SIMILAR PATTERNS OF AMINO ACIDS FOR 2XRL_A_DXTA1211_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0f | GLUTATHIONES-TRANSFERASE (Escherichiacoli) |
PF00043(GST_C)PF13409(GST_N_2) | 5 | PRO A 111THR A 124VAL A 125GLN A 128LEU A 129 | None | 0.85A | 2xrlA-1a0fA:undetectable | 2xrlA-1a0fA:25.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aug | PYROGLUTAMYLPEPTIDASE-1 (Bacillusamyloliquefaciens) |
PF01470(Peptidase_C15) | 5 | ASN A 19PHE A 10VAL A 25LEU A 193ILE A 169 | None | 1.50A | 2xrlA-1augA:undetectable | 2xrlA-1augA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhq | CD11B (Homo sapiens) |
PF00092(VWA) | 5 | ASN 1 310THR 1 159VAL 1 160GLN 1 163LEU 1 164 | None | 1.37A | 2xrlA-1bhq1:undetectable | 2xrlA-1bhq1:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cq3 | VIRAL CHEMOKINEINHIBITOR (Cowpox virus) |
PF02250(Orthopox_35kD) | 5 | SER A 133ASN A 34THR A 71ILE A 37SER A 139 | None | 1.33A | 2xrlA-1cq3A:undetectable | 2xrlA-1cq3A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fsu | N-ACETYLGALACTOSAMINE-4-SULFATASE (Homo sapiens) |
PF00884(Sulfatase) | 5 | SER A 428ASN A 426THR A 471LEU A 440SER A 423 | NAG A 602 ( 4.7A)NAG A 602 (-2.0A)NoneNoneNone | 1.35A | 2xrlA-1fsuA:undetectable | 2xrlA-1fsuA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | ASN A 393THR A 207GLN A 397LEU A 400ILE A 387 | None HG A6005 ( 4.7A) HG A6005 (-2.2A)NoneNone | 1.06A | 2xrlA-1g8kA:0.0 | 2xrlA-1g8kA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | PHE A 405PRO A 343THR A 398VAL A 419SER A 412 | None | 1.37A | 2xrlA-1gkrA:0.0 | 2xrlA-1gkrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcu | CONSERVED PROTEINMTH1692 (Methanothermobacterthermautotrophicus) |
PF01300(Sua5_yciO_yrdC) | 5 | SER A 65THR A 97VAL A 98ILE A 74SER A 78 | None | 1.32A | 2xrlA-1jcuA:undetectable | 2xrlA-1jcuA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js8 | HEMOCYANIN (Enteroctopusdofleini) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | ASN A2534PRO A2739THR A2750GLN A2577LEU A2574 | None | 1.40A | 2xrlA-1js8A:undetectable | 2xrlA-1js8A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pn9 | GLUTATHIONES-TRANSFERASE 1-6 (Anophelesgambiae) |
PF00043(GST_C)PF02798(GST_N) | 5 | SER A 158PRO A 53VAL A 15GLN A 69LEU A 72 | NoneGTX A 301 (-4.4A)NoneNoneNone | 1.38A | 2xrlA-1pn9A:0.2 | 2xrlA-1pn9A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxz | MAJOR POLLENALLERGEN JUN A 1 (Juniperus ashei) |
PF00544(Pec_lyase_C) | 5 | SER A 188ASN A 190THR A 186LEU A 201ILE A 176 | None | 1.29A | 2xrlA-1pxzA:undetectable | 2xrlA-1pxzA:20.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86HIS A 100THR A 112GLN A 116SER A 138 | NoneNoneNoneIMD A 1 (-4.0A)NoneNoneNone | 0.70A | 2xrlA-1qpiA:25.3 | 2xrlA-1qpiA:99.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 8 | HIS A 64ASN A 82PHE A 86THR A 112VAL A 113GLN A 116LEU A 117ILE A 134 | None | 0.63A | 2xrlA-1qpiA:25.3 | 2xrlA-1qpiA:99.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 8 | HIS A 64ASN A 82PHE A 86THR A 112VAL A 113GLN A 116LEU A 117SER A 138 | None | 0.66A | 2xrlA-1qpiA:25.3 | 2xrlA-1qpiA:99.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 8 | HIS A 64SER A 67ASN A 82THR A 112VAL A 113GLN A 116LEU A 117ILE A 134 | None | 0.65A | 2xrlA-1qpiA:25.3 | 2xrlA-1qpiA:99.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s1f | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 5 | ASN A 248HIS A 172PRO A 151THR A 145LEU A 366 | None | 1.49A | 2xrlA-1s1fA:undetectable | 2xrlA-1s1fA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdh | MUCONOLACTONEISOMERASE-LIKEPROTEIN (Thermusthermophilus) |
PF06778(Chlor_dismutase) | 5 | SER A 110PRO A 134VAL A 112LEU A 114ILE A 187 | None | 1.36A | 2xrlA-1vdhA:undetectable | 2xrlA-1vdhA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkr | POLYPOROPEPSIN (Irpex lacteus) |
PF00026(Asp) | 5 | SER A 154THR A 8VAL A 15GLN A 10LEU A 30 | None | 1.45A | 2xrlA-1wkrA:undetectable | 2xrlA-1wkrA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7p | RRNAMETHYLTRANSFERASE (Streptomycesviridochromogenes) |
PF00588(SpoU_methylase) | 5 | PRO A 134VAL A 157LEU A 155ILE A 144SER A 169 | None | 1.15A | 2xrlA-1x7pA:0.4 | 2xrlA-1x7pA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2g | THREONINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | HIS A 153SER A 431PHE A 134THR A 405LEU A 412 | None | 1.27A | 2xrlA-2c2gA:undetectable | 2xrlA-2c2gA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eid | GALACTOSE OXIDASE (Fusariumgraminearum) |
PF00754(F5_F8_type_C)PF01344(Kelch_1)PF09118(DUF1929) | 5 | SER A 633PRO A 629LEU A 501ILE A 574SER A 572 | None | 1.04A | 2xrlA-2eidA:undetectable | 2xrlA-2eidA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2l | PEPTIDOGLYCANRECOGNITIONPROTEIN-LC ISOFORMLCX (Drosophilamelanogaster) |
PF01510(Amidase_2) | 5 | HIS X 365SER X 481PHE X 438LEU X 470ILE X 490 | MLD X 201 (-3.9A)MLD X 201 (-3.4A)NoneNoneNone | 1.19A | 2xrlA-2f2lX:undetectable | 2xrlA-2f2lX:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fca | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Bacillussubtilis) |
PF02390(Methyltransf_4) | 5 | PHE A 35PRO A 24VAL A 103LEU A 100ILE A 43 | None | 1.29A | 2xrlA-2fcaA:undetectable | 2xrlA-2fcaA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fu0 | CYCLOPHILIN,PUTATIVE (Plasmodiumfalciparum) |
PF00160(Pro_isomerase) | 5 | SER A 20PHE A 123THR A 127VAL A 126ILE A 10 | None | 1.46A | 2xrlA-2fu0A:undetectable | 2xrlA-2fu0A:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsi | PUTATIVE PEPTIDASEM23 (Pseudomonasaeruginosa) |
PF01551(Peptidase_M23) | 5 | HIS A 218SER A 224VAL A 214LEU A 229ILE A 193 | None | 1.49A | 2xrlA-2hsiA:undetectable | 2xrlA-2hsiA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | HIS A 211THR A 160VAL A 161GLN A 125ILE A 122 | ZN A 401 (-3.4A)ADE A1114 ( 4.3A)NoneADE A1114 (-3.3A)None | 1.11A | 2xrlA-2icsA:undetectable | 2xrlA-2icsA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgz | G2/MITOTIC-SPECIFICCYCLIN-B1 (Homo sapiens) |
PF00134(Cyclin_N)PF02984(Cyclin_C) | 5 | SER B 413VAL B 387GLN B 417LEU B 422ILE B 355 | None | 1.24A | 2xrlA-2jgzB:1.6 | 2xrlA-2jgzB:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l01 | UNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF10771(DUF2582) | 5 | PHE A 43THR A 57VAL A 66LEU A 19ILE A 15 | None | 1.23A | 2xrlA-2l01A:undetectable | 2xrlA-2l01A:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l26 | UNCHARACTERIZEDPROTEINRV0899/MT0922 (Mycobacteriumtuberculosis) |
PF00691(OmpA)PF04972(BON) | 5 | SER A 87THR A 90VAL A 91LEU A 93ILE A 84 | None | 1.45A | 2xrlA-2l26A:undetectable | 2xrlA-2l26A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nux | 2-KETO-3-DEOXYGLUCONATE/2-KETO-3-DEOXY-6-PHOSPHO GLUCONATEALDOLASE (Sulfolobusacidocaldarius) |
PF00701(DHDPS) | 5 | PRO A 10THR A 24LEU A 61ILE A 37SER A 5 | None | 1.34A | 2xrlA-2nuxA:undetectable | 2xrlA-2nuxA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogj | DIHYDROOROTASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | PHE A 132PRO A 329THR A 102VAL A 74LEU A 304 | None | 1.02A | 2xrlA-2ogjA:undetectable | 2xrlA-2ogjA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ohf | GTP-BINDING PROTEIN9 (Homo sapiens) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 5 | SER A 62PHE A 87THR A 43LEU A 292ILE A 296 | None | 1.25A | 2xrlA-2ohfA:undetectable | 2xrlA-2ohfA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okj | GLUTAMATEDECARBOXYLASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | ASN A 256PRO A 403LEU A 417ILE A 416SER A 249 | LLP A 405 ( 4.6A)NoneNoneNoneNone | 1.31A | 2xrlA-2okjA:undetectable | 2xrlA-2okjA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov9 | HYPOTHETICAL PROTEIN (Rhodococcusjostii) |
PF03061(4HBT) | 5 | PRO A 100THR A 117VAL A 116LEU A 174ILE A 192 | None | 1.46A | 2xrlA-2ov9A:undetectable | 2xrlA-2ov9A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz4 | INTERCELLULARADHESION MOLECULE 1 (Homo sapiens) |
no annotation | 5 | PRO A 197THR A 277VAL A 278LEU A 227ILE A 280 | None | 1.34A | 2xrlA-2oz4A:undetectable | 2xrlA-2oz4A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk3 | GDP-6-DEOXY-D-LYXO-4-HEXULOSE REDUCTASE (Aneurinibacillusthermoaerophilus) |
PF16363(GDP_Man_Dehyd) | 5 | ASN A 169PHE A 168THR A 242VAL A 208SER A 115 | GDD A 410 (-3.1A)NoneNoneNoneGDD A 410 (-2.4A) | 1.48A | 2xrlA-2pk3A:undetectable | 2xrlA-2pk3A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy1 | PECTATE LYASE II (Xanthomonascampestris) |
PF00544(Pec_lyase_C) | 5 | SER A 190ASN A 192THR A 188LEU A 141ILE A 139 | None | 0.84A | 2xrlA-2qy1A:undetectable | 2xrlA-2qy1A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6f | EXCINUCLEASE ABCSUBUNIT A (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 5 | PHE A 632HIS A 872THR A 916LEU A 932ILE A 891 | None | 1.41A | 2xrlA-2r6fA:undetectable | 2xrlA-2r6fA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yyb | HYPOTHETICAL PROTEINTTHA1606 (Thermusthermophilus) |
PF01784(NIF3) | 5 | HIS A 210HIS A 64THR A 187VAL A 169LEU A 176 | None | 1.49A | 2xrlA-2yybA:undetectable | 2xrlA-2yybA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 5 | PHE A 220PRO A 242VAL A 44LEU A 93ILE A 95 | None | 1.42A | 2xrlA-2zieA:undetectable | 2xrlA-2zieA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beo | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillusanthracis) |
PF02350(Epimerase_2) | 5 | ASN A 213THR A 284VAL A 302LEU A 320SER A 132 | None | 1.45A | 2xrlA-3beoA:undetectable | 2xrlA-3beoA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bit | FACT COMPLEX SUBUNITSPT16 (Saccharomycescerevisiae) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | PHE A 267THR A 302LEU A 198ILE A 261SER A 263 | None | 1.38A | 2xrlA-3bitA:undetectable | 2xrlA-3bitA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8m | BASEPLATE PROTEIN,RECEPTOR BINDINGPROTEIN (Lactococcusphage TP901-1;Lactococcusvirus P2) |
PF08931(Caudo_bapla_RBP) | 5 | ASN A 159PHE A 91THR A 80VAL A 87LEU A 86 | None | 1.49A | 2xrlA-3d8mA:undetectable | 2xrlA-3d8mA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edn | PHENAZINEBIOSYNTHESISPROTEIN, PHZF FAMILY (Bacillusanthracis) |
PF02567(PhzC-PhzF) | 5 | PHE A 185PRO A 199VAL A 167LEU A 149SER A 141 | None | 1.50A | 2xrlA-3ednA:undetectable | 2xrlA-3ednA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee4 | PROBABLERIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | SER A 278ASN A 279HIS A 164VAL A 217ILE A 288 | None | 1.44A | 2xrlA-3ee4A:undetectable | 2xrlA-3ee4A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6t | ASPARTATEAMINOTRANSFERASE (Lactobacillusacidophilus) |
PF00155(Aminotran_1_2) | 5 | SER A 309PHE A 314LEU A 166ILE A 146SER A 394 | LLP A 312 ( 2.5A)NoneNoneNoneNone | 1.32A | 2xrlA-3f6tA:2.0 | 2xrlA-3f6tA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkd | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Porphyromonasgingivalis) |
PF00155(Aminotran_1_2) | 5 | ASN A 140PHE A 99PRO A 202THR A 22VAL A 24 | None | 1.41A | 2xrlA-3fkdA:undetectable | 2xrlA-3fkdA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7j | GLUTATHIONETRANSFERASE GST1-4 (Anopheles dirus) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | SER A 167PRO A 53VAL A 15GLN A 70LEU A 73 | NoneGTX A 220 (-4.3A)NoneNoneNone | 1.39A | 2xrlA-3g7jA:undetectable | 2xrlA-3g7jA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8m | SERINEHYDROXYMETHYLTRANSFERASE (Escherichiacoli) |
PF00464(SHMT) | 5 | HIS A 129ASN A 102PRO A 216VAL A 223LEU A 240 | None | 1.44A | 2xrlA-3g8mA:undetectable | 2xrlA-3g8mA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i7a | PUTATIVEMETAL-DEPENDENTPHOSPHOHYDROLASE (Shewanellaamazonensis) |
PF08668(HDOD) | 5 | SER A 198PHE A 201PRO A 26LEU A 161ILE A 158 | None | 1.35A | 2xrlA-3i7aA:1.5 | 2xrlA-3i7aA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipw | HYDROLASE TATDFAMILY PROTEIN (Entamoebahistolytica) |
PF01026(TatD_DNase) | 5 | SER A 50THR A 76VAL A 108LEU A 146ILE A 111 | None | 1.39A | 2xrlA-3ipwA:undetectable | 2xrlA-3ipwA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8v | FLAGELLIN HOMOLOG (Sphingomonassp. A1) |
PF00669(Flagellin_N)PF00700(Flagellin_C)PF07196(Flagellin_IN) | 5 | SER A 237ASN A 226THR A 286VAL A 287LEU A 112 | None | 1.35A | 2xrlA-3k8vA:undetectable | 2xrlA-3k8vA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kbh | ANGIOTENSIN-CONVERTING ENZYME 2 (Homo sapiens) |
PF01401(Peptidase_M2) | 5 | ASN A 33THR A 92VAL A 93GLN A 96LEU A 97 | None | 0.94A | 2xrlA-3kbhA:undetectable | 2xrlA-3kbhA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocq | PUTATIVECYTOSINE/ADENOSINEDEAMINASE (Salmonellaenterica) |
PF14437(MafB19-deam) | 5 | HIS A 133PRO A 97VAL A 113LEU A 91ILE A 110 | None | 1.47A | 2xrlA-3ocqA:undetectable | 2xrlA-3ocqA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 1 (Bos taurus) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF08282(Hydrolase_3)PF13246(Cation_ATPase) | 5 | PRO A 312VAL A 62LEU A 65ILE A 307SER A 261 | None | 1.46A | 2xrlA-3tlmA:undetectable | 2xrlA-3tlmA:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ux8 | EXCINUCLEASE ABC, ASUBUNIT (Geobacillus sp.Y412MC52) |
PF00005(ABC_tran) | 5 | PHE A 632HIS A 872THR A 916LEU A 932ILE A 891 | None | 1.38A | 2xrlA-3ux8A:undetectable | 2xrlA-3ux8A:16.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ac0 | TETRACYCLINEREPRESSOR PROTEINCLASS B FROMTRANSPOSON TN1 0 (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 8 | HIS A 64ASN A 82PHE A 86HIS A 100PRO A 105THR A 112GLN A 116LEU A 117 | MIY A1204 (-3.8A)MIY A1204 (-3.0A)MIY A1204 (-3.5A) MG A1205 ( 3.2A)MIY A1204 (-4.4A)MIY A1204 ( 4.7A)MIY A1204 (-2.8A)None | 0.54A | 2xrlA-4ac0A:25.8 | 2xrlA-4ac0A:64.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3g | DNA-BINDING PROTEINSMUBP-2 (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12) | 5 | SER A 582ASN A 511THR A 616VAL A 617LEU A 591 | None | 1.45A | 2xrlA-4b3gA:2.6 | 2xrlA-4b3gA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b5x | 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATEALDOLASE (Escherichiacoli) |
PF03328(HpcH_HpaI) | 5 | SER A 23THR A 52VAL A 53GLN A 56LEU A 57 | PO4 A1253 (-4.3A)NoneNoneNoneNone | 0.48A | 2xrlA-4b5xA:undetectable | 2xrlA-4b5xA:22.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d5c | TETRACYCLINEREPRESSOR PROTEINTETR (Proteusmirabilis) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86HIS A 100PRO A 105GLN A 116LEU A 117 | None | 0.78A | 2xrlA-4d5cA:25.8 | 2xrlA-4d5cA:59.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d5c | TETRACYCLINEREPRESSOR PROTEINTETR (Proteusmirabilis) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86PRO A 105THR A 112GLN A 116LEU A 117 | None | 0.73A | 2xrlA-4d5cA:25.8 | 2xrlA-4d5cA:59.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4da1 | PROTEIN PHOSPHATASE1K, MITOCHONDRIAL (Homo sapiens) |
PF00481(PP2C) | 5 | SER A 209ASN A 301THR A 191LEU A 222ILE A 212 | None | 1.28A | 2xrlA-4da1A:undetectable | 2xrlA-4da1A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exl | PHOSPHATE-BINDINGPROTEIN PSTS 1 (Streptococcuspneumoniae) |
PF12849(PBP_like_2) | 5 | THR A 259VAL A 254GLN A 260LEU A 255ILE A 272 | None | 1.50A | 2xrlA-4exlA:undetectable | 2xrlA-4exlA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fkz | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillussubtilis) |
PF02350(Epimerase_2) | 5 | ASN A 211THR A 282VAL A 300LEU A 318SER A 130 | None | 1.46A | 2xrlA-4fkzA:undetectable | 2xrlA-4fkzA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmz | INTERNALIN (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13855(LRR_8) | 5 | SER A 216PHE A 237THR A 196LEU A 181ILE A 206 | EDO A 401 (-4.5A)NoneNoneNoneNone | 1.27A | 2xrlA-4fmzA:undetectable | 2xrlA-4fmzA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ipe | TNFRECEPTOR-ASSOCIATEDPROTEIN 1 (Danio rerio) |
PF00183(HSP90)PF13589(HATPase_c_3) | 5 | PHE A 636THR A 610VAL A 609LEU A 657ILE A 625 | None | 1.12A | 2xrlA-4ipeA:undetectable | 2xrlA-4ipeA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnl | POSSIBLE GALACTOSEMUTAROTASE (Streptomycesplatensis) |
PF01263(Aldose_epim) | 5 | HIS A 110ASN A 84THR A 177GLN A 307LEU A 276 | GOL A 401 (-4.2A)GOL A 401 (-3.7A)NoneNoneNone | 1.48A | 2xrlA-4rnlA:undetectable | 2xrlA-4rnlA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubs | PENTALENIC ACIDSYNTHASE (Streptomycesavermitilis) |
PF00067(p450) | 5 | SER A 38THR A 52VAL A 51LEU A 60ILE A 306 | None | 1.44A | 2xrlA-4ubsA:undetectable | 2xrlA-4ubsA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkm | XYLOSE ISOMERASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | HIS A 243PRO A 235THR A 251VAL A 252LEU A 256 | None | 1.28A | 2xrlA-4xkmA:1.2 | 2xrlA-4xkmA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ytw | MITOCHONDRIALDISTRIBUTION ANDMORPHOLOGY PROTEIN35PROTEIN UPS1,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF04707(PRELI)PF05254(UPF0203) | 5 | SER B 41ASN B 43PRO A 74THR B 53VAL B 81 | None | 1.23A | 2xrlA-4ytwB:undetectable | 2xrlA-4ytwB:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg5 | 5'-NUCLEOTIDASE SURE (Brucellaabortus) |
no annotation | 5 | SER D 124ASN D 166THR D 106VAL D 107LEU D 162 | None | 1.21A | 2xrlA-4zg5D:undetectable | 2xrlA-4zg5D:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgw | EXTRACELLULARSTREPTODORNASE D (Streptococcuspyogenes) |
PF01223(Endonuclease_NS) | 5 | SER A 92PHE A 68THR A 113LEU A 194ILE A 190 | None | 1.45A | 2xrlA-5fgwA:undetectable | 2xrlA-5fgwA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwj | HISTONE DEMETHYLASEJARID1C (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN)PF02928(zf-C5HC2) | 5 | SER A 472HIS A 527PRO A 55LEU A 462SER A 451 | None | 1.48A | 2xrlA-5fwjA:undetectable | 2xrlA-5fwjA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4i | PHOSPHOLYASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 5 | SER A 222HIS A 148LEU A 229ILE A 176SER A 143 | None | 1.31A | 2xrlA-5g4iA:undetectable | 2xrlA-5g4iA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k79 | CYANOVIRIN-N DOMAINPROTEIN (Cyanothece sp.PCC 7424) |
PF08881(CVNH) | 5 | SER A 34PHE A 21THR A 17LEU A 64ILE A 11 | None | 1.30A | 2xrlA-5k79A:undetectable | 2xrlA-5k79A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loi | RAD26 (Thermothelomycesthermophila) |
PF12331(DUF3636) | 5 | PRO A 597THR A 619VAL A 616ILE A 593SER A 587 | None | 1.46A | 2xrlA-5loiA:undetectable | 2xrlA-5loiA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mm2 | CAPSID PROTEIN VP4A (Nora virus) |
no annotation | 5 | HIS C 51THR C 109GLN C 112LEU C 116ILE C 81 | None | 1.44A | 2xrlA-5mm2C:undetectable | 2xrlA-5mm2C:17.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 5 | HIS A 64SER A 67ASN A 82HIS A 100ILE A 137 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A) MG A 302 ( 3.2A)TDC A 301 ( 4.5A) | 1.31A | 2xrlA-5mruA:23.2 | 2xrlA-5mruA:43.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 9 | HIS A 64SER A 67ASN A 82PHE A 86HIS A 100PRO A 105THR A 112GLN A 116SER A 138 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A)TDC A 301 (-3.3A) MG A 302 ( 3.2A)TDC A 301 (-4.5A)NoneTDC A 301 (-2.8A)TDC A 301 ( 3.7A) | 0.81A | 2xrlA-5mruA:23.2 | 2xrlA-5mruA:43.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 6 | HIS A 64SER A 67ASN A 82THR A 112GLN A 116LEU A 117 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A)NoneTDC A 301 (-2.8A)None | 0.61A | 2xrlA-5mruA:23.2 | 2xrlA-5mruA:43.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n29 | CTP SYNTHASE (Trypanosomabrucei) |
PF00117(GATase) | 5 | PHE A 566PRO A 390VAL A 344LEU A 345ILE A 361 | None | 1.31A | 2xrlA-5n29A:undetectable | 2xrlA-5n29A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | SER A1625ASN A1699LEU A1619ILE A1641SER A1554 | None | 1.41A | 2xrlA-5nugA:undetectable | 2xrlA-5nugA:3.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tth | C-TERMINALSPYCATCHER FUSION OFWILDTYPE ZEBRAFISHTNFRECEPTOR-ASSOCIATEDPROTEIN 1 (Danio rerio;Streptococcuspyogenes) |
PF00183(HSP90)PF13589(HATPase_c_3) | 5 | PHE A 636THR A 610VAL A 609LEU A 657ILE A 625 | None | 1.12A | 2xrlA-5tthA:undetectable | 2xrlA-5tthA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1d | ANTIGEN PEPTIDETRANSPORTER 1ANTIGEN PEPTIDETRANSPORTER 2 (Homo sapiens) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | SER B 254THR B 258LEU B 223ILE A 397SER A 359 | None | 1.50A | 2xrlA-5u1dB:3.0 | 2xrlA-5u1dB:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNIT (Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | HIS A 588ASN A 968PRO A 584THR A 633VAL A 634 | None | 1.26A | 2xrlA-5xogA:3.5 | 2xrlA-5xogA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNIT (Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | THR A1330VAL A1120LEU A1122ILE A1136SER A1139 | None | 1.18A | 2xrlA-5xogA:3.5 | 2xrlA-5xogA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yim | SDEA (Legionellapneumophila) |
no annotation | 5 | SER A 428VAL A 401GLN A 405LEU A 402ILE A 292 | None | 1.31A | 2xrlA-5yimA:3.8 | 2xrlA-5yimA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 5 | SER A1223THR A1219VAL A1218LEU A1017ILE A1002 | None | 1.31A | 2xrlA-6b3rA:1.8 | 2xrlA-6b3rA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0b | TOXIN B (Clostridioidesdifficile) |
no annotation | 5 | SER A1403THR A1405VAL A1348LEU A1327ILE A1389 | None | 1.49A | 2xrlA-6c0bA:undetectable | 2xrlA-6c0bA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d14 | TNFRECEPTOR-ASSOCIATEDPROTEIN 1 (Danio rerio) |
no annotation | 5 | PHE A 636THR A 610VAL A 609LEU A 657ILE A 625 | None | 1.21A | 2xrlA-6d14A:undetectable | 2xrlA-6d14A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN5 (Mus musculus) |
no annotation | 5 | SER L 249PRO L 240VAL L 243LEU L 121ILE L 100 | None | 1.07A | 2xrlA-6g2jL:undetectable | 2xrlA-6g2jL:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7mdh | PROTEIN (MALATEDEHYDROGENASE) (Sorghum bicolor) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASN A 176PHE A 324PRO A 235LEU A 385SER A 355 | NoneNoneNone ZN A 503 (-4.0A)None | 0.84A | 2xrlA-7mdhA:undetectable | 2xrlA-7mdhA:20.00 |