SIMILAR PATTERNS OF AMINO ACIDS FOR 2XFS_B_J01B500_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | TRP B 437VAL B 76ILE B 127LEU B 562GLY B 24 | None | 1.27A | 2xfsB-1e9yB:0.0 | 2xfsB-1e9yB:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fvp | FLAVOPROTEIN 390 (Photobacteriumphosphoreum) |
no annotation | 5 | HIS A 126VAL A 124ILE A 121LEU A 106ALA A 76 | None | 1.47A | 2xfsB-1fvpA:0.0 | 2xfsB-1fvpA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihj | INAD (Drosophilamelanogaster) |
PF00595(PDZ) | 5 | VAL A 87ILE A 88LEU A 20GLY A 29ALA A 59 | None | 1.27A | 2xfsB-1ihjA:undetectable | 2xfsB-1ihjA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrt | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH) | 5 | VAL A 38ILE A 48LEU A 250GLY A 235ALA A 236 | None | 1.28A | 2xfsB-1lrtA:0.0 | 2xfsB-1lrtA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 5 | VAL D 239ILE D 217LEU D 204GLY D 113ALA D 117 | None | 1.32A | 2xfsB-1mhzD:0.0 | 2xfsB-1mhzD:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svv | THREONINE ALDOLASE (Leishmaniamajor) |
PF01212(Beta_elim_lyase) | 5 | VAL A 69ILE A 226LEU A 260GLY A 213ALA A 214 | None | 1.23A | 2xfsB-1svvA:0.0 | 2xfsB-1svvA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ub7 | 3-OXOACYL-[ACYL-CARRIER PROTEIN]SYNTHASE (Thermusthermophilus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | VAL A 290ILE A 295LEU A 5GLY A 321ALA A 322 | None | 1.27A | 2xfsB-1ub7A:0.1 | 2xfsB-1ub7A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2can | ORNITHINEAMINOTRANSFERASE (Homo sapiens) |
PF00202(Aminotran_3) | 5 | VAL A 238ILE A 232LEU A 418GLY A 273ALA A 349 | None | 1.12A | 2xfsB-2canA:0.0 | 2xfsB-2canA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkj | SERINEHYDROXYMETHYLTRANSFERASE (Thermusthermophilus) |
PF00464(SHMT) | 5 | VAL A 305ILE A 344LEU A 385GLY A 325ALA A 328 | None | 1.32A | 2xfsB-2dkjA:0.0 | 2xfsB-2dkjA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehq | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 5 | VAL A 178ILE A 180LEU A 40GLY A 238ALA A 71 | NoneNAP A1518 (-4.0A)NoneNoneNone | 1.39A | 2xfsB-2ehqA:undetectable | 2xfsB-2ehqA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g0w | LMO2234 PROTEIN (Listeriamonocytogenes) |
PF01261(AP_endonuc_2) | 5 | HIS A 109VAL A 244LEU A 137GLY A 106ALA A 102 | None | 1.06A | 2xfsB-2g0wA:undetectable | 2xfsB-2g0wA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ihy | ABC TRANSPORTER,ATP-BINDING PROTEIN (Staphylococcusaureus) |
PF00005(ABC_tran) | 5 | VAL A 200ILE A 198LEU A 157GLY A 81ALA A 156 | None | 1.47A | 2xfsB-2ihyA:undetectable | 2xfsB-2ihyA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf7 | STRICTOSIDINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 5 | VAL A 486ILE A 93LEU A 111GLY A 52ALA A 51 | None | 1.21A | 2xfsB-2jf7A:undetectable | 2xfsB-2jf7A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 5 | ILE A 257LEU A 364ARG A 136GLY A 135ALA A 134 | None | 1.49A | 2xfsB-2o3iA:undetectable | 2xfsB-2o3iA:24.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtc | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 9 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 158ILE A 150LEU A 277ARG A 224GLY A 225 | VIN A6331 (-4.7A)VIN A6331 (-4.0A)NoneNoneNone | 1.46A | 2xfsB-3dtcA:undetectable | 2xfsB-3dtcA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipc | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (AMINO ACID) (Agrobacteriumfabrum) |
PF13458(Peripla_BP_6) | 5 | VAL A 3ILE A 44LEU A 305GLY A 288ALA A 289 | None | 1.14A | 2xfsB-3ipcA:undetectable | 2xfsB-3ipcA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owa | ACYL-COADEHYDROGENASE (Bacillusanthracis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 497ILE A 496LEU A 483GLY A 473ALA A 476 | None | 1.29A | 2xfsB-3owaA:undetectable | 2xfsB-3owaA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qan | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE1 (Bacillushalodurans) |
PF00171(Aldedh) | 5 | VAL A 176ILE A 178LEU A 39GLY A 236ALA A 70 | None | 1.19A | 2xfsB-3qanA:undetectable | 2xfsB-3qanA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjl | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Bacilluslicheniformis) |
PF00171(Aldedh) | 5 | VAL A 177ILE A 179LEU A 40GLY A 237ALA A 71 | None | 1.23A | 2xfsB-3rjlA:undetectable | 2xfsB-3rjlA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpb | RABPHILIN 3-A (Rattusnorvegicus) |
PF00168(C2) | 5 | HIS A 657VAL A 546ILE A 627ARG A 654GLY A 647 | None | 1.30A | 2xfsB-3rpbA:undetectable | 2xfsB-3rpbA:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | VAL A 415ILE A 430LEU A 198GLY A 145ALA A 147 | None | 1.21A | 2xfsB-3uk1A:undetectable | 2xfsB-3uk1A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqe | 6-PHOSPHOFRUCTOKINASE ISOZYME 2 (Escherichiacoli) |
PF00294(PfkB) | 5 | VAL A 135ILE A 164LEU A 51GLY A 279ALA A 282 | None | 1.39A | 2xfsB-3uqeA:undetectable | 2xfsB-3uqeA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6f | PUTATIVE ALCOHOLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 325LEU A 181ARG A 207GLY A 208ALA A 209 | None | 1.19A | 2xfsB-4j6fA:undetectable | 2xfsB-4j6fA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE,DIHYDROXYACETONE-BINDING SUBUNIT DHAK (Escherichiacoli) |
PF02733(Dak1) | 5 | VAL A 130ILE A 102LEU A 342GLY A 161ALA A 163 | None | 1.45A | 2xfsB-4lryA:undetectable | 2xfsB-4lryA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n75 | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag) | 5 | VAL A 660LEU A 501GLY A 707ALA A 705LYS A 671 | None | 1.25A | 2xfsB-4n75A:0.7 | 2xfsB-4n75A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppm | AMINOTRANSFERASE (Serratia sp.FS14) |
PF00202(Aminotran_3) | 5 | VAL A 591ILE A 585LEU A 827GLY A 626ALA A 707 | None | 1.19A | 2xfsB-4ppmA:undetectable | 2xfsB-4ppmA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pxd | ALLANTOATEAMIDOHYDROLASE (Escherichiacoli) |
PF01546(Peptidase_M20) | 5 | VAL A 75ILE A 183LEU A 400GLY A 79ALA A 100 | None | 0.96A | 2xfsB-4pxdA:undetectable | 2xfsB-4pxdA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rm7 | ACYL-COADEHYDROGENASE (Slackiaheliotrinireducens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | TRP A 264VAL A 281ILE A 337ARG A 268GLY A 267 | None | 1.43A | 2xfsB-4rm7A:0.0 | 2xfsB-4rm7A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfd | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Pseudomonasaeruginosa) |
PF02540(NAD_synthase) | 5 | VAL A 24ILE A 28LEU A 58GLY A 207ALA A 208 | None | 1.23A | 2xfsB-4xfdA:undetectable | 2xfsB-4xfdA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlv | ORNITHINEAMINOTRANSFERASE,MITOCHONDRIAL,PUTATIVE (Toxoplasmagondii) |
PF00202(Aminotran_3) | 5 | VAL A 232ILE A 226LEU A 414GLY A 267ALA A 343 | None | 1.12A | 2xfsB-4zlvA:1.4 | 2xfsB-4zlvA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjp | O-SUCCINYLBENZOATESYNTHASE (Amycolatopsissp.) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TRP A 168VAL A 188ILE A 164LEU A 146ALA A 175 | None | 1.21A | 2xfsB-5fjpA:undetectable | 2xfsB-5fjpA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7d | PUTRESCINEAMINOTRANSFERASE,IMMUNOGLOBULING-BINDING PROTEIN A (Escherichiacoli;Staphylococcusaureus) |
PF00202(Aminotran_3)PF02216(B) | 5 | VAL A 246ILE A 240LEU A 431GLY A 281ALA A 359 | None | 1.12A | 2xfsB-5h7dA:undetectable | 2xfsB-5h7dA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdi | UBIQUITIN-ASSOCIATEDAND SH3DOMAIN-CONTAININGPROTEIN A (Homo sapiens) |
PF00300(His_Phos_1) | 5 | VAL A 582ILE A 475LEU A 620GLY A 465ALA A 464 | None | 0.99A | 2xfsB-5wdiA:undetectable | 2xfsB-5wdiA:21.04 |