SIMILAR PATTERNS OF AMINO ACIDS FOR 2XZ5_B_ACHB1211

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 TYR A 138
SER A  35
GLN A  99
ILE A 132
 None
 1.04A 2xz5B-1b5fA:
0.0
2xz5E-1b5fA:
0.0		 2xz5B-1b5fA:
22.13
2xz5E-1b5fA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 GLN A 282
GLN A 226
ILE A 222
SER A 281
 None
 1.12A 2xz5B-1b7fA:
0.0
2xz5E-1b7fA:
0.0		 2xz5B-1b7fA:
20.09
2xz5E-1b7fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 TYR A 171
SER A 173
GLN A 137
ILE A 111
 None
 1.05A 2xz5B-1bh6A:
0.0
2xz5E-1bh6A:
0.0		 2xz5B-1bh6A:
21.62
2xz5E-1bh6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 TYR A 171
SER A 173
GLN A 137
ILE A 111
 None
 1.04A 2xz5B-1c3lA:
0.0
2xz5E-1c3lA:
0.0		 2xz5B-1c3lA:
22.39
2xz5E-1c3lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 TYR A 243
SER A 362
GLN A 197
SER A 239
 B12  A 800 ( 4.6A)
DCA  A 801 (-3.4A)
None
DCA  A 801 ( 4.1A)
 1.00A 2xz5B-1e1cA:
0.0
2xz5E-1e1cA:
0.0		 2xz5B-1e1cA:
15.66
2xz5E-1e1cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 TYR A 187
TYR A 299
ILE A 272
SER A 295
 PPE  A 413 (-4.4A)
None
None
None
 1.11A 2xz5B-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5B-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR A  49
SER A 401
GLN A 812
ILE A 814
 None
 1.18A 2xz5B-1hwwA:
0.0
2xz5E-1hwwA:
0.0		 2xz5B-1hwwA:
12.07
2xz5E-1hwwA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j25 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF02732
(ERCC4) 		4 TYR A  75
SER A  76
ILE A  79
SER A  42
 None
 1.17A 2xz5B-1j25A:
0.0
2xz5E-1j25A:
0.0		 2xz5B-1j25A:
23.29
2xz5E-1j25A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 871
SER A 872
GLN A 866
ILE A 875
 None
 1.00A 2xz5B-1kcwA:
0.7
2xz5E-1kcwA:
0.2		 2xz5B-1kcwA:
12.11
2xz5E-1kcwA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		4 GLN A 357
GLN A 334
ILE A 351
SER A 211
 None
869  A1501 ( 3.8A)
None
None
 1.03A 2xz5B-1sqiA:
undetectable
2xz5E-1sqiA:
undetectable		 2xz5B-1sqiA:
21.43
2xz5E-1sqiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 SER A 377
GLN A 352
ILE A 303
SER A 361
 None
 1.11A 2xz5B-1uc4A:
undetectable
2xz5E-1uc4A:
undetectable		 2xz5B-1uc4A:
16.93
2xz5E-1uc4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		4 TYR A  88
SER A  89
ILE A 140
SER A  52
 None
 1.08A 2xz5B-1wlsA:
undetectable
2xz5E-1wlsA:
undetectable		 2xz5B-1wlsA:
18.69
2xz5E-1wlsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5t PROTEIN C7ORF24

(Homo sapiens) 		PF13772
(AIG2_2) 		4 TYR A 139
SER A 136
ILE A 176
SER A  61
 None
 1.12A 2xz5B-2i5tA:
undetectable
2xz5E-2i5tA:
undetectable		 2xz5B-2i5tA:
22.52
2xz5E-2i5tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		4 TYR A 251
SER A 176
GLN A 273
ILE A 256
 None
35G  A   1 (-2.7A)
None
None
 1.16A 2xz5B-2k31A:
undetectable
2xz5E-2k31A:
undetectable		 2xz5B-2k31A:
23.81
2xz5E-2k31A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 TYR A  69
SER A 348
ILE A 333
SER A 129
 None
 1.16A 2xz5B-2pajA:
undetectable
2xz5E-2pajA:
undetectable		 2xz5B-2pajA:
18.18
2xz5E-2pajA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		4 TYR A  47
SER A  49
ILE A  69
SER A  55
 None
None
GLU  A1620 (-4.9A)
None
 1.07A 2xz5B-2pyyA:
undetectable
2xz5E-2pyyA:
undetectable		 2xz5B-2pyyA:
20.88
2xz5E-2pyyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 TYR A 188
TYR A 242
ILE A 272
SER A 245
 None
 1.05A 2xz5B-2q3rA:
undetectable
2xz5E-2q3rA:
undetectable		 2xz5B-2q3rA:
19.89
2xz5E-2q3rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI

(Bacillus
pumilus) 		PF11564
(BpuJI_N) 		4 SER A 167
GLN A 137
GLN A 172
ILE A 133
 None
 1.17A 2xz5B-2vlaA:
undetectable
2xz5E-2vlaA:
undetectable		 2xz5B-2vlaA:
19.93
2xz5E-2vlaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		4 TYR A 258
GLN A  84
GLN A  17
SER A  83
 None
NAD  A1353 (-3.8A)
NAD  A1353 (-4.4A)
None
 1.14A 2xz5B-2vutA:
undetectable
2xz5E-2vutA:
undetectable		 2xz5B-2vutA:
19.66
2xz5E-2vutA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhf PEROXIREDOXIN 5

(Alvinella
pompejana) 		PF08534
(Redoxin) 		4 SER A 173
GLN A 190
ILE A 169
SER A 186
 None
 1.09A 2xz5B-2xhfA:
undetectable
2xz5E-2xhfA:
undetectable		 2xz5B-2xhfA:
22.12
2xz5E-2xhfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 TYR A 548
SER A 767
GLN A 593
GLN A 686
 None
 1.06A 2xz5B-2xsgA:
undetectable
2xz5E-2xsgA:
undetectable		 2xz5B-2xsgA:
14.54
2xz5E-2xsgA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 TYR A 124
SER A  58
GLN A 178
ILE A 147
 None
 0.88A 2xz5B-3b8oA:
undetectable
2xz5E-3b8oA:
undetectable		 2xz5B-3b8oA:
19.34
2xz5E-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 TYR B 231
GLN B 275
ILE B 239
SER B 274
 None
 0.90A 2xz5B-3bg0B:
undetectable
2xz5E-3bg0B:
undetectable		 2xz5B-3bg0B:
20.32
2xz5E-3bg0B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A 112
TYR A  89
GLN A 157
SER A  87
 None
 1.15A 2xz5B-3bvmA:
undetectable
2xz5E-3bvmA:
undetectable		 2xz5B-3bvmA:
23.37
2xz5E-3bvmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A 185
SER A 182
ILE A 164
SER A 219
 None
 0.86A 2xz5B-3c5hA:
undetectable
2xz5E-3c5hA:
undetectable		 2xz5B-3c5hA:
23.13
2xz5E-3c5hA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c85 PUTATIVE
GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFB

(Vibrio
parahaemolyticus) 		PF02254
(TrkA_N) 		4 TYR A 156
SER A 157
GLN A 140
ILE A 134
 None
 0.93A 2xz5B-3c85A:
undetectable
2xz5E-3c85A:
undetectable		 2xz5B-3c85A:
21.03
2xz5E-3c85A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A 298
CYH A 299
GLN A 360
ILE A 265
 None
 1.12A 2xz5B-3c8tA:
undetectable
2xz5E-3c8tA:
undetectable		 2xz5B-3c8tA:
19.48
2xz5E-3c8tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		4 TYR A  49
SER A  80
GLN A 111
ILE A 106
 None
 1.09A 2xz5B-3dn7A:
undetectable
2xz5E-3dn7A:
undetectable		 2xz5B-3dn7A:
21.59
2xz5E-3dn7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 TYR A 124
SER A 304
ILE A  85
SER A 171
 None
 1.17A 2xz5B-3gweA:
undetectable
2xz5E-3gweA:
undetectable		 2xz5B-3gweA:
19.13
2xz5E-3gweA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic4 GLUTAREDOXIN (GRX-1)

(Archaeoglobus
fulgidus) 		PF00462
(Glutaredoxin) 		4 TYR A  56
SER A  57
ILE A  34
SER A  53
 None
 1.11A 2xz5B-3ic4A:
undetectable
2xz5E-3ic4A:
undetectable		 2xz5B-3ic4A:
14.90
2xz5E-3ic4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 TYR A1232
GLN A1276
ILE A1240
SER A1275
 None
 0.84A 2xz5B-3jroA:
undetectable
2xz5E-3jroA:
undetectable		 2xz5B-3jroA:
14.38
2xz5E-3jroA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kop UNCHARACTERIZED
PROTEIN

(Arthrobacter
sp. FB24) 		PF12903
(DUF3830) 		4 TYR A  53
GLN A 105
ILE A 107
SER A  40
 None
 0.81A 2xz5B-3kopA:
undetectable
2xz5E-3kopA:
undetectable		 2xz5B-3kopA:
22.57
2xz5E-3kopA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7v PIWI-LIKE PROTEIN 1

(Homo sapiens) 		PF02170
(PAZ) 		4 TYR X 350
TYR X 345
SER X 341
ILE X 354
 C  A  12 ( 4.4A)
None
None
None
 1.13A 2xz5B-3o7vX:
undetectable
2xz5E-3o7vX:
undetectable		 2xz5B-3o7vX:
20.64
2xz5E-3o7vX:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7v PIWI-LIKE PROTEIN 1

(Homo sapiens) 		PF02170
(PAZ) 		4 TYR X 350
TYR X 345
SER X 341
ILE X 383
 C  A  12 ( 4.4A)
None
None
None
 1.06A 2xz5B-3o7vX:
undetectable
2xz5E-3o7vX:
undetectable		 2xz5B-3o7vX:
20.64
2xz5E-3o7vX:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		4 TYR A 141
SER A 172
GLN A 185
ILE A  75
 None
EDO  A  10 (-2.7A)
None
None
 1.06A 2xz5B-3qnbA:
undetectable
2xz5E-3qnbA:
undetectable		 2xz5B-3qnbA:
20.91
2xz5E-3qnbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 TYR A 209
SER A 159
GLN A 211
ILE A 154
 None
 1.09A 2xz5B-3rrlA:
undetectable
2xz5E-3rrlA:
undetectable		 2xz5B-3rrlA:
20.87
2xz5E-3rrlA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 SER A 243
CYH A 244
GLN A  14
ILE A 249
 None
 1.00A 2xz5B-3rrwA:
undetectable
2xz5E-3rrwA:
undetectable		 2xz5B-3rrwA:
21.03
2xz5E-3rrwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		4 TYR A 128
SER A 130
ILE A  97
SER A  58
 None
F6R  A 226 (-2.8A)
None
None
 0.95A 2xz5B-3s1vA:
undetectable
2xz5E-3s1vA:
undetectable		 2xz5B-3s1vA:
21.90
2xz5E-3s1vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 TYR A  86
SER A  85
ILE A  92
SER A 122
 None
 0.97A 2xz5B-3si1A:
undetectable
2xz5E-3si1A:
undetectable		 2xz5B-3si1A:
19.51
2xz5E-3si1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 TYR A 306
TYR A 331
SER A 330
ILE A 309
 GAL  A 900 (-4.6A)
None
None
None
 1.08A 2xz5B-3thcA:
undetectable
2xz5E-3thcA:
undetectable		 2xz5B-3thcA:
15.70
2xz5E-3thcA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr4 INORGANIC
PYROPHOSPHATASE

(Coxiella
burnetii) 		PF00719
(Pyrophosphatase) 		4 TYR A 140
TYR A  50
CYH A  52
ILE A 133
 None
 0.93A 2xz5B-3tr4A:
undetectable
2xz5E-3tr4A:
undetectable		 2xz5B-3tr4A:
25.00
2xz5E-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 SER A1051
GLN A1147
ILE A1102
SER A1011
 None
 1.02A 2xz5B-3u9wA:
3.5
2xz5E-3u9wA:
3.3		 2xz5B-3u9wA:
17.32
2xz5E-3u9wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uws HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF03415
(Peptidase_C11) 		4 TYR B 233
SER B 330
GLN B 282
SER B 200
 None
 1.17A 2xz5B-3uwsB:
undetectable
2xz5E-3uwsB:
undetectable		 2xz5B-3uwsB:
20.82
2xz5E-3uwsB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A4010
GLN A4017
ILE A4005
SER A4041
 None
 1.14A 2xz5B-3vkgA:
undetectable
2xz5E-3vkgA:
undetectable		 2xz5B-3vkgA:
5.52
2xz5E-3vkgA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn)
PF16543
(DFRP_C) 		4 TYR A 297
SER A 344
GLN A 348
ILE C 275
 None
 1.00A 2xz5B-4a9aA:
undetectable
2xz5E-4a9aA:
undetectable		 2xz5B-4a9aA:
19.48
2xz5E-4a9aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 TYR A  13
SER A  30
ILE A  17
SER A 331
 None
 1.14A 2xz5B-4bl0A:
undetectable
2xz5E-4bl0A:
undetectable		 2xz5B-4bl0A:
22.22
2xz5E-4bl0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		4 SER A 567
GLN A 168
ILE A 176
SER A 152
 None
 1.13A 2xz5B-4ccaA:
undetectable
2xz5E-4ccaA:
undetectable		 2xz5B-4ccaA:
15.53
2xz5E-4ccaA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa;
Neurospora
crassa) 		no annotation
no annotation 		4 SER A  96
GLN B 634
ILE A 100
SER B 631
 None
 0.97A 2xz5B-4czxA:
undetectable
2xz5E-4czxA:
undetectable		 2xz5B-4czxA:
22.76
2xz5E-4czxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 TYR A2114
SER A2025
GLN A2107
ILE A2143
 None
 1.13A 2xz5B-4d0oA:
undetectable
2xz5E-4d0oA:
undetectable		 2xz5B-4d0oA:
20.00
2xz5E-4d0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 TYR A 236
GLN A 200
GLN A 409
ILE A 368
 None
 1.08A 2xz5B-4fixA:
undetectable
2xz5E-4fixA:
undetectable		 2xz5B-4fixA:
16.01
2xz5E-4fixA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 TYR A 378
SER A 220
CYH A 219
GLN A 162
 None
None
PLP  A 501 (-3.6A)
None
 0.96A 2xz5B-4fl0A:
undetectable
2xz5E-4fl0A:
undetectable		 2xz5B-4fl0A:
18.98
2xz5E-4fl0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 TYR B 407
SER B 215
GLN B 410
ILE B 415
 None
 1.17A 2xz5B-4g68B:
undetectable
2xz5E-4g68B:
undetectable		 2xz5B-4g68B:
18.16
2xz5E-4g68B:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN
HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set)
PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 SER C 139
GLN D  10
ILE D  31
SER C   8
 None
 0.92A 2xz5B-4i0pC:
undetectable
2xz5E-4i0pC:
3.5		 2xz5B-4i0pC:
23.01
2xz5E-4i0pC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 TYR A 546
TYR A 508
SER A 505
GLN A 440
 None
 1.14A 2xz5B-4ifqA:
undetectable
2xz5E-4ifqA:
undetectable		 2xz5B-4ifqA:
12.92
2xz5E-4ifqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 TYR B 613
TYR B 413
GLN B 388
ILE B 439
 None
 1.13A 2xz5B-4iglB:
undetectable
2xz5E-4iglB:
undetectable		 2xz5B-4iglB:
16.62
2xz5E-4iglB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 4 SER C 143
GLN C 153
ILE C 194
SER C 150
 NAP  C 304 (-3.3A)
None
NAP  C 304 (-3.2A)
FMT  C 301 (-3.1A)
 0.96A 2xz5B-4iqgC:
undetectable
2xz5E-4iqgC:
undetectable		 2xz5B-4iqgC:
21.13
2xz5E-4iqgC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 364
GLN A 371
ILE A 325
SER A 368
 None
 1.17A 2xz5B-4irnA:
undetectable
2xz5E-4irnA:
undetectable		 2xz5B-4irnA:
19.74
2xz5E-4irnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 SER A  52
GLN A  47
GLN A 213
SER A  46
 None
 1.07A 2xz5B-4j5tA:
undetectable
2xz5E-4j5tA:
undetectable		 2xz5B-4j5tA:
14.19
2xz5E-4j5tA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 TYR A 261
SER A 264
ILE A 337
SER A 395
 None
 1.09A 2xz5B-4ldsA:
undetectable
2xz5E-4ldsA:
undetectable		 2xz5B-4ldsA:
20.25
2xz5E-4ldsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxe N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13880
(Acetyltransf_13) 		4 TYR A 731
SER A 759
CYH A 758
ILE A 834
 None
 1.09A 2xz5B-4mxeA:
undetectable
2xz5E-4mxeA:
undetectable		 2xz5B-4mxeA:
21.46
2xz5E-4mxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 GLN A 246
GLN A 242
ILE A 160
SER A  99
 DAL  A 402 (-4.0A)
None
DAL  A 402 (-4.9A)
DAL  A 402 (-4.5A)
 1.10A 2xz5B-4nguA:
undetectable
2xz5E-4nguA:
undetectable		 2xz5B-4nguA:
20.44
2xz5E-4nguA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmi ECTD

(Virgibacillus
salexigens) 		PF05721
(PhyH) 		4 TYR A   5
SER A 186
ILE A  15
SER A 147
 None
 0.84A 2xz5B-4nmiA:
undetectable
2xz5E-4nmiA:
undetectable		 2xz5B-4nmiA:
22.05
2xz5E-4nmiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TYR A2114
TYR A1913
GLN A1890
ILE A1939
 None
 1.07A 2xz5B-4o9xA:
undetectable
2xz5E-4o9xA:
undetectable		 2xz5B-4o9xA:
7.18
2xz5E-4o9xA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv5 LACTOYLGLUTATHIONE
LYASE

(Mus musculus) 		PF00903
(Glyoxalase) 		4 TYR A 136
SER A 137
CYH A 139
ILE A 174
 None
 1.02A 2xz5B-4pv5A:
undetectable
2xz5E-4pv5A:
undetectable		 2xz5B-4pv5A:
20.35
2xz5E-4pv5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 422
SER A 423
CYH A 425
SER A 443
 None
 1.13A 2xz5B-4pwnA:
undetectable
2xz5E-4pwnA:
undetectable		 2xz5B-4pwnA:
22.26
2xz5E-4pwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pws PROLINE-RICH 28 KDA
ANTIGEN

(Mycobacterium
tuberculosis) 		PF10738
(Lpp-LpqN) 		4 TYR A 218
SER A 190
GLN A 167
SER A 246
 None
 1.13A 2xz5B-4pwsA:
undetectable
2xz5E-4pwsA:
undetectable		 2xz5B-4pwsA:
23.36
2xz5E-4pwsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 TYR A 125
SER A 253
GLN A 138
ILE A 148
 None
 1.15A 2xz5B-4q7gA:
2.2
2xz5E-4q7gA:
2.3		 2xz5B-4q7gA:
18.81
2xz5E-4q7gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		4 TYR A 271
SER A 259
GLN A 295
ILE A 293
 None
 1.08A 2xz5B-4r5oA:
undetectable
2xz5E-4r5oA:
undetectable		 2xz5B-4r5oA:
18.33
2xz5E-4r5oA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 TYR A 277
GLN A 288
GLN A 243
ILE A 143
 None
 1.10A 2xz5B-4rhhA:
undetectable
2xz5E-4rhhA:
undetectable		 2xz5B-4rhhA:
15.48
2xz5E-4rhhA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 TYR A 302
SER A 300
ILE A 306
SER A 346
 PEG  A 507 ( 4.1A)
None
None
PEG  A 507 (-2.6A)
 1.15A 2xz5B-4u09A:
undetectable
2xz5E-4u09A:
undetectable		 2xz5B-4u09A:
19.80
2xz5E-4u09A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 TYR A  82
GLN A 101
ILE A 104
SER A  99
 None
 1.10A 2xz5B-4v20A:
undetectable
2xz5E-4v20A:
undetectable		 2xz5B-4v20A:
19.50
2xz5E-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 TYR A 124
SER A  58
GLN A 178
ILE A 147
 None
 1.03A 2xz5B-4wl1A:
undetectable
2xz5E-4wl1A:
undetectable		 2xz5B-4wl1A:
20.11
2xz5E-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		4 SER B 127
GLN B 120
GLN B 145
ILE B 132
 None
 1.17A 2xz5B-4x33B:
undetectable
2xz5E-4x33B:
undetectable		 2xz5B-4x33B:
20.06
2xz5E-4x33B:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF04084
(ORC2)
PF07034
(ORC3_N) 		4 TYR C 307
GLN B 477
ILE C 606
SER C 310
 None
 1.11A 2xz5B-4xgcC:
undetectable
2xz5E-4xgcC:
undetectable		 2xz5B-4xgcC:
14.89
2xz5E-4xgcC:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 TYR B 232
GLN B 276
ILE B 240
SER B 275
 None
 1.17A 2xz5B-4xmmB:
undetectable
2xz5E-4xmmB:
undetectable		 2xz5B-4xmmB:
16.64
2xz5E-4xmmB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 TYR C 122
SER C  72
CYH C  71
GLN C  64
 None
None
None
MG  C 502 (-4.3A)
 1.13A 2xz5B-4xruC:
undetectable
2xz5E-4xruC:
undetectable		 2xz5B-4xruC:
20.89
2xz5E-4xruC:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 GLN A  38
GLN A  57
ILE A 118
SER A 167
 None
 0.71A 2xz5B-4zjsA:
29.3
2xz5E-4zjsA:
29.2		 2xz5B-4zjsA:
77.63
2xz5E-4zjsA:
77.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		4 SER A 120
GLN A 125
ILE A 140
SER A 115
 None
 1.03A 2xz5B-5bo6A:
undetectable
2xz5E-5bo6A:
undetectable		 2xz5B-5bo6A:
20.00
2xz5E-5bo6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 309
GLN A 231
ILE A 321
SER A 228
 None
 1.16A 2xz5B-5bqsA:
undetectable
2xz5E-5bqsA:
undetectable		 2xz5B-5bqsA:
19.75
2xz5E-5bqsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 TYR A 468
GLN A 191
ILE A 317
SER A 376
 None
 1.08A 2xz5B-5cniA:
undetectable
2xz5E-5cniA:
undetectable		 2xz5B-5cniA:
17.94
2xz5E-5cniA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 TYR A 703
GLN A 149
ILE A 697
SER A 150
 None
 0.95A 2xz5B-5d0fA:
undetectable
2xz5E-5d0fA:
undetectable		 2xz5B-5d0fA:
8.67
2xz5E-5d0fA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		4 TYR A  62
SER A  63
GLN A 154
SER A 152
 None
 1.15A 2xz5B-5dlyA:
undetectable
2xz5E-5dlyA:
undetectable		 2xz5B-5dlyA:
21.76
2xz5E-5dlyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 SER A 326
GLN A 168
ILE A 332
SER A 163
 NAP  A 401 (-2.5A)
None
None
NAP  A 401 (-2.6A)
 1.13A 2xz5B-5dp2A:
undetectable
2xz5E-5dp2A:
undetectable		 2xz5B-5dp2A:
23.30
2xz5E-5dp2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 TYR A 813
SER A 812
GLN A 784
ILE A 779
 GLC  A1106 (-3.7A)
None
None
None
 1.17A 2xz5B-5f7uA:
undetectable
2xz5E-5f7uA:
undetectable		 2xz5B-5f7uA:
11.45
2xz5E-5f7uA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 293
SER A 364
CYH A 367
ILE A 316
 None
 1.17A 2xz5B-5i2gA:
undetectable
2xz5E-5i2gA:
undetectable		 2xz5B-5i2gA:
13.94
2xz5E-5i2gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TYR A 374
GLN A 872
ILE A 590
SER A 651
 None
 1.16A 2xz5B-5im3A:
undetectable
2xz5E-5im3A:
undetectable		 2xz5B-5im3A:
11.85
2xz5E-5im3A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 TYR A 190
SER A 176
ILE A 185
SER A 199
 None
 1.03A 2xz5B-5isoA:
undetectable
2xz5E-5isoA:
undetectable		 2xz5B-5isoA:
18.71
2xz5E-5isoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00620
(RhoGAP) 		4 TYR A1016
GLN A1042
ILE A1081
SER A1086
 None
 0.79A 2xz5B-5jd0A:
undetectable
2xz5E-5jd0A:
undetectable		 2xz5B-5jd0A:
16.96
2xz5E-5jd0A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 TYR B 612
TYR B 413
GLN B 388
ILE B 438
 None
CL  B1002 (-4.8A)
None
None
 1.11A 2xz5B-5kisB:
undetectable
2xz5E-5kisB:
undetectable		 2xz5B-5kisB:
13.80
2xz5E-5kisB:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		4 TYR A 224
TYR A  13
SER A 118
GLN A 225
 None
 1.17A 2xz5B-5kkgA:
undetectable
2xz5E-5kkgA:
undetectable		 2xz5B-5kkgA:
18.09
2xz5E-5kkgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 168
CYH A 201
ILE A 376
SER A 188
 None
 0.92A 2xz5B-5mjsA:
undetectable
2xz5E-5mjsA:
undetectable		 2xz5B-5mjsA:
undetectable
2xz5E-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 TYR A 348
SER A 349
CYH A 351
SER A 369
 None
 1.13A 2xz5B-5o2cA:
undetectable
2xz5E-5o2cA:
undetectable		 2xz5B-5o2cA:
19.79
2xz5E-5o2cA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Bos taurus;
Mus musculus) 		PF00654
(Voltage_CLC)
PF07686
(V-set) 		4 TYR L  94
GLN L  27
ILE L   2
SER A 366
 None
 1.12A 2xz5B-5tr1L:
undetectable
2xz5E-5tr1L:
undetectable		 2xz5B-5tr1L:
21.62
2xz5E-5tr1L:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 GLN A  36
GLN A  55
ILE A 116
SER A 165
 None
 0.48A 2xz5B-5xglA:
30.8
2xz5E-5xglA:
30.9		 2xz5B-5xglA:
undetectable
2xz5E-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4m -

(-) 		no annotation 4 TYR A  58
SER A  53
GLN A  83
ILE A 172
 None
 1.09A 2xz5B-5y4mA:
undetectable
2xz5E-5y4mA:
undetectable		 2xz5B-5y4mA:
undetectable
2xz5E-5y4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 4 SER A 128
CYH A 130
GLN A 122
ILE A  75
 None
 1.17A 2xz5B-5yksA:
undetectable
2xz5E-5yksA:
undetectable		 2xz5B-5yksA:
19.85
2xz5E-5yksA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 TYR A 549
TYR A 527
GLN A 540
ILE A 529
 None
 1.16A 2xz5B-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable		 2xz5B-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 TYR A1926
SER A2510
GLN A1919
ILE A1930
 None
 1.02A 2xz5B-6fayA:
undetectable
2xz5E-6fayA:
undetectable		 2xz5B-6fayA:
undetectable
2xz5E-6fayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		no annotation 4 TYR A 137
TYR A 150
GLN A 201
ILE A 282
 None
 1.11A 2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable		 2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 SER A 140
CYH A 139
ILE A 135
SER A  32
 None
 1.07A 2xz5B-6g9oA:
undetectable
2xz5E-6g9oA:
undetectable		 2xz5B-6g9oA:
undetectable
2xz5E-6g9oA:
undetectable