SIMILAR PATTERNS OF AMINO ACIDS FOR 2XRH_A_NIOA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ILE A 162
THR A 161
GLN A 165
LEU A 201
 None
 1.01A 2xrhA-1flcA:
undetectable		 2xrhA-1flcA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		4 GLY S 347
ILE S 317
THR S 304
ARG S 516
 None
 0.77A 2xrhA-1g4uS:
undetectable		 2xrhA-1g4uS:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 800
ILE A 388
ARG A 384
GLN A 381
 None
 0.80A 2xrhA-1h0hA:
0.2		 2xrhA-1h0hA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 GLY A 120
ILE A 211
THR A 107
LEU A 121
 None
 1.01A 2xrhA-1iu9A:
undetectable		 2xrhA-1iu9A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 GLY A 341
THR A 112
ARG A 319
LEU A 342
 None
 1.01A 2xrhA-1js6A:
undetectable		 2xrhA-1js6A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 GLY A  61
ILE A  70
MET A  51
LEU A  32
 None
 0.90A 2xrhA-1kyhA:
undetectable		 2xrhA-1kyhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 GLY A 130
ILE A 101
GLN A 112
LEU A 132
 None
 0.68A 2xrhA-1kyhA:
undetectable		 2xrhA-1kyhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 GLY A  88
ILE A  47
THR A  48
LEU A  85
 None
 0.80A 2xrhA-1m9iA:
0.3		 2xrhA-1m9iA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 4 GLY B 272
ILE B 366
THR B 361
LEU B 270
 None
 0.91A 2xrhA-1p3wB:
1.4		 2xrhA-1p3wB:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A 319
ARG A 358
GLN A 369
LEU A 317
 None
 0.97A 2xrhA-1pguA:
undetectable		 2xrhA-1pguA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 GLY M  56
ILE M  50
ARG M 132
LEU M  60
 None
U10  L 272 ( 4.8A)
None
None
 0.96A 2xrhA-1pssM:
undetectable		 2xrhA-1pssM:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd7 2-KETO
ACID:FERREDOXIN
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF01855
(POR_N) 		4 GLY A  74
ILE A  69
THR A  84
MET A  62
 None
 0.93A 2xrhA-1yd7A:
undetectable		 2xrhA-1yd7A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 GLY C 418
ILE C 242
GLN C 246
LEU C 415
 None
 0.65A 2xrhA-1zq1C:
undetectable		 2xrhA-1zq1C:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 GLY A  67
ILE A  35
THR A 278
LEU A  63
 None
 1.02A 2xrhA-2cw6A:
0.6		 2xrhA-2cw6A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 GLY A 162
ILE A  83
THR A  85
LEU A 174
 None
 0.98A 2xrhA-2fwrA:
undetectable		 2xrhA-2fwrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz4 DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII) 		4 GLY A 162
ILE A  83
THR A  85
LEU A 174
 None
 0.99A 2xrhA-2fz4A:
undetectable		 2xrhA-2fz4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kij COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00122
(E1-E2_ATPase) 		4 GLY A  40
ILE A  17
THR A  19
GLN A  38
 None
 1.02A 2xrhA-2kijA:
undetectable		 2xrhA-2kijA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 GLY A 298
ILE A 395
GLN A 322
LEU A 319
 None
None
HEM  A 501 (-3.9A)
None
 0.92A 2xrhA-2m56A:
undetectable		 2xrhA-2m56A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 437
ILE A 112
THR A 290
LEU A 131
 HEM  A 500 ( 3.7A)
HEM  A 500 (-4.1A)
None
HEM  A 500 ( 4.9A)
 0.94A 2xrhA-2nnjA:
undetectable		 2xrhA-2nnjA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 GLY A 161
ILE A 113
ARG A  83
LEU A 182
 None
 0.92A 2xrhA-2pbfA:
undetectable		 2xrhA-2pbfA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 GLY A 173
ILE A 146
THR A 157
LEU A 174
 None
 1.02A 2xrhA-2pl3A:
undetectable		 2xrhA-2pl3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE

(Neurospora
crassa) 		PF00579
(tRNA-synt_1b) 		4 ILE A 369
THR A 373
ARG A  74
LEU A 361
 None
 0.99A 2xrhA-2rkjA:
undetectable		 2xrhA-2rkjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 GLY A 157
ILE A 101
THR A 105
LEU A 126
 None
 0.88A 2xrhA-2vfwA:
undetectable		 2xrhA-2vfwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		4 ILE A 278
THR A 274
GLN A 309
LEU A 303
 None
 0.92A 2xrhA-2xgoA:
undetectable		 2xrhA-2xgoA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 GLY A 343
ILE A 321
THR A 297
LEU A 345
 None
 0.89A 2xrhA-2yijA:
undetectable		 2xrhA-2yijA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 370
ILE A 360
ARG A 362
LEU A 343
 None
 0.97A 2xrhA-2zu6A:
undetectable		 2xrhA-2zu6A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 GLY A 139
ILE A  67
THR A  71
LEU A 138
 None
 1.02A 2xrhA-3a7kA:
undetectable		 2xrhA-3a7kA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 GLY A 139
ILE A 144
THR A  58
LEU A 138
 None
 0.89A 2xrhA-3b5oA:
undetectable		 2xrhA-3b5oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		4 GLY A  41
ILE A  77
THR A  79
LEU A  10
 None
 0.90A 2xrhA-3bf5A:
undetectable		 2xrhA-3bf5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgi PROPANEDIOL
UTILIZATION PROTEIN
PDUU

(Salmonella
enterica) 		PF00936
(BMC) 		4 GLY A  47
ILE A 113
THR A  99
LEU A  49
 None
 0.96A 2xrhA-3cgiA:
undetectable		 2xrhA-3cgiA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 GLY A 296
ILE A 154
THR A 274
LEU A 298
 None
 0.93A 2xrhA-3dahA:
undetectable		 2xrhA-3dahA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		4 GLY A 305
ILE A 328
GLN A 353
LEU A 325
 None
 1.00A 2xrhA-3fgbA:
undetectable		 2xrhA-3fgbA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 GLY A  86
ILE A  92
MET A  45
LEU A 302
 None
 0.90A 2xrhA-3focA:
undetectable		 2xrhA-3focA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id9 MUTT/NUDIX FAMILY
PROTEIN

(Bacillus
thuringiensis) 		PF00293
(NUDIX) 		4 GLY A 146
ILE A  27
THR A  97
LEU A 142
 None
 1.00A 2xrhA-3id9A:
undetectable		 2xrhA-3id9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 GLY A 185
ILE A 199
THR A 201
LEU A 186
 None
 0.99A 2xrhA-3kljA:
undetectable		 2xrhA-3kljA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 GLY E 165
ILE E  85
MET E  14
LEU E 166
 None
 1.02A 2xrhA-3lvrE:
undetectable		 2xrhA-3lvrE:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		4 GLY A  68
ILE A  22
GLN A  29
MET A  36
 None
 0.97A 2xrhA-3m5wA:
undetectable		 2xrhA-3m5wA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 GLY A  46
ILE A 120
THR A 122
GLN A  78
 None
 1.02A 2xrhA-3mlpA:
undetectable		 2xrhA-3mlpA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmz PUTATIVE HAD FAMILY
HYDROLASE

(Streptomyces
avermitilis) 		PF08282
(Hydrolase_3) 		4 GLY A  45
ILE A 151
MET A  58
LEU A  76
 CL  A 503 ( 3.8A)
None
None
None
 0.98A 2xrhA-3mmzA:
undetectable		 2xrhA-3mmzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		5 GLY A 101
ILE A 106
THR A 109
ARG A 157
LEU A  97
 None
 1.23A 2xrhA-3onkA:
undetectable		 2xrhA-3onkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 156
THR A  86
MET A  96
LEU A  74
 None
 0.73A 2xrhA-3pdkA:
undetectable		 2xrhA-3pdkA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 132
ILE A 127
THR A 124
MET A 113
 None
 0.96A 2xrhA-3plrA:
undetectable		 2xrhA-3plrA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 298
THR A 426
MET A 457
LEU A 443
 None
 0.86A 2xrhA-3qdkA:
undetectable		 2xrhA-3qdkA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 GLY L 317
ILE L 402
GLN L 315
LEU L 291
 None
 1.01A 2xrhA-3rkoL:
undetectable		 2xrhA-3rkoL:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		4 GLY A 306
ILE A 329
GLN A 354
LEU A 326
 None
 0.85A 2xrhA-3scyA:
undetectable		 2xrhA-3scyA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 GLY A  57
ILE A  81
GLN A  76
LEU A  84
 None
 0.91A 2xrhA-3sqlA:
undetectable		 2xrhA-3sqlA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  52
ILE A  77
GLN A  66
LEU A  80
 None
 1.02A 2xrhA-3u4aA:
undetectable		 2xrhA-3u4aA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		4 GLY A 312
ILE A 259
MET A 253
LEU A 273
 None
 0.79A 2xrhA-3uyjA:
undetectable		 2xrhA-3uyjA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vut DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 294
ILE A 230
THR A 212
LEU A 297
 None
 0.95A 2xrhA-3vutA:
undetectable		 2xrhA-3vutA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLY A 406
THR A 436
GLN A 333
MET A 213
 None
 1.02A 2xrhA-3wdjA:
undetectable		 2xrhA-3wdjA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY B 105
ILE B  77
THR B  74
LEU B  84
 None
 1.02A 2xrhA-4af0B:
undetectable		 2xrhA-4af0B:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 GLY A 524
ILE A 364
GLN A 369
MET A 216
 None
 0.79A 2xrhA-4akvA:
undetectable		 2xrhA-4akvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 ILE A 442
THR A 479
MET A 315
LEU A 235
 None
 0.95A 2xrhA-4b2gA:
undetectable		 2xrhA-4b2gA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		4 GLY A 129
ILE A 132
THR A 135
LEU A 125
 SO4  A1496 (-3.2A)
SO4  A1496 (-3.7A)
None
None
 0.98A 2xrhA-4b67A:
undetectable		 2xrhA-4b67A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		4 GLY A 338
ILE A 331
THR A 327
LEU A  90
 None
 0.89A 2xrhA-4bvtA:
0.0		 2xrhA-4bvtA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		4 GLY A 130
ILE A  74
MET A  45
LEU A  91
 None
 1.02A 2xrhA-4cr6A:
undetectable		 2xrhA-4cr6A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		4 GLY C 165
ILE C  85
MET C  14
LEU C 166
 None
 0.91A 2xrhA-4fmeC:
undetectable		 2xrhA-4fmeC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 544
ARG A 698
GLN A 694
LEU A 935
 None
 1.01A 2xrhA-4h6yA:
undetectable		 2xrhA-4h6yA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 GLY A 268
ILE A   6
THR A   8
LEU A 266
 None
 0.75A 2xrhA-4i6kA:
undetectable		 2xrhA-4i6kA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 GLY A 152
ILE A 157
GLN A 147
LEU A 150
 None
 0.98A 2xrhA-4j0kA:
undetectable		 2xrhA-4j0kA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 GLY A 254
ILE A 374
THR A 378
LEU A 250
 None
 0.86A 2xrhA-4jc8A:
undetectable		 2xrhA-4jc8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 GLY A 111
ILE A 140
GLN A 245
LEU A 113
 None
 0.85A 2xrhA-4k28A:
undetectable		 2xrhA-4k28A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ILE A 428
THR A 432
MET A 564
LEU A 353
 None
 0.91A 2xrhA-4k90A:
undetectable		 2xrhA-4k90A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 224
ILE A 304
ARG A 303
LEU A 222
 None
 0.98A 2xrhA-4kamA:
undetectable		 2xrhA-4kamA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 GLY A 206
ILE A 158
THR A 160
LEU A 203
 None
 0.86A 2xrhA-4lb0A:
undetectable		 2xrhA-4lb0A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 ILE A 100
THR A 104
MET A 153
LEU A 160
 None
 0.89A 2xrhA-4m0mA:
undetectable		 2xrhA-4m0mA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2

(Homo sapiens) 		no annotation 4 GLY X  33
ILE X  14
THR X  16
GLN X  42
 None
 0.79A 2xrhA-4n9fX:
0.4		 2xrhA-4n9fX:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsy RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		4 GLY F 352
ILE F 235
THR F 231
GLN F 357
 None
 1.02A 2xrhA-4xsyF:
undetectable		 2xrhA-4xsyF:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A  63
ILE A 195
ARG A  67
LEU A  60
 None
 0.96A 2xrhA-4xxnA:
undetectable		 2xrhA-4xxnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT
NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY B  77
ILE B 184
GLN A 905
LEU B 181
 None
 1.00A 2xrhA-5aw4B:
undetectable		 2xrhA-5aw4B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 339
ILE A 394
GLN A 212
LEU A 341
 4UW  A 600 ( 4.8A)
None
None
None
 0.95A 2xrhA-5bswA:
undetectable		 2xrhA-5bswA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 GLY A 162
ILE A 188
THR A 229
LEU A 160
 None
None
None
TRS  A 409 ( 3.8A)
 0.95A 2xrhA-5c0pA:
undetectable		 2xrhA-5c0pA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 GLY A 161
ILE A 166
THR A  28
GLN A 159
 None
 0.98A 2xrhA-5c65A:
undetectable		 2xrhA-5c65A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		4 GLY A 166
ILE A 126
MET A 134
LEU A 152
 None
 0.94A 2xrhA-5cxuA:
undetectable		 2xrhA-5cxuA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		4 GLY B 136
ILE B 216
THR B 208
GLN B 111
 None
 0.96A 2xrhA-5dhxB:
undetectable		 2xrhA-5dhxB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		4 GLY A 714
ILE A 694
MET A 627
LEU A 712
 MPD  A 802 ( 3.8A)
None
MPD  A 802 (-4.0A)
MPD  A 802 ( 4.5A)
 0.82A 2xrhA-5e1rA:
undetectable		 2xrhA-5e1rA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE

(Influenza B
virus) 		PF00603
(Flu_PA)
no annotation 		4 GLY B  82
ILE A 755
THR B  12
LEU B  42
 None
 1.01A 2xrhA-5fmlB:
1.0		 2xrhA-5fmlB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		4 GLY A  69
ILE A 413
THR A 364
LEU A  70
 None
 0.81A 2xrhA-5i6cA:
0.7		 2xrhA-5i6cA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		4 GLY A 387
ILE A 545
ARG A 529
LEU A 422
 None
 0.94A 2xrhA-5il0A:
undetectable		 2xrhA-5il0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Saccharomyces
cerevisiae) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		4 GLY E 189
ILE E 109
ARG E  26
LEU E 186
 None
 0.89A 2xrhA-5ip7E:
undetectable		 2xrhA-5ip7E:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 321
ILE B 297
ARG B 287
GLN B 325
 None
 1.00A 2xrhA-5ip9B:
undetectable		 2xrhA-5ip9B:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		4 GLY A  15
ILE A  74
GLN A  18
LEU A  48
 None
 0.99A 2xrhA-5it0A:
undetectable		 2xrhA-5it0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLY A  18
ILE A   3
MET A  78
LEU A  54
 None
 0.90A 2xrhA-5k8rA:
undetectable		 2xrhA-5k8rA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		4 GLY A 220
ILE A  46
THR A 475
LEU A 214
 None
FAD  A1801 ( 4.9A)
FAD  A1801 (-3.2A)
None
 0.99A 2xrhA-5laeA:
undetectable		 2xrhA-5laeA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 GLY A 153
ILE A 133
THR A  91
LEU A 152
 None
 0.99A 2xrhA-5lx0A:
undetectable		 2xrhA-5lx0A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 171
ILE A 248
THR A 232
GLN A 200
 None
 1.02A 2xrhA-5nz7A:
undetectable		 2xrhA-5nz7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLY A 157
ILE A 161
ARG A 205
GLN A 203
 None
 0.80A 2xrhA-5t1pA:
undetectable		 2xrhA-5t1pA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		4 GLY A 387
ILE A 545
ARG A 529
LEU A 422
 None
 0.88A 2xrhA-5teyA:
undetectable		 2xrhA-5teyA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 4 GLY A 300
THR A 153
GLN A 104
LEU A 297
 None
POP  A 401 (-4.2A)
None
None
 1.03A 2xrhA-5ub6A:
undetectable		 2xrhA-5ub6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		4 GLY A 168
ILE A 215
THR A  57
MET A 106
 NA  A 401 ( 4.5A)
None
None
None
 1.00A 2xrhA-5ubuA:
undetectable		 2xrhA-5ubuA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 238
ILE A 245
THR A 199
ARG A 273
 None
 1.01A 2xrhA-5uhpA:
undetectable		 2xrhA-5uhpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Providencia
stuartii) 		PF13673
(Acetyltransf_10) 		4 GLY A 155
ILE A 104
THR A 100
LEU A 113
 None
None
None
8MM  A 201 ( 4.9A)
 0.93A 2xrhA-5us1A:
undetectable		 2xrhA-5us1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 GLY A 603
ILE A 584
THR A 588
LEU A 618
 None
 0.85A 2xrhA-5v7vA:
undetectable		 2xrhA-5v7vA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 4 GLY A  89
ARG A  93
MET A  21
LEU A  87
 None
None
None
SAH  A 301 (-4.4A)
 0.95A 2xrhA-5w7kA:
undetectable		 2xrhA-5w7kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 4 GLY A 277
ILE A 323
THR A 281
LEU A 326
 None
 0.84A 2xrhA-5xncA:
undetectable		 2xrhA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY A 563
ILE A 483
MET A 412
LEU A 564
 None
 0.95A 2xrhA-6bbpA:
undetectable		 2xrhA-6bbpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 GLY A 976
ILE A1030
THR A 906
ARG A1032
 None
 0.99A 2xrhA-6c90A:
undetectable		 2xrhA-6c90A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 GLY K 612
ILE K 597
THR K 659
LEU K 613
 None
 0.89A 2xrhA-6d6qK:
undetectable		 2xrhA-6d6qK:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 GLY A  80
ILE A  56
THR A  54
LEU A  73
 None
 1.00A 2xrhA-6f5dA:
undetectable		 2xrhA-6f5dA:
22.64