SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN5_A_FUNA1356

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		5 SER A4011
ALA A4014
LEU A4038
LEU A4029
LEU A2087
 None
 1.01A 2xn5A-1914A:
0.0		 2xn5A-1914A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4

(Rattus
norvegicus) 		PF05790
(C2-set)
PF09191
(CD4-extracel) 		5 LEU A  66
LEU A  72
SER A  25
LEU A  48
LEU A  89
 None
 0.94A 2xn5A-1cidA:
0.0		 2xn5A-1cidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)

(Murine leukemia
virus) 		PF00078
(RVT_1) 		5 ALA A  32
GLN A 221
LEU A 203
LEU A 226
LEU A 219
 None
 1.11A 2xn5A-1d1uA:
0.0		 2xn5A-1d1uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 SER A  75
SER A  74
LEU A  30
SER A  72
LEU A  95
 None
 1.06A 2xn5A-1fy1A:
0.0		 2xn5A-1fy1A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 323
LEU A 354
SER A 313
LEU A 316
LEU A 303
 None
 1.09A 2xn5A-1i8qA:
0.0		 2xn5A-1i8qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 SER A 171
LEU A 177
LEU A 199
LEU A 193
LEU A 186
 None
 1.02A 2xn5A-1i9gA:
0.1		 2xn5A-1i9gA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 SER A 354
LEU A 344
LEU A 389
SER A 326
LEU A 329
 None
 1.04A 2xn5A-1kfiA:
0.5		 2xn5A-1kfiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		5 SER A  86
SER A  85
LEU A  45
SER A 106
LEU A 105
 None
 0.87A 2xn5A-1pq5A:
undetectable		 2xn5A-1pq5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		6 SER A  98
ALA A 148
LEU A 111
LEU A 131
LEU A 145
LEU A 138
 None
 1.38A 2xn5A-1q2lA:
0.0		 2xn5A-1q2lA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 507
LEU A 370
SER A 506
LEU A 505
LEU A 360
 None
 1.12A 2xn5A-1r9jA:
undetectable		 2xn5A-1r9jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 SER A 153
GLN A 222
SER A 197
LEU A 198
ASN A 240
 None
 0.91A 2xn5A-1snyA:
undetectable		 2xn5A-1snyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 5 SER A 292
SER A 291
GLN A 228
SER A 275
LEU A 274
 None
 1.08A 2xn5A-1xksA:
undetectable		 2xn5A-1xksA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuo HYPOTHETICAL PROTEIN
LOC92912

(Homo sapiens) 		PF00179
(UQ_con) 		5 SER A 228
LEU A 303
LEU A 330
LEU A 243
LEU A 292
 None
 0.99A 2xn5A-1zuoA:
undetectable		 2xn5A-1zuoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 LEU A  51
LEU A  44
SER A 143
LEU A 142
LEU A 154
 None
 0.77A 2xn5A-2bv8A:
undetectable		 2xn5A-2bv8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d04 NEOCULIN ACIDIC
SUBUNIT

(Molineria
latifolia) 		PF01453
(B_lectin) 		6 SER A  18
LEU A  31
LEU A  54
SER A   2
LEU A  16
LEU A  62
 None
 1.12A 2xn5A-2d04A:
undetectable		 2xn5A-2d04A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 ALA A   8
LEU A 171
LEU A 184
LEU A   6
LEU A 163
 TTP  A 500 (-3.5A)
None
None
TTP  A 500 (-4.0A)
None
 1.10A 2xn5A-2ggqA:
undetectable		 2xn5A-2ggqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		5 SER A 423
LEU A 389
SER A 367
LEU A 370
LEU A 444
 None
 1.09A 2xn5A-2i4cA:
undetectable		 2xn5A-2i4cA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd0 LRR REPEATS AND
UBIQUITIN-LIKE
DOMAIN-CONTAINING
PROTEIN AT2G30105

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		5 SER A  23
LEU A  54
LEU A  37
LEU A  26
LEU A  67
 None
 0.98A 2xn5A-2kd0A:
undetectable		 2xn5A-2kd0A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 SER B  79
SER B  80
ALA B  83
LEU B  43
ASN B  54
 None
 1.04A 2xn5A-2km8B:
undetectable		 2xn5A-2km8B:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063

(Plasmodium
falciparum) 		PF00004
(AAA) 		5 SER A  88
LEU A 107
LEU A 144
SER A  87
LEU A  86
 None
 0.91A 2xn5A-2p65A:
undetectable		 2xn5A-2p65A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A 228
LEU A 207
SER A  42
LEU A 234
LEU A 182
 None
 1.10A 2xn5A-2pqdA:
undetectable		 2xn5A-2pqdA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
 None
None
None
UNX  A 202 ( 4.2A)
None
 1.06A 2xn5A-2qq8A:
undetectable		 2xn5A-2qq8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ALA A 616
LEU A 495
LEU A 622
LEU A 582
LEU A 734
 None
 1.00A 2xn5A-2vdcA:
undetectable		 2xn5A-2vdcA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 SER A 310
GLN A 277
LEU A 293
LEU A 279
ASN A 303
 None
None
None
None
ADP  A1490 (-3.2A)
 1.11A 2xn5A-2vosA:
undetectable		 2xn5A-2vosA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.91A 2xn5A-2vxpA:
undetectable		 2xn5A-2vxpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 ALA A 503
LEU A 412
SER A 472
LEU A 475
LYS A 476
 None
 1.11A 2xn5A-2w2gA:
undetectable		 2xn5A-2w2gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 SER A 256
LEU A  12
LEU A 294
LEU A 260
LEU A  23
 None
 1.09A 2xn5A-2x5fA:
undetectable		 2xn5A-2x5fA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		6 GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
 1.18A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		8 SER A  23
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
 0.95A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		10 SER A  23
SER A  24
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.48A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		10 SER A  23
SER A  24
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.75A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		6 SER A  24
GLN A 238
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
None
T44  A1370 (-4.0A)
None
 1.25A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 474
LEU A 492
SER A 460
ASN A 479
LEU A 503
 None
 0.95A 2xn5A-3b2dA:
undetectable		 2xn5A-3b2dA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg9 PROTEIN OF UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		5 SER A  26
SER A  27
ALA A  30
LEU A 141
LEU A 120
 None
 1.02A 2xn5A-3fg9A:
undetectable		 2xn5A-3fg9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		5 ALA A  99
LEU A  46
LEU A  42
SER A  86
LEU A  88
 None
 1.05A 2xn5A-3ij6A:
undetectable		 2xn5A-3ij6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		5 SER B 334
SER B 333
ALA B 336
SER B 352
LEU B 355
 None
 1.04A 2xn5A-3jb9B:
undetectable		 2xn5A-3jb9B:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER A 213
ALA A 211
LEU A 248
SER A 261
LEU A 269
 None
 1.08A 2xn5A-3jrpA:
undetectable		 2xn5A-3jrpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		5 GLN A  19
LEU A  16
SER A 146
LEU A 149
LEU A 125
 None
 1.07A 2xn5A-3jx9A:
undetectable		 2xn5A-3jx9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		5 SER A  82
LEU A   6
LEU A   4
SER A 166
LEU A 193
 None
 1.09A 2xn5A-3lntA:
undetectable		 2xn5A-3lntA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 SER A 624
LEU A 616
LEU A 585
LYS A 586
LEU A 592
 None
 1.09A 2xn5A-3nmzA:
undetectable		 2xn5A-3nmzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns5 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 LEU A 155
LEU A 149
LEU A  95
LYS A  96
LEU A 102
 None
 1.06A 2xn5A-3ns5A:
undetectable		 2xn5A-3ns5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 SER B  73
SER B  72
ALA B  71
LEU B 415
LEU B 102
 None
 1.06A 2xn5A-3q75B:
undetectable		 2xn5A-3q75B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh7 HYPOTHETICAL
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01613
(Flavin_Reduct) 		5 SER A 270
SER A 269
SER A 195
LEU A 196
LEU A 210
 None
 1.05A 2xn5A-3rh7A:
undetectable		 2xn5A-3rh7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		5 SER A 305
LEU A 320
LEU A 280
LYS A 311
LEU A 315
 None
 1.02A 2xn5A-3rw7A:
undetectable		 2xn5A-3rw7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 621
LEU A 668
SER A 682
LEU A 685
LEU A 634
 None
 1.06A 2xn5A-3s1sA:
undetectable		 2xn5A-3s1sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY

(Syntrophus
aciditrophicus) 		PF00440
(TetR_N) 		5 SER A 136
LEU A 197
SER A 154
LEU A 157
LEU A 164
 None
 0.85A 2xn5A-3s5rA:
undetectable		 2xn5A-3s5rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 137
LEU A  97
LEU A 153
LEU A 139
LEU A  86
 None
 1.06A 2xn5A-3t58A:
undetectable		 2xn5A-3t58A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		5 SER A 445
ALA A  39
LEU A 131
LEU A 135
LEU A  94
 None
 1.11A 2xn5A-3vilA:
undetectable		 2xn5A-3vilA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		5 SER A   8
LEU A 179
LEU A  19
LEU A  73
LEU A  90
 None
 1.07A 2xn5A-3zpmA:
undetectable		 2xn5A-3zpmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 LEU A  57
LEU A  31
SER A  91
LEU A  92
LEU A 114
 None
 1.10A 2xn5A-4aioA:
undetectable		 2xn5A-4aioA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ALA A 287
LEU A 245
SER A 288
LEU A 292
LEU A  74
 None
 1.12A 2xn5A-4bb9A:
undetectable		 2xn5A-4bb9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzj PROTEIN TRANSPORT
PROTEIN SEC13

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER B 213
ALA B 211
LEU B 248
SER B 261
LEU B 269
 None
 1.06A 2xn5A-4bzjB:
undetectable		 2xn5A-4bzjB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 SER A 355
ALA A 353
LEU A 245
LEU A 247
LEU A 368
 None
 0.91A 2xn5A-4eclA:
undetectable		 2xn5A-4eclA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ALA A 106
LEU A 121
LEU A  99
LEU A  87
LEU A 115
 None
 1.06A 2xn5A-4ezgA:
undetectable		 2xn5A-4ezgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 LEU A  51
LEU A  44
SER A 145
LEU A 144
LEU A 166
 None
 1.00A 2xn5A-4f0tA:
undetectable		 2xn5A-4f0tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 LEU A 356
LEU A 333
SER A 319
LEU A 320
LEU A 350
 None
 1.06A 2xn5A-4fcgA:
undetectable		 2xn5A-4fcgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 LEU A  11
LEU A  32
SER A 459
LEU A  27
LEU A  71
 None
 1.12A 2xn5A-4g2cA:
undetectable		 2xn5A-4g2cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		5 LEU A 215
LEU A 123
SER A 137
LEU A 136
LEU A 155
 MLY  A 124 ( 4.7A)
MLY  A 124 ( 4.0A)
None
None
None
 1.03A 2xn5A-4h3wA:
undetectable		 2xn5A-4h3wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		6 SER A 271
SER A 272
GLN A 217
LEU A 264
LEU A 257
SER A 249
 None
 1.37A 2xn5A-4hdjA:
undetectable		 2xn5A-4hdjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 SER M 402
ALA M 401
LEU L 222
SER M 398
LEU L 211
 None
 1.08A 2xn5A-4heaM:
undetectable		 2xn5A-4heaM:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		5 SER A1105
SER A1099
LEU A1074
SER A1098
LEU A1097
 None
 1.07A 2xn5A-4jmpA:
undetectable		 2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		5 SER A1105
SER A1099
LEU A1147
SER A1098
LEU A1097
 None
 1.09A 2xn5A-4jmpA:
undetectable		 2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		5 SER A 187
LEU A 194
LEU A 252
SER A 184
LEU A 183
 None
 1.04A 2xn5A-4jwgA:
undetectable		 2xn5A-4jwgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A3231
SER A3232
LEU A3063
LEU A3414
LEU A3419
 None
 1.11A 2xn5A-4kc5A:
0.0		 2xn5A-4kc5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A3232
ALA A3485
LEU A3379
SER A3477
LEU A3395
 None
 1.09A 2xn5A-4kc5A:
0.0		 2xn5A-4kc5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 5 ALA A 113
LEU A 128
LEU A 106
LEU A  94
LEU A 122
 None
 1.08A 2xn5A-4l3aA:
undetectable		 2xn5A-4l3aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.80A 2xn5A-4ll6A:
undetectable		 2xn5A-4ll6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.92A 2xn5A-4ll8A:
undetectable		 2xn5A-4ll8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ALA A 314
LEU A 298
LEU A 323
SER A 312
LEU A 311
 None
 1.10A 2xn5A-4m7eA:
undetectable		 2xn5A-4m7eA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 170
ALA A 174
LEU A   9
LEU A  28
LEU A 140
 None
 1.00A 2xn5A-4nf2A:
undetectable		 2xn5A-4nf2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 SER A 455
LEU A 388
LEU A 414
LEU A 431
LYS A 430
 None
 1.11A 2xn5A-4om9A:
undetectable		 2xn5A-4om9A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 LEU A 111
LEU A  87
SER A  74
LEU A  75
LEU A 105
 None
 1.09A 2xn5A-4p8sA:
undetectable		 2xn5A-4p8sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 276
LEU A 253
SER A 239
LEU A 240
LEU A 270
 None
 1.08A 2xn5A-4u09A:
undetectable		 2xn5A-4u09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		5 LEU A  68
LEU A  89
SER A  58
LEU A  61
LEU A 159
 None
 1.09A 2xn5A-4xjxA:
undetectable		 2xn5A-4xjxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjj ALPHA SUBUNIT OF
CYANOBACTERIAL
PHYCOCYANINE PROTEIN

(Phormidium) 		PF00502
(Phycobilisome) 		5 LEU A  51
LEU A  44
SER A 143
LEU A 142
LEU A 154
 None
 1.05A 2xn5A-4yjjA:
undetectable		 2xn5A-4yjjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		6 SER A 276
ALA A 277
LEU A 342
LEU A 308
SER A 278
LEU A 301
 NAG  A 907 ( 4.6A)
None
None
None
NAG  A 907 (-3.5A)
None
 1.49A 2xn5A-4z0cA:
undetectable		 2xn5A-4z0cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 SER A 120
SER A 119
LEU A 176
LEU A 268
LEU A 105
 None
 1.06A 2xn5A-5b58A:
undetectable		 2xn5A-5b58A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		5 ALA A 471
LEU A 497
LEU A 519
SER B  20
LEU B  27
 None
 1.06A 2xn5A-5c6gA:
undetectable		 2xn5A-5c6gA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 136
LEU A 132
SER A  37
LEU A  40
LYS A  41
 None
 1.07A 2xn5A-5ed4A:
undetectable		 2xn5A-5ed4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		5 SER A 571
LEU A 439
LEU A 612
SER A 574
LEU A 477
 None
 0.95A 2xn5A-5emiA:
undetectable		 2xn5A-5emiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grq DEATH
DOMAIN-ASSOCIATED
PROTEIN 6

(Homo sapiens) 		PF03344
(Daxx) 		5 GLN A  77
LEU A  73
SER A 110
LEU A 113
LEU A 123
 None
 1.07A 2xn5A-5grqA:
undetectable		 2xn5A-5grqA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26

(Homo sapiens) 		PF00782
(DSPc) 		5 ALA A  94
GLN A 131
SER A 159
LEU A 162
LEU A 169
 None
None
PO4  A 301 ( 4.1A)
None
None
 0.82A 2xn5A-5gtjA:
undetectable		 2xn5A-5gtjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		5 LEU A 103
LEU A 118
SER A 191
LEU A 192
ASN A 197
 None
 0.96A 2xn5A-5gvvA:
undetectable		 2xn5A-5gvvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		6 SER A  66
LEU A 247
LEU A  25
SER A  61
LEU A  60
LEU A 300
 None
 1.44A 2xn5A-5husA:
undetectable		 2xn5A-5husA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 ALA A 399
LEU A 386
LEU A 328
LEU A 356
LEU A 316
 None
 1.00A 2xn5A-5irmA:
undetectable		 2xn5A-5irmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 ALA A 819
LEU A 858
LEU A 856
LEU A 846
LEU A 871
 None
 1.02A 2xn5A-5irmA:
undetectable		 2xn5A-5irmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		5 ALA A 213
LEU A 246
LEU A 249
SER A 214
LEU A 268
 None
 1.08A 2xn5A-5jjoA:
undetectable		 2xn5A-5jjoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 SER B 391
SER B 727
ALA B 387
LEU B 337
LEU B 341
 None
 0.94A 2xn5A-5khnB:
undetectable		 2xn5A-5khnB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 ALA A 118
LEU A  93
LEU A  97
LEU A 282
LEU A 336
 None
 1.12A 2xn5A-5lh9A:
undetectable		 2xn5A-5lh9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)

(Helicobacter
pylori) 		PF04085
(MreC) 		5 SER C 111
LEU C 243
SER C 113
LEU C 114
LEU C 120
 None
 1.09A 2xn5A-5lp5C:
undetectable		 2xn5A-5lp5C:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.89A 2xn5A-5nv6A:
undetectable		 2xn5A-5nv6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5w INTERFERON LAMBDA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac) 		5 ALA B 141
LEU B 166
LEU B 119
SER B 177
LEU B 176
 None
 1.04A 2xn5A-5t5wB:
undetectable		 2xn5A-5t5wB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 336
LEU A 315
LEU A 317
SER A 296
LEU A 299
 None
 0.94A 2xn5A-5uxnA:
undetectable		 2xn5A-5uxnA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU B 468
LEU B 522
SER B 463
LYS B 488
LEU B 535
 None
 1.07A 2xn5A-5xbfB:
undetectable		 2xn5A-5xbfB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 5 ALA A 407
LEU A 102
LEU A 104
SER A 132
LEU A 131
 None
 1.09A 2xn5A-5y92A:
undetectable		 2xn5A-5y92A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 6 LEU A 240
LEU A 219
SER A 201
LEU A 203
LYS A 204
LEU A 231
 None
 1.47A 2xn5A-5yq5A:
undetectable		 2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 5 SER A  74
SER A  75
LEU A 140
LEU A  96
LEU A 146
 None
 1.07A 2xn5A-5yq5A:
undetectable		 2xn5A-5yq5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 341
LEU A 369
SER A 365
LEU A 366
LEU A 356
 None
 1.08A 2xn5A-5zlnA:
undetectable		 2xn5A-5zlnA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 SER A 154
ALA A 181
LEU A 285
LEU A 228
SER A 251
 None
 1.11A 2xn5A-6f9mA:
undetectable		 2xn5A-6f9mA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 ALA A 236
LEU A  99
LEU A 103
LEU A 233
LEU A 226
 HEM  A 401 (-3.4A)
None
None
HEM  A 401 ( 4.4A)
None
 1.11A 2xn5A-6fshA:
undetectable		 2xn5A-6fshA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b07 PROTEIN
(PROTO-ONCOGENE CRK
(CRK))

(Mus musculus) 		PF00018
(SH3_1) 		3 LEU A 151
ARG A 179
ILE A 182
 None
 0.63A 2xn5B-1b07A:
0.0		 2xn5B-1b07A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buy PROTEIN
(ERYTHROPOIETIN)

(Homo sapiens) 		PF00758
(EPO_TPO) 		3 LEU A   5
ARG A 162
ILE A   6
 None
 0.64A 2xn5B-1buyA:
undetectable		 2xn5B-1buyA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		3 LEU A   6
ARG A  90
ILE A   7
 None
 0.63A 2xn5B-1c3eA:
0.4		 2xn5B-1c3eA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 LEU A 128
ARG A 122
ILE A 363
 None
 0.69A 2xn5B-1fn9A:
0.0		 2xn5B-1fn9A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 LEU A 206
ARG A  30
ILE A 208
 None
 0.62A 2xn5B-1fp9A:
0.0		 2xn5B-1fp9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		3 LEU A 289
ARG A 284
ILE A 286
 None
 0.59A 2xn5B-1gpjA:
0.0		 2xn5B-1gpjA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 LEU A 198
ARG A 194
ILE A 200
 None
 0.39A 2xn5B-1im4A:
0.0		 2xn5B-1im4A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		3 LEU A  25
ARG A  22
ILE A 233
 None
 0.62A 2xn5B-1iugA:
0.0		 2xn5B-1iugA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		3 LEU A 146
ARG A 142
ILE A 160
 None
 0.57A 2xn5B-1jv1A:
0.0		 2xn5B-1jv1A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LEU A 347
ARG A 443
ILE A 348
 None
 0.58A 2xn5B-1kejA:
0.0		 2xn5B-1kejA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		3 LEU A  67
ARG A  42
ILE A  66
 None
 0.68A 2xn5B-1l1qA:
undetectable		 2xn5B-1l1qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		3 LEU A 200
ARG A 199
ILE A 201
 None
 0.64A 2xn5B-1ldkA:
undetectable		 2xn5B-1ldkA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LEU A 282
ARG A 281
ILE A 283
 None
SO4  A1312 (-3.6A)
None
 0.57A 2xn5B-1mu2A:
undetectable		 2xn5B-1mu2A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 379
ARG A 377
ILE A 371
 None
 0.00A 2xn5B-1q5aA:
undetectable		 2xn5B-1q5aA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnx VES V 5

(Vespula
vulgaris) 		PF00188
(CAP) 		3 LEU A  45
ARG A  52
ILE A  44
 None
 0.69A 2xn5B-1qnxA:
undetectable		 2xn5B-1qnxA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  47
ARG A  43
ILE A  49
 None
NDP  A1501 ( 4.1A)
None
 0.66A 2xn5B-1rpnA:
undetectable		 2xn5B-1rpnA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A  75
ARG A   5
ILE A   3
 None
 0.55A 2xn5B-1tkkA:
undetectable		 2xn5B-1tkkA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Thermotoga
maritima) 		PF01029
(NusB) 		3 LEU A  58
ARG A  82
ILE A  61
 None
 0.61A 2xn5B-1tzxA:
undetectable		 2xn5B-1tzxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		3 LEU A 340
ARG A 430
ILE A 339
 None
 0.64A 2xn5B-1u2xA:
undetectable		 2xn5B-1u2xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		3 LEU A  78
ARG A 129
ILE A  77
 None
 0.66A 2xn5B-1uxoA:
undetectable		 2xn5B-1uxoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 LEU A 341
ARG A 343
ILE A 340
 None
 0.64A 2xn5B-1x1nA:
undetectable		 2xn5B-1x1nA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe7 HYPOTHETICAL 22.5
KDA PROTEIN IN
TUB1-CPR3 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF06172
(Cupin_5) 		3 LEU A 106
ARG A 108
ILE A 163
 None
 0.57A 2xn5B-1xe7A:
undetectable		 2xn5B-1xe7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		3 LEU 1  15
ARG 1  11
ILE 1  18
 None
 0.59A 2xn5B-1zud1:
undetectable		 2xn5B-1zud1:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx4 PLASMID PARTITION
PAR B PROTEIN

(Escherichia
virus P1) 		PF08775
(ParB) 		3 LEU A 259
ARG A 258
ILE A 260
 None
 0.68A 2xn5B-1zx4A:
undetectable		 2xn5B-1zx4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		3 LEU A 254
ARG A 250
ILE A  52
 None
ANP  A1304 ( 4.5A)
None
 0.62A 2xn5B-2c49A:
undetectable		 2xn5B-2c49A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv8 TRNA-SPLICING
ENDONUCLEASE

(Sulfurisphaera
tokodaii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		3 LEU A  20
ARG A  19
ILE A  21
 None
 0.66A 2xn5B-2cv8A:
undetectable		 2xn5B-2cv8A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		3 LEU A 126
ARG A 123
ILE A 129
 None
 0.58A 2xn5B-2e8gA:
undetectable		 2xn5B-2e8gA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 LEU A 349
ARG A 352
ILE A 345
 None
 0.62A 2xn5B-2efjA:
undetectable		 2xn5B-2efjA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli) 		PF01039
(Carboxyl_trans) 		3 LEU B 251
ARG B 247
ILE B 252
 None
 0.64A 2xn5B-2f9yB:
undetectable		 2xn5B-2f9yB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		3 LEU A 320
ARG A 325
ILE A 248
 None
 0.62A 2xn5B-2gmhA:
undetectable		 2xn5B-2gmhA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		3 LEU A 256
ARG A 254
ILE A 184
 None
 0.68A 2xn5B-2hrzA:
undetectable		 2xn5B-2hrzA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 213
ARG A 220
ILE A 218
 None
 0.67A 2xn5B-2izoA:
undetectable		 2xn5B-2izoA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24

(Trypanosoma
brucei) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 LEU A 126
ARG A  52
ILE A 129
 None
 0.69A 2xn5B-2lvvA:
undetectable		 2xn5B-2lvvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 PROTEIN SRN2

(Saccharomyces
cerevisiae) 		PF07200
(Mod_r) 		3 LEU C 189
ARG C 192
ILE C 185
 None
 0.66A 2xn5B-2p22C:
undetectable		 2xn5B-2p22C:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbb GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Paraburkholderia
phytofirmans) 		PF00903
(Glyoxalase) 		3 LEU A  73
ARG A  71
ILE A  80
 None
 0.59A 2xn5B-2rbbA:
undetectable		 2xn5B-2rbbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		3 LEU A  46
ARG A  49
ILE A  47
 None
 0.58A 2xn5B-2rdlA:
undetectable		 2xn5B-2rdlA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		3 LEU A  63
ARG A  61
ILE A 107
 None
 0.62A 2xn5B-2w87A:
undetectable		 2xn5B-2w87A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		3 LEU A  21
ARG A  20
ILE A  22
 None
 0.57A 2xn5B-2wzvA:
undetectable		 2xn5B-2wzvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum) 		PF02458
(Transferase) 		3 LEU A  41
ARG A  39
ILE A 159
 None
 0.66A 2xn5B-2xr7A:
undetectable		 2xn5B-2xr7A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yax SULFUR
OXYGENASE/REDUCTASE

(Acidianus
ambivalens) 		PF07682
(SOR) 		3 LEU B 293
ARG B  73
ILE B 292
 None
 0.67A 2xn5B-2yaxB:
undetectable		 2xn5B-2yaxB:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		3 LEU C 185
ARG C 184
ILE C 187
 None
 0.67A 2xn5B-2ynmC:
undetectable		 2xn5B-2ynmC:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		3 LEU A  66
ARG A  65
ILE A  68
 None
 0.64A 2xn5B-3alyA:
undetectable		 2xn5B-3alyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		3 LEU A   7
ARG A  91
ILE A   8
 None
 0.60A 2xn5B-3aufA:
undetectable		 2xn5B-3aufA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		3 LEU A  20
ARG A  36
ILE A  42
 None
 0.60A 2xn5B-3cq9A:
undetectable		 2xn5B-3cq9A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 LEU A   5
ARG A   4
ILE A   6
 None
 0.64A 2xn5B-3fcaA:
undetectable		 2xn5B-3fcaA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 LEU A1743
ARG A1776
ILE A1742
 None
 0.62A 2xn5B-3ff6A:
undetectable		 2xn5B-3ff6A:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		3 LEU A 319
ARG A 315
ILE A 321
 None
 0.60A 2xn5B-3gonA:
undetectable		 2xn5B-3gonA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 LEU A1861
ARG A1839
ILE A1864
 None
 0.63A 2xn5B-3ig3A:
undetectable		 2xn5B-3ig3A:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 LEU A1110
ARG A 767
ILE A 764
 None
 0.56A 2xn5B-3jclA:
undetectable		 2xn5B-3jclA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvi PROTEIN TYROSINE
PHOSPHATASE

(Entamoeba
histolytica) 		PF01451
(LMWPc) 		3 LEU A 139
ARG A  13
ILE A 136
 None
SO4  A 201 (-4.5A)
None
 0.64A 2xn5B-3jviA:
undetectable		 2xn5B-3jviA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		3 LEU A  38
ARG A  36
ILE A  52
 None
 0.55A 2xn5B-3kh5A:
undetectable		 2xn5B-3kh5A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		3 LEU A  62
ARG A 113
ILE A 117
 None
 0.60A 2xn5B-3knuA:
undetectable		 2xn5B-3knuA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		3 LEU A 175
ARG A 228
ILE A 177
 None
 0.55A 2xn5B-3l5aA:
undetectable		 2xn5B-3l5aA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		3 LEU A 535
ARG A 571
ILE A 574
 None
 0.52A 2xn5B-3lh5A:
undetectable		 2xn5B-3lh5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		3 LEU A   8
ARG A  13
ILE A   9
 None
 0.55A 2xn5B-3lpmA:
undetectable		 2xn5B-3lpmA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m45 CELL ADHESION
MOLECULE 2

(Mus musculus) 		PF07686
(V-set) 		3 LEU A  88
ARG A  90
ILE A  98
 None
 0.68A 2xn5B-3m45A:
undetectable		 2xn5B-3m45A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 LEU A 138
ARG A 134
ILE A 140
 None
 0.48A 2xn5B-3oetA:
undetectable		 2xn5B-3oetA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LEU A 979
ARG A 976
ILE A 980
 None
 0.68A 2xn5B-3psfA:
undetectable		 2xn5B-3psfA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		3 LEU A 426
ARG A 425
ILE A 427
 None
 0.68A 2xn5B-3pukA:
undetectable		 2xn5B-3pukA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 LEU A 148
ARG A 147
ILE A 149
 None
 0.67A 2xn5B-3qkaA:
undetectable		 2xn5B-3qkaA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 LEU A 152
ARG A 151
ILE A 153
 None
 0.60A 2xn5B-3r9qA:
undetectable		 2xn5B-3r9qA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		3 LEU A  46
ARG A  49
ILE A  47
 None
 0.61A 2xn5B-3rp2A:
undetectable		 2xn5B-3rp2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		3 LEU A 658
ARG A 657
ILE A 659
 None
None
MLY  A 656 ( 4.3A)
 0.66A 2xn5B-4a5pA:
undetectable		 2xn5B-4a5pA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		3 LEU A 235
ARG A 254
ILE A 232
 None
 0.66A 2xn5B-4akkA:
undetectable		 2xn5B-4akkA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LEU A 321
ARG A 320
ILE A 322
 None
 0.64A 2xn5B-4aw2A:
undetectable		 2xn5B-4aw2A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbk FERMITIN FAMILY
HOMOLOG 1

(Mus musculus) 		PF00169
(PH) 		3 LEU A 490
ARG A 463
ILE A 487
 None
 0.64A 2xn5B-4bbkA:
undetectable		 2xn5B-4bbkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 LEU A 237
ARG A 234
ILE A 238
 None
 0.69A 2xn5B-4cukA:
undetectable		 2xn5B-4cukA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 LEU A 250
ARG A 248
ILE A 334
 None
 0.68A 2xn5B-4hykA:
undetectable		 2xn5B-4hykA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 LEU C  37
ARG C  33
ILE C  39
 None
 0.63A 2xn5B-4ifdC:
undetectable		 2xn5B-4ifdC:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 LEU A 191
ARG A 187
ILE A 193
 None
 0.62A 2xn5B-4ivfA:
undetectable		 2xn5B-4ivfA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyq PHOSPHOGLUCAN
PHOSPHATASE LSF2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc) 		3 LEU A  95
ARG A  97
ILE A 101
 None
 0.69A 2xn5B-4kyqA:
undetectable		 2xn5B-4kyqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 LEU A 159
ARG A 158
ILE A 160
 None
 0.64A 2xn5B-4mi2A:
undetectable		 2xn5B-4mi2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		3 LEU A 427
ARG A 144
ILE A 424
 None
 0.67A 2xn5B-4nphA:
undetectable		 2xn5B-4nphA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 LEU A 382
ARG A 325
ILE A 383
 None
 0.68A 2xn5B-4p22A:
undetectable		 2xn5B-4p22A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		3 LEU A  19
ARG A 243
ILE A  16
 None
 0.55A 2xn5B-4pvcA:
undetectable		 2xn5B-4pvcA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		3 LEU A 230
ARG A 183
ILE A 231
 None
 0.68A 2xn5B-4rhhA:
undetectable		 2xn5B-4rhhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LEU M 384
ARG M 325
ILE M 383
 None
 0.68A 2xn5B-4wj3M:
undetectable		 2xn5B-4wj3M:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpm MRNA EXPORT PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 LEU A 161
ARG A 160
ILE A 173
 None
SO4  A 303 ( 3.5A)
None
 0.64A 2xn5B-4wpmA:
undetectable		 2xn5B-4wpmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 3 LEU C 236
ARG C 232
ILE C 237
 None
 0.62A 2xn5B-4wzsC:
undetectable		 2xn5B-4wzsC:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfz OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 LEU A 109
ARG A 162
ILE A 108
 None
 0.63A 2xn5B-4yfzA:
undetectable		 2xn5B-4yfzA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		3 LEU A  73
ARG A 186
ILE A  67
 GOL  A 203 ( 4.7A)
None
None
 0.61A 2xn5B-4zbzA:
undetectable		 2xn5B-4zbzA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 3 LEU A 816
ARG A 797
ILE A 813
 None
 0.67A 2xn5B-4zuzA:
undetectable		 2xn5B-4zuzA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0d SURFACE ANCHORED
PROTEIN

(Clostridium
perfringens) 		PF08341
(TED) 		3 LEU A 198
ARG A 187
ILE A 200
 None
 0.60A 2xn5B-5a0dA:
undetectable		 2xn5B-5a0dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		3 LEU A  98
ARG A  34
ILE A  91
 None
 0.59A 2xn5B-5c17A:
undetectable		 2xn5B-5c17A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		3 LEU A1096
ARG A1094
ILE A1153
 None
 0.58A 2xn5B-5dczA:
undetectable		 2xn5B-5dczA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 LEU A  25
ARG A  23
ILE A  32
 None
 0.53A 2xn5B-5e6sA:
undetectable		 2xn5B-5e6sA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		3 LEU A  80
ARG A  90
ILE A  82
 None
 0.57A 2xn5B-5ewtA:
undetectable		 2xn5B-5ewtA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		3 LEU C  64
ARG C  67
ILE C  65
 None
 0.68A 2xn5B-5g52C:
undetectable		 2xn5B-5g52C:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis) 		PF01370
(Epimerase) 		3 LEU A  21
ARG A 239
ILE A  18
 None
 0.64A 2xn5B-5gmoA:
undetectable		 2xn5B-5gmoA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 LEU A 767
ARG A 766
ILE A 768
 None
 0.67A 2xn5B-5h64A:
undetectable		 2xn5B-5h64A:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hck HEMATOPOIETIC CELL
KINASE

(Homo sapiens) 		PF00018
(SH3_1) 		3 LEU A  97
ARG A 118
ILE A 128
 None
 0.68A 2xn5B-5hckA:
undetectable		 2xn5B-5hckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB

(Homo sapiens) 		PF00382
(TFIIB)
PF08271
(TF_Zn_Ribbon) 		3 LEU M 291
ARG M 290
ILE M 292
 None
 0.69A 2xn5B-5iy7M:
undetectable		 2xn5B-5iy7M:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 3 LEU A 654
ARG A 650
ILE A 641
 None
 0.60A 2xn5B-5jyuA:
undetectable		 2xn5B-5jyuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 LEU B 109
ARG B 107
ILE B 131
 None
 0.62A 2xn5B-5mrwB:
undetectable		 2xn5B-5mrwB:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 LEU A2758
ARG A2757
ILE A2759
 None
 0.63A 2xn5B-5nugA:
undetectable		 2xn5B-5nugA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7b PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE SLR0328

(Synechocystis
sp. PCC 6803) 		no annotation 3 LEU A 140
ARG A  13
ILE A 137
 None
 0.36A 2xn5B-5o7bA:
undetectable		 2xn5B-5o7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 3 LEU A 118
ARG A 120
ILE A  34
 None
 0.68A 2xn5B-5ol0A:
undetectable		 2xn5B-5ol0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		3 LEU E 161
ARG E 258
ILE E 165
 None
C  A 629 ( 3.6A)
None
 0.57A 2xn5B-5x8tE:
undetectable		 2xn5B-5x8tE:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjp HUMAN CHYMASE

(Homo sapiens) 		no annotation 3 LEU A  46
ARG A  49
ILE A  47
 None
 0.60A 2xn5B-5yjpA:
undetectable		 2xn5B-5yjpA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 3 LEU X   6
ARG X  20
ILE X  12
 None
 0.60A 2xn5B-6elqX:
undetectable		 2xn5B-6elqX:
16.00