SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN6_A_T44A1370

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		5 ALA A 151
GLN A  90
LEU A  93
ASN A  66
LEU A  61
 None
 1.18A 2xn6A-1b5lA:
0.2
2xn6B-1b5lA:
undetectable		 2xn6A-1b5lA:
19.60
2xn6B-1b5lA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ALA A 311
GLN A 360
LEU A 308
ASN A 300
LEU A 356
 None
 1.04A 2xn6A-1dj2A:
undetectable
2xn6B-1dj2A:
0.0		 2xn6A-1dj2A:
21.79
2xn6B-1dj2A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		6 LEU A  42
LEU A  16
LEU A  20
LEU A 100
ARG A 104
ARG A 103
 None
 1.35A 2xn6A-1drtA:
0.0
2xn6B-1drtA:
0.0		 2xn6A-1drtA:
21.58
2xn6B-1drtA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A 173
LEU A 146
LEU A 139
LEU A 190
ARG A 189
 None
 1.19A 2xn6A-1ee8A:
0.0
2xn6B-1ee8A:
0.0		 2xn6A-1ee8A:
21.22
2xn6B-1ee8A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B

(Bacillus
subtilis) 		PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		5 LEU A 146
LEU A 148
LEU A 113
LYS A 112
LEU A 191
 None
 0.93A 2xn6A-1f51A:
1.3
2xn6B-1f51A:
0.0		 2xn6A-1f51A:
20.29
2xn6B-1f51A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.13A 2xn6A-1g8xA:
0.0
2xn6B-1g8xA:
0.0		 2xn6A-1g8xA:
16.83
2xn6B-1g8xA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 403
LEU A 436
LEU A 365
LEU A 400
LEU A 432
 None
 1.10A 2xn6A-1jx2A:
0.0
2xn6B-1jx2A:
0.0		 2xn6A-1jx2A:
15.27
2xn6B-1jx2A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 ALA N 209
GLN N 267
LEU N 236
LEU N 177
ARG N 175
 None
 1.14A 2xn6A-1k7sN:
0.0
2xn6B-1k7sN:
0.0		 2xn6A-1k7sN:
24.59
2xn6B-1k7sN:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj BETA-CATENIN-INTERAC
TING PROTEIN 1
CATENIN BETA-1

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF06384
(ICAT) 		5 ALA A 656
LEU B  41
LEU B  33
LEU B  23
ARG B  21
 None
 1.18A 2xn6A-1lujA:
0.0
2xn6B-1lujA:
undetectable		 2xn6A-1lujA:
20.62
2xn6B-1lujA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 LEU A 389
LEU A 371
LEU A 289
LEU A 281
ARG A 270
 None
 1.18A 2xn6A-1morA:
undetectable
2xn6B-1morA:
undetectable		 2xn6A-1morA:
21.55
2xn6B-1morA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 GLN A 229
LEU A 236
LEU A 148
LEU A 238
ARG A 221
 None
 1.18A 2xn6A-1nneA:
undetectable
2xn6B-1nneA:
0.0		 2xn6A-1nneA:
17.19
2xn6B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A  54
LEU A  50
LEU A  33
LEU A  85
ARG A  84
 None
 1.17A 2xn6A-1nneA:
undetectable
2xn6B-1nneA:
0.0		 2xn6A-1nneA:
17.19
2xn6B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  33
LEU A 115
LEU A  90
ASN A 111
LEU A 102
 None
 1.13A 2xn6A-1p88A:
undetectable
2xn6B-1p88A:
0.0		 2xn6A-1p88A:
21.57
2xn6B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  33
LEU A 115
LEU A  90
LEU A  60
LEU A 102
 None
 1.07A 2xn6A-1p88A:
undetectable
2xn6B-1p88A:
0.0		 2xn6A-1p88A:
21.57
2xn6B-1p88A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjz THIOPURINE
S-METHYLTRANSFERASE

(Pseudomonas
syringae) 		PF05724
(TPMT) 		5 ALA A 107
LEU A 145
LEU A 188
LEU A 139
LEU A 146
 None
 1.16A 2xn6A-1pjzA:
undetectable
2xn6B-1pjzA:
undetectable		 2xn6A-1pjzA:
19.89
2xn6B-1pjzA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8r CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUSA

(Escherichia
coli) 		PF05866
(RusA) 		5 ALA A  85
LEU A 110
LEU A 112
LEU A  82
LEU A   8
 None
 1.11A 2xn6A-1q8rA:
undetectable
2xn6B-1q8rA:
undetectable		 2xn6A-1q8rA:
15.66
2xn6B-1q8rA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		6 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
 None
 1.13A 2xn6A-1xkwA:
undetectable
2xn6B-1xkwA:
undetectable		 2xn6A-1xkwA:
18.01
2xn6B-1xkwA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.04A 2xn6A-2braA:
0.5
2xn6B-2braA:
undetectable		 2xn6A-2braA:
21.89
2xn6B-2braA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF01648
(ACPS) 		5 ALA A 130
LEU A  94
LEU A 104
LYS A  84
ARG A  78
 None
MG  A1301 ( 4.9A)
None
None
MG  A1301 (-4.2A)
 1.00A 2xn6A-2cg5A:
undetectable
2xn6B-2cg5A:
undetectable		 2xn6A-2cg5A:
23.45
2xn6B-2cg5A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ALA A  80
LEU A  92
LEU A  73
LEU A  13
LEU A  88
 None
 1.05A 2xn6A-2dwuA:
undetectable
2xn6B-2dwuA:
undetectable		 2xn6A-2dwuA:
20.61
2xn6B-2dwuA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.16A 2xn6A-2hxoA:
undetectable
2xn6B-2hxoA:
undetectable		 2xn6A-2hxoA:
20.64
2xn6B-2hxoA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 LEU A 275
LEU A 279
LEU A 234
LEU A 267
ARG A  64
 None
 1.10A 2xn6A-2ijaA:
undetectable
2xn6B-2ijaA:
undetectable		 2xn6A-2ijaA:
21.07
2xn6B-2ijaA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		5 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.10A 2xn6A-2is8A:
undetectable
2xn6B-2is8A:
undetectable		 2xn6A-2is8A:
19.12
2xn6B-2is8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		5 ALA A 180
LEU A 141
LEU A 162
LEU A 177
LEU A 136
 None
 1.14A 2xn6A-2kn6A:
undetectable
2xn6B-2kn6A:
undetectable		 2xn6A-2kn6A:
20.23
2xn6B-2kn6A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  24
LEU A  58
LEU A 117
ASN A 118
LEU A  54
 None
 1.08A 2xn6A-2l3gA:
undetectable
2xn6B-2l3gA:
undetectable		 2xn6A-2l3gA:
17.72
2xn6B-2l3gA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF05739
(SNARE)
no annotation 		5 ALA B 241
LEU D 222
LEU B 237
LEU A 106
ARG A 107
 None
 1.03A 2xn6A-2npsB:
undetectable
2xn6B-2npsB:
undetectable		 2xn6A-2npsB:
13.36
2xn6B-2npsB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		5 ALA B  46
LEU B  94
LEU B  78
LEU B  42
LEU B  99
 None
 1.14A 2xn6A-2o8vB:
undetectable
2xn6B-2o8vB:
undetectable		 2xn6A-2o8vB:
17.38
2xn6B-2o8vB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qen WALKER-TYPE ATPASE

(Pyrococcus
abyssi) 		PF01637
(ATPase_2) 		5 LEU A  37
LEU A  35
LEU A 181
LYS A 182
LEU A 177
 None
 1.16A 2xn6A-2qenA:
undetectable
2xn6B-2qenA:
undetectable		 2xn6A-2qenA:
23.50
2xn6B-2qenA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 0.98A 2xn6A-2qfqA:
undetectable
2xn6B-2qfqA:
undetectable		 2xn6A-2qfqA:
23.06
2xn6B-2qfqA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.06A 2xn6A-2qq8A:
undetectable
2xn6B-2qq8A:
undetectable		 2xn6A-2qq8A:
21.69
2xn6B-2qq8A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 290
LEU A 203
LEU A 275
LEU A 210
LEU A 206
 None
 1.17A 2xn6A-2rb9A:
undetectable
2xn6B-2rb9A:
undetectable		 2xn6A-2rb9A:
23.58
2xn6B-2rb9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ALA A 160
GLN A 109
LEU A 156
LEU A 101
ARG A 155
 None
 1.18A 2xn6A-2uuuA:
undetectable
2xn6B-2uuuA:
undetectable		 2xn6A-2uuuA:
21.40
2xn6B-2uuuA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.86A 2xn6A-2vxpA:
undetectable
2xn6B-2vxpA:
undetectable		 2xn6A-2vxpA:
16.67
2xn6B-2vxpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A  39
LEU A  36
LEU A 295
LEU A  43
ARG A  44
 None
 1.12A 2xn6A-2yijA:
undetectable
2xn6B-2yijA:
undetectable		 2xn6A-2yijA:
19.43
2xn6B-2yijA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		5 ALA A  45
LEU A  93
LEU A  77
LEU A  41
LEU A  98
 None
 1.14A 2xn6A-2yn1A:
undetectable
2xn6B-2yn1A:
undetectable		 2xn6A-2yn1A:
16.62
2xn6B-2yn1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		5 LEU A 197
LEU A 221
LEU A 187
LEU A 158
ARG A 104
 None
 1.14A 2xn6A-3ay3A:
undetectable
2xn6B-3ay3A:
undetectable		 2xn6A-3ay3A:
22.01
2xn6B-3ay3A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 ALA A  23
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.04A 2xn6A-3dl1A:
undetectable
2xn6B-3dl1A:
undetectable		 2xn6A-3dl1A:
20.51
2xn6B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 GLN A 245
LEU A  78
LEU A  75
LEU A  29
LEU A  40
 None
 1.16A 2xn6A-3dl1A:
undetectable
2xn6B-3dl1A:
undetectable		 2xn6A-3dl1A:
20.51
2xn6B-3dl1A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A  17
LEU A 385
LEU A 348
ARG A 352
ARG A 387
 None
 1.05A 2xn6A-3euoA:
undetectable
2xn6B-3euoA:
undetectable		 2xn6A-3euoA:
21.52
2xn6B-3euoA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ALA A 129
LEU A 109
LEU A 166
LEU A 115
ARG A 145
 None
 1.00A 2xn6A-3gzgA:
undetectable
2xn6B-3gzgA:
undetectable		 2xn6A-3gzgA:
22.82
2xn6B-3gzgA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h35 UNCHARACTERIZED
PROTEIN ABO_0056

(Alcanivorax
borkumensis) 		no annotation 5 ALA A  62
LEU A  71
LEU A 108
ASN A  91
LEU A 160
 None
 1.14A 2xn6A-3h35A:
undetectable
2xn6B-3h35A:
undetectable		 2xn6A-3h35A:
19.32
2xn6B-3h35A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		5 ALA A  54
LEU A  64
LEU A 109
LEU A  95
LEU A  60
 None
 1.16A 2xn6A-3hoiA:
undetectable
2xn6B-3hoiA:
undetectable		 2xn6A-3hoiA:
20.11
2xn6B-3hoiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 696
LEU A 678
LEU A 733
LEU A 670
LEU A 736
 None
UNX  A 908 ( 4.7A)
None
None
None
 1.17A 2xn6A-3hzjA:
undetectable
2xn6B-3hzjA:
undetectable		 2xn6A-3hzjA:
20.33
2xn6B-3hzjA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js4 SUPEROXIDE DISMUTASE

(Anaplasma
phagocytophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A 203
LEU A 132
LEU A 141
LEU A 200
LEU A 161
 None
 1.16A 2xn6A-3js4A:
undetectable
2xn6B-3js4A:
undetectable		 2xn6A-3js4A:
19.65
2xn6B-3js4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.10A 2xn6A-3lezA:
undetectable
2xn6B-3lezA:
undetectable		 2xn6A-3lezA:
20.17
2xn6B-3lezA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		5 ALA A 284
LEU A  54
LEU A  58
LEU A 286
LEU A 229
 None
 1.09A 2xn6A-3lg3A:
undetectable
2xn6B-3lg3A:
undetectable		 2xn6A-3lg3A:
20.65
2xn6B-3lg3A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 ALA X  94
LEU X  30
LEU X  47
ASN X  45
LEU X  34
 None
 1.08A 2xn6A-3m7mX:
undetectable
2xn6B-3m7mX:
undetectable		 2xn6A-3m7mX:
20.79
2xn6B-3m7mX:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE

(Pelobacter
carbinolicus) 		PF00072
(Response_reg) 		6 ALA A  36
LEU A  79
LEU A  77
LEU A  66
LYS A  65
LEU A  50
 None
 1.48A 2xn6A-3n53A:
undetectable
2xn6B-3n53A:
undetectable		 2xn6A-3n53A:
19.02
2xn6B-3n53A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		5 ALA A 145
LEU A 115
LEU A 132
LYS A  78
LEU A 113
 None
None
None
SO4  A 231 (-2.6A)
None
 1.04A 2xn6A-3ne9A:
undetectable
2xn6B-3ne9A:
undetectable		 2xn6A-3ne9A:
17.87
2xn6B-3ne9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		5 ALA A  61
LEU A 178
LEU A 117
LEU A  32
ARG A  29
 None
 1.08A 2xn6A-3p9nA:
undetectable
2xn6B-3p9nA:
undetectable		 2xn6A-3p9nA:
19.32
2xn6B-3p9nA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.15A 2xn6A-3qvoA:
undetectable
2xn6B-3qvoA:
undetectable		 2xn6A-3qvoA:
22.19
2xn6B-3qvoA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 AGRIN

(Rattus
norvegicus) 		PF00054
(Laminin_G_1) 		5 ALA A1860
LEU A1920
LEU A1800
LEU A1824
LEU A1798
 None
 0.88A 2xn6A-3v65A:
undetectable
2xn6B-3v65A:
undetectable		 2xn6A-3v65A:
21.61
2xn6B-3v65A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 1.05A 2xn6A-3vkgA:
undetectable
2xn6B-3vkgA:
undetectable		 2xn6A-3vkgA:
7.75
2xn6B-3vkgA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 288
LEU A 290
LEU A 298
LYS A 300
LEU A 312
 None
 1.06A 2xn6A-3wpeA:
undetectable
2xn6B-3wpeA:
undetectable		 2xn6A-3wpeA:
19.05
2xn6B-3wpeA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 ALA A 248
LEU A 183
LEU A 206
ASN A 207
LEU A 186
 None
 1.15A 2xn6A-3zheA:
undetectable
2xn6B-3zheA:
undetectable		 2xn6A-3zheA:
23.14
2xn6B-3zheA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18

(Mus musculus) 		PF06487
(SAP18) 		5 LEU A  30
LEU A 122
LEU A  66
LYS A  67
LEU A 133
 None
 1.14A 2xn6A-4a6qA:
undetectable
2xn6B-4a6qA:
undetectable		 2xn6A-4a6qA:
16.24
2xn6B-4a6qA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 408
LEU A 404
LEU A 526
LEU A 665
ARG A 518
 None
 1.00A 2xn6A-4bocA:
undetectable
2xn6B-4bocA:
undetectable		 2xn6A-4bocA:
14.02
2xn6B-4bocA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 ALA A  86
LEU A   9
LEU A   7
LEU A 104
ARG A  32
 None
 1.13A 2xn6A-4c98A:
undetectable
2xn6B-4c98A:
undetectable		 2xn6A-4c98A:
23.37
2xn6B-4c98A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 751
LEU A 837
LEU A 880
LEU A 905
LEU A 833
 None
 1.04A 2xn6A-4ckrA:
undetectable
2xn6B-4ckrA:
undetectable		 2xn6A-4ckrA:
21.03
2xn6B-4ckrA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.90A 2xn6A-4f1pA:
undetectable
2xn6B-4f1pA:
undetectable		 2xn6A-4f1pA:
23.02
2xn6B-4f1pA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 203
LYS A 177
LEU A 171
ARG A 172
ARG A 173
 None
 1.12A 2xn6A-4f4cA:
undetectable
2xn6B-4f4cA:
undetectable		 2xn6A-4f4cA:
13.72
2xn6B-4f4cA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		5 LEU A 229
LEU A  45
LEU A  49
ARG A 252
ARG A  46
 None
 1.10A 2xn6A-4gbmA:
undetectable
2xn6B-4gbmA:
undetectable		 2xn6A-4gbmA:
24.47
2xn6B-4gbmA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 LEU A 277
LEU A 327
LEU A 350
LEU A 319
ARG A 318
 None
 1.18A 2xn6A-4hh1A:
undetectable
2xn6B-4hh1A:
undetectable		 2xn6A-4hh1A:
22.41
2xn6B-4hh1A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.14A 2xn6A-4izdA:
undetectable
2xn6B-4izdA:
undetectable		 2xn6A-4izdA:
22.10
2xn6B-4izdA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.05A 2xn6A-4ln1A:
undetectable
2xn6B-4ln1A:
undetectable		 2xn6A-4ln1A:
23.23
2xn6B-4ln1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 LEU A 329
LEU A 238
LEU A 205
LYS A 206
LEU A 272
 None
 1.04A 2xn6A-4oj5A:
undetectable
2xn6B-4oj5A:
undetectable		 2xn6A-4oj5A:
18.48
2xn6B-4oj5A:
3.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1128
LEU A1124
LYS A1107
LEU A1127
ARG A1133
 None
 1.18A 2xn6A-4oliA:
undetectable
2xn6B-4oliA:
undetectable		 2xn6A-4oliA:
19.82
2xn6B-4oliA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		PF09409
(PUB) 		5 LEU A  51
LEU A  56
LEU A  72
LEU A 156
ARG A 157
 None
 1.10A 2xn6A-4p0aA:
undetectable
2xn6B-4p0aA:
undetectable		 2xn6A-4p0aA:
21.76
2xn6B-4p0aA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 ALA A  63
LEU A  81
LEU A  52
LEU A  56
LEU A  85
 None
 1.15A 2xn6A-4p53A:
undetectable
2xn6B-4p53A:
undetectable		 2xn6A-4p53A:
23.49
2xn6B-4p53A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 LEU A 471
LEU A 539
LEU A 521
LEU A 601
ARG A 466
 None
 1.14A 2xn6A-4pljA:
0.0
2xn6B-4pljA:
undetectable		 2xn6A-4pljA:
16.52
2xn6B-4pljA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.09A 2xn6A-4plsA:
undetectable
2xn6B-4plsA:
undetectable		 2xn6A-4plsA:
21.69
2xn6B-4plsA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 LEU A 151
LEU A 149
LEU A  96
LYS A  97
LEU A 154
 None
 1.17A 2xn6A-4pspA:
undetectable
2xn6B-4pspA:
undetectable		 2xn6A-4pspA:
22.17
2xn6B-4pspA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3i OSSERK2 D128N

(Oryza sativa) 		PF08263
(LRRNT_2)
PF11921
(DUF3439) 		5 LEU A 148
LEU A 142
LEU A 153
LEU A 127
ARG A 152
 None
 1.16A 2xn6A-4q3iA:
undetectable
2xn6B-4q3iA:
undetectable		 2xn6A-4q3iA:
22.60
2xn6B-4q3iA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rly NAV1.2 - ANKB
CHIMERA

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ALA A2240
LEU A2212
LEU A2252
LEU A2196
ARG A2228
 None
 0.93A 2xn6A-4rlyA:
undetectable
2xn6B-4rlyA:
undetectable		 2xn6A-4rlyA:
23.53
2xn6B-4rlyA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A 150
LEU A 131
LEU A 154
LEU A 136
ARG A 166
 None
 1.14A 2xn6A-4rxlA:
undetectable
2xn6B-4rxlA:
undetectable		 2xn6A-4rxlA:
22.07
2xn6B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
 None
 1.07A 2xn6A-4rxlA:
undetectable
2xn6B-4rxlA:
undetectable		 2xn6A-4rxlA:
22.07
2xn6B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.06A 2xn6A-4txkA:
0.3
2xn6B-4txkA:
undetectable		 2xn6A-4txkA:
21.04
2xn6B-4txkA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 ALA C 143
LEU C 240
LEU C 238
LEU C 223
LEU C 209
 None
 0.76A 2xn6A-4xgcC:
undetectable
2xn6B-4xgcC:
undetectable		 2xn6A-4xgcC:
22.32
2xn6B-4xgcC:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa) 		PF00814
(Peptidase_M22) 		5 ALA A  85
LEU A  47
LEU A   5
LEU A  82
LEU A  54
 None
 1.18A 2xn6A-4y0wA:
undetectable
2xn6B-4y0wA:
undetectable		 2xn6A-4y0wA:
23.16
2xn6B-4y0wA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygu PUTATIVE ADHESIN

(Bacteroides
eggerthii) 		PF10988
(DUF2807) 		5 ALA A 105
LEU A 145
LEU A 108
LYS A 109
LEU A 125
 None
 1.15A 2xn6A-4yguA:
undetectable
2xn6B-4yguA:
undetectable		 2xn6A-4yguA:
22.25
2xn6B-4yguA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 LEU A1423
LEU A1386
LEU A1413
LEU A1431
ARG A1175
 None
 0.98A 2xn6A-4ziuA:
undetectable
2xn6B-4ziuA:
undetectable		 2xn6A-4ziuA:
20.31
2xn6B-4ziuA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1605
LEU A1612
LEU A1259
LEU A1210
LEU A1609
 None
 1.17A 2xn6A-5a31A:
undetectable
2xn6B-5a31A:
undetectable		 2xn6A-5a31A:
13.19
2xn6B-5a31A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 LEU A 197
LEU A 292
LEU A  38
LYS A  39
LEU A 201
 None
 1.15A 2xn6A-5ah0A:
undetectable
2xn6B-5ah0A:
undetectable		 2xn6A-5ah0A:
21.13
2xn6B-5ah0A:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 ALA A1050
LEU A 876
LEU A 879
LEU A1047
LEU A 893
 None
 1.12A 2xn6A-5b16A:
undetectable
2xn6B-5b16A:
undetectable		 2xn6A-5b16A:
14.79
2xn6B-5b16A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		5 ALA A 960
LEU A 893
LEU A 889
LEU A 946
ARG A 846
 None
 1.16A 2xn6A-5hb3A:
undetectable
2xn6B-5hb3A:
undetectable		 2xn6A-5hb3A:
18.16
2xn6B-5hb3A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hso UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		5 ALA A  78
LEU A  28
LEU A  31
LEU A 102
LEU A  33
 None
 1.06A 2xn6A-5hsoA:
undetectable
2xn6B-5hsoA:
undetectable		 2xn6A-5hsoA:
15.56
2xn6B-5hsoA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ALA B  32
LEU B  96
LEU B  69
LEU B  59
LEU B  72
 None
 1.17A 2xn6A-5hzlB:
undetectable
2xn6B-5hzlB:
undetectable		 2xn6A-5hzlB:
23.10
2xn6B-5hzlB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.13A 2xn6A-5it5F:
undetectable
2xn6B-5it5F:
undetectable		 2xn6A-5it5F:
21.25
2xn6B-5it5F:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izh RNA-DIRECTED RNA
POLYMERASE L

(Lassa
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		5 LEU A  93
LEU A  73
LEU A 130
LYS A 131
LEU A  98
 None
 1.13A 2xn6A-5izhA:
undetectable
2xn6B-5izhA:
undetectable		 2xn6A-5izhA:
19.31
2xn6B-5izhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.11A 2xn6A-5jjqA:
undetectable
2xn6B-5jjqA:
undetectable		 2xn6A-5jjqA:
20.77
2xn6B-5jjqA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 ALA A  40
LEU A 147
LEU A 154
LEU A 107
LEU A 118
 None
 1.17A 2xn6A-5ktkA:
undetectable
2xn6B-5ktkA:
undetectable		 2xn6A-5ktkA:
19.73
2xn6B-5ktkA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		5 ALA A 102
LEU A 166
LEU A 162
LEU A  30
ARG A  26
 None
 1.08A 2xn6A-5kvkA:
undetectable
2xn6B-5kvkA:
undetectable		 2xn6A-5kvkA:
17.90
2xn6B-5kvkA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1605
LEU A1612
LEU A1259
LEU A1210
LEU A1609
 None
 1.14A 2xn6A-5lcwA:
undetectable
2xn6B-5lcwA:
undetectable		 2xn6A-5lcwA:
11.49
2xn6B-5lcwA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		5 ALA A  77
LEU A 141
LEU A  97
LEU A  25
LEU A 104
 None
 1.08A 2xn6A-5n2iA:
undetectable
2xn6B-5n2iA:
undetectable		 2xn6A-5n2iA:
22.22
2xn6B-5n2iA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A   7
LEU A  61
LEU A  43
LYS A  42
LEU A  65
 None
 1.01A 2xn6A-5n6vA:
undetectable
2xn6B-5n6vA:
undetectable		 2xn6A-5n6vA:
14.33
2xn6B-5n6vA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.88A 2xn6A-5nv6A:
undetectable
2xn6B-5nv6A:
undetectable		 2xn6A-5nv6A:
19.03
2xn6B-5nv6A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 ALA A 163
LEU A  32
LEU A 160
LEU A  19
ARG A 159
 None
 1.16A 2xn6A-5uouA:
undetectable
2xn6B-5uouA:
undetectable		 2xn6A-5uouA:
20.96
2xn6B-5uouA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		5 ALA A  96
LEU A  81
LEU A  73
LEU A 111
ARG A 110
 None
 1.16A 2xn6A-5x9gA:
undetectable
2xn6B-5x9gA:
undetectable		 2xn6A-5x9gA:
20.95
2xn6B-5x9gA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zyf -

(-) 		no annotation 5 LEU A  10
LEU A  62
ASN A  66
LEU A  74
ARG A  63
 None
None
None
EDO  A 102 (-4.3A)
None
 1.03A 2xn6A-5zyfA:
undetectable
2xn6B-5zyfA:
undetectable		 2xn6A-5zyfA:
undetectable
2xn6B-5zyfA:
undetectable