SIMILAR PATTERNS OF AMINO ACIDS FOR 2XPV_A_MIYA1209

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
5 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
None
1.42A 2xpvA-1gkrA:
0.0
2xpvA-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd1 HYPOTHETICAL 13.9
KDA PROTEIN IN
FCY2-PET117
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF01042
(Ribonuc_L-PSP)
5 SER A  70
ARG A 105
PRO A 103
VAL A  74
ILE A  60
None
1.34A 2xpvA-1jd1A:
undetectable
2xpvA-1jd1A:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)


(Escherichia
coli)
PF00440
(TetR_N)
PF02909
(TetR_C)
9 HIS A  64
ASN A  82
PHE A  86
HIS A 100
THR A 112
VAL A 113
GLN A 116
ILE A 134
SER A 138
None
None
None
IMD  A   1 (-4.0A)
None
None
None
None
None
0.64A 2xpvA-1qpiA:
25.6
2xpvA-1qpiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)


(Escherichia
coli)
PF00440
(TetR_N)
PF02909
(TetR_C)
8 HIS A  64
SER A  67
ASN A  82
PHE A  86
THR A 112
VAL A 113
GLN A 116
ILE A 134
None
0.61A 2xpvA-1qpiA:
25.6
2xpvA-1qpiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN


(Salmonella
enterica)
PF13407
(Peripla_BP_4)
5 SER A 305
PRO A 325
THR A 303
VAL A 302
ILE A 128
None
1.23A 2xpvA-1tjyA:
0.2
2xpvA-1tjyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR


(Geobacillus
stearothermophilus)
PF12146
(Hydrolase_4)
5 HIS A 223
SER A  94
VAL A  98
ILE A 204
SER A 200
4PA  A 701 (-4.4A)
4PA  A 701 (-1.4A)
None
None
None
1.40A 2xpvA-1tqhA:
undetectable
2xpvA-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811


(Sulfurisphaera
tokodaii)
PF01042
(Ribonuc_L-PSP)
5 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
None
1.32A 2xpvA-1x25A:
undetectable
2xpvA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae)
PF01593
(Amino_oxidase)
5 ARG A 447
THR A 252
VAL A 253
ILE A 272
SER A 261
None
FAD  A 803 (-4.6A)
FAD  A 803 (-4.1A)
None
None
1.45A 2xpvA-1yy5A:
undetectable
2xpvA-1yy5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 SER A1070
ASN A1112
THR A1119
VAL A1117
SER A1041
None
1.36A 2xpvA-2boaA:
undetectable
2xpvA-2boaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis)
PF01979
(Amidohydro_1)
5 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
1.15A 2xpvA-2icsA:
0.3
2xpvA-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE


(Vitis vinifera)
PF01370
(Epimerase)
5 SER A 128
THR A 131
VAL A 132
ILE A 252
SER A 254
MYC  A1342 ( 2.2A)
None
None
None
None
1.35A 2xpvA-2iodA:
undetectable
2xpvA-2iodA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens)
PF00246
(Peptidase_M14)
5 SER A  70
ASN A 112
THR A 119
VAL A 117
SER A  41
None
1.37A 2xpvA-2pcuA:
0.6
2xpvA-2pcuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 SER A 269
ARG A 296
THR A 316
VAL A 315
ILE A 311
None
1.45A 2xpvA-2vd9A:
undetectable
2xpvA-2vd9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
5 SER A 278
ASN A 279
HIS A 164
VAL A 217
ILE A 288
None
1.45A 2xpvA-3ee4A:
2.1
2xpvA-3ee4A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
5 HIS A  63
ASN A  82
PHE A  86
HIS A 100
VAL A 112
None
0.81A 2xpvA-3fiwA:
17.3
2xpvA-3fiwA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Porphyromonas
gingivalis)
PF00155
(Aminotran_1_2)
5 ASN A 140
PHE A  99
PRO A 202
THR A  22
VAL A  24
None
1.49A 2xpvA-3fkdA:
undetectable
2xpvA-3fkdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4


(Thermus
thermophilus)
PF00346
(Complex1_49kDa)
5 HIS 4  89
ASN 4 121
HIS 4 129
THR 4 346
SER 4 286
None
1.26A 2xpvA-3i9v4:
1.2
2xpvA-3i9v4:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP2
PROTEIN VP3


(Enterovirus B)
PF00073
(Rhv)
5 HIS C 207
PRO C 119
VAL A 187
ILE B  36
SER C 198
None
1.44A 2xpvA-3j2jC:
undetectable
2xpvA-3j2jC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN


(Homo sapiens)
PF07686
(V-set)
5 SER A  69
ASN A  68
VAL A  74
GLN A 124
ILE A  46
None
1.33A 2xpvA-3kg5A:
undetectable
2xpvA-3kg5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Yersinia
enterocolitica)
PF07071
(KDGP_aldolase)
5 SER A 102
ARG A  75
VAL A  95
GLN A  94
SER A  41
None
1.46A 2xpvA-3lm7A:
undetectable
2xpvA-3lm7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN


(Homo sapiens)
PF13927
(Ig_3)
5 HIS B  32
SER B 103
ARG B  13
PRO B  28
VAL B 105
None
1.39A 2xpvA-3o4oB:
undetectable
2xpvA-3o4oB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor)
PF01244
(Peptidase_M19)
5 HIS A 302
SER A 214
ASN A 224
ARG A 291
VAL A 245
None
1.34A 2xpvA-3s2jA:
undetectable
2xpvA-3s2jA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 ARG A 401
THR A 455
GLN A 458
ILE A 428
SER A 408
None
1.37A 2xpvA-3u7uA:
undetectable
2xpvA-3u7uA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster)
PF00028
(Cadherin)
5 PHE A 714
HIS A 721
ARG A 745
THR A 696
ILE A 660
None
1.48A 2xpvA-3ubgA:
undetectable
2xpvA-3ubgA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0


(Escherichia
coli)
PF00440
(TetR_N)
PF02909
(TetR_C)
7 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
0.43A 2xpvA-4ac0A:
26.5
2xpvA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0


(Escherichia
coli)
PF00440
(TetR_N)
PF02909
(TetR_C)
6 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
0.86A 2xpvA-4ac0A:
26.5
2xpvA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR


(Proteus
mirabilis)
PF00440
(TetR_N)
PF02909
(TetR_C)
7 HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
THR A 112
GLN A 116
None
0.79A 2xpvA-4d5cA:
26.9
2xpvA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR


(Proteus
mirabilis)
PF00440
(TetR_N)
PF02909
(TetR_C)
7 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
None
0.75A 2xpvA-4d5cA:
26.9
2xpvA-4d5cA:
59.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
5 SER A 199
ARG A 232
THR A 201
VAL A 204
ILE A 162
None
1.28A 2xpvA-4dqdA:
undetectable
2xpvA-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1


(Serratia
fonticola)
PF13354
(Beta-lactamase2)
5 SER A 289
ASN A 291
THR A  29
VAL A  28
GLN A  24
EDO  A 402 (-2.5A)
None
EDO  A 402 ( 4.7A)
None
None
1.47A 2xpvA-4ev4A:
undetectable
2xpvA-4ev4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE


(Zymomonas
mobilis)
PF00348
(polyprenyl_synt)
5 PHE A 189
ARG A  48
THR A  57
VAL A  54
ILE A  75
None
1.48A 2xpvA-4kkmA:
2.8
2xpvA-4kkmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN


(Streptococcus
pyogenes)
PF16364
(Antigen_C)
5 PRO A1083
THR A1130
VAL A1027
ILE A1133
SER A1079
None
1.40A 2xpvA-4ofqA:
undetectable
2xpvA-4ofqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens)
PF00230
(MIP)
5 ASN X  68
HIS X 201
PRO X 191
VAL X  24
SER X 182
None
1.43A 2xpvA-4oj2X:
1.8
2xpvA-4oj2X:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2


(Homo sapiens)
PF00168
(C2)
PF17047
(SMP_LBD)
5 SER A 612
ARG A 548
PRO A 532
VAL A 576
ILE A 618
None
1.41A 2xpvA-4p42A:
undetectable
2xpvA-4p42A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE


(Geobacillus
stearothermophilus)
PF07944
(Glyco_hydro_127)
5 ASN A 493
ARG A 447
PRO A 469
THR A 466
VAL A 467
None
1.03A 2xpvA-4qjyA:
undetectable
2xpvA-4qjyA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF04707
(PRELI)
PF05254
(UPF0203)
5 SER B  41
ASN B  43
PRO A  74
THR B  53
VAL B  81
None
1.38A 2xpvA-4ytwB:
undetectable
2xpvA-4ytwB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE


(Homo sapiens)
PF02350
(Epimerase_2)
5 HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
None
1.37A 2xpvA-4zhtA:
undetectable
2xpvA-4zhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
5 PHE A 260
ARG A 215
THR A 210
VAL A 211
ILE A  33
None
1.17A 2xpvA-5cjfA:
undetectable
2xpvA-5cjfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING


(Caenorhabditis
elegans)
PF03828
(PAP_assoc)
no annotation
5 SER A 595
ASN A 598
PHE A 600
ILE E 214
SER A 687
SO4  A1001 ( 2.4A)
EDO  A1005 (-3.7A)
None
None
None
1.32A 2xpvA-5jnbA:
undetectable
2xpvA-5jnbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD


(Escherichia
coli)
PF07072
(ZapD)
5 SER A 209
PHE A 242
ARG A 225
VAL A 236
SER A 186
None
1.50A 2xpvA-5koaA:
undetectable
2xpvA-5koaA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mru TETRACYCLINE
REPRESSOR, CLASS A


(Pseudomonas sp.)
no annotation 5 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
1.46A 2xpvA-5mruA:
24.0
2xpvA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mru TETRACYCLINE
REPRESSOR, CLASS A


(Pseudomonas sp.)
no annotation 9 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
0.69A 2xpvA-5mruA:
24.0
2xpvA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mru TETRACYCLINE
REPRESSOR, CLASS A


(Pseudomonas sp.)
no annotation 9 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
0.77A 2xpvA-5mruA:
24.0
2xpvA-5mruA:
47.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis)
no annotation 5 HIS A 401
HIS A 399
ARG A  76
ILE A 233
SER A 225
None
None
FMT  A 607 (-3.6A)
None
None
1.26A 2xpvA-5odoA:
undetectable
2xpvA-5odoA:
17.42