SIMILAR PATTERNS OF AMINO ACIDS FOR 2XKW_B_P1BB1475_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		4 LEU A 128
ARG A  34
ILE A  37
ILE A 159
 None
 0.93A 2xkwB-1a6cA:
undetectable		 2xkwB-1a6cA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 LEU A 509
ILE A  32
ILE A  59
LEU A  76
 None
 0.75A 2xkwB-1b25A:
0.0		 2xkwB-1b25A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 350
ILE A 365
ILE A 292
LEU A 304
 None
 0.82A 2xkwB-1bk6A:
0.0		 2xkwB-1bk6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		4 LEU A  71
ILE A  98
ILE A 131
LEU A  34
 None
 0.96A 2xkwB-1cbkA:
undetectable		 2xkwB-1cbkA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 LEU A 489
ILE A 424
ILE A 463
LEU A 474
 None
 0.95A 2xkwB-1csjA:
0.0		 2xkwB-1csjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 LEU A  10
ILE A 328
ILE A 295
MET A 294
 None
 0.97A 2xkwB-1ezwA:
0.0		 2xkwB-1ezwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 LEU A 233
ILE A  40
ILE A 448
LEU A  23
 None
 0.88A 2xkwB-1h81A:
0.0		 2xkwB-1h81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id1 PUTATIVE POTASSIUM
CHANNEL PROTEIN

(Escherichia
coli) 		PF02254
(TrkA_N) 		4 ARG A  73
ILE A  71
ILE A 123
LEU A  80
 None
 0.91A 2xkwB-1id1A:
0.0		 2xkwB-1id1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A1113
ILE A1123
ILE A1128
LEU A1162
 None
 0.89A 2xkwB-1ihmA:
undetectable		 2xkwB-1ihmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 233
ARG A  27
ILE A  29
ILE A 164
 None
 0.85A 2xkwB-1kkhA:
undetectable		 2xkwB-1kkhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 225
ILE A  48
ILE A 277
LEU A 250
 None
 0.87A 2xkwB-1mewA:
undetectable		 2xkwB-1mewA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU B 429
ILE B 444
ILE B 370
LEU B 382
 None
 0.84A 2xkwB-1pjmB:
undetectable		 2xkwB-1pjmB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 242
ILE A  66
ILE A 273
LEU A 266
 None
 0.95A 2xkwB-1r8wA:
undetectable		 2xkwB-1r8wA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 895
ILE A 995
ILE A1071
LEU A 984
 None
 0.91A 2xkwB-1sojA:
undetectable		 2xkwB-1sojA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		4 LEU 1   8
ILE 1 106
ILE 1  78
MET 1  82
 None
 0.90A 2xkwB-1t6t1:
undetectable		 2xkwB-1t6t1:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 LEU A 178
ILE A 211
ILE A 120
LEU A 236
 None
 0.96A 2xkwB-1tk1A:
undetectable		 2xkwB-1tk1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 LEU A 178
ILE A 211
ILE A 120
LEU A 236
 None
 0.96A 2xkwB-1tklA:
undetectable		 2xkwB-1tklA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU B 350
ILE B 365
ILE B 292
LEU B 304
 None
 0.62A 2xkwB-1wa5B:
undetectable		 2xkwB-1wa5B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 129
ILE A 199
ILE A 228
LEU A 321
 None
 0.80A 2xkwB-1wpqA:
undetectable		 2xkwB-1wpqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		4 LEU A 173
ARG A  23
ILE A  20
ILE A  87
 None
 0.93A 2xkwB-1ye8A:
undetectable		 2xkwB-1ye8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 307
ARG A 151
ILE A 150
LEU A  91
 None
 0.90A 2xkwB-1yw6A:
undetectable		 2xkwB-1yw6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		4 LEU A  63
ILE A  55
ILE A 199
LEU A 192
 None
 0.89A 2xkwB-1zbmA:
undetectable		 2xkwB-1zbmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088

(Bacillus
anthracis) 		PF12706
(Lactamase_B_2) 		4 LEU A  57
ILE A  68
ILE A  77
LEU A  85
 None
 0.90A 2xkwB-1zkpA:
undetectable		 2xkwB-1zkpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 LEU A 194
ILE A   5
ILE A  62
LEU A  66
 None
 0.93A 2xkwB-1ztcA:
undetectable		 2xkwB-1ztcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		4 LEU A 174
ILE A 157
ILE A 133
LEU A 136
 None
 0.90A 2xkwB-2dg2A:
undetectable		 2xkwB-2dg2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 LEU A  19
ILE A  60
ILE A  78
LEU A  52
 None
 0.93A 2xkwB-2f1kA:
undetectable		 2xkwB-2f1kA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		4 LEU A 592
ARG A 398
ILE A 374
LEU A 634
 None
 0.76A 2xkwB-2gh8A:
undetectable		 2xkwB-2gh8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 LEU A  16
ILE A  28
ILE A  74
LEU A  60
 None
 0.91A 2xkwB-2gnoA:
undetectable		 2xkwB-2gnoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 LEU X  86
ILE X  92
ILE X 139
LEU X 241
 None
 0.96A 2xkwB-2h3gX:
undetectable		 2xkwB-2h3gX:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 LEU A 197
ILE A 132
ILE A 216
LEU A 209
 None
 0.84A 2xkwB-2iexA:
undetectable		 2xkwB-2iexA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 4 ARG A 142
ILE A  79
ILE A 395
LEU A 401
 None
 0.96A 2xkwB-2jdxA:
undetectable		 2xkwB-2jdxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 LEU A 173
ILE A 182
ILE A   2
LEU A   5
 None
 0.90A 2xkwB-2jgvA:
undetectable		 2xkwB-2jgvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 LEU B1248
ILE B1227
ILE B1349
LEU B1193
 None
 0.95A 2xkwB-2nvuB:
undetectable		 2xkwB-2nvuB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		4 LEU A  41
ARG A  69
ILE A  68
ILE A 190
 None
 0.95A 2xkwB-2o8vA:
undetectable		 2xkwB-2o8vA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 247
ARG A 271
ILE A 272
ILE A 317
MET A 320
 None
None
735  A 469 ( 4.2A)
735  A 469 ( 4.8A)
None
 0.84A 2xkwB-2p54A:
34.0		 2xkwB-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE

(Pyrococcus
furiosus) 		PF10120
(ThiP_synth) 		4 ARG A 271
ILE A 272
ILE A 321
LEU A 342
 None
None
None
PO4  A 500 (-4.5A)
 0.97A 2xkwB-2pb9A:
undetectable		 2xkwB-2pb9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 LEU A 313
ILE A 331
ILE A 372
LEU A 395
 None
 0.97A 2xkwB-2pq6A:
undetectable		 2xkwB-2pq6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		4 LEU A 151
ILE A 268
ILE A 299
LEU A 139
 None
 0.91A 2xkwB-2pywA:
undetectable		 2xkwB-2pywA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 LEU A 317
ILE A 332
ILE A 266
LEU A 292
 None
 0.97A 2xkwB-2qjoA:
undetectable		 2xkwB-2qjoA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A 530
ILE A 559
ILE A 505
LEU A 608
 None
 0.81A 2xkwB-2qr7A:
undetectable		 2xkwB-2qr7A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 LEU A 166
ILE A 128
ILE A  62
LEU A  85
 None
 0.85A 2xkwB-2qveA:
undetectable		 2xkwB-2qveA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx0 7,8-DIHYDRO-6-HYDROX
YMETHYLPTERIN-PYROPH
OSPHOKINASE

(Yersinia pestis) 		PF01288
(HPPK) 		4 LEU A  71
ILE A  99
ILE A 132
LEU A  34
 None
APC  A 171 (-4.1A)
CSO  A  37 ( 4.6A)
CSO  A  37 ( 4.3A)
 0.95A 2xkwB-2qx0A:
undetectable		 2xkwB-2qx0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 LEU A 222
ARG A 213
ILE A 211
LEU A 205
 None
 0.97A 2xkwB-2r98A:
undetectable		 2xkwB-2r98A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 LEU A 285
ILE A 243
ILE A 257
LEU A 273
 None
 0.87A 2xkwB-2rchA:
undetectable		 2xkwB-2rchA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ARG G 264
ILE G 455
ILE G 483
LEU G 443
 None
 0.96A 2xkwB-2uv8G:
undetectable		 2xkwB-2uv8G:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		4 LEU A  54
ILE A 141
ILE A 202
LEU A 211
 None
 0.91A 2xkwB-2vdjA:
undetectable		 2xkwB-2vdjA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF01128
(IspD) 		4 LEU A  33
ILE A   6
ILE A 127
LEU A 120
 None
 0.93A 2xkwB-2vsiA:
undetectable		 2xkwB-2vsiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LEU A 235
ILE A 228
ILE A 312
LEU A 188
 None
 0.92A 2xkwB-2wk2A:
undetectable		 2xkwB-2wk2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LEU A 235
ILE A 228
ILE A 312
LEU A 269
 None
 0.91A 2xkwB-2wk2A:
undetectable		 2xkwB-2wk2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 526
ILE A 555
ILE A 501
LEU A 604
 None
 0.84A 2xkwB-2wntA:
undetectable		 2xkwB-2wntA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  32
ILE A  97
ILE A 131
LEU A  78
 None
 0.98A 2xkwB-2wvgA:
undetectable		 2xkwB-2wvgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 LEU A 107
ILE A  94
ILE A 254
LEU A 192
 None
 0.83A 2xkwB-2zqqA:
undetectable		 2xkwB-2zqqA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 LEU A 247
ILE A 226
ILE A 348
LEU A 192
 None
 0.96A 2xkwB-3a3cA:
undetectable		 2xkwB-3a3cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 198
ILE A 235
ILE A 254
LEU A 246
 None
 0.98A 2xkwB-3a9vA:
undetectable		 2xkwB-3a9vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC)
PF06751
(EutB) 		4 ARG B  77
ILE A 400
ILE A 209
LEU A 225
 None
None
None
2A3  A 602 ( 4.6A)
 0.97A 2xkwB-3anyB:
undetectable		 2xkwB-3anyB:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
ARG A 280
ILE A 281
ILE A 326
MET A 329
 None
None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
None
 0.65A 2xkwB-3b0qA:
37.2		 2xkwB-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
ILE A 281
ILE A 326
MET A 329
LEU A 333
 None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
None
None
 0.28A 2xkwB-3b0qA:
37.2		 2xkwB-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 LEU A 340
ARG A 354
ILE A 353
ILE A 155
 HEM  A 450 (-4.9A)
None
HEM  A 450 (-3.8A)
None
 0.84A 2xkwB-3bdzA:
undetectable		 2xkwB-3bdzA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 ARG A  62
ILE A  64
ILE A 145
LEU A  98
 None
 0.91A 2xkwB-3berA:
undetectable		 2xkwB-3berA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		4 LEU A 121
ILE A 135
ILE A 169
LEU A  83
 None
 0.90A 2xkwB-3bywA:
undetectable		 2xkwB-3bywA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7j UNCHARACTERIZED
PROTEIN SCO6650

(Streptomyces
coelicolor) 		PF01242
(PTPS) 		4 LEU A  66
ARG A  94
ILE A  91
ILE A   4
 None
 0.62A 2xkwB-3d7jA:
undetectable		 2xkwB-3d7jA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF09383
(NIL) 		4 LEU C 127
ARG C 189
ILE C 186
ILE C   2
 None
 0.85A 2xkwB-3dhwC:
undetectable		 2xkwB-3dhwC:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 LEU D 255
ARG D 280
ILE D 281
ILE D 326
MET D 329
LEU D 333
 None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
None
PLB  D 701 (-4.4A)
 0.66A 2xkwB-3dzuD:
34.5		 2xkwB-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 LEU A 277
ARG A 224
ILE A 227
ILE A 136
 None
 0.90A 2xkwB-3emqA:
undetectable		 2xkwB-3emqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 4 LEU A  20
ILE A  45
ILE A 159
LEU A 120
 None
 0.75A 2xkwB-3ewiA:
undetectable		 2xkwB-3ewiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		4 LEU A 199
ILE A 183
ILE A 257
LEU A 223
 None
 0.93A 2xkwB-3ewmA:
undetectable		 2xkwB-3ewmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 LEU A  30
ILE A 336
ILE A 167
LEU A  77
 None
 0.89A 2xkwB-3fefA:
undetectable		 2xkwB-3fefA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 LEU A 319
ARG A 301
ILE A 346
LEU A 354
 None
 0.90A 2xkwB-3fqdA:
undetectable		 2xkwB-3fqdA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 353
ILE B 394
ILE B  80
LEU B 123
 None
 0.92A 2xkwB-3hkzB:
undetectable		 2xkwB-3hkzB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		5 LEU A  77
ARG A 297
ILE A 298
ILE A 311
LEU A 266
 None
 1.31A 2xkwB-3htzA:
undetectable		 2xkwB-3htzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 LEU A  77
ARG A 311
ILE A 312
LEU A 280
 None
 0.96A 2xkwB-3hxwA:
undetectable		 2xkwB-3hxwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		4 LEU A 100
ILE A  91
ILE A  52
LEU A  55
 None
 0.94A 2xkwB-3ibyA:
undetectable		 2xkwB-3ibyA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 LEU A 111
ILE A 146
ILE A 331
LEU A 373
 None
 0.97A 2xkwB-3ij3A:
undetectable		 2xkwB-3ij3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 LEU A 207
ILE A 209
ILE A 331
LEU A 319
 None
 0.95A 2xkwB-3ij3A:
undetectable		 2xkwB-3ij3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 301
ARG A  10
ILE A  11
LEU A 247
 None
 0.91A 2xkwB-3il4A:
undetectable		 2xkwB-3il4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LEU A 521
ILE A 533
ILE A 455
LEU A 450
 None
 0.89A 2xkwB-3j08A:
undetectable		 2xkwB-3j08A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 LEU A 521
ILE A 533
ILE A 455
LEU A 450
 None
 0.94A 2xkwB-3j09A:
undetectable		 2xkwB-3j09A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		4 LEU A  25
ILE A  44
ILE A 173
LEU A 183
 None
 0.98A 2xkwB-3k9tA:
undetectable		 2xkwB-3k9tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		4 LEU A 205
ILE A 178
ILE A 352
LEU A 285
 None
 0.95A 2xkwB-3ke6A:
undetectable		 2xkwB-3ke6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 LEU A 240
ILE A 275
ILE A 332
MET A 296
 None
 0.93A 2xkwB-3kjxA:
undetectable		 2xkwB-3kjxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmv ALPHA-L-ARABINOFURAN
OSIDASE B

(Ruminiclostridium
thermocellum) 		PF05270
(AbfB) 		4 ARG A  31
ILE A  32
ILE A  96
LEU A 100
 None
 0.90A 2xkwB-3kmvA:
undetectable		 2xkwB-3kmvA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 226
ARG A  50
ILE A 215
ILE A 513
 None
 0.84A 2xkwB-3ljpA:
undetectable		 2xkwB-3ljpA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 LEU A 469
ILE A 481
ILE A 425
LEU A 428
 None
 0.74A 2xkwB-3lq1A:
undetectable		 2xkwB-3lq1A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		5 LEU A 171
ARG A 317
ILE A 230
ILE A 116
LEU A 101
 None
 1.29A 2xkwB-3lunA:
undetectable		 2xkwB-3lunA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 LEU A 239
ILE A 223
ILE A 135
LEU A 213
 None
 0.96A 2xkwB-3m1tA:
undetectable		 2xkwB-3m1tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		4 LEU A 247
ILE A 226
ILE A 348
LEU A 192
 None
 0.96A 2xkwB-3mq9A:
undetectable		 2xkwB-3mq9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n53 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE

(Pelobacter
carbinolicus) 		PF00072
(Response_reg) 		4 LEU A 118
ILE A   4
ILE A  54
LEU A  79
 None
 0.92A 2xkwB-3n53A:
undetectable		 2xkwB-3n53A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no2 UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		no annotation 4 LEU A 277
ILE A  38
ILE A  79
LEU A  51
 None
 0.92A 2xkwB-3no2A:
undetectable		 2xkwB-3no2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 LEU A 444
ARG A 368
ILE A 369
ILE A 239
 None
 0.89A 2xkwB-3oksA:
undetectable		 2xkwB-3oksA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK)
no annotation 		4 LEU B 759
ILE B 931
ILE I 296
LEU I 350
 None
 0.96A 2xkwB-3opyB:
undetectable		 2xkwB-3opyB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 LEU A  90
ILE A  63
ILE A 261
LEU A 323
 None
 0.87A 2xkwB-3orwA:
undetectable		 2xkwB-3orwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovk AMINOPEPTIDASE P,
XAA-PRO DIPEPTIDASE

(Streptococcus
pyogenes) 		PF01321
(Creatinase_N) 		4 LEU A  35
ILE A  47
ILE A 116
LEU A  80
 None
 0.97A 2xkwB-3ovkA:
undetectable		 2xkwB-3ovkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		4 LEU A 156
ARG A 181
ILE A 168
ILE A 216
 None
 0.95A 2xkwB-3p1tA:
undetectable		 2xkwB-3p1tA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 LEU A 377
ILE A 273
ILE A 339
LEU A 333
 None
 0.95A 2xkwB-3p27A:
undetectable		 2xkwB-3p27A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 ARG A 159
ILE A 162
ILE A 270
LEU A 276
 None
 0.97A 2xkwB-3pkoA:
2.2		 2xkwB-3pkoA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		4 ARG A 188
ILE A 214
ILE A 153
LEU A 100
 None
None
F9F  A   1 (-4.3A)
F9F  A   1 (-3.6A)
 0.98A 2xkwB-3pr2A:
undetectable		 2xkwB-3pr2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr6 TRAPP-ASSOCIATED
PROTEIN TCA17

(Saccharomyces
cerevisiae) 		PF04628
(Sedlin_N) 		4 LEU A   3
ILE A 105
ILE A  79
LEU A  10
 None
None
CL  A 158 ( 4.5A)
None
 0.96A 2xkwB-3pr6A:
undetectable		 2xkwB-3pr6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 LEU A 459
ILE A 190
ILE A  56
LEU A 128
 None
 0.95A 2xkwB-3sutA:
undetectable		 2xkwB-3sutA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 LEU A 333
ILE A 302
ILE A 222
LEU A 249
 None
 0.76A 2xkwB-3tc9A:
undetectable		 2xkwB-3tc9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		4 LEU A 165
ILE A  44
ILE A 129
LEU A 148
 None
 0.98A 2xkwB-3trcA:
undetectable		 2xkwB-3trcA:
22.10