SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN5_A_FUNA1356_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN


(Mus musculus)
PF02290
(SRP14)
PF05486
(SRP9-21)
5 SER A4011
ALA A4014
LEU A4038
LEU A4029
LEU A2087
None
1.01A 2xn5A-1914A:
0.0
2xn5A-1914A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4


(Rattus
norvegicus)
PF05790
(C2-set)
PF09191
(CD4-extracel)
5 LEU A  66
LEU A  72
SER A  25
LEU A  48
LEU A  89
None
0.94A 2xn5A-1cidA:
0.0
2xn5A-1cidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)


(Murine leukemia
virus)
PF00078
(RVT_1)
5 ALA A  32
GLN A 221
LEU A 203
LEU A 226
LEU A 219
None
1.11A 2xn5A-1d1uA:
0.0
2xn5A-1d1uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
5 SER A  75
SER A  74
LEU A  30
SER A  72
LEU A  95
None
1.06A 2xn5A-1fy1A:
0.0
2xn5A-1fy1A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 LEU A 323
LEU A 354
SER A 313
LEU A 316
LEU A 303
None
1.09A 2xn5A-1i8qA:
0.0
2xn5A-1i8qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C


(Mycobacterium
tuberculosis)
PF08704
(GCD14)
PF14801
(GCD14_N)
5 SER A 171
LEU A 177
LEU A 199
LEU A 193
LEU A 186
None
1.02A 2xn5A-1i9gA:
0.1
2xn5A-1i9gA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 SER A 354
LEU A 344
LEU A 389
SER A 326
LEU A 329
None
1.04A 2xn5A-1kfiA:
0.5
2xn5A-1kfiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum)
PF00089
(Trypsin)
5 SER A  86
SER A  85
LEU A  45
SER A 106
LEU A 105
None
0.87A 2xn5A-1pq5A:
undetectable
2xn5A-1pq5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M)
6 SER A  98
ALA A 148
LEU A 111
LEU A 131
LEU A 145
LEU A 138
None
1.38A 2xn5A-1q2lA:
0.0
2xn5A-1q2lA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 SER A 507
LEU A 370
SER A 506
LEU A 505
LEU A 360
None
1.12A 2xn5A-1r9jA:
undetectable
2xn5A-1r9jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster)
PF00106
(adh_short)
5 SER A 153
GLN A 222
SER A 197
LEU A 198
ASN A 240
None
0.91A 2xn5A-1snyA:
undetectable
2xn5A-1snyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133


(Homo sapiens)
no annotation 5 SER A 292
SER A 291
GLN A 228
SER A 275
LEU A 274
None
1.08A 2xn5A-1xksA:
undetectable
2xn5A-1xksA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912


(Homo sapiens)
PF00179
(UQ_con)
5 SER A 228
LEU A 303
LEU A 330
LEU A 243
LEU A 292
None
0.99A 2xn5A-1zuoA:
undetectable
2xn5A-1zuoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT


(Gracilaria
chilensis)
PF00502
(Phycobilisome)
5 LEU A  51
LEU A  44
SER A 143
LEU A 142
LEU A 154
None
0.77A 2xn5A-2bv8A:
undetectable
2xn5A-2bv8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d04 NEOCULIN ACIDIC
SUBUNIT


(Molineria
latifolia)
PF01453
(B_lectin)
6 SER A  18
LEU A  31
LEU A  54
SER A   2
LEU A  16
LEU A  62
None
1.12A 2xn5A-2d04A:
undetectable
2xn5A-2d04A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ALA A   8
LEU A 171
LEU A 184
LEU A   6
LEU A 163
TTP  A 500 (-3.5A)
None
None
TTP  A 500 (-4.0A)
None
1.10A 2xn5A-2ggqA:
undetectable
2xn5A-2ggqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER


(Synechocystis
sp. PCC 6803)
PF13379
(NMT1_2)
5 SER A 423
LEU A 389
SER A 367
LEU A 370
LEU A 444
None
1.09A 2xn5A-2i4cA:
undetectable
2xn5A-2i4cA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd0 LRR REPEATS AND
UBIQUITIN-LIKE
DOMAIN-CONTAINING
PROTEIN AT2G30105


(Arabidopsis
thaliana)
PF00240
(ubiquitin)
5 SER A  23
LEU A  54
LEU A  37
LEU A  26
LEU A  67
None
0.98A 2xn5A-2kd0A:
undetectable
2xn5A-2kd0A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
5 SER B  79
SER B  80
ALA B  83
LEU B  43
ASN B  54
None
1.04A 2xn5A-2km8B:
undetectable
2xn5A-2km8B:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063


(Plasmodium
falciparum)
PF00004
(AAA)
5 SER A  88
LEU A 107
LEU A 144
SER A  87
LEU A  86
None
0.91A 2xn5A-2p65A:
undetectable
2xn5A-2p65A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Agrobacterium
sp.)
PF00275
(EPSP_synthase)
5 LEU A 228
LEU A 207
SER A  42
LEU A 234
LEU A 182
None
1.10A 2xn5A-2pqdA:
undetectable
2xn5A-2pqdA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14


(Homo sapiens)
PF00566
(RabGAP-TBC)
5 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
None
None
None
UNX  A 202 ( 4.2A)
None
1.06A 2xn5A-2qq8A:
undetectable
2xn5A-2qq8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 ALA A 616
LEU A 495
LEU A 622
LEU A 582
LEU A 734
None
1.00A 2xn5A-2vdcA:
undetectable
2xn5A-2vdcA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC


(Mycobacterium
tuberculosis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 SER A 310
GLN A 277
LEU A 293
LEU A 279
ASN A 303
None
None
None
None
ADP  A1490 (-3.2A)
1.11A 2xn5A-2vosA:
undetectable
2xn5A-2vosA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3


(Homo sapiens)
PF02469
(Fasciclin)
5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
None
0.91A 2xn5A-2vxpA:
undetectable
2xn5A-2vxpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3


(Severe acute
respiratory
syndrome-related
coronavirus)
PF11633
(SUD-M)
5 ALA A 503
LEU A 412
SER A 472
LEU A 475
LYS A 476
None
1.11A 2xn5A-2w2gA:
undetectable
2xn5A-2w2gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE


(Staphylococcus
aureus)
PF00155
(Aminotran_1_2)
5 SER A 256
LEU A  12
LEU A 294
LEU A 260
LEU A  23
None
1.09A 2xn5A-2x5fA:
undetectable
2xn5A-2x5fA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
6 GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
1.18A 2xn5A-2xn6A:
53.6
2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
8 SER A  23
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
0.95A 2xn5A-2xn6A:
53.6
2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
10 SER A  23
SER A  24
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
0.48A 2xn5A-2xn6A:
53.6
2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
10 SER A  23
SER A  24
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
LYS A 270
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
0.75A 2xn5A-2xn6A:
53.6
2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
6 SER A  24
GLN A 238
LEU A 248
SER A 265
LEU A 269
LEU A 276
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
None
T44  A1370 (-4.0A)
None
1.25A 2xn5A-2xn6A:
53.6
2xn5A-2xn6A:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A 474
LEU A 492
SER A 460
ASN A 479
LEU A 503
None
0.95A 2xn5A-3b2dA:
undetectable
2xn5A-3b2dA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg9 PROTEIN OF UNIVERSAL
STRESS PROTEIN USPA
FAMILY


(Lactobacillus
plantarum)
PF00582
(Usp)
5 SER A  26
SER A  27
ALA A  30
LEU A 141
LEU A 120
None
1.02A 2xn5A-3fg9A:
undetectable
2xn5A-3fg9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Lactobacillus
acidophilus)
PF04909
(Amidohydro_2)
5 ALA A  99
LEU A  46
LEU A  42
SER A  86
LEU A  88
None
1.05A 2xn5A-3ij6A:
undetectable
2xn5A-3ij6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2)
5 SER B 334
SER B 333
ALA B 336
SER B 352
LEU B 355
None
1.04A 2xn5A-3jb9B:
undetectable
2xn5A-3jb9B:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 SER A 213
ALA A 211
LEU A 248
SER A 261
LEU A 269
None
1.08A 2xn5A-3jrpA:
undetectable
2xn5A-3jrpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE


(Exiguobacterium
sibiricum)
PF10740
(DUF2529)
5 GLN A  19
LEU A  16
SER A 146
LEU A 149
LEU A 125
None
1.07A 2xn5A-3jx9A:
undetectable
2xn5A-3jx9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Burkholderia
pseudomallei)
PF00300
(His_Phos_1)
5 SER A  82
LEU A   6
LEU A   4
SER A 166
LEU A 193
None
1.09A 2xn5A-3lntA:
undetectable
2xn5A-3lntA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens)
PF00514
(Arm)
5 SER A 624
LEU A 616
LEU A 585
LYS A 586
LEU A 592
None
1.09A 2xn5A-3nmzA:
undetectable
2xn5A-3nmzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns5 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
5 LEU A 155
LEU A 149
LEU A  95
LYS A  96
LEU A 102
None
1.06A 2xn5A-3ns5A:
undetectable
2xn5A-3ns5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT


(Cryptococcus
neoformans)
PF00432
(Prenyltrans)
5 SER B  73
SER B  72
ALA B  71
LEU B 415
LEU B 102
None
1.06A 2xn5A-3q75B:
undetectable
2xn5A-3q75B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh7 HYPOTHETICAL
OXIDOREDUCTASE


(Sinorhizobium
meliloti)
PF01613
(Flavin_Reduct)
5 SER A 270
SER A 269
SER A 195
LEU A 196
LEU A 210
None
1.05A 2xn5A-3rh7A:
undetectable
2xn5A-3rh7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1


(Homo sapiens)
PF09162
(Tap-RNA_bind)
5 SER A 305
LEU A 320
LEU A 280
LYS A 311
LEU A 315
None
1.02A 2xn5A-3rw7A:
undetectable
2xn5A-3rw7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
5 LEU A 621
LEU A 668
SER A 682
LEU A 685
LEU A 634
None
1.06A 2xn5A-3s1sA:
undetectable
2xn5A-3s1sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY


(Syntrophus
aciditrophicus)
PF00440
(TetR_N)
5 SER A 136
LEU A 197
SER A 154
LEU A 157
LEU A 164
None
0.85A 2xn5A-3s5rA:
undetectable
2xn5A-3s5rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus)
PF00085
(Thioredoxin)
PF04777
(Evr1_Alr)
5 ALA A 137
LEU A  97
LEU A 153
LEU A 139
LEU A  86
None
1.06A 2xn5A-3t58A:
undetectable
2xn5A-3t58A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis)
PF00232
(Glyco_hydro_1)
5 SER A 445
ALA A  39
LEU A 131
LEU A 135
LEU A  94
None
1.11A 2xn5A-3vilA:
undetectable
2xn5A-3vilA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus)
PF01273
(LBP_BPI_CETP)
5 SER A   8
LEU A 179
LEU A  19
LEU A  73
LEU A  90
None
1.07A 2xn5A-3zpmA:
undetectable
2xn5A-3zpmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
5 LEU A  57
LEU A  31
SER A  91
LEU A  92
LEU A 114
None
1.10A 2xn5A-4aioA:
undetectable
2xn5A-4aioA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 5 ALA A 287
LEU A 245
SER A 288
LEU A 292
LEU A  74
None
1.12A 2xn5A-4bb9A:
undetectable
2xn5A-4bb9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzj PROTEIN TRANSPORT
PROTEIN SEC13


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 SER B 213
ALA B 211
LEU B 248
SER B 261
LEU B 269
None
1.06A 2xn5A-4bzjB:
undetectable
2xn5A-4bzjB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 SER A 355
ALA A 353
LEU A 245
LEU A 247
LEU A 368
None
0.91A 2xn5A-4eclA:
undetectable
2xn5A-4eclA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN


(Listeria
monocytogenes)
no annotation 5 ALA A 106
LEU A 121
LEU A  99
LEU A  87
LEU A 115
None
1.06A 2xn5A-4ezgA:
undetectable
2xn5A-4ezgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN


(Synechocystis
sp. PCC 6803)
PF00502
(Phycobilisome)
5 LEU A  51
LEU A  44
SER A 145
LEU A 144
LEU A 166
None
1.00A 2xn5A-4f0tA:
undetectable
2xn5A-4f0tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN


(Xanthomonas
euvesicatoria)
PF13855
(LRR_8)
5 LEU A 356
LEU A 333
SER A 319
LEU A 320
LEU A 350
None
1.06A 2xn5A-4fcgA:
undetectable
2xn5A-4fcgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116)
no annotation 5 LEU A  11
LEU A  32
SER A 459
LEU A  27
LEU A  71
None
1.12A 2xn5A-4g2cA:
undetectable
2xn5A-4g2cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF15414
(DUF4621)
5 LEU A 215
LEU A 123
SER A 137
LEU A 136
LEU A 155
MLY  A 124 ( 4.7A)
MLY  A 124 ( 4.0A)
None
None
None
1.03A 2xn5A-4h3wA:
undetectable
2xn5A-4h3wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB


(Pseudomonas
aeruginosa)
PF13360
(PQQ_2)
6 SER A 271
SER A 272
GLN A 217
LEU A 264
LEU A 257
SER A 249
None
1.37A 2xn5A-4hdjA:
undetectable
2xn5A-4hdjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
5 SER M 402
ALA M 401
LEU L 222
SER M 398
LEU L 211
None
1.08A 2xn5A-4heaM:
undetectable
2xn5A-4heaM:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE


(Staphylococcus
aureus)
PF01656
(CbiA)
5 SER A1105
SER A1099
LEU A1074
SER A1098
LEU A1097
None
1.07A 2xn5A-4jmpA:
undetectable
2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE


(Staphylococcus
aureus)
PF01656
(CbiA)
5 SER A1105
SER A1099
LEU A1147
SER A1098
LEU A1097
None
1.09A 2xn5A-4jmpA:
undetectable
2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE


(Schizosaccharomyces
pombe)
PF01746
(tRNA_m1G_MT)
5 SER A 187
LEU A 194
LEU A 252
SER A 184
LEU A 183
None
1.04A 2xn5A-4jwgA:
undetectable
2xn5A-4jwgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 SER A3231
SER A3232
LEU A3063
LEU A3414
LEU A3419
None
1.11A 2xn5A-4kc5A:
0.0
2xn5A-4kc5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 SER A3232
ALA A3485
LEU A3379
SER A3477
LEU A3395
None
1.09A 2xn5A-4kc5A:
0.0
2xn5A-4kc5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes)
no annotation 5 ALA A 113
LEU A 128
LEU A 106
LEU A  94
LEU A 122
None
1.08A 2xn5A-4l3aA:
undetectable
2xn5A-4l3aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
None
0.80A 2xn5A-4ll6A:
undetectable
2xn5A-4ll6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
None
0.92A 2xn5A-4ll8A:
undetectable
2xn5A-4ll8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ALA A 314
LEU A 298
LEU A 323
SER A 312
LEU A 311
None
1.10A 2xn5A-4m7eA:
undetectable
2xn5A-4m7eA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE


(Bacillus
anthracis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 SER A 170
ALA A 174
LEU A   9
LEU A  28
LEU A 140
None
1.00A 2xn5A-4nf2A:
undetectable
2xn5A-4nf2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 SER A 455
LEU A 388
LEU A 414
LEU A 431
LYS A 430
None
1.11A 2xn5A-4om9A:
undetectable
2xn5A-4om9A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2


(Rattus
norvegicus)
PF13855
(LRR_8)
5 LEU A 111
LEU A  87
SER A  74
LEU A  75
LEU A 105
None
1.09A 2xn5A-4p8sA:
undetectable
2xn5A-4p8sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans)
PF13855
(LRR_8)
5 LEU A 276
LEU A 253
SER A 239
LEU A 240
LEU A 270
None
1.08A 2xn5A-4u09A:
undetectable
2xn5A-4u09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli)
PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C)
5 LEU A  68
LEU A  89
SER A  58
LEU A  61
LEU A 159
None
1.09A 2xn5A-4xjxA:
undetectable
2xn5A-4xjxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjj ALPHA SUBUNIT OF
CYANOBACTERIAL
PHYCOCYANINE PROTEIN


(Phormidium)
PF00502
(Phycobilisome)
5 LEU A  51
LEU A  44
SER A 143
LEU A 142
LEU A 154
None
1.05A 2xn5A-4yjjA:
undetectable
2xn5A-4yjjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13


(Mus musculus)
PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8)
6 SER A 276
ALA A 277
LEU A 342
LEU A 308
SER A 278
LEU A 301
NAG  A 907 ( 4.6A)
None
None
None
NAG  A 907 (-3.5A)
None
1.49A 2xn5A-4z0cA:
undetectable
2xn5A-4z0cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN


(Burkholderia
cenocepacia)
PF01032
(FecCD)
5 SER A 120
SER A 119
LEU A 176
LEU A 268
LEU A 105
None
1.06A 2xn5A-5b58A:
undetectable
2xn5A-5b58A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
5 ALA A 471
LEU A 497
LEU A 519
SER B  20
LEU B  27
None
1.06A 2xn5A-5c6gA:
undetectable
2xn5A-5c6gA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 LEU A 136
LEU A 132
SER A  37
LEU A  40
LYS A  41
None
1.07A 2xn5A-5ed4A:
undetectable
2xn5A-5ed4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN


(Nostoc
punctiforme)
PF01520
(Amidase_3)
5 SER A 571
LEU A 439
LEU A 612
SER A 574
LEU A 477
None
0.95A 2xn5A-5emiA:
undetectable
2xn5A-5emiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grq DEATH
DOMAIN-ASSOCIATED
PROTEIN 6


(Homo sapiens)
PF03344
(Daxx)
5 GLN A  77
LEU A  73
SER A 110
LEU A 113
LEU A 123
None
1.07A 2xn5A-5grqA:
undetectable
2xn5A-5grqA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26


(Homo sapiens)
PF00782
(DSPc)
5 ALA A  94
GLN A 131
SER A 159
LEU A 162
LEU A 169
None
None
PO4  A 301 ( 4.1A)
None
None
0.82A 2xn5A-5gtjA:
undetectable
2xn5A-5gtjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8


(Streptococcus
pneumoniae)
PF01501
(Glyco_transf_8)
5 LEU A 103
LEU A 118
SER A 191
LEU A 192
ASN A 197
None
0.96A 2xn5A-5gvvA:
undetectable
2xn5A-5gvvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN


(Candida
albicans)
PF02358
(Trehalose_PPase)
6 SER A  66
LEU A 247
LEU A  25
SER A  61
LEU A  60
LEU A 300
None
1.44A 2xn5A-5husA:
undetectable
2xn5A-5husA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN


(Oryctolagus
cuniculus)
PF05729
(NACHT)
PF13516
(LRR_6)
5 ALA A 399
LEU A 386
LEU A 328
LEU A 356
LEU A 316
None
1.00A 2xn5A-5irmA:
undetectable
2xn5A-5irmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN


(Oryctolagus
cuniculus)
PF05729
(NACHT)
PF13516
(LRR_6)
5 ALA A 819
LEU A 858
LEU A 856
LEU A 846
LEU A 871
None
1.02A 2xn5A-5irmA:
undetectable
2xn5A-5irmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF08238
(Sel1)
5 ALA A 213
LEU A 246
LEU A 249
SER A 214
LEU A 268
None
1.08A 2xn5A-5jjoA:
undetectable
2xn5A-5jjoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans)
no annotation 5 SER B 391
SER B 727
ALA B 387
LEU B 337
LEU B 341
None
0.94A 2xn5A-5khnB:
undetectable
2xn5A-5khnB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.)
PF00202
(Aminotran_3)
5 ALA A 118
LEU A  93
LEU A  97
LEU A 282
LEU A 336
None
1.12A 2xn5A-5lh9A:
undetectable
2xn5A-5lh9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)


(Helicobacter
pylori)
PF04085
(MreC)
5 SER C 111
LEU C 243
SER C 113
LEU C 114
LEU C 120
None
1.09A 2xn5A-5lp5C:
undetectable
2xn5A-5lp5C:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3


(Homo sapiens)
PF02469
(Fasciclin)
5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
None
0.89A 2xn5A-5nv6A:
undetectable
2xn5A-5nv6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1


(Homo sapiens)
PF01108
(Tissue_fac)
5 ALA B 141
LEU B 166
LEU B 119
SER B 177
LEU B 176
None
1.04A 2xn5A-5t5wB:
undetectable
2xn5A-5t5wB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Pseudomonas
aeruginosa)
no annotation 5 ALA A 336
LEU A 315
LEU A 317
SER A 296
LEU A 299
None
0.94A 2xn5A-5uxnA:
undetectable
2xn5A-5uxnA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf HARMONIN

(Homo sapiens)
PF00595
(PDZ)
5 LEU B 468
LEU B 522
SER B 463
LYS B 488
LEU B 535
None
1.07A 2xn5A-5xbfB:
undetectable
2xn5A-5xbfB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2


(Arabidopsis
thaliana)
no annotation 5 ALA A 407
LEU A 102
LEU A 104
SER A 132
LEU A 131
None
1.09A 2xn5A-5y92A:
undetectable
2xn5A-5y92A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens)
no annotation 6 LEU A 240
LEU A 219
SER A 201
LEU A 203
LYS A 204
LEU A 231
None
1.47A 2xn5A-5yq5A:
undetectable
2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens)
no annotation 5 SER A  74
SER A  75
LEU A 140
LEU A  96
LEU A 146
None
1.07A 2xn5A-5yq5A:
undetectable
2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus)
no annotation 5 LEU A 341
LEU A 369
SER A 365
LEU A 366
LEU A 356
None
1.08A 2xn5A-5zlnA:
undetectable
2xn5A-5zlnA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis)
no annotation 5 SER A 154
ALA A 181
LEU A 285
LEU A 228
SER A 251
None
1.11A 2xn5A-6f9mA:
undetectable
2xn5A-6f9mA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus)
no annotation 5 ALA A 236
LEU A  99
LEU A 103
LEU A 233
LEU A 226
HEM  A 401 (-3.4A)
None
None
HEM  A 401 ( 4.4A)
None
1.11A 2xn5A-6fshA:
undetectable
2xn5A-6fshA:
11.98