SIMILAR PATTERNS OF AMINO ACIDS FOR 2XZ5_A_ACHA1211

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 TYR A 171
SER A 173
GLN A 137
ILE A 111
 None
 1.08A 2xz5A-1bh6A:
undetectable
2xz5B-1bh6A:
0.0		 2xz5A-1bh6A:
21.62
2xz5B-1bh6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 TYR A 171
SER A 173
GLN A 137
ILE A 111
 None
 1.08A 2xz5A-1c3lA:
0.0
2xz5B-1c3lA:
0.0		 2xz5A-1c3lA:
22.39
2xz5B-1c3lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j25 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF02732
(ERCC4) 		4 TYR A  75
SER A  76
ILE A  79
SER A  42
 None
 1.18A 2xz5A-1j25A:
undetectable
2xz5B-1j25A:
0.0		 2xz5A-1j25A:
23.29
2xz5B-1j25A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 871
SER A 872
GLN A 866
ILE A 875
 None
 0.94A 2xz5A-1kcwA:
0.8
2xz5B-1kcwA:
0.7		 2xz5A-1kcwA:
12.11
2xz5B-1kcwA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Escherichia
coli) 		PF02261
(Asp_decarbox) 		4 TYR A  22
SER A  25
CYH A  26
ILE A  28
 None
 1.29A 2xz5A-1ppyA:
0.0
2xz5B-1ppyA:
0.0		 2xz5A-1ppyA:
20.47
2xz5B-1ppyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 TYR A 136
CYH A 114
GLN A  15
ILE A  20
 None
 1.29A 2xz5A-1tk1A:
0.0
2xz5B-1tk1A:
0.0		 2xz5A-1tk1A:
20.65
2xz5B-1tk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 SER A 377
GLN A 352
ILE A 303
SER A 361
 None
 1.12A 2xz5A-1uc4A:
0.0
2xz5B-1uc4A:
0.0		 2xz5A-1uc4A:
16.93
2xz5B-1uc4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TRP A 308
TYR A 309
ILE A 282
SER A 177
 None
 1.30A 2xz5A-1vc2A:
undetectable
2xz5B-1vc2A:
undetectable		 2xz5A-1vc2A:
21.92
2xz5B-1vc2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 TYR A 389
SER A 357
GLN A 471
ILE A 482
 None
 1.11A 2xz5A-1wkyA:
0.0
2xz5B-1wkyA:
0.0		 2xz5A-1wkyA:
19.74
2xz5B-1wkyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF04896
(AmoC) 		4 SER C  80
GLN A  38
ILE C 163
SER A  37
 None
 1.30A 2xz5A-1yewC:
undetectable
2xz5B-1yewC:
undetectable		 2xz5A-1yewC:
21.12
2xz5B-1yewC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 TRP A 402
TYR A 394
ILE A 383
SER A 411
 None
 1.02A 2xz5A-2bmfA:
undetectable
2xz5B-2bmfA:
undetectable		 2xz5A-2bmfA:
19.80
2xz5B-2bmfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A  58
SER A 285
CYH A  60
ILE A 143
 None
 1.27A 2xz5A-2c07A:
undetectable
2xz5B-2c07A:
undetectable		 2xz5A-2c07A:
19.52
2xz5B-2c07A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 TRP A 183
SER A 323
CYH A 322
GLN A 318
 NAP  A1518 (-4.0A)
None
NAP  A1518 (-2.0A)
None
 1.22A 2xz5A-2ehqA:
undetectable
2xz5B-2ehqA:
undetectable		 2xz5A-2ehqA:
18.95
2xz5B-2ehqA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 704
CYH A 705
GLN A 672
ILE A 550
 None
 1.19A 2xz5A-2iukA:
undetectable
2xz5B-2iukA:
undetectable		 2xz5A-2iukA:
13.92
2xz5B-2iukA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 TRP A 104
GLN B 351
ILE B  41
SER B 352
 None
 1.13A 2xz5A-2ivfA:
undetectable
2xz5B-2ivfA:
undetectable		 2xz5A-2ivfA:
12.53
2xz5B-2ivfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 TRP A 402
TYR A 394
ILE A 383
SER A 411
 None
 0.90A 2xz5A-2jlsA:
undetectable
2xz5B-2jlsA:
undetectable		 2xz5A-2jlsA:
19.69
2xz5B-2jlsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		4 TYR A  47
SER A  49
ILE A  69
SER A  55
 None
None
GLU  A1620 (-4.9A)
None
 1.08A 2xz5A-2pyyA:
undetectable
2xz5B-2pyyA:
undetectable		 2xz5A-2pyyA:
20.88
2xz5B-2pyyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 TYR A 136
SER A 138
ILE A 228
SER A 144
 None
 1.28A 2xz5A-2r0sA:
undetectable
2xz5B-2r0sA:
undetectable		 2xz5A-2r0sA:
22.07
2xz5B-2r0sA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8o FLAVIVIRIN PROTEASE
NS3

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 TRP A 403
TYR A 395
ILE A 384
SER A 412
 None
 1.00A 2xz5A-2v8oA:
undetectable
2xz5B-2v8oA:
undetectable		 2xz5A-2v8oA:
21.94
2xz5B-2v8oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		4 TRP A 202
SER A 246
CYH A 245
ILE A 267
 None
MPD  A1317 ( 4.0A)
GOL  A1316 (-4.2A)
None
 1.26A 2xz5A-2w48A:
undetectable
2xz5B-2w48A:
undetectable		 2xz5A-2w48A:
19.14
2xz5B-2w48A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 TRP A 402
TYR A 394
ILE A 383
SER A 411
 None
 0.93A 2xz5A-2whxA:
undetectable
2xz5B-2whxA:
undetectable		 2xz5A-2whxA:
16.83
2xz5B-2whxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		4 TRP A 403
TYR A 395
ILE A 384
SER A 412
 None
 1.00A 2xz5A-2wv9A:
undetectable
2xz5B-2wv9A:
undetectable		 2xz5A-2wv9A:
17.42
2xz5B-2wv9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhf PEROXIREDOXIN 5

(Alvinella
pompejana) 		PF08534
(Redoxin) 		4 SER A 173
GLN A 190
ILE A 169
SER A 186
 None
 1.08A 2xz5A-2xhfA:
undetectable
2xz5B-2xhfA:
undetectable		 2xz5A-2xhfA:
22.12
2xz5B-2xhfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Mus musculus) 		PF00017
(SH2)
PF16454
(PI3K_P85_iSH2) 		4 SER B 652
CYH B 651
GLN B 645
ILE B 664
 None
 1.22A 2xz5A-2y3aB:
undetectable
2xz5B-2y3aB:
undetectable		 2xz5A-2y3aB:
20.13
2xz5B-2y3aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 TRP A  51
TYR A 382
GLN A 362
ILE A  52
 None
 1.13A 2xz5A-2zblA:
undetectable
2xz5B-2zblA:
undetectable		 2xz5A-2zblA:
18.00
2xz5B-2zblA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 SER A 261
GLN A 252
ILE A 222
SER A 254
 None
 1.24A 2xz5A-3afgA:
undetectable
2xz5B-3afgA:
undetectable		 2xz5A-3afgA:
17.13
2xz5B-3afgA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		4 TRP A 200
SER A 386
GLN A 404
ILE A 203
 FAD  A   1 (-3.2A)
None
None
None
 1.09A 2xz5A-3ahrA:
undetectable
2xz5B-3ahrA:
undetectable		 2xz5A-3ahrA:
18.16
2xz5B-3ahrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 TRP A 119
SER A  58
GLN A 178
ILE A 147
 None
 1.15A 2xz5A-3b8oA:
undetectable
2xz5B-3b8oA:
undetectable		 2xz5A-3b8oA:
19.34
2xz5B-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A 185
SER A 182
ILE A 164
SER A 219
 None
 0.85A 2xz5A-3c5hA:
undetectable
2xz5B-3c5hA:
undetectable		 2xz5A-3c5hA:
23.13
2xz5B-3c5hA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c85 PUTATIVE
GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFB

(Vibrio
parahaemolyticus) 		PF02254
(TrkA_N) 		4 TYR A 156
SER A 157
GLN A 140
ILE A 134
 None
 0.91A 2xz5A-3c85A:
undetectable
2xz5B-3c85A:
undetectable		 2xz5A-3c85A:
21.03
2xz5B-3c85A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A 298
CYH A 299
GLN A 360
ILE A 265
 None
 1.10A 2xz5A-3c8tA:
undetectable
2xz5B-3c8tA:
undetectable		 2xz5A-3c8tA:
19.48
2xz5B-3c8tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		4 SER A 151
GLN A 111
ILE A 170
SER A 115
 None
 1.24A 2xz5A-3dknA:
undetectable
2xz5B-3dknA:
undetectable		 2xz5A-3dknA:
19.90
2xz5B-3dknA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 SER A 373
GLN A 364
ILE A 391
SER A 367
 None
 1.22A 2xz5A-3e2dA:
undetectable
2xz5B-3e2dA:
undetectable		 2xz5A-3e2dA:
19.96
2xz5B-3e2dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 SER A1263
CYH A1264
GLN A1180
ILE A1216
 None
 1.27A 2xz5A-3f2bA:
undetectable
2xz5B-3f2bA:
undetectable		 2xz5A-3f2bA:
11.89
2xz5B-3f2bA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 TYR A 344
CYH A 145
ILE A 122
SER A 337
 None
None
GOL  A 402 (-4.2A)
None
 1.28A 2xz5A-3fn4A:
undetectable
2xz5B-3fn4A:
undetectable		 2xz5A-3fn4A:
19.51
2xz5B-3fn4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 TYR A 124
SER A 304
ILE A  85
SER A 171
 None
 1.21A 2xz5A-3gweA:
undetectable
2xz5B-3gweA:
undetectable		 2xz5A-3gweA:
19.13
2xz5B-3gweA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 TYR A 589
SER A 445
ILE A 452
SER A 564
 None
 1.30A 2xz5A-3hjeA:
undetectable
2xz5B-3hjeA:
undetectable		 2xz5A-3hjeA:
14.75
2xz5B-3hjeA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic4 GLUTAREDOXIN (GRX-1)

(Archaeoglobus
fulgidus) 		PF00462
(Glutaredoxin) 		4 TYR A  56
SER A  57
ILE A  34
SER A  53
 None
 1.08A 2xz5A-3ic4A:
undetectable
2xz5B-3ic4A:
undetectable		 2xz5A-3ic4A:
14.90
2xz5B-3ic4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 TYR P 327
SER P 328
ILE P 349
SER P 324
 None
 1.26A 2xz5A-3j31P:
undetectable
2xz5B-3j31P:
undetectable		 2xz5A-3j31P:
22.31
2xz5B-3j31P:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kny HYPOTHETICAL PROTEIN
BT_3535

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 194
CYH A 209
ILE A 157
SER A 175
 None
 1.23A 2xz5A-3knyA:
undetectable
2xz5B-3knyA:
undetectable		 2xz5A-3knyA:
23.14
2xz5B-3knyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l87 PEPTIDE DEFORMYLASE

(Streptococcus
mutans) 		PF01327
(Pep_deformylase) 		4 SER A 169
GLN A 121
ILE A 203
SER A 119
 None
 1.19A 2xz5A-3l87A:
undetectable
2xz5B-3l87A:
undetectable		 2xz5A-3l87A:
23.11
2xz5B-3l87A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1

(Homo sapiens) 		PF00790
(VHS) 		4 TRP A 115
SER A  86
CYH A  85
ILE A 128
 None
 1.14A 2xz5A-3ldzA:
undetectable
2xz5B-3ldzA:
undetectable		 2xz5A-3ldzA:
17.94
2xz5B-3ldzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 157
CYH A 156
GLN A 230
ILE A 235
 None
 1.27A 2xz5A-3ledA:
undetectable
2xz5B-3ledA:
undetectable		 2xz5A-3ledA:
16.76
2xz5B-3ledA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		4 TRP A 420
SER A 471
CYH A 469
ILE A 487
 None
 1.01A 2xz5A-3m8lA:
undetectable
2xz5B-3m8lA:
undetectable		 2xz5A-3m8lA:
18.62
2xz5B-3m8lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 TRP A 322
CYH A 276
GLN A 254
ILE A 283
 None
 1.00A 2xz5A-3nowA:
undetectable
2xz5B-3nowA:
undetectable		 2xz5A-3nowA:
13.27
2xz5B-3nowA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 SER A 243
CYH A 244
GLN A  14
ILE A 249
 None
 1.00A 2xz5A-3rrwA:
undetectable
2xz5B-3rrwA:
undetectable		 2xz5A-3rrwA:
21.03
2xz5B-3rrwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 TYR A  86
SER A  85
ILE A  92
SER A 122
 None
 1.03A 2xz5A-3si1A:
undetectable
2xz5B-3si1A:
undetectable		 2xz5A-3si1A:
19.51
2xz5B-3si1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 TRP B 221
SER B 208
ILE B 212
SER B 174
 None
 1.28A 2xz5A-3tniB:
undetectable
2xz5B-3tniB:
undetectable		 2xz5A-3tniB:
21.07
2xz5B-3tniB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 SER A1051
GLN A1147
ILE A1102
SER A1011
 None
 1.02A 2xz5A-3u9wA:
3.5
2xz5B-3u9wA:
3.5		 2xz5A-3u9wA:
17.32
2xz5B-3u9wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 SER A 129
CYH A 131
GLN A 123
ILE A  77
 None
 1.06A 2xz5A-3ujgA:
undetectable
2xz5B-3ujgA:
undetectable		 2xz5A-3ujgA:
18.90
2xz5B-3ujgA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		4 TYR A 328
SER A 330
GLN A 401
SER A 106
 None
None
BXP  A 601 (-3.9A)
None
 1.26A 2xz5A-3vxcA:
undetectable
2xz5B-3vxcA:
undetectable		 2xz5A-3vxcA:
18.94
2xz5B-3vxcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		4 SER A 219
GLN A 190
ILE A 241
SER A 188
 None
 1.22A 2xz5A-3wauA:
undetectable
2xz5B-3wauA:
undetectable		 2xz5A-3wauA:
19.13
2xz5B-3wauA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayc E3 UBIQUITIN-PROTEIN
LIGASE RNF8

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		4 TYR A 425
SER A 424
CYH A 423
ILE A 405
 None
None
ZN  A1485 (-2.3A)
ZN  A1485 (-4.8A)
 1.17A 2xz5A-4aycA:
undetectable
2xz5B-4aycA:
undetectable		 2xz5A-4aycA:
21.43
2xz5B-4aycA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 SER A 410
GLN A 403
ILE A 326
SER A 404
 None
 1.27A 2xz5A-4bjuA:
undetectable
2xz5B-4bjuA:
undetectable		 2xz5A-4bjuA:
18.03
2xz5B-4bjuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		4 SER A 567
GLN A 168
ILE A 176
SER A 152
 None
 1.11A 2xz5A-4ccaA:
undetectable
2xz5B-4ccaA:
undetectable		 2xz5A-4ccaA:
15.53
2xz5B-4ccaA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa;
Neurospora
crassa) 		no annotation
no annotation 		4 SER A  96
GLN B 634
ILE A 100
SER B 631
 None
 0.97A 2xz5A-4czxA:
undetectable
2xz5B-4czxA:
undetectable		 2xz5A-4czxA:
22.76
2xz5B-4czxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eu2 PROTEASOME COMPONENT
C7-ALPHA

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 TYR A  71
SER A  70
GLN A  56
SER A  55
 None
 1.26A 2xz5A-4eu2A:
undetectable
2xz5B-4eu2A:
undetectable		 2xz5A-4eu2A:
20.41
2xz5B-4eu2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 357
CYH A 360
GLN A 346
ILE A 328
 None
 1.29A 2xz5A-4g7fA:
undetectable
2xz5B-4g7fA:
undetectable		 2xz5A-4g7fA:
19.06
2xz5B-4g7fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 TYR A 690
SER A 689
GLN A 703
ILE A 618
 None
 1.20A 2xz5A-4i1pA:
undetectable
2xz5B-4i1pA:
undetectable		 2xz5A-4i1pA:
20.35
2xz5B-4i1pA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 4 SER C 143
GLN C 153
ILE C 194
SER C 150
 NAP  C 304 (-3.3A)
None
NAP  C 304 (-3.2A)
FMT  C 301 (-3.1A)
 1.01A 2xz5A-4iqgC:
undetectable
2xz5B-4iqgC:
undetectable		 2xz5A-4iqgC:
21.13
2xz5B-4iqgC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		4 SER A 126
CYH A 105
GLN A 150
ILE A 103
 None
 1.27A 2xz5A-4ir8A:
undetectable
2xz5B-4ir8A:
undetectable		 2xz5A-4ir8A:
19.71
2xz5B-4ir8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 TYR A 261
SER A 264
ILE A 337
SER A 395
 None
 1.09A 2xz5A-4ldsA:
undetectable
2xz5B-4ldsA:
undetectable		 2xz5A-4ldsA:
20.25
2xz5B-4ldsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxe N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13880
(Acetyltransf_13) 		4 TYR A 731
SER A 759
CYH A 758
ILE A 834
 None
 0.99A 2xz5A-4mxeA:
undetectable
2xz5B-4mxeA:
undetectable		 2xz5A-4mxeA:
21.46
2xz5B-4mxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 TRP A 654
SER A 794
CYH A 793
GLN A 789
 None
 1.30A 2xz5A-4nmeA:
undetectable
2xz5B-4nmeA:
undetectable		 2xz5A-4nmeA:
11.34
2xz5B-4nmeA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 TYR A  63
GLN A 151
ILE A 130
SER A  52
 None
 1.25A 2xz5A-4onoA:
undetectable
2xz5B-4onoA:
undetectable		 2xz5A-4onoA:
19.42
2xz5B-4onoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv5 LACTOYLGLUTATHIONE
LYASE

(Mus musculus) 		PF00903
(Glyoxalase) 		4 TYR A 136
SER A 137
CYH A 139
ILE A 174
 None
 1.03A 2xz5A-4pv5A:
undetectable
2xz5B-4pv5A:
undetectable		 2xz5A-4pv5A:
20.35
2xz5B-4pv5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 422
SER A 423
CYH A 425
SER A 443
 None
 1.15A 2xz5A-4pwnA:
undetectable
2xz5B-4pwnA:
undetectable		 2xz5A-4pwnA:
22.26
2xz5B-4pwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pws PROLINE-RICH 28 KDA
ANTIGEN

(Mycobacterium
tuberculosis) 		PF10738
(Lpp-LpqN) 		4 TYR A 218
SER A 190
GLN A 167
SER A 246
 None
 1.14A 2xz5A-4pwsA:
undetectable
2xz5B-4pwsA:
undetectable		 2xz5A-4pwsA:
23.36
2xz5B-4pwsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 TYR A 125
SER A 253
GLN A 138
ILE A 148
 None
 1.11A 2xz5A-4q7gA:
undetectable
2xz5B-4q7gA:
2.2		 2xz5A-4q7gA:
18.81
2xz5B-4q7gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 TRP A  21
SER A 234
CYH A  59
SER A 228
 None
None
ZN  A 501 (-2.3A)
None
 1.28A 2xz5A-4rvhA:
undetectable
2xz5B-4rvhA:
undetectable		 2xz5A-4rvhA:
18.47
2xz5B-4rvhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 TYR A 302
SER A 300
ILE A 306
SER A 346
 PEG  A 507 ( 4.1A)
None
None
PEG  A 507 (-2.6A)
 1.17A 2xz5A-4u09A:
undetectable
2xz5B-4u09A:
undetectable		 2xz5A-4u09A:
19.80
2xz5B-4u09A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 TYR A  82
GLN A 101
ILE A 104
SER A  99
 None
 1.14A 2xz5A-4v20A:
undetectable
2xz5B-4v20A:
undetectable		 2xz5A-4v20A:
19.50
2xz5B-4v20A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 TRP A 119
SER A  58
GLN A 178
ILE A 147
 None
 1.25A 2xz5A-4wl1A:
undetectable
2xz5B-4wl1A:
undetectable		 2xz5A-4wl1A:
20.11
2xz5B-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 TYR C 122
SER C  72
CYH C  71
GLN C  64
 None
None
None
MG  C 502 (-4.3A)
 1.11A 2xz5A-4xruC:
undetectable
2xz5B-4xruC:
undetectable		 2xz5A-4xruC:
20.89
2xz5B-4xruC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 TYR A1163
CYH A1217
GLN A1190
SER A1182
 None
 1.17A 2xz5A-5amqA:
undetectable
2xz5B-5amqA:
undetectable		 2xz5A-5amqA:
6.82
2xz5B-5amqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 309
GLN A 231
ILE A 321
SER A 228
 None
 1.14A 2xz5A-5bqsA:
undetectable
2xz5B-5bqsA:
undetectable		 2xz5A-5bqsA:
19.75
2xz5B-5bqsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		4 TYR A  13
SER A  14
ILE A  92
SER A 181
 None
None
SAH  A 301 (-3.9A)
None
 1.18A 2xz5A-5e1bA:
undetectable
2xz5B-5e1bA:
undetectable		 2xz5A-5e1bA:
23.05
2xz5B-5e1bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		4 TYR A 399
SER A 388
ILE A 420
SER A 392
 None
 1.25A 2xz5A-5e1rA:
undetectable
2xz5B-5e1rA:
undetectable		 2xz5A-5e1rA:
18.10
2xz5B-5e1rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 438
SER A 434
GLN A 451
ILE A 440
 None
 1.28A 2xz5A-5ficA:
undetectable
2xz5B-5ficA:
undetectable		 2xz5A-5ficA:
17.84
2xz5B-5ficA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 TYR A 492
GLN A 519
ILE A 270
SER A 516
 None
 1.29A 2xz5A-5fnoA:
undetectable
2xz5B-5fnoA:
undetectable		 2xz5A-5fnoA:
19.34
2xz5B-5fnoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hho JM22 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 TYR D 154
SER D 177
GLN D 147
SER D 148
 None
 1.24A 2xz5A-5hhoD:
undetectable
2xz5B-5hhoD:
undetectable		 2xz5A-5hhoD:
20.51
2xz5B-5hhoD:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 SER A 207
GLN A 533
ILE A 159
SER A 537
 None
 1.29A 2xz5A-5kodA:
undetectable
2xz5B-5kodA:
undetectable		 2xz5A-5kodA:
16.67
2xz5B-5kodA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfi LACTOCOCCIN-A
IMMUNITY PROTEIN

(Lactococcus
lactis) 		PF08951
(EntA_Immun) 		4 TYR A  63
SER A  61
GLN A  24
ILE A  67
 None
 1.29A 2xz5A-5lfiA:
undetectable
2xz5B-5lfiA:
undetectable		 2xz5A-5lfiA:
18.35
2xz5B-5lfiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1641
SER A1667
CYH A1670
GLN A1944
 None
 1.29A 2xz5A-5m5pA:
2.9
2xz5B-5m5pA:
3.1		 2xz5A-5m5pA:
8.15
2xz5B-5m5pA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 168
CYH A 201
ILE A 376
SER A 188
 None
 0.93A 2xz5A-5mjsA:
undetectable
2xz5B-5mjsA:
undetectable		 2xz5A-5mjsA:
undetectable
2xz5B-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 TYR K 173
CYH K 175
ILE K 165
SER K  76
 None
 1.13A 2xz5A-5mm7K:
undetectable
2xz5B-5mm7K:
undetectable		 2xz5A-5mm7K:
undetectable
2xz5B-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 4 TYR A 184
SER A 183
GLN A 110
ILE A 146
 None
 1.25A 2xz5A-5ms7A:
undetectable
2xz5B-5ms7A:
undetectable		 2xz5A-5ms7A:
18.79
2xz5B-5ms7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 SER A  91
CYH A  93
ILE A  88
SER A 130
 None
 1.15A 2xz5A-5ngkA:
undetectable
2xz5B-5ngkA:
undetectable		 2xz5A-5ngkA:
19.15
2xz5B-5ngkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 TYR B  71
SER B  33
ILE B  68
SER B 175
 None
 1.25A 2xz5A-5njfB:
undetectable
2xz5B-5njfB:
undetectable		 2xz5A-5njfB:
18.57
2xz5B-5njfB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst LIGHT CHAIN OF
ANTIBODY MGD21
HEAVY CHAIN OF
ANTIBODY MGD21

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2) 		4 TRP B 325
SER B 317
ILE B 347
SER A 116
 None
 1.17A 2xz5A-5nstB:
undetectable
2xz5B-5nstB:
undetectable		 2xz5A-5nstB:
20.44
2xz5B-5nstB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 TYR A 348
SER A 349
CYH A 351
SER A 369
 None
 1.15A 2xz5A-5o2cA:
undetectable
2xz5B-5o2cA:
undetectable		 2xz5A-5o2cA:
19.79
2xz5B-5o2cA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 781
CYH A 782
GLN A 697
ILE A 784
 None
 1.30A 2xz5A-5opjA:
undetectable
2xz5B-5opjA:
undetectable		 2xz5A-5opjA:
undetectable
2xz5B-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjp CYCLOHEXADIENYL
DEHYDRATASE

(Candidatus
Pelagibacter
ubique) 		PF00497
(SBP_bac_3) 		4 TRP A  33
TYR A 109
SER A 247
SER A 105
 None
 1.02A 2xz5A-5wjpA:
undetectable
2xz5B-5wjpA:
undetectable		 2xz5A-5wjpA:
22.68
2xz5B-5wjpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y39 RAGULATOR COMPLEX
PROTEIN LAMTOR1
RAGULATOR COMPLEX
PROTEIN LAMTOR5

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 CYH E 148
GLN A 130
ILE A 124
SER A 133
 None
 1.30A 2xz5A-5y39E:
undetectable
2xz5B-5y39E:
undetectable		 2xz5A-5y39E:
undetectable
2xz5B-5y39E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3t SHARPIN

(Mus musculus) 		no annotation 4 SER C 246
CYH C 245
GLN C 265
ILE C 241
 None
 1.22A 2xz5A-5y3tC:
undetectable
2xz5B-5y3tC:
undetectable		 2xz5A-5y3tC:
undetectable
2xz5B-5y3tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 4 SER A 128
CYH A 130
GLN A 122
ILE A  75
 None
 1.10A 2xz5A-5yksA:
undetectable
2xz5B-5yksA:
undetectable		 2xz5A-5yksA:
19.85
2xz5B-5yksA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 4 SER A  14
CYH A  15
ILE A   5
SER A 264
 None
 1.08A 2xz5A-5zctA:
undetectable
2xz5B-5zctA:
undetectable		 2xz5A-5zctA:
undetectable
2xz5B-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 4 TRP A  79
CYH A  58
GLN A  50
ILE A  86
 None
 1.22A 2xz5A-6cv6A:
undetectable
2xz5B-6cv6A:
undetectable		 2xz5A-6cv6A:
undetectable
2xz5B-6cv6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 4 TYR A 138
CYH A 152
GLN A 128
ILE A 155
 None
 1.25A 2xz5A-6dllA:
undetectable
2xz5B-6dllA:
undetectable		 2xz5A-6dllA:
undetectable
2xz5B-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 SER A 140
CYH A 139
ILE A 135
SER A  32
 None
 1.04A 2xz5A-6g9oA:
undetectable
2xz5B-6g9oA:
undetectable		 2xz5A-6g9oA:
undetectable
2xz5B-6g9oA:
undetectable