SIMILAR PATTERNS OF AMINO ACIDS FOR 2XRZ_A_ACTA1467

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ARG A 225
ASP A 192
ILE A 190
GLU A 224
 None
 1.47A 2xrzA-1d0nA:
undetectable
2xrzB-1d0nA:
undetectable		 2xrzA-1d0nA:
20.56
2xrzB-1d0nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  12
ASP A 216
ILE A 219
GLU A 198
 None
 0.95A 2xrzA-1dm3A:
0.0
2xrzB-1dm3A:
0.2		 2xrzA-1dm3A:
21.60
2xrzB-1dm3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 ARG A  65
ASP A  42
ILE A  49
GLU A  39
 None
 1.36A 2xrzA-1e2tA:
undetectable
2xrzB-1e2tA:
undetectable		 2xrzA-1e2tA:
20.33
2xrzB-1e2tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvp FLAVOPROTEIN 390

(Photobacterium
phosphoreum) 		no annotation 4 ARG A  33
ASP A  38
ILE A 215
GLU A  30
 None
 1.13A 2xrzA-1fvpA:
0.5
2xrzB-1fvpA:
undetectable		 2xrzA-1fvpA:
18.37
2xrzB-1fvpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 ARG  A 237 ( 0.6A)
ASP  A 261 ( 0.6A)
ILE  A 279 ( 0.7A)
GLU  A 236 ( 0.6A)
 1.40A 2xrzA-1fxjA:
0.4
2xrzB-1fxjA:
0.3		 2xrzA-1fxjA:
20.79
2xrzB-1fxjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 ARG A 116
ASP A  65
ILE A  63
GLU A  76
 None
 1.40A 2xrzA-1gkrA:
0.4
2xrzB-1gkrA:
0.0		 2xrzA-1gkrA:
22.46
2xrzB-1gkrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		4 ARG A  33
ASP A  38
ILE A 212
GLU A  30
 None
 0.98A 2xrzA-1nfpA:
undetectable
2xrzB-1nfpA:
0.2		 2xrzA-1nfpA:
20.12
2xrzB-1nfpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 4 ARG B 275
ASP B 240
ILE B 238
GLU B 263
 None
 1.30A 2xrzA-1pbyB:
undetectable
2xrzB-1pbyB:
undetectable		 2xrzA-1pbyB:
21.78
2xrzB-1pbyB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ARG 1 181
ASP 3  17
GLU 1 124
LYS 1 242
 None
 1.43A 2xrzA-1r1a1:
undetectable
2xrzB-1r1a1:
undetectable		 2xrzA-1r1a1:
19.10
2xrzB-1r1a1:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 338
ASP A  20
GLU A 334
LYS A 330
 None
 1.19A 2xrzA-1r2jA:
undetectable
2xrzB-1r2jA:
undetectable		 2xrzA-1r2jA:
22.95
2xrzB-1r2jA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 ARG A  69
ASP A  46
ILE A  53
GLU A  43
 None
 1.19A 2xrzA-1w4tA:
undetectable
2xrzB-1w4tA:
undetectable		 2xrzA-1w4tA:
24.20
2xrzB-1w4tA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ARG A 323
ASP A 279
ILE A 287
GLU A 324
 None
 1.46A 2xrzA-1wu7A:
undetectable
2xrzB-1wu7A:
undetectable		 2xrzA-1wu7A:
23.23
2xrzB-1wu7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ARG A 151
ASP A 148
ILE A 208
GLU A 236
 None
 1.22A 2xrzA-1xfiA:
2.8
2xrzB-1xfiA:
3.0		 2xrzA-1xfiA:
22.22
2xrzB-1xfiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1

(Homo sapiens) 		PF00397
(WW)
PF00639
(Rotamase) 		4 ARG A 127
ASP A 136
ILE A  28
GLU A  51
 None
 1.40A 2xrzA-1zcnA:
undetectable
2xrzB-1zcnA:
undetectable		 2xrzA-1zcnA:
16.82
2xrzB-1zcnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda;
Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ARG A 114
ASP A  15
ILE A  16
GLU D 141
 None
 1.13A 2xrzA-2be7A:
undetectable
2xrzB-2be7A:
undetectable		 2xrzA-2be7A:
24.21
2xrzB-2be7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		4 ARG A 399
ASP A 383
ILE A 411
GLU A 404
 None
 1.27A 2xrzA-2f4oA:
undetectable
2xrzB-2f4oA:
undetectable		 2xrzA-2f4oA:
20.70
2xrzB-2f4oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		4 ARG A 231
ASP A 113
ILE A 112
GLU A 320
 None
 1.17A 2xrzA-2felA:
undetectable
2xrzB-2felA:
undetectable		 2xrzA-2felA:
22.04
2xrzB-2felA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		4 ARG A 218
ASP A 172
ILE A 170
GLU A 248
 MG  A 501 ( 4.1A)
MG  A 501 (-3.2A)
None
MG  A 501 (-2.8A)
 1.25A 2xrzA-2g0wA:
undetectable
2xrzB-2g0wA:
undetectable		 2xrzA-2g0wA:
20.45
2xrzB-2g0wA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  45
ASP A 246
ILE A 249
GLU A 223
 None
 0.88A 2xrzA-2iikA:
undetectable
2xrzB-2iikA:
undetectable		 2xrzA-2iikA:
22.44
2xrzB-2iikA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 None
 1.38A 2xrzA-2oi6A:
undetectable
2xrzB-2oi6A:
undetectable		 2xrzA-2oi6A:
19.88
2xrzB-2oi6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22)
PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ARG B 193
ASP A 107
ILE A  93
GLU B 191
 None
 1.44A 2xrzA-2qbyB:
undetectable
2xrzB-2qbyB:
undetectable		 2xrzA-2qbyB:
21.69
2xrzB-2qbyB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 279
ASP A 417
ILE A 405
GLU A 277
 None
 1.10A 2xrzA-2uxtA:
undetectable
2xrzB-2uxtA:
undetectable		 2xrzA-2uxtA:
21.12
2xrzB-2uxtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ARG B 362
ASP B 745
ILE B 448
GLU B 358
 None
 1.33A 2xrzA-2w55B:
undetectable
2xrzB-2w55B:
undetectable		 2xrzA-2w55B:
19.76
2xrzB-2w55B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 ARG A 475
ASP A 641
ILE A 637
GLU A 480
 None
 1.24A 2xrzA-2x49A:
undetectable
2xrzB-2x49A:
undetectable		 2xrzA-2x49A:
22.70
2xrzB-2x49A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD

(Citrobacter
freundii) 		PF01510
(Amidase_2) 		4 ARG A  12
ASP A  49
ILE A  48
GLU A  83
 None
 1.19A 2xrzA-2y2cA:
undetectable
2xrzB-2y2cA:
undetectable		 2xrzA-2y2cA:
16.84
2xrzB-2y2cA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5

(Homo sapiens) 		PF00686
(CBM_20) 		4 ARG A  16
ASP A 114
ILE A 112
GLU A  53
 None
 1.39A 2xrzA-2z0bA:
undetectable
2xrzB-2z0bA:
undetectable		 2xrzA-2z0bA:
14.35
2xrzB-2z0bA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 ARG A 378
ASP A  61
GLU A 379
LYS A 382
 None
 1.21A 2xrzA-2z1kA:
undetectable
2xrzB-2z1kA:
undetectable		 2xrzA-2z1kA:
21.69
2xrzB-2z1kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		4 ARG A 105
ASP A 530
GLU A 140
LYS A 136
 None
 0.98A 2xrzA-3bf0A:
undetectable
2xrzB-3bf0A:
undetectable		 2xrzA-3bf0A:
23.92
2xrzB-3bf0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		4 ARG A 136
ASP A 116
ILE A 209
GLU A 139
 None
 1.20A 2xrzA-3c1oA:
4.4
2xrzB-3c1oA:
4.4		 2xrzA-3c1oA:
20.97
2xrzB-3c1oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ARG A 179
ASP A 189
ILE A 190
GLU A 175
 None
None
None
CA  A 303 (-2.2A)
 1.24A 2xrzA-3dbkA:
undetectable
2xrzB-3dbkA:
undetectable		 2xrzA-3dbkA:
22.57
2xrzB-3dbkA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 None
 1.35A 2xrzA-3fwwA:
undetectable
2xrzB-3fwwA:
undetectable		 2xrzA-3fwwA:
22.70
2xrzB-3fwwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 675
ASP A 795
ILE A 794
GLU A 701
 None
 1.13A 2xrzA-3ho8A:
undetectable
2xrzB-3ho8A:
undetectable		 2xrzA-3ho8A:
18.54
2xrzB-3ho8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 ASP A 341
ILE A 340
GLU A 249
LYS A 250
 None
 1.22A 2xrzA-3iiwA:
undetectable
2xrzB-3iiwA:
undetectable		 2xrzA-3iiwA:
22.06
2xrzB-3iiwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 ARG A 333
ASP A 270
ILE A 108
GLU A 365
 None
 1.46A 2xrzA-3jurA:
undetectable
2xrzB-3jurA:
undetectable		 2xrzA-3jurA:
22.75
2xrzB-3jurA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 425
ASP A 421
ILE A 417
GLU A 359
 None
EDO  A  22 (-3.7A)
EDO  A  22 ( 4.4A)
None
 1.42A 2xrzA-3l22A:
undetectable
2xrzB-3l22A:
undetectable		 2xrzA-3l22A:
22.98
2xrzB-3l22A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG A 439
ASP B 363
ILE B 358
GLU A 441
 None
 1.20A 2xrzA-3l4gA:
undetectable
2xrzB-3l4gA:
undetectable		 2xrzA-3l4gA:
20.73
2xrzB-3l4gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 ARG A  62
ASP A  94
ILE A  58
LYS A 143
 None
 1.45A 2xrzA-3l9cA:
undetectable
2xrzB-3l9cA:
undetectable		 2xrzA-3l9cA:
24.69
2xrzB-3l9cA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 ARG A  65
ASP A  42
ILE A  48
GLU A  39
 None
 1.27A 2xrzA-3lnbA:
undetectable
2xrzB-3lnbA:
undetectable		 2xrzA-3lnbA:
23.92
2xrzB-3lnbA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 109
ASP A  95
ILE A  96
GLU A 105
 None
 1.46A 2xrzA-3m5hA:
undetectable
2xrzB-3m5hA:
undetectable		 2xrzA-3m5hA:
19.16
2xrzB-3m5hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpf MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT

(Helicobacter
pylori) 		PF02391
(MoaE) 		4 ARG A 134
ASP A 122
ILE A 124
GLU A 133
 None
 1.13A 2xrzA-3rpfA:
undetectable
2xrzB-3rpfA:
undetectable		 2xrzA-3rpfA:
15.07
2xrzB-3rpfA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 ARG A 271
ASP A  60
ILE A 267
GLU A 238
 None
None
PRF  A1194 (-4.8A)
None
 1.39A 2xrzA-3uxjA:
undetectable
2xrzB-3uxjA:
undetectable		 2xrzA-3uxjA:
20.79
2xrzB-3uxjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 ARG A 401
ASP A 434
ILE A 436
GLU A 463
 None
 1.44A 2xrzA-3vr1A:
undetectable
2xrzB-3vr1A:
undetectable		 2xrzA-3vr1A:
24.01
2xrzB-3vr1A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 ARG A   8
ASP A  14
GLU A  61
LYS A  66
 None
 1.29A 2xrzA-3wr7A:
undetectable
2xrzB-3wr7A:
undetectable		 2xrzA-3wr7A:
18.26
2xrzB-3wr7A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 ARG A 227
ASP A 949
ILE A  92
GLU A 948
 None
 1.49A 2xrzA-3zgbA:
undetectable
2xrzB-3zgbA:
undetectable		 2xrzA-3zgbA:
19.36
2xrzB-3zgbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ARG A 560
ASP A 563
GLU A 650
LYS A 646
 None
 1.44A 2xrzA-4a2wA:
undetectable
2xrzB-4a2wA:
undetectable		 2xrzA-4a2wA:
20.09
2xrzB-4a2wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Mus musculus;
Homo sapiens) 		PF00957
(Synaptobrevin)
PF13774
(Longin)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ARG B 668
ASP A  68
GLU B 669
LYS B 672
 None
 1.31A 2xrzA-4b93B:
undetectable
2xrzB-4b93B:
undetectable		 2xrzA-4b93B:
19.57
2xrzB-4b93B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crq ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 ARG A  90
ILE A 127
GLU A  44
LYS A  92
 ACT  A1257 (-4.0A)
ACT  A1257 (-4.6A)
ACT  A1257 (-2.6A)
ACT  A1257 (-3.0A)
 1.45A 2xrzA-4crqA:
undetectable
2xrzB-4crqA:
undetectable		 2xrzA-4crqA:
15.93
2xrzB-4crqA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 493
ASP A 341
ILE A 380
GLU A 514
 None
 1.45A 2xrzA-4d25A:
undetectable
2xrzB-4d25A:
undetectable		 2xrzA-4d25A:
20.56
2xrzB-4d25A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  16
ASP A 221
ILE A 224
GLU A 203
 None
 1.01A 2xrzA-4dd5A:
undetectable
2xrzB-4dd5A:
undetectable		 2xrzA-4dd5A:
22.00
2xrzB-4dd5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  11
ASP A 217
ILE A 190
GLU A 198
 None
None
IOD  A 404 ( 4.8A)
None
 0.82A 2xrzA-4e1lA:
undetectable
2xrzB-4e1lA:
undetectable		 2xrzA-4e1lA:
22.84
2xrzB-4e1lA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 ARG A 178
ILE A  62
GLU A 140
LYS A 144
 None
 1.50A 2xrzA-4gyoA:
undetectable
2xrzB-4gyoA:
undetectable		 2xrzA-4gyoA:
22.58
2xrzB-4gyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 4 ARG A  32
ASP A 215
ILE A 216
GLU A  29
 None
 1.05A 2xrzA-4ix1A:
undetectable
2xrzB-4ix1A:
undetectable		 2xrzA-4ix1A:
19.42
2xrzB-4ix1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		4 ARG A 347
ASP A 427
ILE A 425
GLU A 435
 None
 1.36A 2xrzA-4qlaA:
undetectable
2xrzB-4qlaA:
undetectable		 2xrzA-4qlaA:
23.99
2xrzB-4qlaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 ARG A  10
ASP A  16
GLU A  63
LYS A  68
 None
 1.44A 2xrzA-4r9mA:
undetectable
2xrzB-4r9mA:
undetectable		 2xrzA-4r9mA:
18.76
2xrzB-4r9mA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utt PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Clostridium
perfringens) 		PF04131
(NanE) 		4 ARG A  43
ASP A 126
ILE A 127
GLU A 180
 CL  A1221 (-3.9A)
None
None
None
 1.07A 2xrzA-4uttA:
undetectable
2xrzB-4uttA:
undetectable		 2xrzA-4uttA:
21.10
2xrzB-4uttA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A  11
ASP A 216
ILE A 190
GLU A 198
 None
 0.77A 2xrzA-4wyrA:
undetectable
2xrzB-4wyrA:
undetectable		 2xrzA-4wyrA:
22.92
2xrzB-4wyrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 ARG A 202
ASP A 107
ILE A 157
GLU A 216
 None
 1.28A 2xrzA-4yaiA:
3.2
2xrzB-4yaiA:
3.1		 2xrzA-4yaiA:
21.22
2xrzB-4yaiA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq0 14-3-3 PROTEIN

(Giardia
intestinalis) 		PF00244
(14-3-3) 		4 ARG A  31
ASP A 104
ILE A 101
GLU A  28
 None
 1.22A 2xrzA-4zq0A:
undetectable
2xrzB-4zq0A:
1.5		 2xrzA-4zq0A:
17.93
2xrzB-4zq0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 ARG A 506
ASP A 498
GLU A 503
LYS A 553
 None
 1.40A 2xrzA-5b48A:
undetectable
2xrzB-5b48A:
undetectable		 2xrzA-5b48A:
21.62
2xrzB-5b48A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Enterovirus D;
Enterovirus D) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ARG A 181
ASP C  17
GLU A 118
LYS A 242
 None
 1.11A 2xrzA-5bnnA:
undetectable
2xrzB-5bnnA:
undetectable		 2xrzA-5bnnA:
20.54
2xrzB-5bnnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d50 REPRESSOR

(Salmonella
virus SPN1S) 		PF01381
(HTH_3) 		4 ARG A  54
ASP A  68
ILE A   7
GLU A  57
 None
 1.39A 2xrzA-5d50A:
undetectable
2xrzB-5d50A:
undetectable		 2xrzA-5d50A:
19.28
2xrzB-5d50A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dma ATP-DEPENDENT DNA
HELICASE PCRA

(Geobacillus
stearothermophilus) 		no annotation 4 ARG A 693
ASP A 702
ILE A 711
GLU A 700
 None
 1.49A 2xrzA-5dmaA:
undetectable
2xrzB-5dmaA:
undetectable		 2xrzA-5dmaA:
7.10
2xrzB-5dmaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 ASP A  71
ILE A  70
GLU A   2
LYS A   5
 None
 1.27A 2xrzA-5e3xA:
1.9
2xrzB-5e3xA:
2.2		 2xrzA-5e3xA:
23.10
2xrzB-5e3xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG B  11
ASP B 217
ILE B 191
GLU B 199
 None
 0.82A 2xrzA-5f38B:
undetectable
2xrzB-5f38B:
undetectable		 2xrzA-5f38B:
23.11
2xrzB-5f38B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG A 546
ASP A 511
ILE A 513
GLU A 537
 None
 1.25A 2xrzA-5gjeA:
undetectable
2xrzB-5gjeA:
undetectable		 2xrzA-5gjeA:
21.94
2xrzB-5gjeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ARG A 320
ASP A  75
ILE A 303
GLU A 324
 None
 1.39A 2xrzA-5gxdA:
2.9
2xrzB-5gxdA:
3.0		 2xrzA-5gxdA:
22.57
2xrzB-5gxdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 ARG A 217
ASP A 214
GLU A 249
LYS A 245
 None
 1.43A 2xrzA-5hzhA:
undetectable
2xrzB-5hzhA:
undetectable		 2xrzA-5hzhA:
21.69
2xrzB-5hzhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 ARG A 202
ASP A 106
ILE A 155
GLU A 199
 None
 1.03A 2xrzA-5ig2A:
2.9
2xrzB-5ig2A:
3.2		 2xrzA-5ig2A:
23.12
2xrzB-5ig2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		4 ARG A 270
ASP A 373
ILE B 116
GLU A 231
 None
 1.29A 2xrzA-5ivaA:
undetectable
2xrzB-5ivaA:
undetectable		 2xrzA-5ivaA:
21.84
2xrzB-5ivaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Aspergillus
fumigatus) 		PF01487
(DHquinase_I) 		4 ARG A1121
ASP A1153
ILE A1117
LYS A1208
 None
 1.45A 2xrzA-5swuA:
undetectable
2xrzB-5swuA:
undetectable		 2xrzA-5swuA:
20.21
2xrzB-5swuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 ARG A 288
ASP A 279
ILE A 130
GLU A 292
 None
 1.32A 2xrzA-5um2A:
undetectable
2xrzB-5um2A:
undetectable		 2xrzA-5um2A:
23.78
2xrzB-5um2A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		4 ARG A 175
ASP A 325
ILE A 324
GLU A 172
 None
 1.05A 2xrzA-5yacA:
1.7
2xrzB-5yacA:
1.8		 2xrzA-5yacA:
24.30
2xrzB-5yacA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 4 ARG A 516
ASP A 250
ILE A 278
GLU A 506
 None
 1.45A 2xrzA-6ercA:
undetectable
2xrzB-6ercA:
undetectable		 2xrzA-6ercA:
undetectable
2xrzB-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ARG C  48
ASP A 510
ILE A 565
GLU C  42
 C  R  11 ( 3.4A)
C  R  11 ( 4.6A)
None
C  R  11 ( 4.1A)
 1.36A 2xrzA-6f5oC:
undetectable
2xrzB-6f5oC:
undetectable		 2xrzA-6f5oC:
undetectable
2xrzB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		no annotation
no annotation 		4 ARG e 110
ASP g 177
ILE g 158
GLU g 206
 None
 1.50A 2xrzA-6fkhe:
undetectable
2xrzB-6fkhe:
undetectable		 2xrzA-6fkhe:
undetectable
2xrzB-6fkhe:
undetectable