SIMILAR PATTERNS OF AMINO ACIDS FOR 2XP2_A_VGHA9000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 2xp2A-1k9aA:
32.9		 2xp2A-1k9aA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
ALA A 606
MET A 657
GLY A 660
LEU A 731
ASP A 742
 None
 0.68A 2xp2A-1lufA:
32.7		 2xp2A-1lufA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.58A 2xp2A-1opkA:
30.8		 2xp2A-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
VAL A  86
ALA A  99
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.46A 2xp2A-1s9iA:
8.1		 2xp2A-1s9iA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.84A 2xp2A-1u59A:
32.0		 2xp2A-1u59A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.72A 2xp2A-1u5qA:
8.0		 2xp2A-1u5qA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.83A 2xp2A-1zltA:
21.4		 2xp2A-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.72A 2xp2A-2bujA:
23.9		 2xp2A-2bujA:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
MET X  85
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.76A 2xp2A-2dq7X:
31.7		 2xp2A-2dq7X:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
MET A  96
LEU A 144
ASP A 155
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
 0.75A 2xp2A-2f9gA:
22.6		 2xp2A-2f9gA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
None
STU  A 400 (-3.6A)
 0.68A 2xp2A-2gcdA:
8.7		 2xp2A-2gcdA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.67A 2xp2A-2h8hA:
30.0		 2xp2A-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 2xp2A-2hckA:
29.4		 2xp2A-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.49A 2xp2A-2hk5A:
32.0		 2xp2A-2hk5A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
ALA A 269
MET A 318
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.85A 2xp2A-2hz0A:
31.2		 2xp2A-2hz0A:
37.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.68A 2xp2A-2j0jA:
32.9		 2xp2A-2j0jA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.81A 2xp2A-2og8A:
30.5		 2xp2A-2og8A:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLY A 669
LEU A 785
GLY A 795
ASP A 796
 None
 0.76A 2xp2A-2ogvA:
30.4		 2xp2A-2ogvA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.65A 2xp2A-2phkA:
23.0		 2xp2A-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  21
ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.72A 2xp2A-2pmiA:
21.5		 2xp2A-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.50A 2xp2A-2qkwB:
6.8		 2xp2A-2qkwB:
27.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.47A 2xp2A-2qobA:
34.3		 2xp2A-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 689
ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.37A 2xp2A-2r2pA:
34.4		 2xp2A-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.58A 2xp2A-2r4bA:
30.4		 2xp2A-2r4bA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
MET A 156
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.85A 2xp2A-2v55A:
19.6		 2xp2A-2v55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 226
VAL A 234
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.78A 2xp2A-2xk9A:
21.7		 2xp2A-2xk9A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
None
 0.63A 2xp2A-2xyuA:
33.8		 2xp2A-2xyuA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.87A 2xp2A-2z7rA:
8.2		 2xp2A-2z7rA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
MET A1079
GLY A1082
GLY A1149
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-3.3A)
None
None
 0.55A 2xp2A-2z8cA:
10.8		 2xp2A-2z8cA:
44.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
ALA A 273
MET A 322
GLY A 325
LEU A 374
ASP A 385
 None
 0.50A 2xp2A-2zv7A:
32.8		 2xp2A-2zv7A:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 2xp2A-3d7uA:
33.2		 2xp2A-3d7uA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 431
VAL A 439
ALA A 455
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
None
 0.76A 2xp2A-3fzpA:
13.9		 2xp2A-3fzpA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
 None
 0.72A 2xp2A-3i6uA:
6.6		 2xp2A-3i6uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
VAL A 234
ALA A 247
LEU A 301
MET A 304
LEU A 354
 None
 0.63A 2xp2A-3i6uA:
6.6		 2xp2A-3i6uA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.69A 2xp2A-3kulA:
33.1		 2xp2A-3kulA:
32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ALA A 700
LEU A 745
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 ( 4.4A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.42A 2xp2A-3lj0A:
7.5		 2xp2A-3lj0A:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1005
VAL A1013
ALA A1031
MET A1082
GLY A1085
GLY A1152
 None
None
None
None
None
CCX  A   1 (-3.6A)
 0.51A 2xp2A-3lw0A:
30.1		 2xp2A-3lw0A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1005
VAL A1013
ALA A1031
MET A1082
GLY A1152
ASP A1153
 None
None
None
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
 0.79A 2xp2A-3lw0A:
30.1		 2xp2A-3lw0A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
ALA A 109
GLY A 165
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
SO4  A   5 ( 4.5A)
 0.74A 2xp2A-3nuuA:
6.4		 2xp2A-3nuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
ALA A 109
LEU A 159
GLY A 165
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
JOZ  A 361 (-4.0A)
None
SO4  A   5 ( 4.5A)
 0.79A 2xp2A-3nuuA:
6.4		 2xp2A-3nuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 2xp2A-3nyoA:
7.5		 2xp2A-3nyoA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.54A 2xp2A-3pp0A:
31.9		 2xp2A-3pp0A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
 None
 0.50A 2xp2A-3ulzA:
5.7		 2xp2A-3ulzA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.62A 2xp2A-3v5qA:
13.6		 2xp2A-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.34A 2xp2A-3v5qA:
13.6		 2xp2A-3v5qA:
39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
ALA A 160
LEU A 210
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 ( 4.8A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.72A 2xp2A-3w18A:
22.1		 2xp2A-3w18A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.45A 2xp2A-3wigA:
8.3		 2xp2A-3wigA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
 0.35A 2xp2A-3zbfA:
34.7		 2xp2A-3zbfA:
48.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.39A 2xp2A-3zfxA:
34.8		 2xp2A-3zfxA:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
ALA A 104
LEU A 154
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.61A 2xp2A-4af3A:
20.0		 2xp2A-4af3A:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.66A 2xp2A-4at3A:
30.9		 2xp2A-4at3A:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.37A 2xp2A-4aw5A:
14.1		 2xp2A-4aw5A:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  69
ALA A  82
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.76A 2xp2A-4b99A:
6.5		 2xp2A-4b99A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 2xp2A-4crsA:
8.2		 2xp2A-4crsA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
 None
 0.65A 2xp2A-4f0iA:
30.7		 2xp2A-4f0iA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.50A 2xp2A-4f4pA:
31.6		 2xp2A-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
 0.88A 2xp2A-4feqA:
28.1		 2xp2A-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.40A 2xp2A-4fodA:
17.7		 2xp2A-4fodA:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
ALA A 880
GLY A 935
LEU A 983
GLY A 993
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.5A)
 0.64A 2xp2A-4gl9A:
29.2		 2xp2A-4gl9A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
ALA A 880
GLY A 935
LEU A 983
GLY A 993
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 0.59A 2xp2A-4gl9A:
29.2		 2xp2A-4gl9A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
GLY A 269
 None
 0.38A 2xp2A-4hzsA:
28.8		 2xp2A-4hzsA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.57A 2xp2A-4id7A:
31.2		 2xp2A-4id7A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 LEU A 258
VAL A 266
ALA A 279
LEU A 416
GLY A 426
ASP A 427
 ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
 0.60A 2xp2A-4jrnA:
19.9		 2xp2A-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.78A 2xp2A-4jxfA:
19.0		 2xp2A-4jxfA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.45A 2xp2A-4k11A:
30.0		 2xp2A-4k11A:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
VAL A 486
ALA A 506
GLY A 561
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.62A 2xp2A-4k33A:
32.7		 2xp2A-4k33A:
38.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.38A 2xp2A-4lggA:
30.3		 2xp2A-4lggA:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		6 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.84A 2xp2A-4mk0A:
9.0		 2xp2A-4mk0A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.70A 2xp2A-4o38A:
20.8		 2xp2A-4o38A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
ALA A 928
GLY A 984
LEU A1030
GLY A1040
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.72A 2xp2A-4oliA:
28.6		 2xp2A-4oliA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 627
ALA A 644
MET A 695
GLY A 698
LEU A 746
ASP A 757
 None
 0.61A 2xp2A-4p2kA:
35.0		 2xp2A-4p2kA:
36.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.63A 2xp2A-4tnbA:
7.9		 2xp2A-4tnbA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.44A 2xp2A-4ueuA:
32.7		 2xp2A-4ueuA:
40.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 138
ALA A 149
LEU A 200
GLY A 206
LEU A 270
ASP A 289
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
None
AGS  A1438 (-4.7A)
AGS  A1438 (-2.7A)
 0.67A 2xp2A-4uyaA:
27.3		 2xp2A-4uyaA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.57A 2xp2A-4wboA:
23.5		 2xp2A-4wboA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.79A 2xp2A-4wsqA:
23.5		 2xp2A-4wsqA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ALA B 288
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.41A 2xp2A-4xeyB:
13.4		 2xp2A-4xeyB:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 None
 0.71A 2xp2A-4xi2A:
31.2		 2xp2A-4xi2A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.34A 2xp2A-4y93A:
31.4		 2xp2A-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.56A 2xp2A-4yhjA:
21.4		 2xp2A-4yhjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
AN2  A 601 (-3.0A)
 0.75A 2xp2A-4yhjA:
21.4		 2xp2A-4yhjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.89A 2xp2A-5eykA:
24.8		 2xp2A-5eykA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.70A 2xp2A-5f1zA:
28.2		 2xp2A-5f1zA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
LEU A1157
MET A1160
GLY A1163
ASP A1222
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
None
 0.62A 2xp2A-5horA:
13.6		 2xp2A-5horA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.77A 2xp2A-5hu3A:
7.4		 2xp2A-5hu3A:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.36A 2xp2A-5j9zA:
32.9		 2xp2A-5j9zA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
GLY A 471
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.65A 2xp2A-5jznA:
7.7		 2xp2A-5jznA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.55A 2xp2A-5lpyA:
23.5		 2xp2A-5lpyA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.45A 2xp2A-5lpzA:
6.4		 2xp2A-5lpzA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.41A 2xp2A-5td2A:
29.4		 2xp2A-5td2A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
VAL A 550
ALA A 565
LEU A 620
MET A 623
GLY A 626
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
 0.51A 2xp2A-5u6bA:
30.5		 2xp2A-5u6bA:
40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.60A 2xp2A-5u7qA:
20.7		 2xp2A-5u7qA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 0.78A 2xp2A-5uuuA:
22.5		 2xp2A-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 2xp2A-5w5jA:
23.1		 2xp2A-5w5jA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 VAL A  36
ALA A  49
MET A  99
GLY A 102
LEU A 150
ASP A 161
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 0.50A 2xp2A-5wnmA:
28.8		 2xp2A-5wnmA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.60A 2xp2A-6c7yA:
9.3		 2xp2A-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
VAL A 283
ALA A 296
GLY A 349
GLY A 410
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.1A)
MG  A 602 ( 2.6A)
 0.78A 2xp2A-6cthA:
22.6		 2xp2A-6cthA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.85A 2xp2A-6cz4A:
17.6		 2xp2A-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 VAL A 200
ALA A 211
MET A 265
GLY A 268
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.51A 2xp2A-6f3dA:
24.5		 2xp2A-6f3dA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
VAL U  28
ALA U  42
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.64A 2xp2A-6fdyU:
5.4		 2xp2A-6fdyU:
undetectable