SIMILAR PATTERNS OF AMINO ACIDS FOR 2XN3_A_ID8A1356

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A  83
LEU A  66
LYS A  67
LEU A  93
 None
 1.15A 2xn3A-1a9nA:
undetectable
2xn3B-1a9nA:
0.0		 2xn3A-1a9nA:
18.95
2xn3B-1a9nA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		4 LEU 1  73
LEU 1  16
LEU 1 176
ARG 1  13
 None
None
None
SO4  1 190 (-3.7A)
 1.02A 2xn3A-1cnt1:
0.0
2xn3B-1cnt1:
undetectable		 2xn3A-1cnt1:
18.99
2xn3B-1cnt1:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deb ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF16689
(APC_N_CC) 		4 LEU A  16
LYS A  17
ASN A  20
LEU A  23
 None
 0.42A 2xn3A-1debA:
undetectable
2xn3B-1debA:
undetectable		 2xn3A-1debA:
13.50
2xn3B-1debA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 244
LEU A 164
LEU A 234
ARG A 167
 None
 0.98A 2xn3A-1dgsA:
0.0
2xn3B-1dgsA:
0.0		 2xn3A-1dgsA:
19.73
2xn3B-1dgsA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk4 VIMENTIN

(Homo sapiens) 		PF00038
(Filament) 		4 LEU A 333
LYS A 334
ASN A 337
LEU A 340
 None
 0.55A 2xn3A-1gk4A:
undetectable
2xn3B-1gk4A:
undetectable		 2xn3A-1gk4A:
14.37
2xn3B-1gk4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ilk INTERLEUKIN-10

(Homo sapiens) 		PF00726
(IL10) 		4 LEU A  65
LEU A  98
LYS A  99
LEU A 105
 None
 1.01A 2xn3A-1ilkA:
0.0
2xn3B-1ilkA:
undetectable		 2xn3A-1ilkA:
18.82
2xn3B-1ilkA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlk RESPONSE REGULATOR
RCP1

(Synechocystis
sp. PCC 6803) 		PF00072
(Response_reg) 		4 LEU A  13
LEU A  23
LEU A  28
ARG A  22
 None
 1.14A 2xn3A-1jlkA:
0.0
2xn3B-1jlkA:
undetectable		 2xn3A-1jlkA:
19.58
2xn3B-1jlkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 349
LEU A 504
LEU A 399
ARG A 509
 None
 1.03A 2xn3A-1nneA:
0.0
2xn3B-1nneA:
0.0		 2xn3A-1nneA:
17.73
2xn3B-1nneA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugk SYNAPTOTAGMIN IV

(Homo sapiens) 		PF00168
(C2) 		4 LEU A  15
LEU A  11
LEU A 126
ARG A 129
 None
 1.17A 2xn3A-1ugkA:
0.0
2xn3B-1ugkA:
0.0		 2xn3A-1ugkA:
17.48
2xn3B-1ugkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uii GEMININ

(Homo sapiens) 		PF07412
(Geminin) 		4 LEU A 134
LYS A 135
ASN A 138
LEU A 141
 None
 0.52A 2xn3A-1uiiA:
undetectable
2xn3B-1uiiA:
undetectable		 2xn3A-1uiiA:
13.02
2xn3B-1uiiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 247
LEU A 169
LEU A 237
ARG A 172
 None
 1.00A 2xn3A-1v9pA:
0.0
2xn3B-1v9pA:
0.0		 2xn3A-1v9pA:
19.39
2xn3B-1v9pA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 LEU A 191
LEU A  90
LYS A  87
ARG A  92
 None
 1.15A 2xn3A-2aafA:
0.0
2xn3B-2aafA:
0.0		 2xn3A-2aafA:
21.16
2xn3B-2aafA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 GLN A 215
LEU A 211
LEU A 218
ARG A 112
 None
 1.16A 2xn3A-2atmA:
undetectable
2xn3B-2atmA:
0.0		 2xn3A-2atmA:
20.44
2xn3B-2atmA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		4 LEU A 265
LEU A 168
LYS A 165
LEU A 279
 None
 1.19A 2xn3A-2c6xA:
undetectable
2xn3B-2c6xA:
0.0		 2xn3A-2c6xA:
23.15
2xn3B-2c6xA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  15
LEU A 271
LEU A  66
ARG A 262
 None
 1.02A 2xn3A-2cfoA:
undetectable
2xn3B-2cfoA:
0.0		 2xn3A-2cfoA:
21.40
2xn3B-2cfoA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 133
LEU A 250
LEU A 257
ARG A 114
 None
None
None
CIT  A1585 (-3.1A)
 1.15A 2xn3A-2d1cA:
undetectable
2xn3B-2d1cA:
undetectable		 2xn3A-2d1cA:
20.52
2xn3B-2d1cA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		4 GLN A 175
LEU A 116
LYS A 117
LEU A 144
 None
 1.19A 2xn3A-2dfaA:
undetectable
2xn3B-2dfaA:
undetectable		 2xn3A-2dfaA:
23.94
2xn3B-2dfaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis) 		PF01351
(RNase_HII) 		4 LEU A  52
ASN A  54
LEU A  57
ARG A 154
 None
 1.04A 2xn3A-2dfeA:
undetectable
2xn3B-2dfeA:
undetectable		 2xn3A-2dfeA:
21.04
2xn3B-2dfeA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Chlorobaculum
tepidum) 		PF13419
(HAD_2) 		4 LEU A 101
LEU A 127
LYS A 128
LEU A  93
 None
 1.19A 2xn3A-2hcfA:
undetectable
2xn3B-2hcfA:
undetectable		 2xn3A-2hcfA:
19.10
2xn3B-2hcfA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		4 GLN A 330
LEU A 326
LYS A 282
LEU A 288
 None
 1.18A 2xn3A-2ilrA:
undetectable
2xn3B-2ilrA:
undetectable		 2xn3A-2ilrA:
23.58
2xn3B-2ilrA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		4 LEU A 534
LEU A 485
LYS A 486
ARG A 529
 None
 0.95A 2xn3A-2j04A:
undetectable
2xn3B-2j04A:
undetectable		 2xn3A-2j04A:
20.26
2xn3B-2j04A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 LEU A  96
LYS A  97
ASN A 100
LEU A 103
 None
 0.59A 2xn3A-2j5uA:
undetectable
2xn3B-2j5uA:
undetectable		 2xn3A-2j5uA:
21.71
2xn3B-2j5uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5t UNCHARACTERIZED
PROTEIN YHHK

(Escherichia
coli) 		PF12568
(DUF3749) 		4 LEU A  63
ASN A  89
LEU A  86
ARG A  38
 None
 0.95A 2xn3A-2k5tA:
undetectable
2xn3B-2k5tA:
undetectable		 2xn3A-2k5tA:
16.17
2xn3B-2k5tA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkz RNA-BINDING PROTEIN
5

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLN A  74
LEU A  14
LEU A  70
ARG A  15
 None
 1.19A 2xn3A-2lkzA:
undetectable
2xn3B-2lkzA:
undetectable		 2xn3A-2lkzA:
13.13
2xn3B-2lkzA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lp0 HOMEOBOX PROTEIN
HOX-C9

(Homo sapiens) 		PF00046
(Homeobox) 		4 GLN A  60
LEU A  56
LYS A  26
LEU A  32
 None
 1.10A 2xn3A-2lp0A:
undetectable
2xn3B-2lp0A:
undetectable		 2xn3A-2lp0A:
11.18
2xn3B-2lp0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		4 LEU A  14
LEU A 273
LEU A  65
ARG A 264
 None
 1.06A 2xn3A-2o5rA:
undetectable
2xn3B-2o5rA:
undetectable		 2xn3A-2o5rA:
21.63
2xn3B-2o5rA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A  66
LYS A 110
ASN A 109
LEU A 106
 None
 1.15A 2xn3A-2o6rA:
undetectable
2xn3B-2o6rA:
undetectable		 2xn3A-2o6rA:
20.00
2xn3B-2o6rA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oa5 HYPOTHETICAL PROTEIN
BQLF2

(Murid
gammaherpesvirus
4) 		PF05812
(Herpes_BLRF2) 		4 LEU A  20
LYS A  21
ASN A  24
LEU A  27
 None
PE5  A4870 (-3.2A)
None
None
 0.59A 2xn3A-2oa5A:
undetectable
2xn3B-2oa5A:
undetectable		 2xn3A-2oa5A:
15.22
2xn3B-2oa5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A  59
LEU A  92
LYS A  93
LEU A  47
 None
 0.82A 2xn3A-2og2A:
undetectable
2xn3B-2og2A:
undetectable		 2xn3A-2og2A:
23.18
2xn3B-2og2A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vh2 CELL DIVISION
PROTEIN FTSQ

(Yersinia
enterocolitica) 		PF03799
(FtsQ)
PF08478
(POTRA_1) 		4 LEU A 160
LYS A 179
ASN A 178
LEU A 188
 None
 1.05A 2xn3A-2vh2A:
undetectable
2xn3B-2vh2A:
undetectable		 2xn3A-2vh2A:
20.56
2xn3B-2vh2A:
11.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		6 GLN A 238
LEU A 246
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.18A 2xn3A-2xn6A:
53.6
2xn3B-2xn6A:
undetectable		 2xn3A-2xn6A:
99.42
2xn3B-2xn6A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 GLN A 871
LEU A 770
LYS A 771
LEU A 777
 None
 0.90A 2xn3A-3a6pA:
undetectable
2xn3B-3a6pA:
undetectable		 2xn3A-3a6pA:
15.11
2xn3B-3a6pA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 LEU C 141
LEU C 381
LEU C 192
ARG C 372
 None
 1.06A 2xn3A-3al0C:
undetectable
2xn3B-3al0C:
undetectable		 2xn3A-3al0C:
20.47
2xn3B-3al0C:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 GLN B 342
LEU B 277
LEU B 370
ARG B 349
 None
 0.95A 2xn3A-3bxwB:
undetectable
2xn3B-3bxwB:
undetectable		 2xn3A-3bxwB:
21.07
2xn3B-3bxwB:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		4 LEU A   6
LYS A   7
LEU A  10
ARG A   5
 None
 1.18A 2xn3A-3cjtA:
undetectable
2xn3B-3cjtA:
undetectable		 2xn3A-3cjtA:
21.95
2xn3B-3cjtA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF04121
(Nup84_Nup100)
no annotation 		4 LEU B 953
LEU A 904
LEU A 919
ARG A 905
 None
 0.95A 2xn3A-3cqcB:
undetectable
2xn3B-3cqcB:
undetectable		 2xn3A-3cqcB:
21.33
2xn3B-3cqcB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djw ORF99

(Acidianus
filamentous
virus 1) 		PF07118
(DUF1374) 		4 LEU A  29
LEU A   9
LYS A   8
LEU A  41
 None
 1.14A 2xn3A-3djwA:
undetectable
2xn3B-3djwA:
undetectable		 2xn3A-3djwA:
17.06
2xn3B-3djwA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h20 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		4 LEU A  51
LYS A  52
ASN A  55
ARG A 145
 None
None
None
DPO  A 327 (-4.0A)
 0.75A 2xn3A-3h20A:
undetectable
2xn3B-3h20A:
undetectable		 2xn3A-3h20A:
20.22
2xn3B-3h20A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h25 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		4 LEU A  51
LYS A  52
ASN A  55
ARG A 145
 None
 0.67A 2xn3A-3h25A:
undetectable
2xn3B-3h25A:
undetectable		 2xn3A-3h25A:
18.60
2xn3B-3h25A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3he5 SYNZIP2

(synthetic
construct) 		no annotation 4 LEU B  13
LYS B  14
ASN B  17
LEU B  20
 None
 0.60A 2xn3A-3he5B:
undetectable
2xn3B-3he5B:
undetectable		 2xn3A-3he5B:
12.80
2xn3B-3he5B:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv2 RESPONSE
REGULATOR/HD DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF00072
(Response_reg) 		4 LEU A  90
LEU A  31
LEU A  17
ARG A  27
 None
 1.20A 2xn3A-3hv2A:
undetectable
2xn3B-3hv2A:
undetectable		 2xn3A-3hv2A:
21.27
2xn3B-3hv2A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		4 GLN A  60
LEU A 153
LYS A 152
ASN A 151
 None
 1.08A 2xn3A-3ixrA:
undetectable
2xn3B-3ixrA:
undetectable		 2xn3A-3ixrA:
20.41
2xn3B-3ixrA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 4 LEU B  93
LEU B  45
LYS B  44
LEU B  34
 None
 1.15A 2xn3A-3k1lB:
undetectable
2xn3B-3k1lB:
undetectable		 2xn3A-3k1lB:
23.15
2xn3B-3k1lB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6e CBS DOMAIN PROTEIN

(Streptococcus
pneumoniae) 		PF00571
(CBS) 		4 LEU A 134
LYS A 135
ASN A 138
LEU A 141
 None
 0.96A 2xn3A-3k6eA:
undetectable
2xn3B-3k6eA:
undetectable		 2xn3A-3k6eA:
19.13
2xn3B-3k6eA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns5 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 LEU A 155
LEU A  95
LYS A  96
LEU A 102
 None
 0.89A 2xn3A-3ns5A:
undetectable
2xn3B-3ns5A:
undetectable		 2xn3A-3ns5A:
18.15
2xn3B-3ns5A:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 356
LEU A 297
ASN A 301
LEU A 304
 LEU  A 356 ( 0.6A)
LEU  A 297 ( 0.6A)
ASN  A 301 ( 0.6A)
LEU  A 304 ( 0.6A)
 1.10A 2xn3A-3sagA:
undetectable
2xn3B-3sagA:
undetectable		 2xn3A-3sagA:
21.97
2xn3B-3sagA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 LEU A1181
LEU A1275
ASN A1271
LEU A1268
 None
 1.20A 2xn3A-3swhA:
undetectable
2xn3B-3swhA:
undetectable		 2xn3A-3swhA:
23.57
2xn3B-3swhA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 434
LEU A 437
ASN A 458
ARG A 421
 None
 1.01A 2xn3A-3szeA:
undetectable
2xn3B-3szeA:
undetectable		 2xn3A-3szeA:
16.89
2xn3B-3szeA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmx VOLTAGE-GATED
HYDROGEN CHANNEL 1

(Mus musculus) 		PF16799
(VGPC1_C) 		4 LEU A 227
LYS A 228
ASN A 231
LEU A 234
 None
 0.57A 2xn3A-3vmxA:
undetectable
2xn3B-3vmxA:
undetectable		 2xn3A-3vmxA:
13.04
2xn3B-3vmxA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 GLN A 100
LEU A 107
LEU A 293
ARG A 132
 None
 1.15A 2xn3A-3wwxA:
undetectable
2xn3B-3wwxA:
undetectable		 2xn3A-3wwxA:
22.51
2xn3B-3wwxA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA

(Homo sapiens) 		PF01504
(PIP5K) 		4 LEU A 179
LEU A 261
LYS A 258
ASN A 259
 None
 0.95A 2xn3A-3x05A:
undetectable
2xn3B-3x05A:
undetectable		 2xn3A-3x05A:
21.38
2xn3B-3x05A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 114
LEU A 147
LYS A 148
LEU A 102
 None
 0.85A 2xn3A-4ak9A:
undetectable
2xn3B-4ak9A:
undetectable		 2xn3A-4ak9A:
23.76
2xn3B-4ak9A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 GLN A 102
LEU A  39
LYS A  40
LEU A  46
 None
 0.72A 2xn3A-4ckgA:
undetectable
2xn3B-4ckgA:
undetectable		 2xn3A-4ckgA:
20.60
2xn3B-4ckgA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		4 LEU A 319
LEU A 357
LEU A 378
ARG A 312
 None
 0.87A 2xn3A-4cswA:
undetectable
2xn3B-4cswA:
undetectable		 2xn3A-4cswA:
20.19
2xn3B-4cswA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 GLN A 110
LEU A 107
LEU A 268
ARG A  78
 None
 1.06A 2xn3A-4cvqA:
undetectable
2xn3B-4cvqA:
undetectable		 2xn3A-4cvqA:
22.53
2xn3B-4cvqA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 LEU A 177
ASN A 158
LEU A 161
ARG A 155
 None
 1.08A 2xn3A-4fe2A:
undetectable
2xn3B-4fe2A:
undetectable		 2xn3A-4fe2A:
22.67
2xn3B-4fe2A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 LEU A 113
LEU A  99
LEU A  92
ARG A  98
 None
 1.03A 2xn3A-4g3aA:
undetectable
2xn3B-4g3aA:
undetectable		 2xn3A-4g3aA:
21.84
2xn3B-4g3aA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		4 LEU A 226
LEU A  21
LYS A  20
ASN A  19
 None
 0.99A 2xn3A-4gxtA:
undetectable
2xn3B-4gxtA:
undetectable		 2xn3A-4gxtA:
21.83
2xn3B-4gxtA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 LEU A 127
LEU A  90
ASN A  92
LEU A  95
 None
 1.18A 2xn3A-4i6nA:
undetectable
2xn3B-4i6nA:
undetectable		 2xn3A-4i6nA:
21.59
2xn3B-4i6nA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		4 LEU A 292
LEU A 262
LYS A 263
LEU A 269
 None
 0.88A 2xn3A-4i8oA:
undetectable
2xn3B-4i8oA:
undetectable		 2xn3A-4i8oA:
23.62
2xn3B-4i8oA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iff FUSION OF PHAGE
PHI29 GP7 PROTEIN
AND CELL DIVISION
PROTEIN FTSB

(Bacillus virus
phi29;
Escherichia
coli) 		PF04977
(DivIC)
PF11418
(Scaffolding_pro) 		4 LEU A 146
LYS A 147
ASN A 150
LEU A 153
 None
 0.63A 2xn3A-4iffA:
undetectable
2xn3B-4iffA:
undetectable		 2xn3A-4iffA:
12.84
2xn3B-4iffA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 LEU A  49
LEU A  93
LEU A   6
ARG A  90
 None
 0.94A 2xn3A-4iwhA:
undetectable
2xn3B-4iwhA:
undetectable		 2xn3A-4iwhA:
22.25
2xn3B-4iwhA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9u RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A 758
LYS A 759
ASN A 762
LEU A 765
 None
 0.62A 2xn3A-4l9uA:
undetectable
2xn3B-4l9uA:
undetectable		 2xn3A-4l9uA:
13.16
2xn3B-4l9uA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.41A 2xn3A-4ll6A:
undetectable
2xn3B-4ll6A:
undetectable		 2xn3A-4ll6A:
22.50
2xn3B-4ll6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.56A 2xn3A-4ll8A:
undetectable
2xn3B-4ll8A:
undetectable		 2xn3A-4ll8A:
21.08
2xn3B-4ll8A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E  70
LYS E  71
ASN E  74
LEU E  77
 None
 0.62A 2xn3A-4ll8E:
undetectable
2xn3B-4ll8E:
undetectable		 2xn3A-4ll8E:
22.91
2xn3B-4ll8E:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		4 GLN A 253
LYS A 177
LEU A 180
ARG A 243
 None
 1.10A 2xn3A-4mwzA:
undetectable
2xn3B-4mwzA:
undetectable		 2xn3A-4mwzA:
21.74
2xn3B-4mwzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng2 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU E  74
LEU E 106
LEU E  99
ARG E 105
 None
 0.91A 2xn3A-4ng2E:
undetectable
2xn3B-4ng2E:
undetectable		 2xn3A-4ng2E:
15.16
2xn3B-4ng2E:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		4 LEU X  66
LEU X 366
LYS X 367
LEU X 373
 None
 0.77A 2xn3A-4pkaX:
undetectable
2xn3B-4pkaX:
undetectable		 2xn3A-4pkaX:
21.74
2xn3B-4pkaX:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 LEU A 610
LEU A 620
LYS A 644
ASN A 645
 None
 1.11A 2xn3A-4ru5A:
undetectable
2xn3B-4ru5A:
undetectable		 2xn3A-4ru5A:
19.74
2xn3B-4ru5A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 386
LEU A 418
LEU A 376
ARG A 415
 None
 1.15A 2xn3A-4u08A:
undetectable
2xn3B-4u08A:
undetectable		 2xn3A-4u08A:
23.13
2xn3B-4u08A:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 LEU A 222
LEU A 163
LYS A 217
LEU A 249
 None
 1.03A 2xn3A-4u3vA:
undetectable
2xn3B-4u3vA:
undetectable		 2xn3A-4u3vA:
22.87
2xn3B-4u3vA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 350
LYS A 351
ASN A 354
LEU A 357
 None
 1.12A 2xn3A-4uygA:
undetectable
2xn3B-4uygA:
undetectable		 2xn3A-4uygA:
18.93
2xn3B-4uygA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B  77
LYS B 121
ASN B 120
LEU B 117
 None
 1.18A 2xn3A-4y61B:
undetectable
2xn3B-4y61B:
undetectable		 2xn3A-4y61B:
23.77
2xn3B-4y61B:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 LEU A 421
LEU A 447
LYS A 448
LEU A 454
 None
 0.89A 2xn3A-4zu9A:
undetectable
2xn3B-4zu9A:
undetectable		 2xn3A-4zu9A:
22.00
2xn3B-4zu9A:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy8 PROTEIN LST4

(Kluyveromyces
lactis) 		no annotation 4 GLN C  17
LEU C 129
LYS C 130
LEU C 140
 None
 1.10A 2xn3A-4zy8C:
undetectable
2xn3B-4zy8C:
undetectable		 2xn3A-4zy8C:
20.29
2xn3B-4zy8C:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 LEU A  12
LYS A  13
ASN A  16
LEU A  19
 None
 0.56A 2xn3A-5a5tA:
undetectable
2xn3B-5a5tA:
undetectable		 2xn3A-5a5tA:
11.63
2xn3B-5a5tA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 GLN C 648
LEU C 646
LEU C 682
ASN C 678
 None
 1.17A 2xn3A-5a5tC:
undetectable
2xn3B-5a5tC:
undetectable		 2xn3A-5a5tC:
16.67
2xn3B-5a5tC:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 GLN A 356
LEU A 352
LEU A 448
LEU A 413
 None
 1.01A 2xn3A-5b5rA:
undetectable
2xn3B-5b5rA:
undetectable		 2xn3A-5b5rA:
21.77
2xn3B-5b5rA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 GLN A  46
LEU A 156
LYS A 155
LEU A 149
 None
 1.11A 2xn3A-5bykA:
undetectable
2xn3B-5bykA:
undetectable		 2xn3A-5bykA:
21.78
2xn3B-5bykA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58
NUCLEOPORIN NUP62

(Xenopus laevis) 		PF05064
(Nsp1_C)
PF15967
(Nucleoporin_FG2) 		4 GLN B 397
LEU C 469
LYS C 470
LEU C 476
 None
 0.69A 2xn3A-5c3lB:
undetectable
2xn3B-5c3lB:
undetectable		 2xn3A-5c3lB:
17.51
2xn3B-5c3lB:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0p SORTING NEXIN-3

(Homo sapiens) 		PF00787
(PX) 		4 LEU C 145
LYS C 128
ASN C 127
LEU C  29
 None
 0.96A 2xn3A-5f0pC:
undetectable
2xn3B-5f0pC:
undetectable		 2xn3A-5f0pC:
19.93
2xn3B-5f0pC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fiy PRKC APOPTOSIS WT1
REGULATOR PROTEIN

(Rattus
norvegicus) 		no annotation 4 LEU A 316
LYS A 317
ASN A 320
LEU A 323
 None
 0.62A 2xn3A-5fiyA:
undetectable
2xn3B-5fiyA:
undetectable		 2xn3A-5fiyA:
15.16
2xn3B-5fiyA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		4 LEU D 103
LEU D  45
LEU D 117
ARG D  30
 None
 1.17A 2xn3A-5ganD:
undetectable
2xn3B-5ganD:
undetectable		 2xn3A-5ganD:
18.15
2xn3B-5ganD:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX

(Homo sapiens) 		no annotation 4 LEU D  39
LEU D  91
LYS D  90
ASN D  89
 None
 1.10A 2xn3A-5h7sD:
undetectable
2xn3B-5h7sD:
undetectable		 2xn3A-5h7sD:
18.15
2xn3B-5h7sD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU A 844
LYS A 843
ASN A 846
ARG A 842
 None
 1.10A 2xn3A-5hzrA:
undetectable
2xn3B-5hzrA:
undetectable		 2xn3A-5hzrA:
19.84
2xn3B-5hzrA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 309
LEU A 314
ASN A 313
LEU A 336
 None
 1.04A 2xn3A-5ixqA:
undetectable
2xn3B-5ixqA:
undetectable		 2xn3A-5ixqA:
21.91
2xn3B-5ixqA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 GLN A 182
LEU A 149
ASN A 151
LEU A 155
 None
AU  A 301 (-4.7A)
None
None
 1.12A 2xn3A-5jjoA:
undetectable
2xn3B-5jjoA:
undetectable		 2xn3A-5jjoA:
21.41
2xn3B-5jjoA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 GLN A 182
LEU A 149
ASN A 151
LEU A 155
 None
 1.11A 2xn3A-5jkpA:
undetectable
2xn3B-5jkpA:
undetectable		 2xn3A-5jkpA:
20.95
2xn3B-5jkpA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 LEU A 528
LYS A 476
ASN A 470
LEU A 469
 None
 1.16A 2xn3A-5jtvA:
undetectable
2xn3B-5jtvA:
undetectable		 2xn3A-5jtvA:
19.97
2xn3B-5jtvA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koa CELL DIVISION
PROTEIN ZAPD

(Escherichia
coli) 		PF07072
(ZapD) 		4 LEU A 244
ASN A 204
LEU A 205
ARG A 202
 None
 0.96A 2xn3A-5koaA:
undetectable
2xn3B-5koaA:
undetectable		 2xn3A-5koaA:
20.87
2xn3B-5koaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 LEU A 157
LEU A 184
LYS A 185
LEU A 191
 None
 0.86A 2xn3A-5lq4A:
undetectable
2xn3B-5lq4A:
undetectable		 2xn3A-5lq4A:
20.34
2xn3B-5lq4A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN

(Kutzneria
albida) 		PF09017
(Transglut_prok) 		4 LEU A  59
LEU A  64
ASN A  65
ARG A  56
 None
None
MES  A 301 (-3.5A)
None
 1.11A 2xn3A-5m6qA:
undetectable
2xn3B-5m6qA:
undetectable		 2xn3A-5m6qA:
19.83
2xn3B-5m6qA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 GLN A1207
LEU A1250
LYS A1251
ASN A1252
 None
 1.00A 2xn3A-5mznA:
undetectable
2xn3B-5mznA:
undetectable		 2xn3A-5mznA:
19.79
2xn3B-5mznA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLN A 265
LEU A 253
LYS A 254
LEU A  54
 None
 1.08A 2xn3A-5na7A:
undetectable
2xn3B-5na7A:
undetectable		 2xn3A-5na7A:
19.55
2xn3B-5na7A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 LEU C 442
LEU C 406
LEU C 377
ARG C 466
 None
 1.01A 2xn3A-5wqlC:
undetectable
2xn3B-5wqlC:
undetectable		 2xn3A-5wqlC:
21.00
2xn3B-5wqlC:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 LEU A  77
LEU A  58
LEU A 104
ARG A  57
 None
 0.86A 2xn3A-5xnpA:
undetectable
2xn3B-5xnpA:
undetectable		 2xn3A-5xnpA:
13.74
2xn3B-5xnpA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Trypanosoma
brucei) 		no annotation 4 LEU A 133
ASN A 132
LEU A 130
ARG A 134
 None
 0.90A 2xn3A-6aqoA:
undetectable
2xn3B-6aqoA:
undetectable		 2xn3A-6aqoA:
12.24
2xn3B-6aqoA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 4 GLN C  66
LEU C  19
LEU C  56
ARG C 218
 None
 1.05A 2xn3A-6c4mC:
undetectable
2xn3B-6c4mC:
undetectable		 2xn3A-6c4mC:
13.51
2xn3B-6c4mC:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6j HIT FAMILY HYDROLASE

(Legionella
pneumophila) 		no annotation 4 LEU A  64
ASN A  62
LEU A  59
ARG A  66
 None
CL  A 203 (-4.3A)
CL  A 203 (-4.1A)
CL  A 201 (-4.5A)
 1.19A 2xn3A-6d6jA:
undetectable
2xn3B-6d6jA:
undetectable		 2xn3A-6d6jA:
13.25
2xn3B-6d6jA:
21.74