SIMILAR PATTERNS OF AMINO ACIDS FOR 2XF3_A_J01A500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 HIS A 263
VAL A 238
LEU A 150
GLY A  38
ALA A  41
 None
 1.07A 2xf3A-1c4xA:
0.0		 2xf3A-1c4xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 5 VAL A  79
ILE A 122
LEU A  90
LEU A 142
GLY A 139
 None
None
None
None
DGP  A 301 (-3.4A)
 1.10A 2xf3A-1delA:
0.0		 2xf3A-1delA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxt HYDROGENASE
MATURATION PROTEIN
HYPF

(Escherichia
coli) 		PF00708
(Acylphosphatase) 		5 VAL A  46
ILE A  13
LEU A  35
LEU A  61
ALA A  30
 CL  A1092 (-4.9A)
None
None
None
None
 1.00A 2xf3A-1gxtA:
0.0		 2xf3A-1gxtA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 VAL A 535
LEU A 837
LEU A 806
GLY A 802
ALA A 799
 None
 1.26A 2xf3A-1h7wA:
0.0		 2xf3A-1h7wA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im9 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL1

(Homo sapiens) 		PF00047
(ig) 		5 ILE D 102
LEU D  97
LEU D  17
GLY D  15
ALA D  12
 None
 1.17A 2xf3A-1im9D:
0.0		 2xf3A-1im9D:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 VAL A 522
ILE A 465
LEU A 469
ARG A 517
ALA A 513
 None
 1.23A 2xf3A-1jeqA:
0.3		 2xf3A-1jeqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3s SIGE

(Salmonella
enterica) 		PF07824
(Chaperone_III) 		5 VAL A  31
ILE A  24
LEU A   4
LEU A  12
ALA A  94
 None
 1.02A 2xf3A-1k3sA:
0.0		 2xf3A-1k3sA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 377
LEU A 215
LEU A 223
GLY A 196
ALA A 199
 None
 1.09A 2xf3A-1k4qA:
0.0		 2xf3A-1k4qA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 VAL A  80
ILE A  54
LEU A  29
ALA A 229
LYS A 228
 None
 1.13A 2xf3A-1m6yA:
0.0		 2xf3A-1m6yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 VAL A 692
ILE A 696
LEU A 117
LEU A 297
GLY A 294
 None
 1.22A 2xf3A-1mhsA:
undetectable		 2xf3A-1mhsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B

(Thermobifida
fusca) 		PF00079
(Serpin)
no annotation 		5 ILE B 344
LEU A 162
LEU A 305
GLY A 314
ALA A 164
 None
 1.22A 2xf3A-1mtpB:
undetectable		 2xf3A-1mtpB:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndl NUCLEOSIDE
DIPHOSPHATE KINASE

(Drosophila
melanogaster) 		PF00334
(NDK) 		5 VAL A  12
ILE A 118
LEU A  92
ARG A  89
GLY A  88
 None
 1.19A 2xf3A-1ndlA:
undetectable		 2xf3A-1ndlA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 VAL A  49
ILE A  80
LEU A 117
GLY A  65
ALA A  63
 None
 1.08A 2xf3A-1og6A:
undetectable		 2xf3A-1og6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 VAL A 277
LEU A 324
LEU A 306
GLY A 267
ALA A 268
 None
AOG  A 452 ( 4.2A)
HG  A 402 ( 4.2A)
None
None
 1.25A 2xf3A-1r82A:
undetectable		 2xf3A-1r82A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		5 VAL A  69
ILE A 226
LEU A 260
GLY A 213
ALA A 214
 None
 1.24A 2xf3A-1svvA:
undetectable		 2xf3A-1svvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 606
ILE B 491
LEU B 522
ARG B 565
GLY B 523
 None
 1.20A 2xf3A-1t3qB:
1.1		 2xf3A-1t3qB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t82 HYPOTHETICAL
ACETYLTRANSFERASE

(Shewanella
oneidensis) 		PF09500
(YiiD_C) 		5 HIS A  13
TRP A  12
ILE A  16
LEU A  61
ALA A  38
 None
 1.20A 2xf3A-1t82A:
undetectable		 2xf3A-1t82A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 ILE C 932
LEU C 970
LEU C 958
GLY C 956
ALA C 988
 None
 1.22A 2xf3A-1u6gC:
undetectable		 2xf3A-1u6gC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		5 VAL A  96
LEU A 196
LEU A  16
GLY A  19
ALA A 195
 None
 1.25A 2xf3A-1xfgA:
undetectable		 2xf3A-1xfgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		5 VAL B  20
ILE B  44
LEU B  33
GLY B  29
ALA B 115
 None
 1.17A 2xf3A-1y8qB:
undetectable		 2xf3A-1y8qB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE

(Ruminiclostridium
thermocellum) 		PF00551
(Formyl_trans_N) 		5 VAL A  72
ILE A 103
LEU A  90
LEU A  78
GLY A  81
 None
 0.95A 2xf3A-1zghA:
undetectable		 2xf3A-1zghA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6y EMP47P (FORM1)

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 VAL A 180
ILE A 164
LEU A 115
GLY A 129
ALA A 149
 None
 0.89A 2xf3A-2a6yA:
undetectable		 2xf3A-2a6yA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a70 EMP47P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 VAL A 180
ILE A 164
LEU A 115
GLY A 129
ALA A 149
 None
None
None
None
EDO  A   4 ( 4.9A)
 0.96A 2xf3A-2a70A:
undetectable		 2xf3A-2a70A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 898
LEU A 812
LEU A 712
ALA A 719
LYS A 720
 None
 1.27A 2xf3A-2ax9A:
undetectable		 2xf3A-2ax9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 VAL A 238
ILE A 232
LEU A 418
GLY A 273
ALA A 349
 None
 1.12A 2xf3A-2canA:
undetectable		 2xf3A-2canA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A  16
ILE A 134
LEU A  27
GLY A   6
ALA A 171
 None
None
None
FAD  A1002 (-3.3A)
None
 1.18A 2xf3A-2e5vA:
undetectable		 2xf3A-2e5vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		5 HIS A 109
VAL A 244
LEU A 137
GLY A 106
ALA A 102
 None
 1.07A 2xf3A-2g0wA:
undetectable		 2xf3A-2g0wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		5 HIS A 161
VAL A 114
LEU A 176
LEU A  93
GLY A  95
 None
 1.04A 2xf3A-2hlsA:
undetectable		 2xf3A-2hlsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		5 VAL A 486
ILE A  93
LEU A 111
GLY A  52
ALA A  51
 None
 1.22A 2xf3A-2jf7A:
undetectable		 2xf3A-2jf7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 VAL A 149
LEU A  21
ARG A  22
GLY A  19
ALA A 107
 None
 1.09A 2xf3A-2qa1A:
undetectable		 2xf3A-2qa1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 VAL A 149
LEU A  21
ARG A  22
GLY A  19
ALA A 107
 None
 1.11A 2xf3A-2qa2A:
undetectable		 2xf3A-2qa2A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 ILE A 797
LEU A 869
LEU A 825
GLY A 823
ALA A 865
 None
 1.21A 2xf3A-2qnaA:
undetectable		 2xf3A-2qnaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 569
ILE A 573
LEU A 514
LEU A 536
GLY A 535
 None
 1.25A 2xf3A-2rghA:
undetectable		 2xf3A-2rghA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo8 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF12135
(Sialidase_penC) 		5 VAL A 973
ILE A1022
LEU A1046
LEU A1028
GLY A 963
 None
 1.14A 2xf3A-2vo8A:
undetectable		 2xf3A-2vo8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 VAL A 912
ILE A1059
LEU A 919
LEU A1032
GLY A 890
 None
 1.12A 2xf3A-2vz9A:
undetectable		 2xf3A-2vz9A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 372
LEU A 219
LEU A 227
GLY A 197
ALA A 200
 None
None
None
NDP  A1488 (-3.2A)
None
 1.13A 2xf3A-2x50A:
undetectable		 2xf3A-2x50A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		10 HIS A  84
TRP A  91
VAL A  93
ILE A 103
LEU A 362
LEU A 415
ARG A 418
GLY A 419
ALA A 422
LYS A 423
 J01  A 500 (-3.5A)
J01  A 500 (-4.6A)
None
None
None
None
J01  A 600 ( 2.8A)
J01  A 500 (-3.4A)
J01  A 500 (-3.4A)
J01  A 500 (-3.7A)
 0.14A 2xf3A-2xfsA:
67.5		 2xf3A-2xfsA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 217
ILE A  14
LEU A 385
GLY A 371
ALA A 303
 None
 1.23A 2xf3A-3euoA:
undetectable		 2xf3A-3euoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1x SERINE
ACETYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00132
(Hexapep) 		5 VAL A 174
ILE A  87
LEU A 123
LEU A  83
ALA A  49
 None
 1.28A 2xf3A-3f1xA:
0.5		 2xf3A-3f1xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 VAL A 104
ILE A  95
LEU A 119
GLY A 120
ALA A  27
 None
 1.15A 2xf3A-3f8rA:
undetectable		 2xf3A-3f8rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8n KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DS4

(Homo sapiens) 		PF00047
(ig) 		5 ILE A 102
LEU A  97
LEU A  17
GLY A  15
ALA A  12
 None
 1.20A 2xf3A-3h8nA:
undetectable		 2xf3A-3h8nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		5 HIS A 323
VAL A 326
ILE A 370
LEU A 363
ALA A  31
 None
 1.07A 2xf3A-3h9cA:
undetectable		 2xf3A-3h9cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A  88
LEU A  12
LEU A  93
GLY A 103
ALA A 106
 None
 1.24A 2xf3A-3ic1A:
undetectable		 2xf3A-3ic1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 VAL A   3
ILE A  44
LEU A 305
GLY A 288
ALA A 289
 None
 1.15A 2xf3A-3ipcA:
undetectable		 2xf3A-3ipcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 VAL G 109
ILE G  45
LEU F   3
LEU G  68
ALA G  59
 None
 1.08A 2xf3A-3jb9G:
undetectable		 2xf3A-3jb9G:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 VAL A 137
ILE A 126
LEU A 198
GLY A 215
ALA A 112
 None
 1.26A 2xf3A-3kd8A:
undetectable		 2xf3A-3kd8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3q MMOQ

(Methylococcus
capsulatus) 		PF08668
(HDOD) 		5 ILE A 141
LEU A 220
LEU A 138
GLY A 157
ALA A 160
 None
 1.20A 2xf3A-3p3qA:
undetectable		 2xf3A-3p3qA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 VAL A 176
ILE A 178
LEU A  39
GLY A 236
ALA A  70
 None
 1.19A 2xf3A-3qanA:
undetectable		 2xf3A-3qanA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		5 VAL A 177
ILE A 179
LEU A  40
GLY A 237
ALA A  71
 None
 1.23A 2xf3A-3rjlA:
undetectable		 2xf3A-3rjlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		5 TRP A 113
VAL A 115
ILE A 194
LEU A 149
ALA A 139
 None
 1.06A 2xf3A-3rleA:
undetectable		 2xf3A-3rleA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 272
LEU A  63
LEU A 262
ARG A 267
GLY A 264
 None
 1.02A 2xf3A-3tcsA:
undetectable		 2xf3A-3tcsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thn EXONUCLEASE,
PUTATIVE

(Thermotoga
maritima) 		PF00149
(Metallophos) 		5 HIS A  16
ILE A 236
LEU A  60
LEU A  34
GLY A  18
 MN  A 360 (-3.9A)
None
None
None
None
 1.14A 2xf3A-3thnA:
undetectable		 2xf3A-3thnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tho EXONUCLEASE,
PUTATIVE

(Thermotoga
maritima) 		PF00149
(Metallophos) 		5 HIS B  16
ILE B 236
LEU B  60
LEU B  34
GLY B  18
 MN  B   1 (-3.9A)
None
None
None
None
 1.17A 2xf3A-3thoB:
undetectable		 2xf3A-3thoB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		5 VAL A 140
ILE A 153
LEU A   6
LEU A 193
ALA A 189
 None
 1.22A 2xf3A-3tqrA:
undetectable		 2xf3A-3tqrA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 415
ILE A 430
LEU A 198
GLY A 145
ALA A 147
 None
 1.19A 2xf3A-3uk1A:
undetectable		 2xf3A-3uk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 ILE A 116
LEU A  29
LEU A  92
GLY A 442
ALA A 445
 None
 1.16A 2xf3A-3wc3A:
undetectable		 2xf3A-3wc3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 VAL A 185
LEU A  29
LEU A  92
GLY A 442
ALA A 445
 None
 1.27A 2xf3A-3wc3A:
undetectable		 2xf3A-3wc3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 VAL A 110
LEU A 154
LEU A 122
GLY A 246
ALA A 245
 None
 1.20A 2xf3A-3zvtA:
0.0		 2xf3A-3zvtA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 VAL A  77
ILE A 125
LEU A 252
GLY A 320
ALA A 141
 None
 1.15A 2xf3A-4b43A:
undetectable		 2xf3A-4b43A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 ILE A 142
LEU A  80
LEU A 145
GLY A  47
ALA A  50
 None
 1.18A 2xf3A-4bjuA:
undetectable		 2xf3A-4bjuA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		5 VAL A 179
LEU A  69
LEU A 146
GLY A 133
ALA A 132
 None
None
None
None
FRU  A1415 ( 4.7A)
 1.26A 2xf3A-4d47A:
1.9		 2xf3A-4d47A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 351
LEU A 198
LEU A 206
GLY A 179
ALA A 182
 None
 1.08A 2xf3A-4dnaA:
undetectable		 2xf3A-4dnaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 547
ILE A 528
LEU A 110
ARG A 112
GLY A 113
 None
 1.26A 2xf3A-4epaA:
0.6		 2xf3A-4epaA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		5 VAL A   8
LEU A 108
ARG A  93
GLY A  92
ALA A  60
 None
 1.18A 2xf3A-4f1rA:
undetectable		 2xf3A-4f1rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 325
LEU A 181
ARG A 207
GLY A 208
ALA A 209
 None
 1.22A 2xf3A-4j6fA:
undetectable		 2xf3A-4j6fA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		5 VAL A  11
LEU A 111
ARG A  96
GLY A  95
ALA A  63
 None
 1.15A 2xf3A-4jg3A:
undetectable		 2xf3A-4jg3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A  21
ILE A 353
LEU A 356
GLY A 251
ALA A  93
 None
 1.24A 2xf3A-4jgaA:
undetectable		 2xf3A-4jgaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 VAL A 163
LEU A  31
ARG A  32
GLY A  29
ALA A 121
 None
 1.12A 2xf3A-4k5rA:
undetectable		 2xf3A-4k5rA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 103
ILE A 119
LEU A 143
LEU A 134
ARG A 137
 None
 0.98A 2xf3A-4mrqA:
undetectable		 2xf3A-4mrqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		5 VAL A1157
ILE A1138
LEU A1196
LEU A1142
ALA A1093
 None
 1.20A 2xf3A-4n3wA:
undetectable		 2xf3A-4n3wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.24A 2xf3A-4n75A:
undetectable		 2xf3A-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		5 VAL A 261
ILE A 253
LEU A  43
GLY A  41
ALA A  35
 None
 1.18A 2xf3A-4oteA:
undetectable		 2xf3A-4oteA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		5 VAL A 591
ILE A 585
LEU A 827
GLY A 626
ALA A 707
 None
 1.18A 2xf3A-4ppmA:
undetectable		 2xf3A-4ppmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		5 VAL A  75
ILE A 183
LEU A 400
GLY A  79
ALA A 100
 None
 0.96A 2xf3A-4pxdA:
undetectable		 2xf3A-4pxdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		5 ILE A 675
LEU A 731
LEU A 673
ALA A 769
LYS A 768
 None
 1.20A 2xf3A-4q8gA:
undetectable		 2xf3A-4q8gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 VAL A  49
ILE A  80
LEU A 117
GLY A  65
ALA A  63
 None
 1.09A 2xf3A-4r9oA:
undetectable		 2xf3A-4r9oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 VAL A  77
ILE A 112
LEU A  96
LEU A 146
GLY A  98
 None
 1.28A 2xf3A-4rg1A:
undetectable		 2xf3A-4rg1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9u ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 329
LEU A 261
ARG A  87
GLY A 259
ALA A  86
 None
 1.21A 2xf3A-4w9uA:
undetectable		 2xf3A-4w9uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29

(Homo sapiens) 		PF12352
(V-SNARE_C)
no annotation 		5 VAL C  75
ILE D 219
LEU C  64
LEU D 216
GLY D 212
 None
 1.21A 2xf3A-4wy4C:
undetectable		 2xf3A-4wy4C:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 VAL A 149
LEU A  21
ARG A  22
GLY A  19
ALA A 107
 None
 1.03A 2xf3A-4x4jA:
undetectable		 2xf3A-4x4jA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 VAL A 395
ILE A 254
LEU A 353
LEU A 335
GLY A 332
 None
 1.27A 2xf3A-4y0xA:
undetectable		 2xf3A-4y0xA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 VAL A 277
LEU A 324
LEU A 306
GLY A 267
ALA A 268
 None
 1.19A 2xf3A-4y63A:
undetectable		 2xf3A-4y63A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		5 VAL A 232
ILE A 226
LEU A 414
GLY A 267
ALA A 343
 None
 1.12A 2xf3A-4zlvA:
1.5		 2xf3A-4zlvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 5 ILE A  33
LEU A  37
ARG A 140
GLY A 139
ALA A 141
 None
 1.17A 2xf3A-5a7yA:
undetectable		 2xf3A-5a7yA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 VAL A 147
ILE A 269
LEU A 267
GLY A 152
ALA A 237
 None
 1.24A 2xf3A-5avoA:
undetectable		 2xf3A-5avoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TRP A 168
VAL A 188
ILE A 164
LEU A 146
ALA A 175
 None
 1.27A 2xf3A-5fjpA:
undetectable		 2xf3A-5fjpA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		5 VAL A 246
ILE A 240
LEU A 431
GLY A 281
ALA A 359
 None
 1.12A 2xf3A-5h7dA:
undetectable		 2xf3A-5h7dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 VAL A 350
LEU A 374
LEU A 324
ARG A 322
GLY A 390
 None
NAG  A 803 (-4.8A)
None
None
None
 1.23A 2xf3A-5k47A:
undetectable		 2xf3A-5k47A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 HIS A  21
VAL A  70
ILE A  97
LEU A   9
GLY A   6
 None
 1.14A 2xf3A-5npuA:
undetectable		 2xf3A-5npuA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 ILE A 323
LEU A 390
LEU A 136
GLY A 135
ALA A 169
 None
 1.20A 2xf3A-5o1mA:
undetectable		 2xf3A-5o1mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 354
LEU A 199
LEU A 207
GLY A 180
ALA A 183
 None
 1.16A 2xf3A-5u1oA:
undetectable		 2xf3A-5u1oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 VAL A 746
ILE A 705
LEU A 723
LEU A 694
ALA A 499
 None
 0.83A 2xf3A-5uj7A:
undetectable		 2xf3A-5uj7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 ILE A 767
LEU A 805
LEU A 858
ARG A 779
ALA A 780
 None
 1.27A 2xf3A-5ujmA:
undetectable		 2xf3A-5ujmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 VAL A 746
ILE A 705
LEU A 723
LEU A 694
ALA A 499
 None
 0.84A 2xf3A-5ujmA:
undetectable		 2xf3A-5ujmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 349
LEU A 195
LEU A 203
GLY A 176
ALA A 179
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.15A 2xf3A-5v36A:
undetectable		 2xf3A-5v36A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 359
LEU A 205
LEU A 213
GLY A 186
ALA A 189
 None
 1.14A 2xf3A-5vdnA:
undetectable		 2xf3A-5vdnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 ILE A 693
LEU A 595
LEU A 665
GLY A 634
ALA A 637
 None
 1.15A 2xf3A-5wblA:
2.3		 2xf3A-5wblA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE A 418
LEU A 573
LEU A 451
GLY A 587
ALA A 589
 None
 1.24A 2xf3A-5xxoA:
undetectable		 2xf3A-5xxoA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica) 		no annotation 5 HIS A 137
ILE A 193
LEU A 190
GLY A 189
ALA A 246
 None
 1.26A 2xf3A-5ynlA:
undetectable		 2xf3A-5ynlA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 VAL A 148
LEU A  20
ARG A  21
GLY A  18
ALA A 109
 None
 1.00A 2xf3A-6brdA:
undetectable		 2xf3A-6brdA:
11.40