SIMILAR PATTERNS OF AMINO ACIDS FOR 2XKK_E_MFXE1100_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a21 TISSUE FACTOR

(Oryctolagus
cuniculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 ARG A  72
GLU A  88
SER A  45
 None
 0.88A 2xkkA-1a21A:
undetectable
2xkkC-1a21A:
undetectable		 2xkkA-1a21A:
14.36
2xkkC-1a21A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ARG A 462
GLU A 495
SER A 542
 None
 0.94A 2xkkA-1dgjA:
undetectable
2xkkC-1dgjA:
0.0		 2xkkA-1dgjA:
22.33
2xkkC-1dgjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 ARG A 269
GLU A 132
SER A 266
 None
GOL  A 900 ( 4.5A)
None
 0.72A 2xkkA-1dl2A:
undetectable
2xkkC-1dl2A:
0.0		 2xkkA-1dl2A:
22.15
2xkkC-1dl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 ARG A 273
GLU A 526
SER A 203
 None
GOL  A 900 (-3.1A)
None
 0.91A 2xkkA-1dl2A:
undetectable
2xkkC-1dl2A:
0.0		 2xkkA-1dl2A:
22.15
2xkkC-1dl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ARG A1230
GLU A1548
SER A1229
 None
 0.92A 2xkkA-1e6yA:
2.7
2xkkC-1e6yA:
2.7		 2xkkA-1e6yA:
20.38
2xkkC-1e6yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2r CASPASE-ACTIVATED
DNASE
INHIBITOR OF
CASPASE-ACTIVATED
DNASE

(Mus musculus) 		PF02017
(CIDE-N) 		3 ARG C  14
GLU I  65
SER C  18
 None
 0.89A 2xkkA-1f2rC:
undetectable
2xkkC-1f2rC:
undetectable		 2xkkA-1f2rC:
7.49
2xkkC-1f2rC:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		3 ARG A 166
GLU A  96
SER A 113
 None
None
PEG  A 600 ( 3.9A)
 0.95A 2xkkA-1gajA:
undetectable
2xkkC-1gajA:
undetectable		 2xkkA-1gajA:
17.13
2xkkC-1gajA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		3 ARG A  87
GLU A 121
SER A  88
 None
 0.77A 2xkkA-1gppA:
undetectable
2xkkC-1gppA:
undetectable		 2xkkA-1gppA:
15.24
2xkkC-1gppA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ARG A 165
GLU A 361
SER A 420
 OXL  A1583 ( 2.8A)
None
NAP  A1581 ( 3.9A)
 0.74A 2xkkA-1gq2A:
4.1
2xkkC-1gq2A:
3.7		 2xkkA-1gq2A:
22.38
2xkkC-1gq2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 121
GLU A 460
SER A 202
 None
IPA  A1514 (-4.6A)
None
 0.76A 2xkkA-1gycA:
undetectable
2xkkC-1gycA:
undetectable		 2xkkA-1gycA:
22.93
2xkkC-1gycA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 ARG P 295
GLU P  85
SER P 224
 None
 0.82A 2xkkA-1hynP:
undetectable
2xkkC-1hynP:
undetectable		 2xkkA-1hynP:
19.95
2xkkC-1hynP:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 ARG L 337
GLU L 470
SER L 241
 None
 0.94A 2xkkA-1kfuL:
undetectable
2xkkC-1kfuL:
undetectable		 2xkkA-1kfuL:
22.71
2xkkC-1kfuL:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT

(Homo sapiens) 		PF08646
(Rep_fac-A_C) 		3 ARG C 612
GLU C 601
SER C 613
 None
 0.94A 2xkkA-1l1oC:
undetectable
2xkkC-1l1oC:
undetectable		 2xkkA-1l1oC:
13.96
2xkkC-1l1oC:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ARG A 426
GLU A  53
SER A 430
 None
 0.90A 2xkkA-1m64A:
undetectable
2xkkC-1m64A:
undetectable		 2xkkA-1m64A:
21.41
2xkkC-1m64A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ARG A 216
GLU A 528
SER A 215
 None
 0.80A 2xkkA-1mroA:
2.7
2xkkC-1mroA:
2.6		 2xkkA-1mroA:
21.59
2xkkC-1mroA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		3 ARG A 202
GLU E 996
SER A 201
 None
 0.89A 2xkkA-1o7dA:
undetectable
2xkkC-1o7dA:
undetectable		 2xkkA-1o7dA:
16.54
2xkkC-1o7dA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		3 ARG A 672
GLU A 662
SER A 673
 None
 0.89A 2xkkA-1pk0A:
2.7
2xkkC-1pk0A:
3.5		 2xkkA-1pk0A:
22.09
2xkkC-1pk0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		3 ARG A 303
GLU A 347
SER A 299
 None
 0.91A 2xkkA-1pswA:
2.5
2xkkC-1pswA:
undetectable		 2xkkA-1pswA:
19.14
2xkkC-1pswA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 ARG A  53
GLU A 803
SER A  42
 None
 0.84A 2xkkA-1qb4A:
undetectable
2xkkC-1qb4A:
3.2		 2xkkA-1qb4A:
24.08
2xkkC-1qb4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 209
GLU A 155
SER A 205
 None
 0.78A 2xkkA-1qh4A:
undetectable
2xkkC-1qh4A:
1.8		 2xkkA-1qh4A:
19.53
2xkkC-1qh4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 ARG A 286
GLU A 228
SER A 215
 None
 0.83A 2xkkA-1qi9A:
undetectable
2xkkC-1qi9A:
undetectable		 2xkkA-1qi9A:
21.44
2xkkC-1qi9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqg INSULIN RECEPTOR
SUBSTRATE 1

(Homo sapiens) 		PF00169
(PH)
PF02174
(IRS) 		3 ARG A  20
GLU A  50
SER A  24
 None
 0.65A 2xkkA-1qqgA:
undetectable
2xkkC-1qqgA:
undetectable		 2xkkA-1qqgA:
16.25
2xkkC-1qqgA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 ARG A 109
GLU A 323
SER A 108
 PO4  A 601 (-3.7A)
None
PO4  A 601 (-3.1A)
 0.93A 2xkkA-1tj7A:
undetectable
2xkkC-1tj7A:
undetectable		 2xkkA-1tj7A:
23.17
2xkkC-1tj7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 ARG C1174
GLU C1165
SER C1204
 None
 0.83A 2xkkA-1u6gC:
undetectable
2xkkC-1u6gC:
undetectable		 2xkkA-1u6gC:
21.84
2xkkC-1u6gC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 208
GLU A 154
SER A 204
 None
 0.74A 2xkkA-1u6rA:
undetectable
2xkkC-1u6rA:
undetectable		 2xkkA-1u6rA:
19.97
2xkkC-1u6rA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ARG A 121
GLU A 216
SER A 120
 None
 0.88A 2xkkA-1ulqA:
undetectable
2xkkC-1ulqA:
undetectable		 2xkkA-1ulqA:
20.52
2xkkC-1ulqA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 121
GLU A 459
SER A 207
 None
 0.80A 2xkkA-1v10A:
undetectable
2xkkC-1v10A:
undetectable		 2xkkA-1v10A:
21.76
2xkkC-1v10A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 209
GLU A 155
SER A 205
 None
 0.72A 2xkkA-1vrpA:
undetectable
2xkkC-1vrpA:
undetectable		 2xkkA-1vrpA:
20.13
2xkkC-1vrpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens;
Mus musculus) 		PF00400
(WD40)
PF13472
(Lipase_GDSL_2) 		3 ARG A  60
GLU C 100
SER A  64
 None
 0.89A 2xkkA-1vyhA:
3.2
2xkkC-1vyhA:
3.4		 2xkkA-1vyhA:
15.52
2xkkC-1vyhA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		3 ARG A 656
GLU A 316
SER A 328
 None
 0.88A 2xkkA-1w27A:
undetectable
2xkkC-1w27A:
undetectable		 2xkkA-1w27A:
23.13
2xkkC-1w27A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whb KIAA0055

(Homo sapiens) 		PF00581
(Rhodanese) 		3 ARG A 109
GLU A 132
SER A 110
 None
 0.91A 2xkkA-1whbA:
3.6
2xkkC-1whbA:
2.9		 2xkkA-1whbA:
11.99
2xkkC-1whbA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		3 ARG A 172
GLU A 224
SER A 169
 None
 0.87A 2xkkA-1xtzA:
3.2
2xkkC-1xtzA:
3.5		 2xkkA-1xtzA:
17.10
2xkkC-1xtzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN

(Leishmania
major) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 ARG A 162
GLU A 153
SER A 121
 None
 0.86A 2xkkA-1y1xA:
undetectable
2xkkC-1y1xA:
undetectable		 2xkkA-1y1xA:
12.17
2xkkC-1y1xA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 ARG R  78
GLU R   4
SER R  50
 None
 0.84A 2xkkA-1y6nR:
undetectable
2xkkC-1y6nR:
undetectable		 2xkkA-1y6nR:
13.55
2xkkC-1y6nR:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		3 ARG A 125
GLU A  63
SER A 103
 None
 0.89A 2xkkA-1yewA:
undetectable
2xkkC-1yewA:
undetectable		 2xkkA-1yewA:
17.96
2xkkC-1yewA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		3 ARG A  74
GLU A  49
SER A  80
 None
 0.86A 2xkkA-1yllA:
undetectable
2xkkC-1yllA:
undetectable		 2xkkA-1yllA:
13.59
2xkkC-1yllA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN
ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		3 ARG U 393
GLU E 336
SER U 352
 None
 0.83A 2xkkA-1z5xU:
undetectable
2xkkC-1z5xU:
undetectable		 2xkkA-1z5xU:
17.54
2xkkC-1z5xU:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21
INTERCELLULAR
ADHESION MOLECULE-1

(Enterovirus C;
Homo sapiens) 		PF00073
(Rhv)
PF03921
(ICAM_N) 		3 ARG 3 180
GLU 1 277
SER I  74
 None
 0.94A 2xkkA-1z7z3:
undetectable
2xkkC-1z7z3:
undetectable		 2xkkA-1z7z3:
14.93
2xkkC-1z7z3:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a46 GFP-LIKE FLUORESCENT
CHROMOPROTEIN
AMFP486

(Anemonia majano) 		PF01353
(GFP) 		3 ARG A 200
GLU A  39
SER A 148
 None
None
CR7  A  68 ( 2.5A)
 0.90A 2xkkA-2a46A:
undetectable
2xkkC-2a46A:
undetectable		 2xkkA-2a46A:
14.90
2xkkC-2a46A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 ARG A  66
GLU A 108
SER A  70
 C  D   2 ( 2.9A)
C  D   1 ( 3.2A)
None
 0.90A 2xkkA-2a8vA:
undetectable
2xkkC-2a8vA:
undetectable		 2xkkA-2a8vA:
10.84
2xkkC-2a8vA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		3 ARG A 117
GLU A 101
SER A 118
 3PG  A 408 (-2.8A)
None
None
 0.94A 2xkkA-2a9jA:
undetectable
2xkkC-2a9jA:
undetectable		 2xkkA-2a9jA:
16.15
2xkkC-2a9jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ARG A 327
GLU A 787
SER A 326
 None
 0.75A 2xkkA-2b5mA:
undetectable
2xkkC-2b5mA:
undetectable		 2xkkA-2b5mA:
22.20
2xkkC-2b5mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 ARG A 206
GLU A 278
SER A 304
 None
 0.92A 2xkkA-2bp1A:
undetectable
2xkkC-2bp1A:
undetectable		 2xkkA-2bp1A:
18.13
2xkkC-2bp1A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 433
GLU A 448
SER A 486
 None
 0.87A 2xkkA-2bucA:
1.9
2xkkC-2bucA:
2.6		 2xkkA-2bucA:
20.45
2xkkC-2bucA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 129
GLU A 144
SER A 236
 None
 0.82A 2xkkA-2cduA:
undetectable
2xkkC-2cduA:
undetectable		 2xkkA-2cduA:
19.97
2xkkC-2cduA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 ARG A 310
GLU A 315
SER A 308
 None
 0.81A 2xkkA-2d4eA:
2.1
2xkkC-2d4eA:
2.1		 2xkkA-2d4eA:
21.85
2xkkC-2d4eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 ARG A 221
GLU A 340
SER A 238
 NGA  A 702 (-3.6A)
None
UDP  A 705 (-2.8A)
 0.94A 2xkkA-2d7iA:
1.7
2xkkC-2d7iA:
undetectable		 2xkkA-2d7iA:
20.46
2xkkC-2d7iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		3 ARG A 178
GLU A 429
SER A 176
 MLC  A1001 (-3.7A)
None
None
 0.94A 2xkkA-2e1tA:
undetectable
2xkkC-2e1tA:
undetectable		 2xkkA-2e1tA:
20.03
2xkkC-2e1tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 ARG A1049
GLU A1040
SER A 199
 None
 0.91A 2xkkA-2eyqA:
undetectable
2xkkC-2eyqA:
4.0		 2xkkA-2eyqA:
22.26
2xkkC-2eyqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 ARG A 117
GLU A  36
SER A 111
 GOL  A 301 (-2.8A)
None
None
 0.87A 2xkkA-2fmlA:
undetectable
2xkkC-2fmlA:
3.9		 2xkkA-2fmlA:
16.88
2xkkC-2fmlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		3 ARG A 247
GLU A 231
SER A 245
 MG  A 997 ( 4.4A)
None
None
 0.86A 2xkkA-2fq1A:
3.1
2xkkC-2fq1A:
2.8		 2xkkA-2fq1A:
17.69
2xkkC-2fq1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		3 ARG A 253
GLU A 107
SER A 252
 None
 0.80A 2xkkA-2gfqA:
undetectable
2xkkC-2gfqA:
undetectable		 2xkkA-2gfqA:
17.23
2xkkC-2gfqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		3 ARG A 117
GLU A 203
SER A  57
 None
 0.78A 2xkkA-2h1yA:
2.6
2xkkC-2h1yA:
2.6		 2xkkA-2h1yA:
17.21
2xkkC-2h1yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 121
GLU A 460
SER A 202
 None
 0.70A 2xkkA-2hzhA:
undetectable
2xkkC-2hzhA:
undetectable		 2xkkA-2hzhA:
20.39
2xkkC-2hzhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		3 ARG A 206
GLU A 317
SER A 200
 None
 0.92A 2xkkA-2i0zA:
undetectable
2xkkC-2i0zA:
undetectable		 2xkkA-2i0zA:
21.04
2xkkC-2i0zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		3 ARG A  52
GLU A 256
SER A 114
 None
 0.92A 2xkkA-2i7gA:
undetectable
2xkkC-2i7gA:
undetectable		 2xkkA-2i7gA:
19.33
2xkkC-2i7gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ARG A 385
GLU A 279
SER A 381
 None
 0.85A 2xkkA-2jbrA:
undetectable
2xkkC-2jbrA:
undetectable		 2xkkA-2jbrA:
22.02
2xkkC-2jbrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 ARG A 594
GLU A 453
SER A 144
 None
 0.91A 2xkkA-2ozoA:
3.4
2xkkC-2ozoA:
3.3		 2xkkA-2ozoA:
21.95
2xkkC-2ozoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		3 ARG A 277
GLU A 269
SER A  56
 None
 0.92A 2xkkA-2qnrA:
3.2
2xkkC-2qnrA:
3.0		 2xkkA-2qnrA:
17.89
2xkkC-2qnrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 ARG A 930
GLU A 546
SER A 926
 None
 0.94A 2xkkA-2r6fA:
undetectable
2xkkC-2r6fA:
undetectable		 2xkkA-2r6fA:
24.34
2xkkC-2r6fA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ARG A 656
GLU A 647
SER A 374
 None
 0.79A 2xkkA-2vdaA:
1.7
2xkkC-2vdaA:
undetectable		 2xkkA-2vdaA:
23.12
2xkkC-2vdaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ARG A  64
GLU A 155
SER A  65
 None
 0.79A 2xkkA-2vosA:
undetectable
2xkkC-2vosA:
undetectable		 2xkkA-2vosA:
21.72
2xkkC-2vosA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		3 ARG A 139
GLU A  59
SER A 138
 None
 0.86A 2xkkA-2wknA:
undetectable
2xkkC-2wknA:
undetectable		 2xkkA-2wknA:
20.10
2xkkC-2wknA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ARG A 538
GLU A 413
SER A 539
 None
 0.92A 2xkkA-2x0sA:
undetectable
2xkkC-2x0sA:
undetectable		 2xkkA-2x0sA:
22.85
2xkkC-2x0sA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A  18
GLU A 269
SER A 371
 None
 0.86A 2xkkA-2xkrA:
undetectable
2xkkC-2xkrA:
undetectable		 2xkkA-2xkrA:
21.04
2xkkC-2xkrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 ARG A 227
GLU A 142
SER A  44
 None
 0.85A 2xkkA-2yp1A:
undetectable
2xkkC-2yp1A:
undetectable		 2xkkA-2yp1A:
18.92
2xkkC-2yp1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ARG A 612
GLU A 602
SER A 614
 None
 0.93A 2xkkA-2zxoA:
3.1
2xkkC-2zxoA:
3.0		 2xkkA-2zxoA:
25.00
2xkkC-2zxoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		3 ARG A 133
GLU A 122
SER A 134
 None
 0.89A 2xkkA-3cljA:
undetectable
2xkkC-3cljA:
undetectable		 2xkkA-3cljA:
12.77
2xkkC-3cljA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A3226
GLU A2068
SER A3070
 None
None
ADP  A3502 (-2.7A)
 0.88A 2xkkA-3cmuA:
undetectable
2xkkC-3cmuA:
undetectable		 2xkkA-3cmuA:
17.81
2xkkC-3cmuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A4226
GLU A3068
SER A4070
 None
None
ADP  A4502 (-2.7A)
 0.91A 2xkkA-3cmuA:
undetectable
2xkkC-3cmuA:
undetectable		 2xkkA-3cmuA:
17.81
2xkkC-3cmuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 ARG A  48
GLU A  39
SER A 215
 None
 0.77A 2xkkA-3cuxA:
undetectable
2xkkC-3cuxA:
2.5		 2xkkA-3cuxA:
23.33
2xkkC-3cuxA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		3 ARG A  48
GLU A  35
SER A  23
 SO4  A   5 (-4.9A)
None
None
 0.69A 2xkkA-3eeqA:
2.4
2xkkC-3eeqA:
2.2		 2xkkA-3eeqA:
18.91
2xkkC-3eeqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG A 268
GLU A 214
SER A 267
 None
 0.94A 2xkkA-3eh2A:
undetectable
2xkkC-3eh2A:
2.5		 2xkkA-3eh2A:
22.64
2xkkC-3eh2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feg CHOLINE/ETHANOLAMINE
KINASE

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 ARG A 151
GLU A 283
SER A 150
 None
UNX  A 400 ( 3.2A)
AMP  A 398 ( 4.0A)
 0.93A 2xkkA-3fegA:
2.1
2xkkC-3fegA:
2.1		 2xkkA-3fegA:
18.89
2xkkC-3fegA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feh CENTAURIN-ALPHA-1

(Homo sapiens) 		PF00169
(PH)
PF01412
(ArfGap) 		3 ARG A 226
GLU A 178
SER A  91
 None
 0.95A 2xkkA-3fehA:
undetectable
2xkkC-3fehA:
undetectable		 2xkkA-3fehA:
17.84
2xkkC-3fehA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		3 ARG A  38
GLU A 292
SER A  39
 None
 0.71A 2xkkA-3fhcA:
undetectable
2xkkC-3fhcA:
undetectable		 2xkkA-3fhcA:
19.28
2xkkC-3fhcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 296
GLU A 101
SER A 252
 None
 0.90A 2xkkA-3fhhA:
undetectable
2xkkC-3fhhA:
undetectable		 2xkkA-3fhhA:
21.66
2xkkC-3fhhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		3 ARG A 495
GLU A 620
SER A 487
 None
 0.88A 2xkkA-3gcwA:
undetectable
2xkkC-3gcwA:
undetectable		 2xkkA-3gcwA:
21.62
2xkkC-3gcwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE

(Bacillus
thuringiensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 175
GLU A 182
SER A 218
 None
 0.84A 2xkkA-3gmsA:
3.4
2xkkC-3gmsA:
2.5		 2xkkA-3gmsA:
19.43
2xkkC-3gmsA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A1190
GLU A1364
SER A1235
 None
 0.86A 2xkkA-3greA:
undetectable
2xkkC-3greA:
undetectable		 2xkkA-3greA:
20.70
2xkkC-3greA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 ARG A 259
GLU A 417
SER A 161
 None
 0.90A 2xkkA-3hagA:
undetectable
2xkkC-3hagA:
undetectable		 2xkkA-3hagA:
20.43
2xkkC-3hagA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ARG A 120
GLU A  49
SER A 165
 None
CO  A 500 ( 4.3A)
None
 0.80A 2xkkA-3hdiA:
undetectable
2xkkC-3hdiA:
2.3		 2xkkA-3hdiA:
20.16
2xkkC-3hdiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 ARG A  55
GLU A  81
SER A  60
 None
 0.93A 2xkkA-3heaA:
2.6
2xkkC-3heaA:
undetectable		 2xkkA-3heaA:
16.78
2xkkC-3heaA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		3 ARG A 389
GLU A 284
SER A 391
 None
 0.63A 2xkkA-3icjA:
undetectable
2xkkC-3icjA:
0.8		 2xkkA-3icjA:
22.90
2xkkC-3icjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 196
GLU A 142
SER A 192
 None
 0.60A 2xkkA-3jq3A:
undetectable
2xkkC-3jq3A:
undetectable		 2xkkA-3jq3A:
19.17
2xkkC-3jq3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		3 ARG A  44
GLU A 493
SER A  47
 None
 0.58A 2xkkA-3kk7A:
undetectable
2xkkC-3kk7A:
undetectable		 2xkkA-3kk7A:
20.43
2xkkC-3kk7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		3 ARG A 381
GLU A 372
SER A 289
 None
 0.73A 2xkkA-3ky9A:
undetectable
2xkkC-3ky9A:
undetectable		 2xkkA-3ky9A:
21.34
2xkkC-3ky9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 220
GLU A 166
SER A 216
 None
 0.83A 2xkkA-3l2eA:
undetectable
2xkkC-3l2eA:
undetectable		 2xkkA-3l2eA:
20.23
2xkkC-3l2eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ARG A 250
GLU A 208
SER A 197
 None
 0.85A 2xkkA-3ldrA:
undetectable
2xkkC-3ldrA:
undetectable		 2xkkA-3ldrA:
20.56
2xkkC-3ldrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 ARG A 337
GLU A 356
SER A 320
 None
 0.90A 2xkkA-3n2cA:
undetectable
2xkkC-3n2cA:
undetectable		 2xkkA-3n2cA:
21.48
2xkkC-3n2cA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 ARG D 342
GLU D 118
SER D 341
 None
 0.81A 2xkkA-3oaaD:
undetectable
2xkkC-3oaaD:
undetectable		 2xkkA-3oaaD:
20.65
2xkkC-3oaaD:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		3 ARG A 279
GLU S  84
SER A 281
 None
 0.93A 2xkkA-3oqnA:
2.1
2xkkC-3oqnA:
undetectable		 2xkkA-3oqnA:
18.69
2xkkC-3oqnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		3 ARG A 259
GLU A 225
SER A 249
 None
 0.78A 2xkkA-3otxA:
undetectable
2xkkC-3otxA:
undetectable		 2xkkA-3otxA:
19.97
2xkkC-3otxA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 784
GLU A 719
SER A 783
 None
None
03Q  A   1 (-3.3A)
 0.95A 2xkkA-3pp0A:
undetectable
2xkkC-3pp0A:
undetectable		 2xkkA-3pp0A:
17.96
2xkkC-3pp0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 121
GLU A 460
SER A 202
 None
 0.69A 2xkkA-3pxlA:
undetectable
2xkkC-3pxlA:
undetectable		 2xkkA-3pxlA:
21.74
2xkkC-3pxlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 367
GLU A 303
SER A 352
 None
 0.86A 2xkkA-3qnkA:
undetectable
2xkkC-3qnkA:
2.0		 2xkkA-3qnkA:
21.92
2xkkC-3qnkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		3 ARG A  67
GLU A 115
SER A  75
 None
 0.95A 2xkkA-3qyfA:
3.0
2xkkC-3qyfA:
1.7		 2xkkA-3qyfA:
17.78
2xkkC-3qyfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 299
GLU A 208
SER A 300
 None
 0.91A 2xkkA-3tl2A:
undetectable
2xkkC-3tl2A:
1.9		 2xkkA-3tl2A:
19.79
2xkkC-3tl2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ARG A  99
GLU A 221
SER A  74
 SO4  A 405 (-2.9A)
None
None
 0.71A 2xkkA-3tz6A:
undetectable
2xkkC-3tz6A:
undetectable		 2xkkA-3tz6A:
18.32
2xkkC-3tz6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u NEUREGULIN 1
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00008
(EGF)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 ARG A  99
GLU A  18
SER G   3
 None
 0.84A 2xkkA-3u7uA:
undetectable
2xkkC-3u7uA:
undetectable		 2xkkA-3u7uA:
21.43
2xkkC-3u7uA:
21.43