SIMILAR PATTERNS OF AMINO ACIDS FOR 2XYT_B_TC9B1206

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 SER A 318
THR A 398
TYR A 400
SER A 328
SER A 327
 None
 1.48A 2xytB-1g0dA:
0.6
2xytC-1g0dA:
0.1
2xytG-1g0dA:
0.2		 2xytB-1g0dA:
17.12
2xytC-1g0dA:
17.12
2xytG-1g0dA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 SER A 114
THR A  53
SER A  68
SER A  55
SER A  65
 None
 1.33A 2xytB-4a5wA:
0.0
2xytC-4a5wA:
1.0
2xytG-4a5wA:
2.4		 2xytB-4a5wA:
9.40
2xytC-4a5wA:
9.40
2xytG-4a5wA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 5 TYR A  53
SER A   5
SER A 114
SER A   8
SER A  98
 None
None
None
None
ADP  A 401 (-2.7A)
 1.44A 2xytB-4rkzA:
0.0
2xytC-4rkzA:
0.0
2xytG-4rkzA:
0.0		 2xytB-4rkzA:
18.40
2xytC-4rkzA:
18.40
2xytG-4rkzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A1067
TYR A 592
THR A1077
GLN A1040
SER A 765
 None
 1.47A 2xytB-4yswA:
0.0
2xytC-4yswA:
0.0
2xytG-4yswA:
0.0		 2xytB-4yswA:
10.69
2xytC-4yswA:
10.69
2xytG-4yswA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 THR A 170
TYR A 169
SER A 346
SER A 345
SER A  53
 None
None
NA  A 502 (-2.3A)
NA  A 502 (-2.3A)
None
 1.38A 2xytB-5nvaA:
undetectable
2xytC-5nvaA:
undetectable
2xytG-5nvaA:
undetectable		 2xytB-5nvaA:
17.89
2xytC-5nvaA:
17.89
2xytG-5nvaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 5 TYR B 382
TYR B 216
GLN B  23
SER B  85
SER B 111
 5AD  B 504 (-4.8A)
D5E  B 501 ( 4.5A)
None
None
None
 1.30A 2xytB-6fd2B:
0.0
2xytC-6fd2B:
0.0
2xytG-6fd2B:
0.0		 2xytB-6fd2B:
17.86
2xytC-6fd2B:
17.86
2xytG-6fd2B:
17.86