SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN7_A_T44A1355_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		5 LEU A  84
LEU A  39
SER A 422
LEU A 421
LEU A  42
 None
 1.02A 2xn7A-1btcA:
0.0
2xn7B-1btcA:
0.0		 2xn7A-1btcA:
22.35
2xn7B-1btcA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ALA A 311
GLN A 360
LEU A 308
ASN A 300
LEU A 356
 None
 0.98A 2xn7A-1dj2A:
0.0
2xn7B-1dj2A:
0.0		 2xn7A-1dj2A:
21.79
2xn7B-1dj2A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		6 LEU A  42
LEU A  16
LEU A  20
LEU A 100
ARG A 104
ARG A 103
 None
 1.38A 2xn7A-1drtA:
0.0
2xn7B-1drtA:
0.0		 2xn7A-1drtA:
21.15
2xn7B-1drtA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4w ANTIBODY S-20-4, FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  86
LEU H 113
SER H  21
LEU H  20
LEU H  18
 None
 1.08A 2xn7A-1f4wH:
0.8
2xn7B-1f4wH:
0.0		 2xn7A-1f4wH:
21.61
2xn7B-1f4wH:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		5 LEU A 263
SER A 283
LEU A 284
LEU A 165
ARG A 161
 None
None
None
None
UDP  A 337 ( 4.5A)
 1.12A 2xn7A-1fggA:
0.1
2xn7B-1fggA:
0.0		 2xn7A-1fggA:
20.85
2xn7B-1fggA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.13A 2xn7A-1g8xA:
0.0
2xn7B-1g8xA:
0.0		 2xn7A-1g8xA:
16.63
2xn7B-1g8xA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ju5 CRK

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A  87
LEU A 100
SER A  50
LEU A  49
LEU A  97
 None
 1.13A 2xn7A-1ju5A:
undetectable
2xn7B-1ju5A:
0.0		 2xn7A-1ju5A:
13.58
2xn7B-1ju5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 403
LEU A 436
LEU A 365
LEU A 400
LEU A 432
 None
 1.11A 2xn7A-1jx2A:
0.0
2xn7B-1jx2A:
0.0		 2xn7A-1jx2A:
15.27
2xn7B-1jx2A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 ALA N 209
GLN N 267
LEU N 236
LEU N 177
ARG N 175
 None
 1.07A 2xn7A-1k7sN:
0.0
2xn7B-1k7sN:
0.0		 2xn7A-1k7sN:
24.59
2xn7B-1k7sN:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A  54
LEU A  50
LEU A  33
LEU A  85
ARG A  84
 None
 1.13A 2xn7A-1nneA:
undetectable
2xn7B-1nneA:
undetectable		 2xn7A-1nneA:
17.06
2xn7B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.09A 2xn7A-1p88A:
undetectable
2xn7B-1p88A:
undetectable		 2xn7A-1p88A:
21.57
2xn7B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA

(Escherichia
coli) 		PF05866
(RusA) 		5 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.15A 2xn7A-1q8rA:
undetectable
2xn7B-1q8rA:
undetectable		 2xn7A-1q8rA:
14.76
2xn7B-1q8rA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		6 LEU A 712
LEU A 625
SER A 638
LEU A 639
LEU A 735
ARG A 732
 None
 1.42A 2xn7A-1suvA:
undetectable
2xn7B-1suvA:
undetectable		 2xn7A-1suvA:
20.19
2xn7B-1suvA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		5 ALA A 111
LEU A 147
LEU A 135
SER A 103
LEU A 138
 None
 1.13A 2xn7A-1vd6A:
undetectable
2xn7B-1vd6A:
undetectable		 2xn7A-1vd6A:
20.17
2xn7B-1vd6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		5 LEU A 455
LEU A 377
SER A 399
LEU A 400
LEU A 451
 None
 1.12A 2xn7A-1w2dA:
undetectable
2xn7B-1w2dA:
undetectable		 2xn7A-1w2dA:
20.34
2xn7B-1w2dA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyn CALPONIN-2

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  29
LEU A  55
SER A 111
LEU A 115
LEU A  51
 None
 1.08A 2xn7A-1wynA:
undetectable
2xn7B-1wynA:
undetectable		 2xn7A-1wynA:
19.71
2xn7B-1wynA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		6 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
 None
 1.16A 2xn7A-1xkwA:
undetectable
2xn7B-1xkwA:
undetectable		 2xn7A-1xkwA:
18.01
2xn7B-1xkwA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 406
LEU A 397
SER A 447
LEU A 450
LEU A 423
 None
 1.11A 2xn7A-2a8xA:
undetectable
2xn7B-2a8xA:
undetectable		 2xn7A-2a8xA:
21.53
2xn7B-2a8xA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.02A 2xn7A-2braA:
0.4
2xn7B-2braA:
undetectable		 2xn7A-2braA:
21.89
2xn7B-2braA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ALA A  80
LEU A  92
LEU A  73
LEU A  13
LEU A  88
 None
 0.95A 2xn7A-2dwuA:
undetectable
2xn7B-2dwuA:
undetectable		 2xn7A-2dwuA:
20.61
2xn7B-2dwuA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		5 LEU A 270
LEU A 274
LEU A 249
LEU A 259
ARG A 255
 None
 1.11A 2xn7A-2e0zA:
undetectable
2xn7B-2e0zA:
undetectable		 2xn7A-2e0zA:
22.98
2xn7B-2e0zA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  83
LEU A  88
LEU A  58
LEU A 198
ARG A 197
 None
 1.02A 2xn7A-2eq9A:
undetectable
2xn7B-2eq9A:
undetectable		 2xn7A-2eq9A:
22.57
2xn7B-2eq9A:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A 154
LEU A 293
SER A 113
LEU A 123
ARG A 221
 None
None
STU  A 400 ( 4.7A)
None
None
 1.09A 2xn7A-2gcdA:
undetectable
2xn7B-2gcdA:
undetectable		 2xn7A-2gcdA:
22.13
2xn7B-2gcdA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.16A 2xn7A-2hxoA:
undetectable
2xn7B-2hxoA:
undetectable		 2xn7A-2hxoA:
20.93
2xn7B-2hxoA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa THIOREDOXIN

(Bacillus
subtilis) 		PF00085
(Thioredoxin) 		5 LEU A  42
LEU A  39
SER A  87
LEU A  75
LEU A  96
 None
 1.14A 2xn7A-2ipaA:
undetectable
2xn7B-2ipaA:
undetectable		 2xn7A-2ipaA:
13.71
2xn7B-2ipaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqc FANCONI ANEMIA GROUP
F PROTEIN

(Homo sapiens) 		PF11107
(FANCF) 		5 ALA A 257
LEU A 275
SER A 313
LEU A 314
LEU A 278
 None
 1.01A 2xn7A-2iqcA:
undetectable
2xn7B-2iqcA:
undetectable		 2xn7A-2iqcA:
21.41
2xn7B-2iqcA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		5 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.15A 2xn7A-2is8A:
undetectable
2xn7B-2is8A:
undetectable		 2xn7A-2is8A:
19.12
2xn7B-2is8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 221
LEU A 218
ASN A 197
LEU A 331
ARG A 341
 None
 1.01A 2xn7A-2iw1A:
undetectable
2xn7B-2iw1A:
undetectable		 2xn7A-2iw1A:
20.34
2xn7B-2iw1A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		5 ALA A 180
LEU A 141
LEU A 162
LEU A 177
LEU A 136
 None
 1.10A 2xn7A-2kn6A:
undetectable
2xn7B-2kn6A:
undetectable		 2xn7A-2kn6A:
19.65
2xn7B-2kn6A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		6 LEU A  24
LEU A  58
SER A 113
LEU A 117
ASN A 118
LEU A  54
 None
 1.14A 2xn7A-2l3gA:
undetectable
2xn7B-2l3gA:
undetectable		 2xn7A-2l3gA:
15.63
2xn7B-2l3gA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 232
LEU A 100
SER A 242
LEU A 239
ARG A 237
 None
 1.04A 2xn7A-2nmpA:
undetectable
2xn7B-2nmpA:
undetectable		 2xn7A-2nmpA:
20.79
2xn7B-2nmpA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLN A 475
LEU A 531
LEU A 483
SER A 491
LEU A 399
 None
 1.09A 2xn7A-2pjrA:
undetectable
2xn7B-2pjrA:
undetectable		 2xn7A-2pjrA:
21.00
2xn7B-2pjrA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF02542
(YgbB) 		5 ALA A 125
LEU A  43
LEU A  97
LEU A 119
ARG A 116
 None
 1.13A 2xn7A-2pmpA:
undetectable
2xn7B-2pmpA:
undetectable		 2xn7A-2pmpA:
20.14
2xn7B-2pmpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 0.93A 2xn7A-2qfqA:
undetectable
2xn7B-2qfqA:
undetectable		 2xn7A-2qfqA:
22.84
2xn7B-2qfqA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		5 LEU A  97
LEU A 147
LEU A 164
LEU A  48
ARG A 163
 None
 1.08A 2xn7A-2r9qA:
undetectable
2xn7B-2r9qA:
undetectable		 2xn7A-2r9qA:
21.86
2xn7B-2r9qA:
8.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 ALA A  27
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.33A 2xn7A-2xn6A:
53.8
2xn7B-2xn6A:
undetectable		 2xn7A-2xn6A:
99.71
2xn7B-2xn6A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		5 LEU A 197
LEU A 221
LEU A 187
LEU A 158
ARG A 104
 None
 1.07A 2xn7A-3ay3A:
undetectable
2xn7B-3ay3A:
undetectable		 2xn7A-3ay3A:
22.01
2xn7B-3ay3A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.06A 2xn7A-3dl1A:
undetectable
2xn7B-3dl1A:
undetectable		 2xn7A-3dl1A:
20.51
2xn7B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 ALA A 711
LEU A 609
LEU A 777
LEU A 707
ARG A 709
 None
 1.07A 2xn7A-3g06A:
undetectable
2xn7B-3g06A:
undetectable		 2xn7A-3g06A:
21.02
2xn7B-3g06A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 264
LEU A 267
SER A 256
LEU A 257
LEU A 260
 None
 1.10A 2xn7A-3g06A:
undetectable
2xn7B-3g06A:
undetectable		 2xn7A-3g06A:
21.02
2xn7B-3g06A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 344
LEU A 347
SER A 336
LEU A 337
LEU A 340
 None
 1.14A 2xn7A-3g06A:
undetectable
2xn7B-3g06A:
undetectable		 2xn7A-3g06A:
21.02
2xn7B-3g06A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 364
LEU A 367
SER A 356
LEU A 357
LEU A 360
 None
 1.13A 2xn7A-3g06A:
undetectable
2xn7B-3g06A:
undetectable		 2xn7A-3g06A:
21.02
2xn7B-3g06A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ALA A 129
LEU A 109
LEU A 166
LEU A 115
ARG A 145
 None
 1.00A 2xn7A-3gzgA:
undetectable
2xn7B-3gzgA:
undetectable		 2xn7A-3gzgA:
22.82
2xn7B-3gzgA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Salmonella
enterica) 		PF02540
(NAD_synthase) 		5 LEU A 187
LEU A 195
SER A  60
LEU A  59
LEU A 184
 None
 1.12A 2xn7A-3hmqA:
undetectable
2xn7B-3hmqA:
undetectable		 2xn7A-3hmqA:
21.37
2xn7B-3hmqA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		5 ALA A  54
LEU A  64
LEU A 109
LEU A  95
LEU A  60
 None
 1.13A 2xn7A-3hoiA:
undetectable
2xn7B-3hoiA:
undetectable		 2xn7A-3hoiA:
20.11
2xn7B-3hoiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF16922
(SLD5_C) 		5 LEU D 174
SER D 155
LEU D 158
ASN D 162
LEU D 175
 None
 1.09A 2xn7A-3jc7D:
undetectable
2xn7B-3jc7D:
undetectable		 2xn7A-3jc7D:
20.74
2xn7B-3jc7D:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.08A 2xn7A-3lezA:
undetectable
2xn7B-3lezA:
undetectable		 2xn7A-3lezA:
20.17
2xn7B-3lezA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 228
LEU A 121
SER A 167
LEU A 166
LEU A 138
 None
 1.14A 2xn7A-3lm5A:
undetectable
2xn7B-3lm5A:
undetectable		 2xn7A-3lm5A:
20.87
2xn7B-3lm5A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 ALA X  94
LEU X  30
LEU X  47
ASN X  45
LEU X  34
 None
 1.13A 2xn7A-3m7mX:
undetectable
2xn7B-3m7mX:
undetectable		 2xn7A-3m7mX:
21.63
2xn7B-3m7mX:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 107
LEU A 110
LEU A 132
LEU A 307
ARG A 309
 None
 1.08A 2xn7A-3nwrA:
undetectable
2xn7B-3nwrA:
undetectable		 2xn7A-3nwrA:
21.52
2xn7B-3nwrA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05721
(PhyH) 		5 LEU A 237
LEU A 239
SER A   5
LEU A   4
LEU A  20
 None
 0.98A 2xn7A-3obzA:
undetectable
2xn7B-3obzA:
undetectable		 2xn7A-3obzA:
20.72
2xn7B-3obzA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 GLN A  16
LEU A  19
SER A 307
LEU A 328
LEU A 190
 None
 1.14A 2xn7A-3r9bA:
undetectable
2xn7B-3r9bA:
undetectable		 2xn7A-3r9bA:
22.73
2xn7B-3r9bA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 AGRIN

(Rattus
norvegicus) 		PF00054
(Laminin_G_1) 		5 ALA A1860
LEU A1920
LEU A1800
LEU A1824
LEU A1798
 None
 0.90A 2xn7A-3v65A:
undetectable
2xn7B-3v65A:
undetectable		 2xn7A-3v65A:
21.61
2xn7B-3v65A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A 251
LEU A 154
SER A 258
LEU A 230
LEU A 151
 None
 1.11A 2xn7A-3v9aA:
undetectable
2xn7B-3v9aA:
undetectable		 2xn7A-3v9aA:
21.89
2xn7B-3v9aA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 1.04A 2xn7A-3vkgA:
undetectable
2xn7B-3vkgA:
undetectable		 2xn7A-3vkgA:
7.81
2xn7B-3vkgA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		5 LEU A  69
LEU A  67
SER A  50
LEU A  51
LEU A  40
 None
 0.88A 2xn7A-3wyzA:
undetectable
2xn7B-3wyzA:
undetectable		 2xn7A-3wyzA:
22.25
2xn7B-3wyzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ALA A 259
LEU A 229
LEU A 216
LEU A 269
ARG A 267
 None
 1.12A 2xn7A-3zo9A:
undetectable
2xn7B-3zo9A:
undetectable		 2xn7A-3zo9A:
18.87
2xn7B-3zo9A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 408
LEU A 404
LEU A 526
LEU A 665
ARG A 518
 None
 0.97A 2xn7A-4bocA:
undetectable
2xn7B-4bocA:
undetectable		 2xn7A-4bocA:
14.11
2xn7B-4bocA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 751
LEU A 837
LEU A 880
LEU A 905
LEU A 833
 None
 1.11A 2xn7A-4ckrA:
undetectable
2xn7B-4ckrA:
undetectable		 2xn7A-4ckrA:
21.03
2xn7B-4ckrA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 342
LEU A 393
LEU A 363
SER A 346
LEU A 365
 None
 1.01A 2xn7A-4cvmA:
undetectable
2xn7B-4cvmA:
undetectable		 2xn7A-4cvmA:
20.44
2xn7B-4cvmA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.94A 2xn7A-4f1pA:
undetectable
2xn7B-4f1pA:
undetectable		 2xn7A-4f1pA:
22.77
2xn7B-4f1pA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		5 LEU A 185
LEU A 201
SER A 226
LEU A 225
LEU A 170
 None
 1.05A 2xn7A-4ftdA:
undetectable
2xn7B-4ftdA:
undetectable		 2xn7A-4ftdA:
23.28
2xn7B-4ftdA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 LEU A 296
LEU A 298
SER A 326
LEU A 346
LEU A 280
 None
 1.00A 2xn7A-4fwwA:
undetectable
2xn7B-4fwwA:
undetectable		 2xn7A-4fwwA:
20.48
2xn7B-4fwwA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdi IG HEAVY CHAIN V
REGION RF, IG
GAMMA-3 CHAIN C
REGION

(Mus musculus) 		no annotation 5 LEU H  86
LEU H 116
SER H  21
LEU H  20
LEU H  18
 None
 1.15A 2xn7A-4hdiH:
undetectable
2xn7B-4hdiH:
undetectable		 2xn7A-4hdiH:
22.16
2xn7B-4hdiH:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.13A 2xn7A-4izdA:
undetectable
2xn7B-4izdA:
undetectable		 2xn7A-4izdA:
22.10
2xn7B-4izdA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.02A 2xn7A-4ln1A:
undetectable
2xn7B-4ln1A:
undetectable		 2xn7A-4ln1A:
23.23
2xn7B-4ln1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 5 LEU A 238
LEU A 241
SER A 230
LEU A 231
LEU A 234
 None
 1.07A 2xn7A-4nkhA:
undetectable
2xn7B-4nkhA:
undetectable		 2xn7A-4nkhA:
22.22
2xn7B-4nkhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 295
LEU A 298
SER A 287
LEU A 288
LEU A 291
 None
 1.16A 2xn7A-4ow2A:
undetectable
2xn7B-4ow2A:
undetectable		 2xn7A-4ow2A:
23.44
2xn7B-4ow2A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 355
LEU A 358
SER A 347
LEU A 348
LEU A 351
 None
 1.12A 2xn7A-4ow2A:
undetectable
2xn7B-4ow2A:
undetectable		 2xn7A-4ow2A:
23.44
2xn7B-4ow2A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 415
LEU A 418
SER A 407
LEU A 408
LEU A 411
 None
 1.15A 2xn7A-4ow2A:
undetectable
2xn7B-4ow2A:
undetectable		 2xn7A-4ow2A:
23.44
2xn7B-4ow2A:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.14A 2xn7A-4pljA:
0.0
2xn7B-4pljA:
undetectable		 2xn7A-4pljA:
16.52
2xn7B-4pljA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
 None
 1.08A 2xn7A-4rxlA:
undetectable
2xn7B-4rxlA:
undetectable		 2xn7A-4rxlA:
22.07
2xn7B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.04A 2xn7A-4txkA:
undetectable
2xn7B-4txkA:
undetectable		 2xn7A-4txkA:
21.21
2xn7B-4txkA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xef PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF03623
(Focal_AT) 		5 LEU A 920
LEU A 917
SER A 980
LEU A 983
LEU A 887
 None
 1.07A 2xn7A-4xefA:
undetectable
2xn7B-4xefA:
undetectable		 2xn7A-4xefA:
19.83
2xn7B-4xefA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 ALA C 143
LEU C 240
LEU C 238
LEU C 223
LEU C 209
 None
 0.82A 2xn7A-4xgcC:
undetectable
2xn7B-4xgcC:
undetectable		 2xn7A-4xgcC:
22.32
2xn7B-4xgcC:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 5 LEU E 639
LEU E 635
SER E 521
LEU E 520
LEU E 558
 None
 1.13A 2xn7A-4xmmE:
undetectable
2xn7B-4xmmE:
undetectable		 2xn7A-4xmmE:
15.76
2xn7B-4xmmE:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 LEU A1423
LEU A1386
LEU A1413
LEU A1431
ARG A1175
 None
 0.93A 2xn7A-4ziuA:
undetectable
2xn7B-4ziuA:
undetectable		 2xn7A-4ziuA:
20.00
2xn7B-4ziuA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8

(Shigella
flexneri) 		PF12468
(TTSSLRR) 		5 LEU A  82
LEU A  75
LEU A  50
LEU A  61
ARG A  49
 None
 1.14A 2xn7A-5b0nA:
undetectable
2xn7B-5b0nA:
undetectable		 2xn7A-5b0nA:
19.61
2xn7B-5b0nA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 ALA A1050
LEU A 876
LEU A 879
LEU A1047
LEU A 893
 None
 1.11A 2xn7A-5b16A:
undetectable
2xn7B-5b16A:
undetectable		 2xn7A-5b16A:
14.90
2xn7B-5b16A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3n ANTI-H4K20ME1_SCFV

(Mus musculus) 		PF07686
(V-set) 		5 LEU A  88
LEU A 119
SER A  23
LEU A  22
LEU A  20
 None
 1.11A 2xn7A-5b3nA:
undetectable
2xn7B-5b3nA:
undetectable		 2xn7A-5b3nA:
20.60
2xn7B-5b3nA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.08A 2xn7A-5cioA:
undetectable
2xn7B-5cioA:
undetectable		 2xn7A-5cioA:
18.11
2xn7B-5cioA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H) 		5 ALA A 573
LEU A 509
LEU A 624
LEU A 570
LEU A 630
 None
 1.05A 2xn7A-5dmrA:
undetectable
2xn7B-5dmrA:
undetectable		 2xn7A-5dmrA:
21.85
2xn7B-5dmrA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo9 CG32791, ISOFORM A

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 LEU B 207
LEU B 209
SER B 239
LEU B 238
LEU B 165
 None
 1.08A 2xn7A-5eo9B:
undetectable
2xn7B-5eo9B:
undetectable		 2xn7A-5eo9B:
21.25
2xn7B-5eo9B:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fis EXD1

(Bombyx mori) 		PF01612
(DNA_pol_A_exo1) 		5 ALA B 116
LEU B 181
LEU B 162
SER B 136
LEU B 135
 None
 1.05A 2xn7A-5fisB:
undetectable
2xn7B-5fisB:
undetectable		 2xn7A-5fisB:
20.45
2xn7B-5fisB:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA C 163
LEU C 191
SER C 172
LEU C 175
LEU C  37
 None
 1.03A 2xn7A-5fmgC:
undetectable
2xn7B-5fmgC:
undetectable		 2xn7A-5fmgC:
21.85
2xn7B-5fmgC:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A 516
LEU A 534
SER A 490
LEU A 489
ARG A 482
 None
 1.12A 2xn7A-5h42A:
undetectable
2xn7B-5h42A:
undetectable		 2xn7A-5h42A:
15.81
2xn7B-5h42A:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		5 LEU A 893
LEU A 889
LEU A 946
ARG A 846
ARG A 841
 None
 0.99A 2xn7A-5hb3A:
undetectable
2xn7B-5hb3A:
undetectable		 2xn7A-5hb3A:
18.16
2xn7B-5hb3A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.12A 2xn7A-5it5F:
undetectable
2xn7B-5it5F:
undetectable		 2xn7A-5it5F:
21.25
2xn7B-5it5F:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.06A 2xn7A-5jjqA:
undetectable
2xn7B-5jjqA:
undetectable		 2xn7A-5jjqA:
20.77
2xn7B-5jjqA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		5 ALA A 102
LEU A 166
LEU A 162
LEU A  30
ARG A  26
 None
 1.10A 2xn7A-5kvkA:
undetectable
2xn7B-5kvkA:
undetectable		 2xn7A-5kvkA:
17.90
2xn7B-5kvkA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		5 LEU A 290
LEU A 292
SER A 321
LEU A 320
LEU A 259
 None
 1.11A 2xn7A-5lfrA:
undetectable
2xn7B-5lfrA:
undetectable		 2xn7A-5lfrA:
23.69
2xn7B-5lfrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		5 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.07A 2xn7A-5n2iA:
undetectable
2xn7B-5n2iA:
undetectable		 2xn7A-5n2iA:
22.22
2xn7B-5n2iA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 331
LEU A 321
LEU A 356
LEU A 305
ARG A 308
 None
 1.15A 2xn7A-5tvjA:
undetectable
2xn7B-5tvjA:
undetectable		 2xn7A-5tvjA:
20.93
2xn7B-5tvjA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 336
LEU A 315
LEU A 317
SER A 296
LEU A 299
 None
 1.10A 2xn7A-5uxnA:
undetectable
2xn7B-5uxnA:
undetectable		 2xn7A-5uxnA:
11.14
2xn7B-5uxnA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtg FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B  86
LEU B 117
SER B  21
LEU B  20
LEU B  18
 None
 1.05A 2xn7A-5wtgB:
undetectable
2xn7B-5wtgB:
undetectable		 2xn7A-5wtgB:
20.58
2xn7B-5wtgB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		5 ALA A  96
LEU A  81
LEU A  73
LEU A 111
ARG A 110
 None
 1.08A 2xn7A-5x9gA:
undetectable
2xn7B-5x9gA:
undetectable		 2xn7A-5x9gA:
20.95
2xn7B-5x9gA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 5 LEU A 227
SER A 281
LEU A 280
ASN A 278
LEU A 231
 None
 1.12A 2xn7A-6b2yA:
undetectable
2xn7B-6b2yA:
undetectable		 2xn7A-6b2yA:
21.99
2xn7B-6b2yA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 ALA A 141
LEU A  98
LEU A  83
LEU A 136
ARG A 139
 None
 1.15A 2xn7A-6b5vA:
undetectable
2xn7B-6b5vA:
undetectable		 2xn7A-6b5vA:
15.05
2xn7B-6b5vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 ALA A  13
LEU A 250
SER A  64
LEU A  65
LEU A 247
 None
 1.09A 2xn7A-6cjbA:
undetectable
2xn7B-6cjbA:
undetectable		 2xn7A-6cjbA:
11.55
2xn7B-6cjbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 621
LEU A 596
SER A 586
LEU A 587
LEU A 598
 None
 1.16A 2xn7A-6fnwA:
undetectable
2xn7B-6fnwA:
undetectable		 2xn7A-6fnwA:
13.27
2xn7B-6fnwA:
19.72