SIMILAR PATTERNS OF AMINO ACIDS FOR 2XFS_A_J01A500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 LEU A 492
ARG A 435
GLY A 436
ALA A 439
 None
 0.86A 2xfsA-1gk2A:
undetectable		 2xfsA-1gk2A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm1 PROTEIN TYROSINE
PHOSPHATASE

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A  82
LEU A  18
GLY A  26
ALA A  53
 None
 0.95A 2xfsA-1gm1A:
undetectable		 2xfsA-1gm1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzs SOPE

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		4 LEU B 212
ARG B  97
GLY B  98
ALA B 100
 None
 0.88A 2xfsA-1gzsB:
0.0		 2xfsA-1gzsB:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 VAL A 257
LEU A 243
GLY A  54
ALA A  56
 None
None
ATP  A1433 (-3.4A)
None
 0.80A 2xfsA-1h3eA:
0.3		 2xfsA-1h3eA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		4 LEU A 513
ARG A 436
ALA A 440
LYS A 441
 None
 0.81A 2xfsA-1hk7A:
0.4		 2xfsA-1hk7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9g CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF03167
(UDG) 		4 LEU A 166
ARG A  62
GLY A  61
ALA A  63
 None
 0.92A 2xfsA-1l9gA:
undetectable		 2xfsA-1l9gA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		4 ARG A 168
GLY A 169
ALA A 172
LYS A 173
 None
 0.94A 2xfsA-1m6zA:
undetectable		 2xfsA-1m6zA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 152
ARG A 318
GLY A 317
ALA A 294
 None
 0.94A 2xfsA-1o8cA:
0.0		 2xfsA-1o8cA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 VAL A  74
LEU A  58
ARG A  55
ALA A 117
 None
 0.92A 2xfsA-1qhoA:
0.0		 2xfsA-1qhoA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 362
ARG A 332
GLY A 333
ALA A 336
 None
 0.77A 2xfsA-1rw9A:
0.0		 2xfsA-1rw9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		4 LEU E 279
GLY E 344
ALA E 347
LYS E 348
 None
 0.69A 2xfsA-1sxjE:
undetectable		 2xfsA-1sxjE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 VAL A 231
LEU A  96
GLY A 310
ALA A 103
 None
 0.85A 2xfsA-1tjrA:
undetectable		 2xfsA-1tjrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		4 HIS A 173
LEU A 156
GLY A 136
ALA A 139
 SO4  A 518 (-3.9A)
None
SO4  A 517 (-3.3A)
SO4  A 517 (-4.1A)
 0.92A 2xfsA-1v9sA:
undetectable		 2xfsA-1v9sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 ARG A  50
GLY A  51
ALA A  54
LYS A  55
 None
 0.89A 2xfsA-1wehA:
undetectable		 2xfsA-1wehA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE

(Klebsiella
aerogenes) 		PF00144
(Beta-lactamase) 		4 HIS A  93
LEU A 167
GLY A  75
ALA A  78
 None
 0.65A 2xfsA-1zkjA:
14.1		 2xfsA-1zkjA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 220
LEU A 116
GLY A 429
ALA A 430
 None
 0.89A 2xfsA-2bmaA:
undetectable		 2xfsA-2bmaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 VAL A1062
LEU A1202
GLY A1296
ALA A1226
 None
 0.91A 2xfsA-2boaA:
undetectable		 2xfsA-2boaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		4 VAL A 339
LEU A 361
ARG A 359
GLY A 327
 None
 0.85A 2xfsA-2e54A:
undetectable		 2xfsA-2e54A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep8 PESCADILLO HOMOLOG 1

(Homo sapiens) 		PF16589
(BRCT_2) 		4 HIS A 375
VAL A 410
ARG A 390
GLY A 389
 None
 0.84A 2xfsA-2ep8A:
undetectable		 2xfsA-2ep8A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A  70
LEU A  26
GLY A  32
ALA A 120
 None
 0.92A 2xfsA-2fymA:
undetectable		 2xfsA-2fymA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		5 HIS A 109
VAL A 244
LEU A 137
GLY A 106
ALA A 102
 None
 1.07A 2xfsA-2g0wA:
undetectable		 2xfsA-2g0wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		4 LEU A 206
ARG A 249
GLY A 248
ALA A 250
 None
 0.89A 2xfsA-2ie8A:
undetectable		 2xfsA-2ie8A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 HIS A 453
LEU A 943
GLY A 825
ALA A 824
 None
 0.95A 2xfsA-2ivfA:
undetectable		 2xfsA-2ivfA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 217
LEU A 253
GLY A 221
ALA A 250
 None
None
ADP  A1556 (-3.3A)
None
 0.90A 2xfsA-2ji9A:
undetectable		 2xfsA-2ji9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltp NUCLEAR RECEPTOR
COREPRESSOR 2

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		5 TRP A  20
VAL A  32
LEU A  48
ARG A  18
GLY A  17
 None
 1.41A 2xfsA-2ltpA:
undetectable		 2xfsA-2ltpA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A) 		PF00073
(Rhv) 		4 LEU 3 195
GLY 3 116
ALA 3 205
LYS 3 206
 None
 0.86A 2xfsA-2mev3:
undetectable		 2xfsA-2mev3:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naf PEPTIDYL-TRNA
HYDROLASE

(Mycolicibacterium
smegmatis) 		PF01195
(Pept_tRNA_hydro) 		4 LEU A   6
GLY A  77
ALA A  80
LYS A  81
 None
 0.83A 2xfsA-2nafA:
undetectable		 2xfsA-2nafA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.63A 2xfsA-2o1tA:
undetectable		 2xfsA-2o1tA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.82A 2xfsA-2o1vA:
undetectable		 2xfsA-2o1vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 580
ARG A 503
ALA A 507
LYS A 508
 None
 0.78A 2xfsA-2o1wA:
undetectable		 2xfsA-2o1wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 VAL A 182
LEU A 134
GLY A  18
ALA A  28
 None
 0.92A 2xfsA-2oi2A:
1.6		 2xfsA-2oi2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		4 VAL A  55
LEU A 291
GLY A 236
ALA A 239
 None
 0.56A 2xfsA-2or0A:
1.8		 2xfsA-2or0A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owa ARFGAP-LIKE FINGER
DOMAIN CONTAINING
PROTEIN

(Cryptosporidium
parvum) 		PF01412
(ArfGap) 		4 LEU A 132
ARG A  99
GLY A  96
ALA A  55
 None
 0.94A 2xfsA-2owaA:
undetectable		 2xfsA-2owaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 VAL A 149
ARG A  22
GLY A  19
ALA A 107
 None
 0.85A 2xfsA-2qa1A:
undetectable		 2xfsA-2qa1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 VAL A 149
ARG A  22
GLY A  19
ALA A 107
 None
 0.87A 2xfsA-2qa2A:
undetectable		 2xfsA-2qa2A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 LEU A 459
ARG A 220
GLY A 219
ALA A 221
 None
 0.85A 2xfsA-2qveA:
undetectable		 2xfsA-2qveA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 VAL A 322
ARG A 330
GLY A 295
ALA A 274
 None
 0.84A 2xfsA-2wqdA:
undetectable		 2xfsA-2wqdA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		4 TRP A1397
LEU A1473
GLY A1418
ALA A1323
 None
 0.82A 2xfsA-3al2A:
undetectable		 2xfsA-3al2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 HIS A 210
VAL A 213
LEU A 282
GLY A 235
 None
 0.86A 2xfsA-3anxA:
undetectable		 2xfsA-3anxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 313
GLY A 314
ALA A 317
LYS A 318
 None
 0.80A 2xfsA-3b96A:
undetectable		 2xfsA-3b96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 VAL A 339
LEU A 387
GLY A 321
ALA A 324
 None
 0.75A 2xfsA-3b9tA:
undetectable		 2xfsA-3b9tA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 LEU A   8
ARG A  88
GLY A  87
ALA A  89
 None
 0.89A 2xfsA-3bjrA:
undetectable		 2xfsA-3bjrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		4 LEU A 219
ARG A 142
GLY A 141
ALA A 204
 None
MG  A 310 (-4.9A)
None
None
 0.94A 2xfsA-3c9rA:
undetectable		 2xfsA-3c9rA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		4 VAL A  85
ARG A  18
GLY A  19
ALA A  22
 None
 0.80A 2xfsA-3i4tA:
undetectable		 2xfsA-3i4tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k67 PUTATIVE DEHYDRATASE
AF1124

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		4 HIS A  67
ARG A  81
GLY A  80
ALA A  73
 None
 0.90A 2xfsA-3k67A:
undetectable		 2xfsA-3k67A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 192
LEU A 433
ARG A 398
ALA A 402
 None
 0.94A 2xfsA-3kd9A:
undetectable		 2xfsA-3kd9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		4 LEU A 407
ARG A 411
GLY A 410
ALA A 385
 None
 0.94A 2xfsA-3kscA:
undetectable		 2xfsA-3kscA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 VAL A 147
LEU A 254
GLY A  26
ALA A  29
 None
 0.92A 2xfsA-3m7dA:
undetectable		 2xfsA-3m7dA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 152
ARG A 318
GLY A 317
ALA A 294
 None
 0.92A 2xfsA-3nx4A:
undetectable		 2xfsA-3nx4A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 HIS A 247
ARG A 248
GLY A 188
ALA A 187
 EDO  A 314 (-4.5A)
None
None
EDO  A 314 ( 4.4A)
 0.77A 2xfsA-3ooxA:
0.8		 2xfsA-3ooxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 TRP A  87
LEU A  19
GLY A 109
ALA A  62
 None
 0.89A 2xfsA-3q0gA:
undetectable		 2xfsA-3q0gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 VAL A 176
LEU A  39
GLY A 236
ALA A  70
 None
 0.79A 2xfsA-3qanA:
undetectable		 2xfsA-3qanA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A  70
LEU A  27
GLY A  33
ALA A 120
 None
 0.93A 2xfsA-3qn3A:
undetectable		 2xfsA-3qn3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 283
LEU A 180
GLY A 491
ALA A 492
 None
 0.95A 2xfsA-3r3jA:
undetectable		 2xfsA-3r3jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7a PHOSPHOGLYCERATE
MUTASE, PUTATIVE

(Bacillus
anthracis) 		PF00300
(His_Phos_1) 		4 TRP A 109
LEU A 135
GLY A 113
ALA A 116
 EPE  A 301 (-3.9A)
None
None
None
 0.93A 2xfsA-3r7aA:
undetectable		 2xfsA-3r7aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		4 VAL A 177
LEU A  40
GLY A 237
ALA A  71
 None
 0.75A 2xfsA-3rjlA:
undetectable		 2xfsA-3rjlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy9 HISTIDINE PORIN OPDC

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 344
GLY A 399
ALA A 365
LYS A 366
 None
 0.93A 2xfsA-3sy9A:
1.1		 2xfsA-3sy9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 272
LEU A  63
ARG A 267
GLY A 264
 None
 0.93A 2xfsA-3tcsA:
undetectable		 2xfsA-3tcsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		4 LEU A 376
ARG A 387
GLY A 388
ALA A 391
 None
None
None
DMU  A 420 (-4.9A)
 0.89A 2xfsA-3tijA:
undetectable		 2xfsA-3tijA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.90A 2xfsA-3tqpA:
undetectable		 2xfsA-3tqpA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 485
ARG A 522
GLY A 521
ALA A 523
 None
 0.94A 2xfsA-3vwaA:
undetectable		 2xfsA-3vwaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 VAL A 185
LEU A  29
GLY A 442
ALA A 445
 None
 0.91A 2xfsA-3wc3A:
undetectable		 2xfsA-3wc3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		4 VAL A  77
LEU A  88
GLY A 123
ALA A 124
 None
 0.94A 2xfsA-3woyA:
undetectable		 2xfsA-3woyA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 VAL A 173
LEU A  46
GLY A 212
ALA A 289
 None
 0.94A 2xfsA-3wy7A:
undetectable		 2xfsA-3wy7A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		4 VAL A 423
LEU A 136
GLY A 466
ALA A 146
 None
 0.90A 2xfsA-4bv6A:
undetectable		 2xfsA-4bv6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cf3 L-HALOACID
DEHALOGENASE

(Rhodobacteraceae) 		PF00702
(Hydrolase) 		4 VAL A 150
ARG A 193
GLY A 189
ALA A 190
 None
 0.88A 2xfsA-4cf3A:
undetectable		 2xfsA-4cf3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 VAL A  59
LEU A  97
GLY A   8
ALA A  75
 None
 0.95A 2xfsA-4e4yA:
undetectable		 2xfsA-4e4yA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TRP A 394
VAL A 491
ARG A 406
GLY A 408
 None
 0.90A 2xfsA-4eqvA:
undetectable		 2xfsA-4eqvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15

(Homo sapiens) 		PF00644
(PARP) 		4 VAL A 598
ARG A 554
GLY A 567
ALA A 557
 None
 0.78A 2xfsA-4f0eA:
undetectable		 2xfsA-4f0eA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmq PUTATIVE RIBOSOME
ASSOCIATED PROTEIN

(Chaetomium
thermophilum) 		PF16717
(RAC_head) 		4 LEU A 388
ARG A 365
GLY A 366
LYS A 369
 None
 0.88A 2xfsA-4gmqA:
undetectable		 2xfsA-4gmqA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 VAL A  80
ARG A 317
GLY A 314
ALA A 318
 None
PO4  A 402 (-3.4A)
None
None
 0.95A 2xfsA-4hkmA:
undetectable		 2xfsA-4hkmA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 VAL A  34
ARG A  54
GLY A 124
ALA A 127
 None
 0.89A 2xfsA-4hstA:
undetectable		 2xfsA-4hstA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2

(Saccharomyces
cerevisiae) 		PF09830
(ATP_transf) 		4 HIS A 203
VAL A 205
LEU A 307
GLY A 283
 None
 0.92A 2xfsA-4i5vA:
undetectable		 2xfsA-4i5vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 VAL A 163
ARG A  32
GLY A  29
ALA A 121
 None
 0.88A 2xfsA-4k5rA:
undetectable		 2xfsA-4k5rA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k92 CLIP-ASSOCIATING
PROTEIN 1

(Homo sapiens) 		PF12348
(CLASP_N) 		4 VAL A 309
LEU A 320
GLY A 355
ALA A 356
 None
 0.90A 2xfsA-4k92A:
undetectable		 2xfsA-4k92A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TRP A 219
LEU A 493
GLY A 478
ALA A 479
 None
None
ACT  A 601 (-3.3A)
ACT  A 601 (-3.5A)
 0.93A 2xfsA-4l7tA:
undetectable		 2xfsA-4l7tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		4 LEU A 224
GLY A 209
ALA A 212
LYS A 213
 None
 0.87A 2xfsA-4muoA:
undetectable		 2xfsA-4muoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.30A 2xfsA-4n75A:
undetectable		 2xfsA-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8m NUCLEOPHOSMIN

(Mus musculus) 		PF03066
(Nucleoplasmin) 		4 HIS A 110
LEU A  49
GLY A 107
ALA A  53
 None
 0.93A 2xfsA-4n8mA:
undetectable		 2xfsA-4n8mA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 VAL A 208
LEU A  63
GLY A 265
ALA A  97
 None
 0.89A 2xfsA-4oe6A:
undetectable		 2xfsA-4oe6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1

(Homo sapiens) 		PF05014
(Nuc_deoxyrib_tr) 		4 VAL A  94
LEU A  84
GLY A 106
ALA A 108
 None
 0.85A 2xfsA-4p5eA:
undetectable		 2xfsA-4p5eA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 VAL A  75
LEU A 400
GLY A  79
ALA A 100
 None
 0.92A 2xfsA-4pxdA:
undetectable		 2xfsA-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzl ADENYLATE KINASE

(Francisella
tularensis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LEU A   5
GLY A  14
ALA A  17
LYS A  18
 None
None
None
GOL  A 303 (-3.6A)
 0.68A 2xfsA-4pzlA:
undetectable		 2xfsA-4pzlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 LEU A 344
GLY A 272
ALA A 275
LYS A 276
 None
 0.95A 2xfsA-4qjyA:
undetectable		 2xfsA-4qjyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 VAL A  99
ARG A  33
GLY A  31
ALA A  32
 None
 0.93A 2xfsA-4rapA:
undetectable		 2xfsA-4rapA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 LEU A 443
ARG A 408
GLY A 409
ALA A 412
 None
 0.89A 2xfsA-4txkA:
undetectable		 2xfsA-4txkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		4 VAL B 280
LEU B 224
GLY B 263
ALA B 266
 None
 0.92A 2xfsA-4u0pB:
undetectable		 2xfsA-4u0pB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		4 VAL A 259
LEU A 183
GLY A  28
ALA A 320
 None
None
TRP  A 601 (-3.3A)
NA  A 701 (-4.1A)
 0.88A 2xfsA-4us4A:
undetectable		 2xfsA-4us4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9u ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 312
ARG A  87
GLY A 259
ALA A  86
 None
 0.76A 2xfsA-4w9uA:
undetectable		 2xfsA-4w9uA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		4 VAL A 618
LEU A 537
GLY A 599
ALA A 549
 None
 0.81A 2xfsA-4wzwA:
undetectable		 2xfsA-4wzwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		4 VAL A 149
ARG A  22
GLY A  19
ALA A 107
 None
 0.87A 2xfsA-4x4jA:
undetectable		 2xfsA-4x4jA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pseudomonas
aeruginosa) 		PF02540
(NAD_synthase) 		4 VAL A  24
LEU A  58
GLY A 207
ALA A 208
 None
 0.83A 2xfsA-4xfdA:
undetectable		 2xfsA-4xfdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 HIS A 295
LEU A 290
GLY A 243
ALA A 246
 None
 0.63A 2xfsA-4xvxA:
undetectable		 2xfsA-4xvxA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.90A 2xfsA-4z17A:
undetectable		 2xfsA-4z17A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 HIS A 657
GLY A 866
ALA A1157
LYS A1156
 None
 0.88A 2xfsA-5a55A:
1.9		 2xfsA-5a55A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 VAL A 377
LEU A  86
GLY A 418
ALA A  82
 None
 0.93A 2xfsA-5a5gA:
undetectable		 2xfsA-5a5gA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		4 VAL A  82
LEU A 210
GLY A 187
ALA A  71
 None
 0.90A 2xfsA-5brlA:
2.1		 2xfsA-5brlA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 VAL A 135
LEU A 175
GLY A 166
ALA A 169
 None
 0.92A 2xfsA-5egwA:
undetectable		 2xfsA-5egwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehd NUCLEOPHOSMIN

(Homo sapiens) 		PF03066
(Nucleoplasmin) 		4 HIS A 110
LEU A  49
GLY A 107
ALA A  53
 None
 0.94A 2xfsA-5ehdA:
undetectable		 2xfsA-5ehdA:
14.02