5D-3q6mA:
undetectable		 2xz5C-3q6mA:
18.36
2xz5D-3q6mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		4 ILE A 419
TYR A 305
VAL A 423
TYR A 325
 None
 1.27A 2xz5C-3qk9A:
undetectable
2xz5D-3qk9A:
undetectable		 2xz5C-3qk9A:
21.31
2xz5D-3qk9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ILE A 749
TYR A 658
VAL A 681
TYR A 533
 None
 1.21A 2xz5C-3s29A:
undetectable
2xz5D-3s29A:
undetectable		 2xz5C-3s29A:
12.27
2xz5D-3s29A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr4 INORGANIC
PYROPHOSPHATASE

(Coxiella
burnetii) 		PF00719
(Pyrophosphatase) 		4 ILE A 133
TYR A 140
TYR A  50
CYH A  52
 None
 0.86A 2xz5C-3tr4A:
undetectable
2xz5D-3tr4A:
undetectable		 2xz5C-3tr4A:
25.00
2xz5D-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 ILE A 340
TYR A  69
VAL A 222
TYR A  80
 None
 1.23A 2xz5C-3vbeA:
undetectable
2xz5D-3vbeA:
undetectable		 2xz5C-3vbeA:
20.93
2xz5D-3vbeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus) 		PF04106
(APG5) 		4 ILE A  13
VAL A  38
CYH A  86
TYR A  48
 None
 0.96A 2xz5C-3vqiA:
undetectable
2xz5D-3vqiA:
undetectable		 2xz5C-3vqiA:
19.79
2xz5D-3vqiA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdh ACETYLCHOLINE
BINDING PROTEIN

(Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 TYR A  89
TRP A 143
TYR A 185
TYR A 192
 None
XRS  A 301 (-3.6A)
XRS  A 301 ( 4.1A)
XRS  A 301 (-3.8A)
 0.60A 2xz5C-3zdhA:
25.2
2xz5D-3zdhA:
25.2		 2xz5C-3zdhA:
35.32
2xz5D-3zdhA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5d CAPITELLA TELETA
ACHBP

(Capitella
teleta) 		PF02931
(Neur_chan_LBD) 		4 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.50A 2xz5C-4b5dA:
22.2
2xz5D-4b5dA:
22.1		 2xz5C-4b5dA:
29.88
2xz5D-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 ILE A 243
TYR A 247
CYH A 298
TYR A 300
 None
 1.22A 2xz5C-4bg2A:
undetectable
2xz5D-4bg2A:
undetectable		 2xz5C-4bg2A:
19.70
2xz5D-4bg2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 678
VAL A 591
TYR A 617
CYH A 615
 None
 1.26A 2xz5C-4d8mA:
undetectable
2xz5D-4d8mA:
undetectable		 2xz5C-4d8mA:
17.90
2xz5D-4d8mA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es1 BH0342 PROTEIN

(Bacillus
halodurans) 		PF09827
(CRISPR_Cas2) 		4 ILE A   5
VAL A  23
TYR A  30
CYH A  41
 None
 0.92A 2xz5C-4es1A:
undetectable
2xz5D-4es1A:
undetectable		 2xz5C-4es1A:
18.43
2xz5D-4es1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 0.99A 2xz5C-4g59C:
undetectable
2xz5D-4g59C:
undetectable		 2xz5C-4g59C:
20.36
2xz5D-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.28A 2xz5C-4g59C:
undetectable
2xz5D-4g59C:
undetectable		 2xz5C-4g59C:
20.36
2xz5D-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		4 ILE A 161
TYR A 179
VAL A 205
TYR A 211
 None
 1.18A 2xz5C-4gdfA:
undetectable
2xz5D-4gdfA:
undetectable		 2xz5C-4gdfA:
17.45
2xz5D-4gdfA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.23A 2xz5C-4gfhA:
undetectable
2xz5D-4gfhA:
undetectable		 2xz5C-4gfhA:
10.54
2xz5D-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.13A 2xz5C-4gvlA:
undetectable
2xz5D-4gvlA:
undetectable		 2xz5C-4gvlA:
16.59
2xz5D-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.19A 2xz5C-4gx0A:
undetectable
2xz5D-4gx0A:
undetectable		 2xz5C-4gx0A:
16.79
2xz5D-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 ILE A 123
VAL A 185
TYR A  96
TYR A 110
 None
 1.26A 2xz5C-4ifaA:
undetectable
2xz5D-4ifaA:
undetectable		 2xz5C-4ifaA:
19.82
2xz5D-4ifaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 418
TYR B 320
TRP B 355
VAL B 351
 None
 1.30A 2xz5C-4l37B:
2.4
2xz5D-4l37B:
undetectable		 2xz5C-4l37B:
14.59
2xz5D-4l37B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 ILE A 296
VAL A 308
TYR A 314
CYH A 315
 None
 1.26A 2xz5C-4l39A:
undetectable
2xz5D-4l39A:
undetectable		 2xz5C-4l39A:
18.75
2xz5D-4l39A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		4 ILE A  56
TYR A  60
VAL A  33
TYR A 330
 None
 1.14A 2xz5C-4qhxA:
undetectable
2xz5D-4qhxA:
undetectable		 2xz5C-4qhxA:
19.53
2xz5D-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 290
TYR A 258
VAL A 266
CYH A 276
 None
 1.06A 2xz5C-4w6zA:
undetectable
2xz5D-4w6zA:
undetectable		 2xz5C-4w6zA:
21.80
2xz5D-4w6zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xco SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Methanocaldococcus
jannaschii) 		PF01922
(SRP19) 		4 TYR A   7
VAL A  64
TYR A  53
CYH A  61
 G  M 166 ( 4.7A)
None
G  M 166 ( 4.5A)
None
 1.05A 2xz5C-4xcoA:
undetectable
2xz5D-4xcoA:
undetectable		 2xz5C-4xcoA:
17.62
2xz5D-4xcoA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ILE A 380
TYR A 168
CYH A 251
TYR A 347
 None
 1.30A 2xz5C-5cozA:
undetectable
2xz5D-5cozA:
undetectable		 2xz5C-5cozA:
19.76
2xz5D-5cozA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A 122
TRP A 178
TYR A 219
TYR A 226
 EPJ  A 300 (-4.6A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
 0.70A 2xz5C-5fjvA:
22.8
2xz5D-5fjvA:
22.8		 2xz5C-5fjvA:
31.39
2xz5D-5fjvA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i20 UNCHARACTERIZED
PROTEIN

(Starkeya
novella) 		PF00892
(EamA) 		4 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.28A 2xz5C-5i20A:
undetectable
2xz5D-5i20A:
undetectable		 2xz5C-5i20A:
19.67
2xz5D-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 275
CYH A 263
CYH A 277
TYR A 274
 MLI  A 303 ( 4.5A)
None
None
None
 1.27A 2xz5C-5jj2A:
undetectable
2xz5D-5jj2A:
undetectable		 2xz5C-5jj2A:
17.99
2xz5D-5jj2A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 ILE A 755
TYR A 656
CYH A 659
TYR A 661
 None
 1.13A 2xz5C-5kd5A:
undetectable
2xz5D-5kd5A:
undetectable		 2xz5C-5kd5A:
17.56
2xz5D-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 TYR A 100
TRP A 156
TYR A 197
TYR A 204
 NCT  A 402 (-4.8A)
NCT  A 402 (-3.9A)
NCT  A 402 ( 4.9A)
NCT  A 402 (-3.8A)
 0.70A 2xz5C-5kxiA:
24.5
2xz5D-5kxiA:
24.5		 2xz5C-5kxiA:
19.00
2xz5D-5kxiA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 ILE A 238
VAL A 229
TYR A 194
CYH A 191
 None
 1.26A 2xz5C-5lmcA:
undetectable
2xz5D-5lmcA:
undetectable		 2xz5C-5lmcA:
19.22
2xz5D-5lmcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04

(Pseudomonas
aeruginosa;
Lama glama) 		no annotation
no annotation 		4 ILE A  55
TYR C  59
VAL A  90
TYR C  52
 None
 1.26A 2xz5C-5mp2A:
undetectable
2xz5D-5mp2A:
undetectable		 2xz5C-5mp2A:
undetectable
2xz5D-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mps PRE-MRNA-PROCESSING
FACTOR 17

(Saccharomyces
cerevisiae) 		PF00249
(Myb_DNA-binding) 		4 ILE o 398
VAL o 344
TYR o 350
CYH o 352
 None
None
C  I  59 ( 4.7A)
None
 1.25A 2xz5C-5mpso:
undetectable
2xz5D-5mpso:
undetectable		 2xz5C-5mpso:
17.76
2xz5D-5mpso:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		4 ILE A 244
TYR A 347
VAL A 162
CYH A  35
 None
 0.87A 2xz5C-5t13A:
undetectable
2xz5D-5t13A:
undetectable		 2xz5C-5t13A:
20.00
2xz5D-5t13A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.12A 2xz5C-5tf2A:
undetectable
2xz5D-5tf2A:
undetectable		 2xz5C-5tf2A:
17.97
2xz5D-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 ILE A 159
TYR A  54
VAL A 161
CYH A 397
 None
 1.21A 2xz5C-5u2nA:
undetectable
2xz5D-5u2nA:
undetectable		 2xz5C-5u2nA:
19.32
2xz5D-5u2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 ILE A 921
VAL A 923
TYR A 904
CYH A 901
 None
 1.30A 2xz5C-5xgjA:
undetectable
2xz5D-5xgjA:
undetectable		 2xz5C-5xgjA:
undetectable
2xz5D-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 ILE A 404
TYR A 249
VAL A 388
CYH A 409
 None
 1.09A 2xz5C-5xwbA:
undetectable
2xz5D-5xwbA:
undetectable		 2xz5C-5xwbA:
18.38
2xz5D-5xwbA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 4 ILE A 188
VAL A 150
TYR A 177
CYH A 181
 None
 1.28A 2xz5C-5ydlA:
undetectable
2xz5D-5ydlA:
undetectable		 2xz5C-5ydlA:
undetectable
2xz5D-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 ILE A 191
TYR A 277
TYR A 262
CYH A 215
 None
 1.06A 2xz5C-6b2wA:
undetectable
2xz5D-6b2wA:
undetectable		 2xz5C-6b2wA:
undetectable
2xz5D-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 ILE A 191
TYR A 277
TYR A 262
CYH A 215
 None
 1.21A 2xz5C-6b2wA:
undetectable
2xz5D-6b2wA:
undetectable		 2xz5C-6b2wA:
undetectable
2xz5D-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 ILE A 134
TYR A   4
VAL A   8
TYR A 129
 None
 1.30A 2xz5C-6b4oA:
undetectable
2xz5D-6b4oA:
undetectable		 2xz5C-6b4oA:
19.29
2xz5D-6b4oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 VAL A 330
TYR A 336
CYH A 566
CYH A 337
 None
 1.09A 2xz5C-6cddA:
undetectable
2xz5D-6cddA:
undetectable		 2xz5C-6cddA:
undetectable
2xz5D-6cddA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 4 VAL A 330
TYR A 336
CYH A 566
CYH A 337
 None
 1.26A 2xz5C-6chsA:
undetectable
2xz5D-6chsA:
undetectable		 2xz5C-6chsA:
undetectable
2xz5D-6chsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 4 ILE A  69
TYR A  98
VAL A 133
TYR A  92
 None
 1.08A 2xz5C-6dgcA:
undetectable
2xz5D-6dgcA:
undetectable		 2xz5C-6dgcA:
undetectable
2xz5D-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CLF1

(Saccharomyces
cerevisiae) 		no annotation 4 TYR S 137
VAL S 166
TYR S 156
CYH S 160
 None
 1.27A 2xz5C-6exnS:
undetectable
2xz5D-6exnS:
undetectable		 2xz5C-6exnS:
undetectable
2xz5D-6exnS:
undetectable