SIMILAR PATTERNS OF AMINO ACIDS FOR 2XRZ_B_ACTB1463_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 ILE A 212
ALA A 101
VAL A 100
GLY A 116
THR A 216
 None
 1.11A 2xrzB-1a8sA:
undetectable		 2xrzB-1a8sA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoh CELLULOSOMAL-SCAFFOL
DING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ILE A 104
ALA A 106
VAL A  21
GLY A 143
 None
 0.80A 2xrzB-1aohA:
undetectable		 2xrzB-1aohA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctm CYTOCHROME F

(Brassica rapa) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 VAL A  31
ILE A  51
ALA A  73
VAL A 150
GLY A 237
 None
 1.39A 2xrzB-1ctmA:
undetectable		 2xrzB-1ctmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcz TRANSCARBOXYLASE
1.3S SUBUNIT

(Propionibacterium
freudenreichii) 		PF00364
(Biotin_lipoyl) 		5 VAL A 102
ILE A 120
ALA A  96
VAL A  76
GLY A 123
 None
 1.24A 2xrzB-1dczA:
undetectable		 2xrzB-1dczA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1g TRANSCRIPTIONAL
REGULATOR LRPA

(Pyrococcus
furiosus) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 VAL A 131
ILE A 118
VAL A 128
GLY A  69
THR A  68
 None
 1.35A 2xrzB-1i1gA:
undetectable		 2xrzB-1i1gA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1g TRANSCRIPTIONAL
REGULATOR LRPA

(Pyrococcus
furiosus) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		4 VAL A 131
ILE A 122
GLY A  69
THR A  68
 None
 0.78A 2xrzB-1i1gA:
undetectable		 2xrzB-1i1gA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 261
VAL A 259
GLY A 174
THR A 173
 NAD  A1403 (-4.9A)
None
None
NAD  A1403 (-3.1A)
 0.75A 2xrzB-1kolA:
1.6		 2xrzB-1kolA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 GLN A 416
VAL A 476
ILE A 473
GLY A 415
THR A 414
 None
 1.29A 2xrzB-1m1cA:
undetectable		 2xrzB-1m1cA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A  20
ILE A  30
ALA A  34
VAL A  41
 None
 0.80A 2xrzB-1m76A:
2.4		 2xrzB-1m76A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 VAL A 239
ILE A 141
GLY A 237
THR A 238
 None
 0.74A 2xrzB-1nffA:
2.9		 2xrzB-1nffA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 VAL A 367
ILE A 378
GLY A 381
THR A 382
 None
 0.76A 2xrzB-1nr6A:
undetectable		 2xrzB-1nr6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 VAL B 211
ILE B 155
ALA B 153
VAL B 213
THR B 137
 None
 1.24A 2xrzB-1nvmB:
1.7		 2xrzB-1nvmB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 VAL A 139
ILE A 186
VAL A 176
GLY A 141
THR A 140
 None
 0.99A 2xrzB-1o3tA:
undetectable		 2xrzB-1o3tA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ILE A 355
ALA A 358
GLY A 260
THR A 259
 None
 0.70A 2xrzB-1oa1A:
undetectable		 2xrzB-1oa1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		4 VAL A  13
ILE A  25
ALA A  29
VAL A  11
 None
 0.72A 2xrzB-1oz9A:
undetectable		 2xrzB-1oz9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prs DEVELOPMENT-SPECIFIC
PROTEIN S

(Myxococcus
xanthus) 		PF00030
(Crystall) 		5 VAL A  84
ILE A   4
ALA A   2
VAL A  48
GLY A  22
 None
 1.43A 2xrzB-1prsA:
undetectable		 2xrzB-1prsA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A 122
ALA A 124
VAL A  32
GLY A  62
 None
 0.76A 2xrzB-1qahA:
undetectable		 2xrzB-1qahA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qju PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL 1 145
ILE 1 151
GLY 1 215
THR 1 216
 None
 0.63A 2xrzB-1qju1:
undetectable		 2xrzB-1qju1:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL 1 148
ILE 1 154
GLY 1 218
THR 1 219
 None
 0.72A 2xrzB-1r1a1:
undetectable		 2xrzB-1r1a1:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		4 VAL A   8
ILE A 243
ALA A 246
GLY A 228
 None
 0.73A 2xrzB-1sq7A:
undetectable		 2xrzB-1sq7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3d SERINE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 VAL A 142
ILE A 144
ALA A 113
VAL A 136
GLY A 107
 None
 1.46A 2xrzB-1t3dA:
undetectable		 2xrzB-1t3dA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 VAL A 290
ILE A 272
ALA A 276
THR A 257
 None
 0.80A 2xrzB-1t90A:
undetectable		 2xrzB-1t90A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		5 VAL A 234
ILE A  18
ALA A 204
GLY A 233
THR A  92
 None
 1.45A 2xrzB-1thmA:
undetectable		 2xrzB-1thmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		4 VAL A   8
ILE A 247
ALA A 250
GLY A 231
 None
 0.79A 2xrzB-1tmhA:
undetectable		 2xrzB-1tmhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u11 PURE
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
MUTASE)

(Acetobacter
aceti) 		PF00731
(AIRC) 		5 VAL A 130
ILE A 121
ALA A  82
GLY A 131
THR A 132
 None
 1.38A 2xrzB-1u11A:
undetectable		 2xrzB-1u11A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 ILE A 348
ALA A 351
GLY A 256
THR A 255
 None
 0.76A 2xrzB-1upxA:
undetectable		 2xrzB-1upxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 4 VAL B 769
ILE B 748
ALA B 752
VAL B 767
 None
 0.79A 2xrzB-1us8B:
undetectable		 2xrzB-1us8B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 167
ILE A 156
ALA A 160
VAL A 162
 None
 0.45A 2xrzB-1uxiA:
undetectable		 2xrzB-1uxiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 VAL A 464
ILE A 433
ALA A 442
GLY A 466
 VAL  A 464 ( 0.6A)
ILE  A 433 ( 0.7A)
ALA  A 442 ( 0.0A)
GLY  A 466 ( 0.0A)
 0.75A 2xrzB-1v0fA:
undetectable		 2xrzB-1v0fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhv DIPHTHINE SYNTHASE

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 VAL A 117
ILE A 191
ALA A 194
GLY A 119
THR A 121
 None
 1.45A 2xrzB-1vhvA:
1.9		 2xrzB-1vhvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3d DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02817
(E3_binding) 		4 GLN A 150
ALA A 165
GLY A 151
THR A 152
 None
 0.79A 2xrzB-1w3dA:
undetectable		 2xrzB-1w3dA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wif RIKEN CDNA
4930408O21

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A  35
ILE A  97
GLY A 100
THR A 101
 None
 0.69A 2xrzB-1wifA:
undetectable		 2xrzB-1wifA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 ILE A 470
ALA A 468
VAL A 415
GLY A 459
 None
 0.63A 2xrzB-1x1nA:
undetectable		 2xrzB-1x1nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 ILE A  18
ALA A  21
GLY A 422
THR A 421
 None
 0.69A 2xrzB-1x3lA:
undetectable		 2xrzB-1x3lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 GLN A  65
VAL A  28
ILE A  42
THR A  49
 None
 0.71A 2xrzB-1xhdA:
undetectable		 2xrzB-1xhdA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 ILE A 285
ALA A 289
VAL A 291
GLY A 249
 None
 0.69A 2xrzB-1xrsA:
undetectable		 2xrzB-1xrsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E

(Lactobacillus
delbrueckii) 		PF00365
(PFK) 		5 VAL A 219
ILE A 150
ALA A 146
VAL A 168
GLY A 181
 None
 1.49A 2xrzB-1zxxA:
undetectable		 2xrzB-1zxxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 VAL A 130
ALA A 253
VAL A 252
GLY A  39
THR A   4
 None
 1.26A 2xrzB-2abqA:
undetectable		 2xrzB-2abqA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 VAL A 139
ALA A 265
VAL A 264
GLY A  42
THR A   4
 None
 1.24A 2xrzB-2ajrA:
2.9		 2xrzB-2ajrA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 VAL A 203
ILE A  44
GLY A 197
THR A 196
 None
 0.67A 2xrzB-2c4mA:
1.8		 2xrzB-2c4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ILE A 104
ALA A 106
VAL A  21
GLY A 140
 None
 0.77A 2xrzB-2cclA:
undetectable		 2xrzB-2cclA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 VAL A 308
ALA A 284
VAL A 290
GLY A 257
THR A 319
 None
 1.36A 2xrzB-2cdqA:
2.1		 2xrzB-2cdqA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE A 296
VAL A 242
GLY A 290
THR A 291
 None
 0.76A 2xrzB-2d2iA:
undetectable		 2xrzB-2d2iA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		4 VAL A  90
ILE A  86
ALA A  60
GLY A  64
 None
 0.79A 2xrzB-2e2nA:
undetectable		 2xrzB-2e2nA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 VAL A  42
ILE A  31
ALA A  35
VAL A  37
 None
 0.67A 2xrzB-2fbqA:
undetectable		 2xrzB-2fbqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum) 		PF02233
(PNTB) 		5 VAL C 124
ILE C  42
ALA C  46
GLY C 158
THR C 159
 None
 1.06A 2xrzB-2fsvC:
undetectable		 2xrzB-2fsvC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 4 VAL A 166
ALA A 170
GLY A 164
THR A 165
 NLT  A 400 (-4.5A)
NLT  A 400 ( 3.7A)
None
None
 0.73A 2xrzB-2g0bA:
undetectable		 2xrzB-2g0bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 VAL A 239
ILE A 253
GLY A 256
THR A 257
 None
 0.56A 2xrzB-2ggqA:
undetectable		 2xrzB-2ggqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		5 VAL A 419
ALA A 530
VAL A 413
GLY A 435
THR A 436
 None
None
None
ACO  A 796 ( 4.2A)
None
 1.19A 2xrzB-2i7nA:
1.9		 2xrzB-2i7nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		5 VAL A 419
ILE A 526
ALA A 530
GLY A 435
THR A 436
 None
None
None
ACO  A 796 ( 4.2A)
None
 1.11A 2xrzB-2i7nA:
1.9		 2xrzB-2i7nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		5 VAL A 194
ALA A 305
VAL A 188
GLY A 210
THR A 211
 None
None
None
ACO  A1604 ( 3.9A)
None
 1.18A 2xrzB-2i7pA:
undetectable		 2xrzB-2i7pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		5 VAL A 194
ILE A 301
ALA A 305
GLY A 210
THR A 211
 None
None
None
ACO  A1604 ( 3.9A)
None
 1.09A 2xrzB-2i7pA:
undetectable		 2xrzB-2i7pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 VAL A   7
ILE A 242
ALA A 245
GLY A 227
 None
 0.74A 2xrzB-2i9eA:
undetectable		 2xrzB-2i9eA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 294
ILE A 236
ALA A 232
VAL A 339
GLY A 224
 None
 1.12A 2xrzB-2ihtA:
undetectable		 2xrzB-2ihtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf3 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 VAL A 177
ILE A 261
ALA A 187
VAL A 171
GLY A 176
 None
 1.36A 2xrzB-2jf3A:
undetectable		 2xrzB-2jf3A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k14 YUAF PROTEIN

(Bacillus
subtilis) 		no annotation 4 VAL A  27
ILE A  60
GLY A  63
THR A  64
 None
 0.70A 2xrzB-2k14A:
undetectable		 2xrzB-2k14A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4y FEOA-LIKE PROTEIN

(Clostridium
acetobutylicum) 		PF04023
(FeoA) 		4 VAL A  18
ILE A  36
GLY A  39
THR A  40
 None
 0.80A 2xrzB-2k4yA:
undetectable		 2xrzB-2k4yA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2maw NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-7

(Homo sapiens) 		PF02932
(Neur_chan_memb) 		5 VAL A  44
ILE A  20
ALA A  24
GLY A  41
THR A  43
 None
 1.18A 2xrzB-2mawA:
undetectable		 2xrzB-2mawA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 370
ILE A 381
GLY A 384
THR A 385
 None
 0.75A 2xrzB-2nnjA:
undetectable		 2xrzB-2nnjA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  28
ILE A 100
ALA A  96
VAL A  42
 None
 0.77A 2xrzB-2o56A:
undetectable		 2xrzB-2o56A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ

(Bradyrhizobium
sp. WM9) 		PF05830
(NodZ) 		4 VAL A 219
ILE A 205
ALA A 208
GLY A 173
 None
 0.76A 2xrzB-2ocxA:
undetectable		 2xrzB-2ocxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of7 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 VAL A  62
ILE A  51
ALA A  55
VAL A  57
 None
 0.43A 2xrzB-2of7A:
undetectable		 2xrzB-2of7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 VAL A 261
ILE A 277
ALA A 281
VAL A 288
 None
 0.80A 2xrzB-2ohhA:
undetectable		 2xrzB-2ohhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 VAL A 326
ILE A 199
ALA A 202
GLY A 328
THR A 330
 None
 1.22A 2xrzB-2p2wA:
undetectable		 2xrzB-2p2wA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 VAL A  54
ILE A  43
ALA A  47
VAL A  49
 None
 0.43A 2xrzB-2pbxA:
undetectable		 2xrzB-2pbxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 ILE A 191
ALA A 188
VAL A 246
GLY A 225
 NAD  A1780 (-4.4A)
NAD  A1780 (-4.5A)
None
None
 0.76A 2xrzB-2pd3A:
2.1		 2xrzB-2pd3A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 VAL A  30
ILE A 114
ALA A 112
VAL A  28
GLY A  14
 None
 1.18A 2xrzB-2qa1A:
undetectable		 2xrzB-2qa1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 VAL A 325
ILE A 337
ALA A 341
VAL A 323
 None
 0.75A 2xrzB-2qmiA:
undetectable		 2xrzB-2qmiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
vanbaalenii) 		PF00440
(TetR_N) 		4 VAL A  47
ILE A  36
ALA A  40
VAL A  42
 None
 0.64A 2xrzB-2qwtA:
undetectable		 2xrzB-2qwtA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 VAL A 345
ILE A 128
ALA A 124
GLY A 347
 None
 0.77A 2xrzB-2r26A:
undetectable		 2xrzB-2r26A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uud NQ10-1.12 ANTI-PHOX
ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		5 VAL K  78
ILE K  75
ALA K  19
VAL K  13
GLY K  16
 None
 1.41A 2xrzB-2uudK:
undetectable		 2xrzB-2uudK:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 VAL A  48
ILE A  37
ALA A  41
VAL A  43
 None
 0.40A 2xrzB-2wgbA:
undetectable		 2xrzB-2wgbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 VAL A  47
ILE A 477
ALA A 322
GLY A  52
THR A  48
 None
 1.11A 2xrzB-2wsxA:
undetectable		 2xrzB-2wsxA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		7 GLN A  16
VAL A  21
ILE A  43
ALA A  47
VAL A  49
GLY A 111
THR A 112
 None
 0.26A 2xrzB-2xryA:
59.6		 2xrzB-2xryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A  53
ILE A  21
ALA A  30
GLY A  55
 None
 0.74A 2xrzB-2yv2A:
undetectable		 2xrzB-2yv2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 GLN A 193
VAL A 284
ILE A 335
ALA A 262
THR A 283
 None
 1.27A 2xrzB-3aqiA:
undetectable		 2xrzB-3aqiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A 141
ALA A 105
GLY A  45
THR A  46
 None
 0.62A 2xrzB-3b4uA:
undetectable		 2xrzB-3b4uA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 VAL A  52
ILE A 106
ALA A  66
GLY A  44
THR A  54
 None
 1.18A 2xrzB-3beuA:
undetectable		 2xrzB-3beuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjn TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Vibrio cholerae) 		PF01614
(IclR) 		4 ILE A 229
ALA A 217
GLY A 102
THR A 101
 None
 0.77A 2xrzB-3bjnA:
undetectable		 2xrzB-3bjnA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 VAL A  56
ILE A 155
ALA A 159
VAL A  54
 None
 0.64A 2xrzB-3cdiA:
undetectable		 2xrzB-3cdiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdl TRANSCRIPTIONAL
REGULATOR AEFR

(Pseudomonas
syringae group
genomosp. 3) 		PF00440
(TetR_N)
PF14246
(TetR_C_7) 		4 VAL A  43
ILE A  32
ALA A  36
VAL A  38
 None
 0.52A 2xrzB-3cdlA:
undetectable		 2xrzB-3cdlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY

(Cytophaga
hutchinsonii) 		PF05343
(Peptidase_M42) 		4 VAL A  73
ILE A 121
GLY A 124
THR A 125
 None
 0.57A 2xrzB-3cpxA:
undetectable		 2xrzB-3cpxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6x (3R)-HYDROXYMYRISTOY
L-[ACYL-CARRIER-PROT
EIN] DEHYDRATASE

(Campylobacter
jejuni) 		PF07977
(FabA) 		4 VAL A  70
ILE A  23
GLY A  68
THR A  67
 None
 0.68A 2xrzB-3d6xA:
undetectable		 2xrzB-3d6xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7i CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY
PROTEIN

(Methanocaldococcus
jannaschii) 		PF02627
(CMD) 		4 VAL A  81
ILE A  48
ALA A  52
VAL A  85
 None
 0.66A 2xrzB-3d7iA:
undetectable		 2xrzB-3d7iA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A  17
VAL A 187
GLY A 211
THR A 212
 None
 0.58A 2xrzB-3dhvA:
2.7		 2xrzB-3dhvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		4 VAL A 158
ILE A 172
GLY A 175
THR A 176
 None
 0.56A 2xrzB-3eh0A:
undetectable		 2xrzB-3eh0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A 491
ILE A 426
ALA A 398
VAL A 397
GLY A 493
 None
 1.35A 2xrzB-3eoeA:
undetectable		 2xrzB-3eoeA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 VAL A 484
ILE A 442
VAL A 507
GLY A 445
THR A 446
 None
 0.94A 2xrzB-3eqnA:
undetectable		 2xrzB-3eqnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ALA A 118
VAL A 113
GLY A 133
THR A 134
 None
 0.65A 2xrzB-3fn9A:
undetectable		 2xrzB-3fn9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		4 VAL D 268
ILE D 282
ALA D 280
THR D 264
 None
None
None
ACT  D 601 (-4.1A)
 0.80A 2xrzB-3fo8D:
undetectable		 2xrzB-3fo8D:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5o UNCHARACTERIZED
PROTEIN RV2866

(Mycobacterium
tuberculosis) 		PF05016
(ParE_toxin) 		4 ILE B  37
ALA B  40
GLY B  73
THR B  74
 None
 0.77A 2xrzB-3g5oB:
undetectable		 2xrzB-3g5oB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 VAL A  33
ILE A 132
ALA A 136
VAL A  31
 None
 0.76A 2xrzB-3gmeA:
undetectable		 2xrzB-3gmeA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 VAL A 134
ILE A 110
ALA A 114
VAL A 128
 None
 0.62A 2xrzB-3gtdA:
undetectable		 2xrzB-3gtdA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		4 VAL A 159
ILE A 197
ALA A 200
GLY A 157
 None
 0.77A 2xrzB-3hnoA:
2.4		 2xrzB-3hnoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 VAL A 374
ALA A 256
GLY A 372
THR A 373
 None
 0.77A 2xrzB-3i0zA:
undetectable		 2xrzB-3i0zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 VAL A  19
ILE A  33
GLY A  36
THR A  37
 None
 0.55A 2xrzB-3i3aA:
undetectable		 2xrzB-3i3aA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 VAL A 252
ILE A 147
ALA A 209
GLY A 187
 None
 0.78A 2xrzB-3i6sA:
undetectable		 2xrzB-3i6sA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id1 REGULATOR OF SIGMA E
PROTEASE

(Escherichia
coli) 		no annotation 4 VAL A 131
ILE A 145
GLY A 148
THR A 149
 None
 0.78A 2xrzB-3id1A:
undetectable		 2xrzB-3id1A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0o RIBOSOMAL PROTEIN
S23

(Oryctolagus
cuniculus) 		PF00164
(Ribosom_S12_S23) 		4 VAL L 101
ALA L  84
VAL L 103
GLY L  50
 None
 0.79A 2xrzB-3j0oL:
undetectable		 2xrzB-3j0oL:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 VAL A 405
ILE A 164
VAL A 185
GLY A 403
THR A 404
 None
 1.23A 2xrzB-3j1eA:
undetectable		 2xrzB-3j1eA:
23.88