SIMILAR PATTERNS OF AMINO ACIDS FOR 2XYT_H_TC9H1206

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efl FORMIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00611
(FCH) 		4 TYR A 272
TYR A  67
CYH A  70
GLU A  64
 None
 1.34A 2xytH-2eflA:
undetectable		 2xytH-2eflA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 TRP A 140
TYR A 190
GLU A 191
TYR A  22
 None
 1.49A 2xytH-2gs9A:
undetectable		 2xytH-2gs9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 TYR A 262
CYH A 142
GLU A 236
TYR A 237
 None
 1.37A 2xytH-2h2wA:
undetectable		 2xytH-2h2wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		4 TYR A 263
CYH A 142
GLU A 237
TYR A 238
 None
HSE  A1298 (-3.3A)
None
None
 1.39A 2xytH-2vdjA:
0.0		 2xytH-2vdjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		4 TYR A 163
TRP A 321
TYR A 110
GLU A 107
 None
 1.35A 2xytH-3ju1A:
undetectable		 2xytH-3ju1A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE

(Yersinia
enterocolitica) 		PF14583
(Pectate_lyase22) 		4 TRP A 130
CYH A 206
GLU A 208
TYR A 127
 None
 1.49A 2xytH-3pe7A:
0.0		 2xytH-3pe7A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		4 TYR A 318
TRP A 335
GLU A 388
TYR A 389
 None
 1.40A 2xytH-3pz9A:
0.0		 2xytH-3pz9A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 TYR A 263
TYR A 225
CYH A 191
CYH A 192
 None
 1.37A 2xytH-3tatA:
0.0		 2xytH-3tatA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 TYR A 633
TRP A 557
GLU A 530
TYR A 527
 None
 1.25A 2xytH-3tswA:
undetectable		 2xytH-3tswA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 TYR A 114
CYH A 573
CYH A 116
GLU A 622
 None
 1.30A 2xytH-4bomA:
0.0		 2xytH-4bomA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		4 TYR A 180
CYH A  44
GLU A  46
TYR A 230
 None
 1.47A 2xytH-4bptA:
undetectable		 2xytH-4bptA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d01 NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-9

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A  95
TRP A 151
GLU A 197
TYR A 199
 EDO  A1220 ( 4.1A)
None
None
EDO  A1220 (-3.8A)
 0.77A 2xytH-4d01A:
23.1		 2xytH-4d01A:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Homo sapiens;
Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.63A 2xytH-4hqpA:
26.2		 2xytH-4hqpA:
36.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR B 374
TRP B 277
GLU B 424
TYR B 421
 None
 1.45A 2xytH-4l37B:
undetectable		 2xytH-4l37B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noh LIPOPROTEIN,
PUTATIVE

(Bacillus
anthracis) 		PF17294
(Lipoprotein_22) 		4 TYR A 146
TYR A  36
GLU A 188
TYR A 142
 None
 1.38A 2xytH-4nohA:
undetectable		 2xytH-4nohA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.24A 2xytH-4rkcA:
undetectable		 2xytH-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0u NKG2-D TYPE II
INTEGRAL MEMBRANE
PROTEIN
RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN

(Homo sapiens) 		PF00059
(Lectin_C)
PF00129
(MHC_I) 		4 TRP C 139
TYR A 199
GLU A 201
TYR C 184
 None
 1.25A 2xytH-4s0uC:
undetectable		 2xytH-4s0uC:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 TYR A  93
TRP A 147
TYR A 188
GLU A 193
TYR A 195
 None
 0.91A 2xytH-4zjsA:
29.4		 2xytH-4zjsA:
78.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 TYR A  77
TRP A 347
TYR A 356
GLU A 288
 None
 1.01A 2xytH-5msyA:
undetectable		 2xytH-5msyA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 TYR A  91
TRP A 145
GLU A 191
TYR A 193
 None
 0.35A 2xytH-5xglA:
31.7		 2xytH-5xglA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 TRP A 102
TYR A  66
GLU A  69
TYR A  71
 EWM  A 301 (-4.9A)
EWM  A 301 (-4.4A)
None
None
 1.45A 2xytH-6cc0A:
undetectable		 2xytH-6cc0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 THR A 531
MET A 521
ILE A 523
ASP A 449
 None
 1.08A 2xytI-1b3qA:
0.0		 2xytI-1b3qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		4 THR A 244
ILE A 392
ASP A 198
SER A 246
 None
 1.00A 2xytI-1dquA:
undetectable		 2xytI-1dquA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 THR A 121
ILE A 174
ASP A 118
SER A 127
 None
 1.08A 2xytI-1e1cA:
0.0		 2xytI-1e1cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 THR A 103
TYR A 196
ILE A 243
SER A 101
 None
 1.00A 2xytI-1ex9A:
undetectable		 2xytI-1ex9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.83A 2xytI-1fskC:
1.3		 2xytI-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7c TUBULIN-SPECIFIC
CHAPERONE A

(Homo sapiens) 		PF02970
(TBCA) 		4 GLN A  53
MET A  40
ILE A  37
SER A  60
 None
 1.19A 2xytI-1h7cA:
undetectable		 2xytI-1h7cA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT

(Galdieria
partita) 		PF00101
(RuBisCO_small) 		4 GLN B  12
ILE B  10
ASP B  47
SER B 147
 None
 1.19A 2xytI-1iwaB:
0.0		 2xytI-1iwaB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		4 TYR A 284
ILE A 281
ASP A 220
SER A 224
 None
None
CIT  A 701 (-2.8A)
None
 1.12A 2xytI-1lt8A:
0.0		 2xytI-1lt8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		4 MET A 373
ILE A 395
ASP A 257
SER A 263
 None
 1.14A 2xytI-1mk2A:
0.0		 2xytI-1mk2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 TYR A 520
GLN A 527
ILE A 523
ASP A 192
 None
 1.09A 2xytI-1n7rA:
0.0		 2xytI-1n7rA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		4 THR A 113
GLN A 115
ILE A 116
ASP A 110
 None
 1.11A 2xytI-1q9hA:
undetectable		 2xytI-1q9hA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		4 THR D 108
TYR D 207
ILE E 277
SER D 106
 None
 1.12A 2xytI-1qgeD:
undetectable		 2xytI-1qgeD:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF04069
(OpuAC) 		4 GLN A 268
MET A 272
ILE A 282
SER A  28
 None
 1.05A 2xytI-1r9lA:
undetectable		 2xytI-1r9lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 4 THR B 108
TYR B 207
ILE B 277
SER B 106
 None
 1.12A 2xytI-1tahB:
undetectable		 2xytI-1tahB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um1 KIAA1849 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 TYR A  39
GLN A  41
ILE A 103
ASP A  27
 None
 1.11A 2xytI-1um1A:
undetectable		 2xytI-1um1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 THR A 267
GLN A 269
ASP A 223
SER A 136
 None
 1.16A 2xytI-1v5wA:
undetectable		 2xytI-1v5wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		4 THR A 113
MET A 137
ILE A  95
SER A 111
 None
FMN  A 500 (-3.6A)
None
None
 1.17A 2xytI-1vp8A:
undetectable		 2xytI-1vp8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdx TCTEX1 LIGHT CHAIN
PROTEIN

(Chlamydomonas
reinhardtii) 		PF03645
(Tctex-1) 		4 THR A 108
MET A  71
ILE A  69
SER A  93
 None
 0.81A 2xytI-1xdxA:
undetectable		 2xytI-1xdxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 TYR 3 106
MET 3  98
ILE 3 102
SER 1 174
 None
 1.23A 2xytI-1z7z3:
undetectable		 2xytI-1z7z3:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Escherichia
coli) 		no annotation 4 THR A  85
GLN A 169
ILE A 167
ASP A  82
 None
 1.07A 2xytI-2aukA:
undetectable		 2xytI-2aukA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 TYR A 385
GLN A 436
ILE A 384
ASP A 387
 None
None
None
UNX  A 601 ( 2.6A)
 0.97A 2xytI-2d1gA:
undetectable		 2xytI-2d1gA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 THR A 163
TYR A 130
ASP A  27
SER A  86
 None
 1.15A 2xytI-2freA:
undetectable		 2xytI-2freA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 TYR A 265
GLN A 263
ILE A 126
SER A 172
 None
 1.16A 2xytI-2isnA:
undetectable		 2xytI-2isnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9u INTEGRASE P46

(Murine leukemia
virus) 		no annotation 4 THR A  85
MET A   9
ILE A  82
ASP A  60
 None
 0.97A 2xytI-2m9uA:
undetectable		 2xytI-2m9uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o79 LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.05A 2xytI-2o79A:
undetectable		 2xytI-2o79A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pau 5'-DEOXYNUCLEOTIDASE
YFBR

(Escherichia
coli) 		PF13023
(HD_3) 		4 GLN A 101
ILE A 120
ASP A  69
SER A  34
 None
None
CO  A 201 ( 2.6A)
None
 1.20A 2xytI-2pauA:
undetectable		 2xytI-2pauA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rpa KATANIN P60
ATPASE-CONTAINING
SUBUNIT A1

(Mus musculus) 		no annotation 4 TYR A  39
GLN A  35
ILE A   6
SER A  42
 None
 1.03A 2xytI-2rpaA:
undetectable		 2xytI-2rpaA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		4 THR A 116
GLN A 110
ILE A 227
SER A 119
 None
 1.23A 2xytI-2ve3A:
undetectable		 2xytI-2ve3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		4 TYR A5133
MET A5097
ILE A5095
ASP A5111
 None
 1.21A 2xytI-2yn3A:
undetectable		 2xytI-2yn3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 GLN A 396
ILE A 410
ASP A 437
SER A 449
 None
 1.21A 2xytI-2ynpA:
undetectable		 2xytI-2ynpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		4 TYR A 225
ILE A 227
ASP A 222
SER A 263
 None
None
DNO  A 387 (-3.9A)
None
 1.20A 2xytI-3bdkA:
undetectable		 2xytI-3bdkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 THR A 302
GLN A 262
ILE A 260
SER A 397
 None
 1.17A 2xytI-3bitA:
undetectable		 2xytI-3bitA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dml PUTATIVE
UNCHARACTERIZED
PROTEIN

(Paracoccus
denitrificans) 		no annotation 4 THR A  30
TYR A  27
GLN A  26
ILE A  23
 None
 1.18A 2xytI-3dmlA:
undetectable		 2xytI-3dmlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 THR A 171
TYR A 198
GLN A 194
ASP A 206
 None
 1.20A 2xytI-3do5A:
undetectable		 2xytI-3do5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 4 THR S 363
MET L  99
ILE L 101
ASP S 359
 None
 1.03A 2xytI-3g9kS:
undetectable		 2xytI-3g9kS:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 THR A 195
GLN A 197
ASP A 192
SER A 131
 None
 1.17A 2xytI-3h4iA:
undetectable		 2xytI-3h4iA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		4 GLN A 122
MET A 125
ILE A 121
SER A  85
 None
 1.21A 2xytI-3hhrA:
undetectable		 2xytI-3hhrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ile PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		PF11646
(DUF3258) 		4 TYR A 133
MET A 142
ILE A 135
SER A 131
 None
 1.20A 2xytI-3ileA:
undetectable		 2xytI-3ileA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE

(Shigella
flexneri) 		PF00294
(PfkB) 		4 THR A 103
MET A 136
ASP A 102
SER A 210
 None
 1.18A 2xytI-3lhxA:
undetectable		 2xytI-3lhxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lua RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		4 THR A  86
TYR A 105
ASP A  55
SER A  88
 None
 1.22A 2xytI-3luaA:
undetectable		 2xytI-3luaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.05A 2xytI-3pblA:
undetectable		 2xytI-3pblA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 TYR A 204
GLN A 419
ILE A 206
SER A 251
 None
 1.03A 2xytI-3pdiA:
undetectable		 2xytI-3pdiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 TYR A 848
ILE A 813
ASP A 851
SER A1123
 None
 1.09A 2xytI-3psfA:
undetectable		 2xytI-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 TYR A 848
ILE A 813
ASP A 851
SER A1123
 None
 1.15A 2xytI-3psiA:
undetectable		 2xytI-3psiA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 THR A 116
TYR A 117
ILE A 129
SER A  77
 None
 1.17A 2xytI-3q3hA:
undetectable		 2xytI-3q3hA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.06A 2xytI-3qakA:
undetectable		 2xytI-3qakA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 TYR B 883
GLN B 885
ILE B 617
SER B 583
 None
 1.04A 2xytI-3qd2B:
undetectable		 2xytI-3qd2B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 THR A 160
MET A 337
ILE A 251
SER A 162
 None
 1.21A 2xytI-3qphA:
undetectable		 2xytI-3qphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 0.92A 2xytI-3szeA:
undetectable		 2xytI-3szeA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 THR B 817
ILE B 943
ASP B 904
SER B 819
 None
 1.16A 2xytI-3tixB:
undetectable		 2xytI-3tixB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 THR A   6
TYR A 123
ILE A 163
ASP A   9
 None
 1.13A 2xytI-3tpfA:
undetectable		 2xytI-3tpfA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		4 THR A  47
GLN A  77
ILE A  80
ASP A  48
 None
 1.21A 2xytI-3tqsA:
undetectable		 2xytI-3tqsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 THR A  49
GLN A  47
MET A  62
ILE A  58
 None
 1.13A 2xytI-3ut3A:
undetectable		 2xytI-3ut3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.03A 2xytI-3vw7A:
undetectable		 2xytI-3vw7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		4 THR A  22
TYR A  21
GLN A  19
ILE A  62
 None
 1.08A 2xytI-3w0dA:
undetectable		 2xytI-3w0dA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		4 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 0.98A 2xytI-3w9uA:
undetectable		 2xytI-3w9uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		4 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.04A 2xytI-4de8A:
undetectable		 2xytI-4de8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A  73
GLN A  80
ILE A  79
SER A  20
 None
 1.08A 2xytI-4egjA:
undetectable		 2xytI-4egjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epi PESTICIN, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Yersinia pestis) 		PF00959
(Phage_lysozyme) 		4 THR A 199
TYR A 190
ILE A 182
SER A 201
 None
 1.09A 2xytI-4epiA:
undetectable		 2xytI-4epiA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 TYR A  88
GLN A  86
ILE A  51
ASP A  10
 None
 1.18A 2xytI-4fgmA:
undetectable		 2xytI-4fgmA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7l LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.05A 2xytI-4i7lA:
undetectable		 2xytI-4i7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 THR A 128
ILE A 134
ASP A 109
SER A 130
 None
 1.05A 2xytI-4immA:
undetectable		 2xytI-4immA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld1 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07202
(Tcp10_C) 		4 THR A1037
GLN A1019
ILE A1031
ASP A1035
 None
MPD  A1204 (-2.9A)
None
None
 1.20A 2xytI-4ld1A:
undetectable		 2xytI-4ld1A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A 899
TYR A 890
ILE A 882
SER A 901
 None
 1.12A 2xytI-4ldeA:
undetectable		 2xytI-4ldeA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 TYR A 285
MET A 289
ILE A 287
ASP A 283
 None
 1.14A 2xytI-4n6dA:
undetectable		 2xytI-4n6dA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 0.97A 2xytI-4n9nA:
undetectable		 2xytI-4n9nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 4 TYR A  46
GLN A  21
ILE A  17
ASP A  45
 None
 1.11A 2xytI-4o87A:
undetectable		 2xytI-4o87A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		4 TYR A 218
GLN A 216
ILE A 219
ASP A 214
 None
 1.17A 2xytI-4okoA:
undetectable		 2xytI-4okoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 THR A  16
ILE A  22
ASP A 107
SER A  18
 None
 1.09A 2xytI-4qloA:
undetectable		 2xytI-4qloA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 THR H 538
ILE H 556
ASP H 536
SER H 766
 None
 1.07A 2xytI-4qslH:
undetectable		 2xytI-4qslH:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA

(Escherichia
virus T4;
Macaca mulatta) 		PF00643
(zf-B_box)
PF00959
(Phage_lysozyme) 		4 THR A 337
TYR A 328
ILE A 320
SER A 339
 None
 1.09A 2xytI-4tn3A:
undetectable		 2xytI-4tn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.00A 2xytI-4xeeA:
undetectable		 2xytI-4xeeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx7 OXYGEN-REGULATED
INVASION PROTEIN
ORGB,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 THR C  67
TYR C  58
ILE C  50
SER C  69
 None
 0.94A 2xytI-4yx7C:
undetectable		 2xytI-4yx7C:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 MET A  99
ILE A  87
ASP A 328
SER A 321
 None
None
None
4LU  A 603 ( 3.7A)
 1.09A 2xytI-4zadA:
undetectable		 2xytI-4zadA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		6 THR A  36
GLN A  57
MET A 116
ILE A 118
ASP A 164
SER A 167
 None
 0.42A 2xytI-4zjsA:
29.4		 2xytI-4zjsA:
78.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 568
MET A 304
ILE A 412
ASP A 381
 None
 1.22A 2xytI-4zohA:
undetectable		 2xytI-4zohA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.08A 2xytI-4zwjA:
undetectable		 2xytI-4zwjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLN A 191
MET A 195
ILE A 317
SER A 376
 None
 1.21A 2xytI-5cniA:
undetectable		 2xytI-5cniA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 THR A1036
TYR A1027
ILE A1019
SER A1038
 None
 1.11A 2xytI-5eutA:
undetectable		 2xytI-5eutA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 THR A 296
TYR A 291
ILE A 290
SER A 300
 None
 1.23A 2xytI-5f4zA:
undetectable		 2xytI-5f4zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 TYR A  73
MET A  85
ILE A  81
SER A  71
 None
 1.08A 2xytI-5fyaA:
undetectable		 2xytI-5fyaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 MET F 404
ILE F 401
ASP F 261
SER F 265
 None
None
None
CA  F1201 (-2.7A)
 0.97A 2xytI-5gjwF:
undetectable		 2xytI-5gjwF:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 218
MET A 190
ILE A 157
ASP A 215
 None
 1.12A 2xytI-5h12A:
undetectable		 2xytI-5h12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 TYR A  11
GLN A1110
ILE A1126
ASP A1133
 None
 1.14A 2xytI-5hy7A:
undetectable		 2xytI-5hy7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 THR A 431
GLN A  17
ASP A 427
SER A 337
 None
GOL  A 501 ( 4.0A)
None
None
 1.19A 2xytI-5jbkA:
undetectable		 2xytI-5jbkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nri D-ALANINE--D-ALANINE
LIGASE

(Burkholderia
pseudomallei) 		no annotation 4 TYR A  73
GLN A  80
ILE A  79
SER A  20
 None
 1.08A 2xytI-5nriA:
undetectable		 2xytI-5nriA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 THR A 126
MET A 287
ILE A 136
SER A 150
 None
 0.99A 2xytI-5oynA:
undetectable		 2xytI-5oynA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 THR A 999
ILE A 350
ASP A1000
SER A 996
 None
 1.22A 2xytI-5ujaA:
undetectable		 2xytI-5ujaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.03A 2xytI-5v88A:
undetectable		 2xytI-5v88A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 TYR A 477
MET A 245
ILE A 481
SER A 946
 None
A  B  -5 ( 3.5A)
None
None
 1.20A 2xytI-5wlhA:
undetectable		 2xytI-5wlhA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		4 THR A 418
ILE A 261
ASP A 265
SER A 420
 None
 1.04A 2xytI-5x5tA:
undetectable		 2xytI-5x5tA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 5 THR A  34
GLN A  55
MET A 114
ILE A 116
SER A 164
 None
 0.97A 2xytI-5xglA:
31.9		 2xytI-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 7 THR A  34
TYR A  53
GLN A  55
MET A 114
ILE A 116
ASP A 162
SER A 165
 None
 0.44A 2xytI-5xglA:
31.9		 2xytI-5xglA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 GLN A 100
ILE A 467
ASP A 243
SER A 246
 None
 1.22A 2xytI-5xjjA:
undetectable		 2xytI-5xjjA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 THR B 545
GLN B 230
ILE B 547
SER B 236
 None
 1.11A 2xytI-5y2zB:
undetectable		 2xytI-5y2zB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 THR B 545
GLN B 230
ILE B 547
SER B 236
 None
 1.14A 2xytI-5y31B:
undetectable		 2xytI-5y31B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 4 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.11A 2xytI-5yhiA:
undetectable		 2xytI-5yhiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 THR A1033
TYR A1024
ILE A1016
SER A1035
 None
 1.01A 2xytI-5zbqA:
undetectable		 2xytI-5zbqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.06A 2xytI-6ffhA:
undetectable		 2xytI-6ffhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 THR B  27
GLN B 702
ASP B  30
SER B  33
 None
None
CLA  B1226 (-3.4A)
None
 1.11A 2xytI-6fosB:
undetectable		 2xytI-6fosB:
14.42