SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN5_A_FUNA1356_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b07 PROTEIN
(PROTO-ONCOGENE CRK
(CRK))

(Mus musculus) 		PF00018
(SH3_1) 		3 LEU A 151
ARG A 179
ILE A 182
 None
 0.63A 2xn5B-1b07A:
0.0		 2xn5B-1b07A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buy PROTEIN
(ERYTHROPOIETIN)

(Homo sapiens) 		PF00758
(EPO_TPO) 		3 LEU A   5
ARG A 162
ILE A   6
 None
 0.64A 2xn5B-1buyA:
undetectable		 2xn5B-1buyA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		3 LEU A   6
ARG A  90
ILE A   7
 None
 0.63A 2xn5B-1c3eA:
0.4		 2xn5B-1c3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 LEU A 128
ARG A 122
ILE A 363
 None
 0.69A 2xn5B-1fn9A:
0.0		 2xn5B-1fn9A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 LEU A 206
ARG A  30
ILE A 208
 None
 0.62A 2xn5B-1fp9A:
0.0		 2xn5B-1fp9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		3 LEU A 289
ARG A 284
ILE A 286
 None
 0.59A 2xn5B-1gpjA:
0.0		 2xn5B-1gpjA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 LEU A 198
ARG A 194
ILE A 200
 None
 0.39A 2xn5B-1im4A:
0.0		 2xn5B-1im4A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		3 LEU A  25
ARG A  22
ILE A 233
 None
 0.62A 2xn5B-1iugA:
0.0		 2xn5B-1iugA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		3 LEU A 146
ARG A 142
ILE A 160
 None
 0.57A 2xn5B-1jv1A:
0.0		 2xn5B-1jv1A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LEU A 347
ARG A 443
ILE A 348
 None
 0.58A 2xn5B-1kejA:
0.0		 2xn5B-1kejA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		3 LEU A  67
ARG A  42
ILE A  66
 None
 0.68A 2xn5B-1l1qA:
undetectable		 2xn5B-1l1qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		3 LEU A 200
ARG A 199
ILE A 201
 None
 0.64A 2xn5B-1ldkA:
undetectable		 2xn5B-1ldkA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LEU A 282
ARG A 281
ILE A 283
 None
SO4  A1312 (-3.6A)
None
 0.57A 2xn5B-1mu2A:
undetectable		 2xn5B-1mu2A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 379
ARG A 377
ILE A 371
 None
 0.00A 2xn5B-1q5aA:
undetectable		 2xn5B-1q5aA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnx VES V 5

(Vespula
vulgaris) 		PF00188
(CAP) 		3 LEU A  45
ARG A  52
ILE A  44
 None
 0.69A 2xn5B-1qnxA:
undetectable		 2xn5B-1qnxA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  47
ARG A  43
ILE A  49
 None
NDP  A1501 ( 4.1A)
None
 0.66A 2xn5B-1rpnA:
undetectable		 2xn5B-1rpnA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A  75
ARG A   5
ILE A   3
 None
 0.55A 2xn5B-1tkkA:
undetectable		 2xn5B-1tkkA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Thermotoga
maritima) 		PF01029
(NusB) 		3 LEU A  58
ARG A  82
ILE A  61
 None
 0.61A 2xn5B-1tzxA:
undetectable		 2xn5B-1tzxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		3 LEU A 340
ARG A 430
ILE A 339
 None
 0.64A 2xn5B-1u2xA:
undetectable		 2xn5B-1u2xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		3 LEU A  78
ARG A 129
ILE A  77
 None
 0.66A 2xn5B-1uxoA:
undetectable		 2xn5B-1uxoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 LEU A 341
ARG A 343
ILE A 340
 None
 0.64A 2xn5B-1x1nA:
undetectable		 2xn5B-1x1nA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe7 HYPOTHETICAL 22.5
KDA PROTEIN IN
TUB1-CPR3 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF06172
(Cupin_5) 		3 LEU A 106
ARG A 108
ILE A 163
 None
 0.57A 2xn5B-1xe7A:
undetectable		 2xn5B-1xe7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		3 LEU 1  15
ARG 1  11
ILE 1  18
 None
 0.59A 2xn5B-1zud1:
undetectable		 2xn5B-1zud1:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx4 PLASMID PARTITION
PAR B PROTEIN

(Escherichia
virus P1) 		PF08775
(ParB) 		3 LEU A 259
ARG A 258
ILE A 260
 None
 0.68A 2xn5B-1zx4A:
undetectable		 2xn5B-1zx4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		3 LEU A 254
ARG A 250
ILE A  52
 None
ANP  A1304 ( 4.5A)
None
 0.62A 2xn5B-2c49A:
undetectable		 2xn5B-2c49A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv8 TRNA-SPLICING
ENDONUCLEASE

(Sulfurisphaera
tokodaii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		3 LEU A  20
ARG A  19
ILE A  21
 None
 0.66A 2xn5B-2cv8A:
undetectable		 2xn5B-2cv8A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		3 LEU A 126
ARG A 123
ILE A 129
 None
 0.58A 2xn5B-2e8gA:
undetectable		 2xn5B-2e8gA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 LEU A 349
ARG A 352
ILE A 345
 None
 0.62A 2xn5B-2efjA:
undetectable		 2xn5B-2efjA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		3 LEU B 251
ARG B 247
ILE B 252
 None
 0.64A 2xn5B-2f9yB:
undetectable		 2xn5B-2f9yB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		3 LEU A 320
ARG A 325
ILE A 248
 None
 0.62A 2xn5B-2gmhA:
undetectable		 2xn5B-2gmhA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		3 LEU A 256
ARG A 254
ILE A 184
 None
 0.68A 2xn5B-2hrzA:
undetectable		 2xn5B-2hrzA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 213
ARG A 220
ILE A 218
 None
 0.67A 2xn5B-2izoA:
undetectable		 2xn5B-2izoA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24

(Trypanosoma
brucei) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 LEU A 126
ARG A  52
ILE A 129
 None
 0.69A 2xn5B-2lvvA:
undetectable		 2xn5B-2lvvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 PROTEIN SRN2

(Saccharomyces
cerevisiae) 		PF07200
(Mod_r) 		3 LEU C 189
ARG C 192
ILE C 185
 None
 0.66A 2xn5B-2p22C:
undetectable		 2xn5B-2p22C:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbb GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Paraburkholderia
phytofirmans) 		PF00903
(Glyoxalase) 		3 LEU A  73
ARG A  71
ILE A  80
 None
 0.59A 2xn5B-2rbbA:
undetectable		 2xn5B-2rbbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		3 LEU A  46
ARG A  49
ILE A  47
 None
 0.58A 2xn5B-2rdlA:
undetectable		 2xn5B-2rdlA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		3 LEU A  63
ARG A  61
ILE A 107
 None
 0.62A 2xn5B-2w87A:
undetectable		 2xn5B-2w87A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		3 LEU A  21
ARG A  20
ILE A  22
 None
 0.57A 2xn5B-2wzvA:
undetectable		 2xn5B-2wzvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum) 		PF02458
(Transferase) 		3 LEU A  41
ARG A  39
ILE A 159
 None
 0.66A 2xn5B-2xr7A:
undetectable		 2xn5B-2xr7A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yax SULFUR
OXYGENASE/REDUCTASE

(Acidianus
ambivalens) 		PF07682
(SOR) 		3 LEU B 293
ARG B  73
ILE B 292
 None
 0.67A 2xn5B-2yaxB:
undetectable		 2xn5B-2yaxB:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		3 LEU C 185
ARG C 184
ILE C 187
 None
 0.67A 2xn5B-2ynmC:
undetectable		 2xn5B-2ynmC:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		3 LEU A  66
ARG A  65
ILE A  68
 None
 0.64A 2xn5B-3alyA:
undetectable		 2xn5B-3alyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		3 LEU A   7
ARG A  91
ILE A   8
 None
 0.60A 2xn5B-3aufA:
undetectable		 2xn5B-3aufA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		3 LEU A  20
ARG A  36
ILE A  42
 None
 0.60A 2xn5B-3cq9A:
undetectable		 2xn5B-3cq9A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 LEU A   5
ARG A   4
ILE A   6
 None
 0.64A 2xn5B-3fcaA:
undetectable		 2xn5B-3fcaA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 LEU A1743
ARG A1776
ILE A1742
 None
 0.62A 2xn5B-3ff6A:
undetectable		 2xn5B-3ff6A:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		3 LEU A 319
ARG A 315
ILE A 321
 None
 0.60A 2xn5B-3gonA:
undetectable		 2xn5B-3gonA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 LEU A1861
ARG A1839
ILE A1864
 None
 0.63A 2xn5B-3ig3A:
undetectable		 2xn5B-3ig3A:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 LEU A1110
ARG A 767
ILE A 764
 None
 0.56A 2xn5B-3jclA:
undetectable		 2xn5B-3jclA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvi PROTEIN TYROSINE
PHOSPHATASE

(Entamoeba
histolytica) 		PF01451
(LMWPc) 		3 LEU A 139
ARG A  13
ILE A 136
 None
SO4  A 201 (-4.5A)
None
 0.64A 2xn5B-3jviA:
undetectable		 2xn5B-3jviA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		3 LEU A  38
ARG A  36
ILE A  52
 None
 0.55A 2xn5B-3kh5A:
undetectable		 2xn5B-3kh5A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		3 LEU A  62
ARG A 113
ILE A 117
 None
 0.60A 2xn5B-3knuA:
undetectable		 2xn5B-3knuA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		3 LEU A 175
ARG A 228
ILE A 177
 None
 0.55A 2xn5B-3l5aA:
undetectable		 2xn5B-3l5aA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		3 LEU A 535
ARG A 571
ILE A 574
 None
 0.52A 2xn5B-3lh5A:
undetectable		 2xn5B-3lh5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		3 LEU A   8
ARG A  13
ILE A   9
 None
 0.55A 2xn5B-3lpmA:
undetectable		 2xn5B-3lpmA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m45 CELL ADHESION
MOLECULE 2

(Mus musculus) 		PF07686
(V-set) 		3 LEU A  88
ARG A  90
ILE A  98
 None
 0.68A 2xn5B-3m45A:
undetectable		 2xn5B-3m45A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 LEU A 138
ARG A 134
ILE A 140
 None
 0.48A 2xn5B-3oetA:
undetectable		 2xn5B-3oetA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LEU A 979
ARG A 976
ILE A 980
 None
 0.68A 2xn5B-3psfA:
undetectable		 2xn5B-3psfA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		3 LEU A 426
ARG A 425
ILE A 427
 None
 0.68A 2xn5B-3pukA:
undetectable		 2xn5B-3pukA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 LEU A 148
ARG A 147
ILE A 149
 None
 0.67A 2xn5B-3qkaA:
undetectable		 2xn5B-3qkaA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 LEU A 152
ARG A 151
ILE A 153
 None
 0.60A 2xn5B-3r9qA:
undetectable		 2xn5B-3r9qA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		3 LEU A  46
ARG A  49
ILE A  47
 None
 0.61A 2xn5B-3rp2A:
undetectable		 2xn5B-3rp2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		3 LEU A 658
ARG A 657
ILE A 659
 None
None
MLY  A 656 ( 4.3A)
 0.66A 2xn5B-4a5pA:
undetectable		 2xn5B-4a5pA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		3 LEU A 235
ARG A 254
ILE A 232
 None
 0.66A 2xn5B-4akkA:
undetectable		 2xn5B-4akkA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LEU A 321
ARG A 320
ILE A 322
 None
 0.64A 2xn5B-4aw2A:
undetectable		 2xn5B-4aw2A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbk FERMITIN FAMILY
HOMOLOG 1

(Mus musculus) 		PF00169
(PH) 		3 LEU A 490
ARG A 463
ILE A 487
 None
 0.64A 2xn5B-4bbkA:
undetectable		 2xn5B-4bbkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 LEU A 237
ARG A 234
ILE A 238
 None
 0.69A 2xn5B-4cukA:
undetectable		 2xn5B-4cukA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 LEU A 250
ARG A 248
ILE A 334
 None
 0.68A 2xn5B-4hykA:
undetectable		 2xn5B-4hykA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 LEU C  37
ARG C  33
ILE C  39
 None
 0.63A 2xn5B-4ifdC:
undetectable		 2xn5B-4ifdC:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 LEU A 191
ARG A 187
ILE A 193
 None
 0.62A 2xn5B-4ivfA:
undetectable		 2xn5B-4ivfA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyq PHOSPHOGLUCAN
PHOSPHATASE LSF2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc) 		3 LEU A  95
ARG A  97
ILE A 101
 None
 0.69A 2xn5B-4kyqA:
undetectable		 2xn5B-4kyqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 LEU A 159
ARG A 158
ILE A 160
 None
 0.64A 2xn5B-4mi2A:
undetectable		 2xn5B-4mi2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		3 LEU A 427
ARG A 144
ILE A 424
 None
 0.67A 2xn5B-4nphA:
undetectable		 2xn5B-4nphA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 LEU A 382
ARG A 325
ILE A 383
 None
 0.68A 2xn5B-4p22A:
undetectable		 2xn5B-4p22A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		3 LEU A  19
ARG A 243
ILE A  16
 None
 0.55A 2xn5B-4pvcA:
undetectable		 2xn5B-4pvcA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		3 LEU A 230
ARG A 183
ILE A 231
 None
 0.68A 2xn5B-4rhhA:
undetectable		 2xn5B-4rhhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LEU M 384
ARG M 325
ILE M 383
 None
 0.68A 2xn5B-4wj3M:
undetectable		 2xn5B-4wj3M:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpm MRNA EXPORT PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 LEU A 161
ARG A 160
ILE A 173
 None
SO4  A 303 ( 3.5A)
None
 0.64A 2xn5B-4wpmA:
undetectable		 2xn5B-4wpmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 3 LEU C 236
ARG C 232
ILE C 237
 None
 0.62A 2xn5B-4wzsC:
undetectable		 2xn5B-4wzsC:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfz OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 LEU A 109
ARG A 162
ILE A 108
 None
 0.63A 2xn5B-4yfzA:
undetectable		 2xn5B-4yfzA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		3 LEU A  73
ARG A 186
ILE A  67
 GOL  A 203 ( 4.7A)
None
None
 0.61A 2xn5B-4zbzA:
undetectable		 2xn5B-4zbzA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 3 LEU A 816
ARG A 797
ILE A 813
 None
 0.67A 2xn5B-4zuzA:
undetectable		 2xn5B-4zuzA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0d SURFACE ANCHORED
PROTEIN

(Clostridium
perfringens) 		PF08341
(TED) 		3 LEU A 198
ARG A 187
ILE A 200
 None
 0.60A 2xn5B-5a0dA:
undetectable		 2xn5B-5a0dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		3 LEU A  98
ARG A  34
ILE A  91
 None
 0.59A 2xn5B-5c17A:
undetectable		 2xn5B-5c17A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		3 LEU A1096
ARG A1094
ILE A1153
 None
 0.58A 2xn5B-5dczA:
undetectable		 2xn5B-5dczA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 LEU A  25
ARG A  23
ILE A  32
 None
 0.53A 2xn5B-5e6sA:
undetectable		 2xn5B-5e6sA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		3 LEU A  80
ARG A  90
ILE A  82
 None
 0.57A 2xn5B-5ewtA:
undetectable		 2xn5B-5ewtA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		3 LEU C  64
ARG C  67
ILE C  65
 None
 0.68A 2xn5B-5g52C:
undetectable		 2xn5B-5g52C:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis) 		PF01370
(Epimerase) 		3 LEU A  21
ARG A 239
ILE A  18
 None
 0.64A 2xn5B-5gmoA:
undetectable		 2xn5B-5gmoA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 LEU A 767
ARG A 766
ILE A 768
 None
 0.67A 2xn5B-5h64A:
undetectable		 2xn5B-5h64A:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hck HEMATOPOIETIC CELL
KINASE

(Homo sapiens) 		PF00018
(SH3_1) 		3 LEU A  97
ARG A 118
ILE A 128
 None
 0.68A 2xn5B-5hckA:
undetectable		 2xn5B-5hckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB

(Homo sapiens) 		PF00382
(TFIIB)
PF08271
(TF_Zn_Ribbon) 		3 LEU M 291
ARG M 290
ILE M 292
 None
 0.69A 2xn5B-5iy7M:
undetectable		 2xn5B-5iy7M:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 3 LEU A 654
ARG A 650
ILE A 641
 None
 0.60A 2xn5B-5jyuA:
undetectable		 2xn5B-5jyuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 LEU B 109
ARG B 107
ILE B 131
 None
 0.62A 2xn5B-5mrwB:
undetectable		 2xn5B-5mrwB:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 LEU A2758
ARG A2757
ILE A2759
 None
 0.63A 2xn5B-5nugA:
undetectable		 2xn5B-5nugA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7b PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE SLR0328

(Synechocystis
sp. PCC 6803) 		no annotation 3 LEU A 140
ARG A  13
ILE A 137
 None
 0.36A 2xn5B-5o7bA:
undetectable		 2xn5B-5o7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 3 LEU A 118
ARG A 120
ILE A  34
 None
 0.68A 2xn5B-5ol0A:
undetectable		 2xn5B-5ol0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		3 LEU E 161
ARG E 258
ILE E 165
 None
C  A 629 ( 3.6A)
None
 0.57A 2xn5B-5x8tE:
undetectable		 2xn5B-5x8tE:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjp HUMAN CHYMASE

(Homo sapiens) 		no annotation 3 LEU A  46
ARG A  49
ILE A  47
 None
 0.60A 2xn5B-5yjpA:
undetectable		 2xn5B-5yjpA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 3 LEU X   6
ARG X  20
ILE X  12
 None
 0.60A 2xn5B-6elqX:
undetectable		 2xn5B-6elqX:
16.00