SIMILAR PATTERNS OF AMINO ACIDS FOR 2XRZ_A_ACTA1468

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		4 LYS A  66
GLU A  93
THR A  94
TYR A  63
 None
 1.32A 2xrzA-2drhA:
0.0		 2xrzA-2drhA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 LYS A 383
LYS A 384
GLU A 387
THR A 437
TYR A 442
 None
 0.55A 2xrzA-2xryA:
61.7		 2xrzA-2xryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 LYS A 401
LYS A 402
GLU A 405
TYR A 460
 None
None
EDO  A 706 (-3.7A)
EDO  A 706 (-4.7A)
 0.48A 2xrzA-3umvA:
51.7		 2xrzA-3umvA:
45.66