SIMILAR PATTERNS OF AMINO ACIDS FOR 2XPV_A_MIYA1209_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | PHE A 405PRO A 343THR A 398VAL A 419SER A 412 | None | 1.42A | 2xpvA-1gkrA:0.0 | 2xpvA-1gkrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jd1 | HYPOTHETICAL 13.9KDA PROTEIN INFCY2-PET117INTERGENIC REGION (Saccharomycescerevisiae) |
PF01042(Ribonuc_L-PSP) | 5 | SER A 70ARG A 105PRO A 103VAL A 74ILE A 60 | None | 1.34A | 2xpvA-1jd1A:undetectable | 2xpvA-1jd1A:18.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 9 | HIS A 64ASN A 82PHE A 86HIS A 100THR A 112VAL A 113GLN A 116ILE A 134SER A 138 | NoneNoneNoneIMD A 1 (-4.0A)NoneNoneNoneNoneNone | 0.64A | 2xpvA-1qpiA:25.6 | 2xpvA-1qpiA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 8 | HIS A 64SER A 67ASN A 82PHE A 86THR A 112VAL A 113GLN A 116ILE A 134 | None | 0.61A | 2xpvA-1qpiA:25.6 | 2xpvA-1qpiA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjy | SUGAR TRANSPORTPROTEIN (Salmonellaenterica) |
PF13407(Peripla_BP_4) | 5 | SER A 305PRO A 325THR A 303VAL A 302ILE A 128 | None | 1.23A | 2xpvA-1tjyA:0.2 | 2xpvA-1tjyA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqh | CARBOXYLESTERASEPRECURSOR (Geobacillusstearothermophilus) |
PF12146(Hydrolase_4) | 5 | HIS A 223SER A 94VAL A 98ILE A 204SER A 200 | 4PA A 701 (-4.4A)4PA A 701 (-1.4A)NoneNoneNone | 1.40A | 2xpvA-1tqhA:undetectable | 2xpvA-1tqhA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x25 | HYPOTHETICAL UPF0076PROTEIN ST0811 (Sulfurisphaeratokodaii) |
PF01042(Ribonuc_L-PSP) | 5 | SER A 67ARG A 102PRO A 100VAL A 71ILE A 57 | None | 1.32A | 2xpvA-1x25A:undetectable | 2xpvA-1x25A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | ARG A 447THR A 252VAL A 253ILE A 272SER A 261 | NoneFAD A 803 (-4.6A)FAD A 803 (-4.1A)NoneNone | 1.45A | 2xpvA-1yy5A:undetectable | 2xpvA-1yy5A:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boa | CARBOXYPEPTIDASE A4 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | SER A1070ASN A1112THR A1119VAL A1117SER A1041 | None | 1.36A | 2xpvA-2boaA:undetectable | 2xpvA-2boaA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | HIS A 211THR A 160VAL A 161GLN A 125ILE A 122 | ZN A 401 (-3.4A)ADE A1114 ( 4.3A)NoneADE A1114 (-3.3A)None | 1.15A | 2xpvA-2icsA:0.3 | 2xpvA-2icsA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iod | DIHYDROFLAVONOL4-REDUCTASE (Vitis vinifera) |
PF01370(Epimerase) | 5 | SER A 128THR A 131VAL A 132ILE A 252SER A 254 | MYC A1342 ( 2.2A)NoneNoneNoneNone | 1.35A | 2xpvA-2iodA:undetectable | 2xpvA-2iodA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcu | CARBOXYPEPTIDASE A4 (Homo sapiens) |
PF00246(Peptidase_M14) | 5 | SER A 70ASN A 112THR A 119VAL A 117SER A 41 | None | 1.37A | 2xpvA-2pcuA:0.6 | 2xpvA-2pcuA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd9 | ALANINE RACEMASE (Bacillusanthracis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | SER A 269ARG A 296THR A 316VAL A 315ILE A 311 | None | 1.45A | 2xpvA-2vd9A:undetectable | 2xpvA-2vd9A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee4 | PROBABLERIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | SER A 278ASN A 279HIS A 164VAL A 217ILE A 288 | None | 1.45A | 2xpvA-3ee4A:2.1 | 2xpvA-3ee4A:23.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fiw | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | HIS A 63ASN A 82PHE A 86HIS A 100VAL A 112 | None | 0.81A | 2xpvA-3fiwA:17.3 | 2xpvA-3fiwA:39.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkd | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Porphyromonasgingivalis) |
PF00155(Aminotran_1_2) | 5 | ASN A 140PHE A 99PRO A 202THR A 22VAL A 24 | None | 1.49A | 2xpvA-3fkdA:undetectable | 2xpvA-3fkdA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 4 (Thermusthermophilus) |
PF00346(Complex1_49kDa) | 5 | HIS 4 89ASN 4 121HIS 4 129THR 4 346SER 4 286 | None | 1.26A | 2xpvA-3i9v4:1.2 | 2xpvA-3i9v4:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP1PROTEIN VP2PROTEIN VP3 (Enterovirus B) |
PF00073(Rhv) | 5 | HIS C 207PRO C 119VAL A 187ILE B 36SER C 198 | None | 1.44A | 2xpvA-3j2jC:undetectable | 2xpvA-3j2jC:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg5 | B-CELL ANTIGENRECEPTORCOMPLEX-ASSOCIATEDPROTEIN BETA CHAIN (Homo sapiens) |
PF07686(V-set) | 5 | SER A 69ASN A 68VAL A 74GLN A 124ILE A 46 | None | 1.33A | 2xpvA-3kg5A:undetectable | 2xpvA-3kg5A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm7 | PUTATIVE4-HYDROXY-2-OXOGLUTARATE ALDOLASE /2-DEHYDRO-3-DEOXYPHOSPHOGLUCONATEALDOLASE (Yersiniaenterocolitica) |
PF07071(KDGP_aldolase) | 5 | SER A 102ARG A 75VAL A 95GLN A 94SER A 41 | None | 1.46A | 2xpvA-3lm7A:undetectable | 2xpvA-3lm7A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4o | INTERLEUKIN-1RECEPTOR ACCESSORYPROTEIN (Homo sapiens) |
PF13927(Ig_3) | 5 | HIS B 32SER B 103ARG B 13PRO B 28VAL B 105 | None | 1.39A | 2xpvA-3o4oB:undetectable | 2xpvA-3o4oB:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2j | DIPEPTIDASE (Streptomycescoelicolor) |
PF01244(Peptidase_M19) | 5 | HIS A 302SER A 214ASN A 224ARG A 291VAL A 245 | None | 1.34A | 2xpvA-3s2jA:undetectable | 2xpvA-3s2jA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7u | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | ARG A 401THR A 455GLN A 458ILE A 428SER A 408 | None | 1.37A | 2xpvA-3u7uA:undetectable | 2xpvA-3u7uA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubg | NEURAL-CADHERIN (Drosophilamelanogaster) |
PF00028(Cadherin) | 5 | PHE A 714HIS A 721ARG A 745THR A 696ILE A 660 | None | 1.48A | 2xpvA-3ubgA:undetectable | 2xpvA-3ubgA:23.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ac0 | TETRACYCLINEREPRESSOR PROTEINCLASS B FROMTRANSPOSON TN1 0 (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86HIS A 100PRO A 105THR A 112GLN A 116 | MIY A1204 (-3.8A)MIY A1204 (-3.0A)MIY A1204 (-3.5A) MG A1205 ( 3.2A)MIY A1204 (-4.4A)MIY A1204 ( 4.7A)MIY A1204 (-2.8A) | 0.43A | 2xpvA-4ac0A:26.5 | 2xpvA-4ac0A:65.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ac0 | TETRACYCLINEREPRESSOR PROTEINCLASS B FROMTRANSPOSON TN1 0 (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 6 | HIS A 64PHE A 86HIS A 100ARG A 104PRO A 105THR A 112 | MIY A1204 (-3.8A)MIY A1204 (-3.5A) MG A1205 ( 3.2A)MIY A1204 (-4.2A)MIY A1204 (-4.4A)MIY A1204 ( 4.7A) | 0.86A | 2xpvA-4ac0A:26.5 | 2xpvA-4ac0A:65.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d5c | TETRACYCLINEREPRESSOR PROTEINTETR (Proteusmirabilis) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86ARG A 104PRO A 105THR A 112GLN A 116 | None | 0.79A | 2xpvA-4d5cA:26.9 | 2xpvA-4d5cA:59.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d5c | TETRACYCLINEREPRESSOR PROTEINTETR (Proteusmirabilis) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64ASN A 82PHE A 86HIS A 100ARG A 104PRO A 105GLN A 116 | None | 0.75A | 2xpvA-4d5cA:26.9 | 2xpvA-4d5cA:59.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqd | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | SER A 199ARG A 232THR A 201VAL A 204ILE A 162 | None | 1.28A | 2xpvA-4dqdA:undetectable | 2xpvA-4dqdA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ev4 | CARBAPENEM-HYDROLIZING BETA-LACTAMASESFC-1 (Serratiafonticola) |
PF13354(Beta-lactamase2) | 5 | SER A 289ASN A 291THR A 29VAL A 28GLN A 24 | EDO A 402 (-2.5A)NoneEDO A 402 ( 4.7A)NoneNone | 1.47A | 2xpvA-4ev4A:undetectable | 2xpvA-4ev4A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kkm | POLYPRENYLSYNTHETASE (Zymomonasmobilis) |
PF00348(polyprenyl_synt) | 5 | PHE A 189ARG A 48THR A 57VAL A 54ILE A 75 | None | 1.48A | 2xpvA-4kkmA:2.8 | 2xpvA-4kkmA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofq | PUTATIVE CELLSURFACE PROTEIN (Streptococcuspyogenes) |
PF16364(Antigen_C) | 5 | PRO A1083THR A1130VAL A1027ILE A1133SER A1079 | None | 1.40A | 2xpvA-4ofqA:undetectable | 2xpvA-4ofqA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj2 | AQUAPORIN-2 (Homo sapiens) |
PF00230(MIP) | 5 | ASN X 68HIS X 201PRO X 191VAL X 24SER X 182 | None | 1.43A | 2xpvA-4oj2X:1.8 | 2xpvA-4oj2X:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p42 | EXTENDEDSYNAPTOTAGMIN-2 (Homo sapiens) |
PF00168(C2)PF17047(SMP_LBD) | 5 | SER A 612ARG A 548PRO A 532VAL A 576ILE A 618 | None | 1.41A | 2xpvA-4p42A:undetectable | 2xpvA-4p42A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 5 | ASN A 493ARG A 447PRO A 469THR A 466VAL A 467 | None | 1.03A | 2xpvA-4qjyA:undetectable | 2xpvA-4qjyA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ytw | MITOCHONDRIALDISTRIBUTION ANDMORPHOLOGY PROTEIN35PROTEIN UPS1,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF04707(PRELI)PF05254(UPF0203) | 5 | SER B 41ASN B 43PRO A 74THR B 53VAL B 81 | None | 1.38A | 2xpvA-4ytwB:undetectable | 2xpvA-4ytwB:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zht | BIFUNCTIONALUDP-N-ACETYLGLUCOSAMINE2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE (Homo sapiens) |
PF02350(Epimerase_2) | 5 | HIS A 167SER A 163HIS A 148THR A 161ILE A 178 | None | 1.37A | 2xpvA-4zhtA:undetectable | 2xpvA-4zhtA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cjf | CARBONIC ANHYDRASE14 (Homo sapiens) |
PF00194(Carb_anhydrase) | 5 | PHE A 260ARG A 215THR A 210VAL A 211ILE A 33 | None | 1.17A | 2xpvA-5cjfA:undetectable | 2xpvA-5cjfA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnb | POLY(A) RNAPOLYMERASE GLD-2RNP (RRM RNA BINDINGDOMAIN) CONTAINING (Caenorhabditiselegans) |
PF03828(PAP_assoc)no annotation | 5 | SER A 595ASN A 598PHE A 600ILE E 214SER A 687 | SO4 A1001 ( 2.4A)EDO A1005 (-3.7A)NoneNoneNone | 1.32A | 2xpvA-5jnbA:undetectable | 2xpvA-5jnbA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koa | CELL DIVISIONPROTEIN ZAPD (Escherichiacoli) |
PF07072(ZapD) | 5 | SER A 209PHE A 242ARG A 225VAL A 236SER A 186 | None | 1.50A | 2xpvA-5koaA:undetectable | 2xpvA-5koaA:22.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 5 | HIS A 64SER A 67ASN A 82HIS A 100ILE A 137 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A) MG A 302 ( 3.2A)TDC A 301 ( 4.5A) | 1.46A | 2xpvA-5mruA:24.0 | 2xpvA-5mruA:47.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 9 | HIS A 64SER A 67ASN A 82PHE A 86HIS A 100ARG A 104PRO A 105THR A 112GLN A 116 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A)TDC A 301 (-3.3A) MG A 302 ( 3.2A)TDC A 301 (-4.0A)TDC A 301 (-4.5A)NoneTDC A 301 (-2.8A) | 0.69A | 2xpvA-5mruA:24.0 | 2xpvA-5mruA:47.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 9 | HIS A 64SER A 67ASN A 82PHE A 86HIS A 100PRO A 105THR A 112GLN A 116SER A 138 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.2A)TDC A 301 (-3.3A) MG A 302 ( 3.2A)TDC A 301 (-4.5A)NoneTDC A 301 (-2.8A)TDC A 301 ( 3.7A) | 0.77A | 2xpvA-5mruA:24.0 | 2xpvA-5mruA:47.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odo | ISOMERASE (Rhodococcuserythropolis) |
no annotation | 5 | HIS A 401HIS A 399ARG A 76ILE A 233SER A 225 | NoneNoneFMT A 607 (-3.6A)NoneNone | 1.26A | 2xpvA-5odoA:undetectable | 2xpvA-5odoA:17.42 |