SIMILAR PATTERNS OF AMINO ACIDS FOR 2XFH_A_CL6A1414_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)


(Klebsiella
aerogenes)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 LEU C 193
ILE C 177
LEU C 181
THR C 490
None
0.74A 2xfhA-1a5lC:
0.0
2xfhA-1a5lC:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus)
PF00191
(Annexin)
4 LEU A  22
ILE A  36
LEU A  40
LEU A  63
None
0.70A 2xfhA-1aowA:
0.0
2xfhA-1aowA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)


(Burkholderia
gladioli)
PF00144
(Beta-lactamase)
5 MET A  65
LEU A 381
LEU A  35
THR A 370
LEU A 368
None
1.40A 2xfhA-1ci9A:
0.0
2xfhA-1ci9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2)
5 MET A  90
LEU A 280
ILE A 257
LEU A 283
LEU A 240
None
1.50A 2xfhA-1cttA:
0.0
2xfhA-1cttA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE


(Homo sapiens)
PF00632
(HECT)
5 MET A 802
LEU A 835
ILE A 770
LEU A 839
LEU A 826
None
1.41A 2xfhA-1d5fA:
0.0
2xfhA-1d5fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE


(Penicillium
roqueforti)
no annotation 4 LEU A 212
LEU A 107
THR A 175
LEU A 208
None
None
None
FOH  A 402 ( 4.7A)
0.80A 2xfhA-1dgpA:
0.7
2xfhA-1dgpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum)
PF00191
(Annexin)
4 LEU A  28
ILE A  42
LEU A  46
LEU A  69
None
0.79A 2xfhA-1dk5A:
0.0
2xfhA-1dk5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli)
PF00328
(His_Phos_2)
4 LEU A 207
ILE A 152
LEU A 198
LEU A 257
None
0.74A 2xfhA-1dkpA:
0.0
2xfhA-1dkpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE


(Medicago sativa)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 LEU A 341
ILE A 175
LEU A 179
THR A 285
LEU A 347
None
1.49A 2xfhA-1fp2A:
0.0
2xfhA-1fp2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens)
PF00089
(Trypsin)
5 LEU A  59
GLN A  63
LEU A  33
THR A  54
LEU A 104
None
1.37A 2xfhA-1fujA:
undetectable
2xfhA-1fujA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1


(Saccharomyces
cerevisiae)
PF00156
(Pribosyltran)
4 LEU A  81
ILE A  60
LEU A  51
LEU A  77
None
0.72A 2xfhA-1g2pA:
undetectable
2xfhA-1g2pA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmv UREE

(Klebsiella
aerogenes)
PF02814
(UreE_N)
PF05194
(UreE_C)
4 LEU A  99
ILE A 101
LEU A 106
LEU A  92
None
0.80A 2xfhA-1gmvA:
undetectable
2xfhA-1gmvA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens)
PF08534
(Redoxin)
5 HIS A  51
LEU A 161
GLN A 160
ILE A 158
LEU A  62
None
1.29A 2xfhA-1h4oA:
undetectable
2xfhA-1h4oA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa)
PF00191
(Annexin)
4 LEU A  51
ILE A  65
LEU A  69
LEU A  92
None
0.77A 2xfhA-1hm6A:
undetectable
2xfhA-1hm6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN


(Escherichia
coli)
PF00392
(GntR)
PF07840
(FadR_C)
4 LEU A  48
ILE A  41
LEU A  37
LEU A  52
None
0.58A 2xfhA-1hw2A:
undetectable
2xfhA-1hw2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus)
PF13304
(AAA_21)
4 LEU B 859
ILE B 837
LEU B 836
LEU B 852
None
0.80A 2xfhA-1ii8B:
undetectable
2xfhA-1ii8B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A


(Rhodobacter
capsulatus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C)
5 LEU A  23
ILE A  70
LEU A  75
THR A  77
LEU A  27
None
1.46A 2xfhA-1jroA:
undetectable
2xfhA-1jroA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus)
PF01979
(Amidohydro_1)
5 LEU A 349
ILE A 359
LEU A 304
THR A 263
LEU A 312
None
1.26A 2xfhA-1k1dA:
undetectable
2xfhA-1k1dA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka8 PUTATIVE P4-SPECIFIC
DNA PRIMASE


(Enterobacteria
phage P4)
PF03288
(Pox_D5)
5 LEU A  67
ILE A   9
LEU A  63
THR A  85
LEU A  87
None
1.46A 2xfhA-1ka8A:
undetectable
2xfhA-1ka8A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
5 MET A  97
HIS A  93
ILE A 114
LEU A 112
LEU A 129
None
1.48A 2xfhA-1kk0A:
undetectable
2xfhA-1kk0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llc L-LACTATE
DEHYDROGENASE


(Lactobacillus
casei)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 HIS A 195
LEU A 136
ILE A 257
LEU A 254
THR A  97
SO4  A   2 ( 3.5A)
None
None
None
None
1.20A 2xfhA-1llcA:
undetectable
2xfhA-1llcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus)
PF00161
(RIP)
4 LEU A   8
ILE A 151
LEU A 147
LEU A   6
None
0.69A 2xfhA-1lpcA:
undetectable
2xfhA-1lpcA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI


(Escherichia
coli)
PF01784
(NIF3)
5 LEU A   6
ILE A  10
LEU A   9
THR A 234
LEU A 236
None
1.45A 2xfhA-1nmoA:
undetectable
2xfhA-1nmoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073


(Haemophilus
influenzae)
PF01909
(NTP_transf_2)
4 LEU A  65
ILE A  20
LEU A  21
LEU A  80
None
0.81A 2xfhA-1no5A:
undetectable
2xfhA-1no5A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE


(Homo sapiens)
PF00620
(RhoGAP)
4 GLN A 241
ILE A 227
LEU A 223
LEU A 293
None
0.75A 2xfhA-1pbwA:
undetectable
2xfhA-1pbwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
4 LEU A 328
LEU A 492
THR A 254
LEU A 258
None
0.74A 2xfhA-1pz3A:
undetectable
2xfhA-1pz3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE


(Pseudomonas
putida)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 LEU A 338
ILE A 125
LEU A 129
LEU A 247
None
0.68A 2xfhA-1re5A:
2.0
2xfhA-1re5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
5 HIS A 233
LEU A 175
ILE A 178
LEU A 195
LEU A 225
None
1.24A 2xfhA-1smaA:
undetectable
2xfhA-1smaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG


(Homo sapiens)
PF03657
(UPF0113)
4 HIS A 175
LEU A 141
ILE A 139
LEU A 108
None
0.79A 2xfhA-1sqwA:
undetectable
2xfhA-1sqwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
4 LEU C 248
ILE C 281
LEU C 285
LEU C 252
None
0.79A 2xfhA-1sxjC:
undetectable
2xfhA-1sxjC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4)
PF00303
(Thymidylat_synt)
5 MET A 201
LEU A  59
ILE A  60
LEU A  63
LEU A 194
None
1.33A 2xfhA-1tisA:
undetectable
2xfhA-1tisA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlq HYPOTHETICAL PROTEIN
YPJQ


(Bacillus
subtilis)
PF04608
(PgpA)
5 MET A   8
LEU A 150
ILE A 106
THR A  15
LEU A  57
None
1.38A 2xfhA-1tlqA:
undetectable
2xfhA-1tlqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Archaeoglobus
fulgidus)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 LEU A 191
ILE A 187
LEU A 231
THR A 308
LEU A 311
None
1.42A 2xfhA-1txgA:
undetectable
2xfhA-1txgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
4 LEU A 462
ILE A 473
LEU A 469
THR A 428
None
0.69A 2xfhA-1uf2A:
undetectable
2xfhA-1uf2A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum)
PF00017
(SH2)
PF09267
(Dict-STAT-coil)
4 LEU A 340
LEU A 298
THR A 261
LEU A 262
None
0.81A 2xfhA-1uusA:
undetectable
2xfhA-1uusA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE


(Escherichia
coli)
PF04262
(Glu_cys_ligase)
4 LEU A 299
ILE A 251
LEU A 249
LEU A 293
None
0.80A 2xfhA-1v4gA:
undetectable
2xfhA-1v4gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF00291
(PALP)
5 LEU A  88
ILE A  65
LEU A  77
THR A  69
LEU A  90
None
1.27A 2xfhA-1ve1A:
undetectable
2xfhA-1ve1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE


(Nostoc sp. PCC
7120)
PF00266
(Aminotran_5)
4 LEU A 273
ILE A  60
LEU A  64
LEU A 211
None
0.67A 2xfhA-1vjoA:
undetectable
2xfhA-1vjoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus)
PF00721
(TMV_coat)
4 LEU P 132
ILE P  24
LEU P  23
LEU P 128
None
0.73A 2xfhA-1vtmP:
undetectable
2xfhA-1vtmP:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE


(Penicillium
simplicissimum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
4 HIS A  62
LEU A  10
THR A  57
LEU A  70
None
0.81A 2xfhA-1w1kA:
undetectable
2xfhA-1w1kA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens)
PF00191
(Annexin)
4 LEU A  30
ILE A  44
LEU A  48
LEU A  71
None
0.77A 2xfhA-1w45A:
undetectable
2xfhA-1w45A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens)
PF00191
(Annexin)
4 LEU A 102
ILE A 116
LEU A 120
LEU A 143
None
0.78A 2xfhA-1w45A:
undetectable
2xfhA-1w45A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus)
PF00063
(Myosin_head)
4 LEU A 592
ILE A 407
LEU A 411
LEU A 588
None
0.65A 2xfhA-1w8jA:
undetectable
2xfhA-1w8jA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE


(Pyrococcus
furiosus)
PF00557
(Peptidase_M24)
4 LEU A  79
ILE A  81
LEU A  54
LEU A  73
None
0.70A 2xfhA-1wkmA:
undetectable
2xfhA-1wkmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 MET A  15
LEU A  85
ILE A 111
THR A  48
LEU A  46
None
1.47A 2xfhA-1wy2A:
undetectable
2xfhA-1wy2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
4 LEU B 351
ILE A  11
LEU A  15
LEU A  26
None
0.68A 2xfhA-1wytB:
undetectable
2xfhA-1wytB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7)
PF00476
(DNA_pol_A)
4 LEU A 610
ILE A 569
LEU A 565
LEU A 614
None
0.79A 2xfhA-1x9sA:
undetectable
2xfhA-1x9sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE


(Bacillus cereus)
PF00132
(Hexapep)
5 LEU A  85
ILE A  90
LEU A  73
THR A  49
LEU A  71
None
1.50A 2xfhA-1xhdA:
undetectable
2xfhA-1xhdA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE


(Chlorobaculum
tepidum)
PF04371
(PAD_porph)
5 LEU A  43
GLN A  46
ILE A 337
THR A  18
LEU A  47
None
1.32A 2xfhA-1xknA:
undetectable
2xfhA-1xknA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE


(Moorella
thermoacetica)
PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B)
5 LEU A  65
ILE A  93
LEU A  74
THR A  47
LEU A  41
None
1.28A 2xfhA-1ycgA:
undetectable
2xfhA-1ycgA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus)
PF00191
(Annexin)
4 LEU A  24
ILE A  38
LEU A  42
LEU A  65
None
0.74A 2xfhA-1yiiA:
undetectable
2xfhA-1yiiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynb HYPOTHETICAL PROTEIN
AF1432


(Archaeoglobus
fulgidus)
PF13023
(HD_3)
5 LEU A 126
ILE A  49
LEU A  53
THR A 153
LEU A 151
None
1.50A 2xfhA-1ynbA:
2.8
2xfhA-1ynbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO


(Schizosaccharomyces
pombe)
no annotation 4 LEU A 161
ILE A 164
LEU A 127
LEU A 149
None
0.68A 2xfhA-1yrgA:
undetectable
2xfhA-1yrgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE


(Escherichia
coli)
PF04952
(AstE_AspA)
4 LEU A  46
ILE A  48
LEU A 144
LEU A 235
None
0.81A 2xfhA-1yw6A:
undetectable
2xfhA-1yw6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT


(Lactococcus
lactis)
PF13393
(tRNA-synt_His)
5 LEU A 172
ILE A 215
LEU A 211
THR A 231
LEU A 236
None
1.18A 2xfhA-1z7mA:
undetectable
2xfhA-1z7mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Thermotoga
maritima)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
4 LEU A  72
ILE A  74
LEU A   8
LEU A  88
None
0.74A 2xfhA-1z82A:
undetectable
2xfhA-1z82A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo2 NUCLEAR TRANSPORT
FACTOR 2


(Cryptosporidium
parvum)
PF02136
(NTF2)
4 GLN A 104
ILE A 118
LEU A  35
THR A  24
None
0.76A 2xfhA-1zo2A:
undetectable
2xfhA-1zo2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3)
PF00523
(Fusion_gly)
5 LEU A  53
ILE A  79
LEU A  78
THR A 211
LEU A 210
None
1.23A 2xfhA-1ztmA:
undetectable
2xfhA-1ztmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 LEU A1051
ILE A1094
LEU A1136
THR A1024
LEU A1043
None
1.24A 2xfhA-2b5mA:
undetectable
2xfhA-2b5mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 LEU A1064
ILE A1193
LEU A1297
THR A1082
LEU A1107
None
1.42A 2xfhA-2boaA:
undetectable
2xfhA-2boaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5


(Homo sapiens)
PF00102
(Y_phosphatase)
5 HIS A 471
LEU A 418
ILE A 416
LEU A 427
THR A 368
SCY  A 472 ( 4.2A)
None
None
None
None
1.39A 2xfhA-2bv5A:
undetectable
2xfhA-2bv5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 MET A 423
LEU A 378
ILE A 387
LEU A 405
LEU A 439
None
1.09A 2xfhA-2cduA:
undetectable
2xfhA-2cduA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 LEU A 272
ILE A 249
THR A 259
LEU A 281
None
0.80A 2xfhA-2d0iA:
undetectable
2xfhA-2d0iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea)
PF00139
(Lectin_legB)
4 LEU A 156
ILE A 209
LEU A  93
LEU A 154
None
0.68A 2xfhA-2d3rA:
undetectable
2xfhA-2d3rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus)
PF00063
(Myosin_head)
PF00612
(IQ)
4 LEU A 592
ILE A 407
LEU A 411
LEU A 588
None
0.79A 2xfhA-2dfsA:
undetectable
2xfhA-2dfsA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eby PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YBAQ


(Escherichia
coli)
PF01381
(HTH_3)
5 MET A  62
LEU A  27
ILE A  34
LEU A  37
LEU A  22
None
1.15A 2xfhA-2ebyA:
undetectable
2xfhA-2ebyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
4 LEU A 637
ILE A 614
LEU A 618
LEU A 664
None
0.77A 2xfhA-2ec5A:
undetectable
2xfhA-2ec5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es6 VTS1P

(Saccharomyces
cerevisiae)
PF07647
(SAM_2)
4 LEU A 460
ILE A 456
LEU A 472
LEU A 502
None
0.80A 2xfhA-2es6A:
undetectable
2xfhA-2es6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE


(Enterococcus
faecalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 LEU A  78
ILE A   5
LEU A  15
THR A 128
LEU A 104
None
1.35A 2xfhA-2ew2A:
undetectable
2xfhA-2ew2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae)
PF01843
(DIL)
4 LEU X 275
LEU X 268
THR X 312
LEU X 316
None
0.67A 2xfhA-2f6hX:
1.4
2xfhA-2f6hX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME


(Agrobacterium
tumefaciens)
PF00206
(Lyase_1)
4 LEU A 335
ILE A 127
LEU A 131
LEU A 248
None
0.62A 2xfhA-2felA:
undetectable
2xfhA-2felA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsw PG_0823 PROTEIN

(Porphyromonas
gingivalis)
PF01638
(HxlR)
4 LEU A  53
ILE A  45
LEU A  41
LEU A  57
None
0.79A 2xfhA-2fswA:
undetectable
2xfhA-2fswA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00180
(Iso_dh)
4 LEU A   3
ILE A   5
LEU A  64
LEU A  23
None
0.77A 2xfhA-2g4oA:
undetectable
2xfhA-2g4oA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 LEU A  61
ILE A  36
LEU A  13
THR A  89
LEU A  92
CAA  A1751 (-3.9A)
None
None
None
CAA  A1751 (-4.2A)
1.22A 2xfhA-2gd2A:
undetectable
2xfhA-2gd2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 LEU A  61
ILE A  36
LEU A  13
THR A  89
LEU A  94
CAA  A1751 (-3.9A)
None
None
None
None
1.44A 2xfhA-2gd2A:
undetectable
2xfhA-2gd2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea)
PF00139
(Lectin_legB)
4 LEU A 156
ILE A 210
LEU A  93
LEU A 154
None
0.80A 2xfhA-2gdfA:
undetectable
2xfhA-2gdfA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis)
PF03098
(An_peroxidase)
5 MET A 397
LEU A 451
ILE A 474
LEU A 464
LEU A 455
None
1.26A 2xfhA-2gjmA:
undetectable
2xfhA-2gjmA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Thermotoga
maritima)
PF02127
(Peptidase_M18)
5 LEU A  84
ILE A 302
LEU A 299
THR A 322
LEU A  88
None
1.49A 2xfhA-2glfA:
undetectable
2xfhA-2glfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL


(Rattus
norvegicus)
PF00755
(Carn_acyltransf)
5 LEU A 327
ILE A 276
LEU A 273
THR A 156
LEU A 325
None
0.95A 2xfhA-2h4tA:
undetectable
2xfhA-2h4tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE


(Escherichia
coli)
PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C)
5 MET A 321
LEU A 396
ILE A 471
LEU A 405
LEU A 314
None
1.36A 2xfhA-2hxgA:
undetectable
2xfhA-2hxgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A


(Homo sapiens)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 LEU A 274
ILE A 277
LEU A 253
LEU A 271
None
0.81A 2xfhA-2id5A:
undetectable
2xfhA-2id5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1


(Anopheles
gambiae)
PF00481
(PP2C)
5 LEU A  85
ILE A 103
LEU A 170
THR A  59
LEU A  90
None
1.29A 2xfhA-2irmA:
undetectable
2xfhA-2irmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069


(Pyrococcus
horikoshii)
PF02676
(TYW3)
4 LEU A  38
ILE A 195
LEU A 191
LEU A 108
None
0.76A 2xfhA-2it2A:
undetectable
2xfhA-2it2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7


(Homo sapiens)
PF02758
(PYRIN)
5 MET A  93
LEU A  19
LEU A  16
THR A  73
LEU A  77
None
1.45A 2xfhA-2km6A:
undetectable
2xfhA-2km6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1g DNA REPAIR PROTEIN
REV1


(Homo sapiens)
PF16727
(REV1_C)
4 LEU A1248
ILE A1210
LEU A1206
LEU A1240
None
0.80A 2xfhA-2n1gA:
undetectable
2xfhA-2n1gA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus)
PF00104
(Hormone_recep)
4 LEU A 135
ILE A 244
THR A 358
LEU A 328
None
0.78A 2xfhA-2o4jA:
undetectable
2xfhA-2o4jA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus)
PF15515
(MvaI_BcnI)
4 LEU A 227
ILE A 222
LEU A  73
LEU A 182
PEG  A 240 ( 4.8A)
None
None
None
0.60A 2xfhA-2odhA:
undetectable
2xfhA-2odhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN


(Canavalia rosea)
PF00139
(Lectin_legB)
4 LEU A 156
ILE A 210
LEU A  93
LEU A 154
None
0.65A 2xfhA-2ow4A:
undetectable
2xfhA-2ow4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens)
PF00246
(Peptidase_M14)
5 LEU A  64
ILE A 193
LEU A 297
THR A  82
LEU A 107
None
1.46A 2xfhA-2pcuA:
undetectable
2xfhA-2pcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg4 UNCHARACTERIZED
PROTEIN


(Aeropyrum
pernix)
no annotation 5 LEU A  17
ILE A  16
LEU A  13
THR A   5
LEU A  59
None
1.44A 2xfhA-2pg4A:
undetectable
2xfhA-2pg4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE


(Pseudomonas
savastanoi)
PF01966
(HD)
5 HIS A  33
LEU A 161
ILE A 111
THR A 179
LEU A 175
None
1.40A 2xfhA-2pgsA:
undetectable
2xfhA-2pgsA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379


(Pseudomonas
syringae group
genomosp. 3)
PF07286
(DUF1445)
5 LEU A  42
ILE A  89
LEU A  85
THR A  77
LEU A 121
None
1.48A 2xfhA-2pifA:
undetectable
2xfhA-2pifA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py8 HYPOTHETICAL PROTEIN
RBCX


(Synechocystis
sp. PCC 6803)
PF02341
(RcbX)
4 LEU A  67
ILE A  26
LEU A  41
LEU A  60
None
0.81A 2xfhA-2py8A:
undetectable
2xfhA-2py8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred)
5 LEU A 353
ILE A 374
LEU A 370
THR A 339
LEU A 340
None
1.30A 2xfhA-2pziA:
undetectable
2xfhA-2pziA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens)
PF00378
(ECH_1)
5 LEU A 124
ILE A 155
LEU A 156
THR A 139
LEU A 120
None
1.25A 2xfhA-2q34A:
undetectable
2xfhA-2q34A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
4 LEU A 138
ILE A 163
LEU A 166
LEU A 191
None
0.62A 2xfhA-2q3yA:
undetectable
2xfhA-2q3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
4 LEU A  83
ILE A 191
LEU A 195
LEU A 121
None
TF4  A 438 (-3.4A)
None
None
0.76A 2xfhA-2q8hA:
undetectable
2xfhA-2q8hA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A   6
ILE A   3
LEU A  76
LEU A  36
None
0.80A 2xfhA-2qddA:
undetectable
2xfhA-2qddA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans)
PF00026
(Asp)
5 LEU A 198
ILE A 213
LEU A 226
THR A 224
LEU A 306
None
1.45A 2xfhA-2qzwA:
undetectable
2xfhA-2qzwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r41 UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF06124
(DUF960)
5 HIS A  61
LEU A  43
ILE A  41
LEU A  37
LEU A  47
None
0.99A 2xfhA-2r41A:
undetectable
2xfhA-2r41A:
15.52