SIMILAR PATTERNS OF AMINO ACIDS FOR 2XDC_F_DVAF8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 TRP A 252
VAL A 357
TRP A 256
 None
 1.26A 2xdcE-1atiA:
undetectable
2xdcF-1atiA:
undetectable		 2xdcE-1atiA:
5.80
2xdcF-1atiA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3a FLAVOCETIN-A: ALPHA
SUBUNIT

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A 128
TRP A  25
 None
 1.24A 2xdcE-1c3aA:
undetectable
2xdcF-1c3aA:
undetectable		 2xdcE-1c3aA:
8.55
2xdcF-1c3aA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		3 TRP A 224
VAL A 219
TRP A 225
 None
 1.34A 2xdcE-1cs1A:
undetectable
2xdcF-1cs1A:
undetectable		 2xdcE-1cs1A:
13.92
2xdcF-1cs1A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		3 TRP A 161
VAL A 168
TRP A 163
 None
 1.12A 2xdcE-1dbnA:
undetectable
2xdcF-1dbnA:
undetectable		 2xdcE-1dbnA:
6.67
2xdcF-1dbnA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dv8 ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 275
TRP A 174
 None
 1.10A 2xdcE-1dv8A:
undetectable
2xdcF-1dv8A:
undetectable		 2xdcE-1dv8A:
15.94
2xdcF-1dv8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		3 TRP A 225
VAL A 309
TRP A 229
 None
 1.25A 2xdcE-1g5iA:
undetectable
2xdcF-1g5iA:
undetectable		 2xdcE-1g5iA:
5.37
2xdcF-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gn4 SUPEROXIDE DISMUTASE

(Mycobacterium
tuberculosis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 TRP A  80
VAL A  74
TRP A  79
 None
 0.39A 2xdcE-1gn4A:
undetectable
2xdcF-1gn4A:
undetectable		 2xdcE-1gn4A:
5.52
2xdcF-1gn4A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 TRP A 179
VAL A 166
TRP A 177
 None
CO  A1724 ( 4.3A)
None
 0.70A 2xdcE-1gqjA:
undetectable
2xdcF-1gqjA:
undetectable		 2xdcE-1gqjA:
2.66
2xdcF-1gqjA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 TRP A 134
VAL A 148
TRP A 280
 None
 1.21A 2xdcE-1guqA:
undetectable
2xdcF-1guqA:
undetectable		 2xdcE-1guqA:
4.36
2xdcF-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz2 OVOCLEIDIN-17

(Gallus gallus) 		PF00059
(Lectin_C) 		3 TRP A  76
VAL A 137
TRP A  26
 None
 1.09A 2xdcE-1gz2A:
undetectable
2xdcF-1gz2A:
undetectable		 2xdcE-1gz2A:
13.41
2xdcF-1gz2A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TRP A 690
VAL A 843
TRP A 688
 None
 1.02A 2xdcE-1hn0A:
undetectable
2xdcF-1hn0A:
undetectable		 2xdcE-1hn0A:
1.98
2xdcF-1hn0A:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijk BOTROCETIN

(Bothrops
jararaca) 		PF00059
(Lectin_C) 		3 TRP B  68
VAL B 127
TRP B  23
 None
 0.99A 2xdcE-1ijkB:
undetectable
2xdcF-1ijkB:
undetectable		 2xdcE-1ijkB:
12.20
2xdcF-1ijkB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  23
 None
 1.11A 2xdcE-1ixxA:
undetectable
2xdcF-1ixxA:
undetectable		 2xdcE-1ixxA:
11.49
2xdcF-1ixxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwi PLATELET AGGREGATION
INDUCER

(Bitis arietans) 		PF00059
(Lectin_C) 		3 TRP B  67
VAL B 120
TRP B  25
 None
 1.04A 2xdcE-1jwiB:
undetectable
2xdcF-1jwiB:
undetectable		 2xdcE-1jwiB:
13.41
2xdcF-1jwiB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 TRP A 541
VAL A  69
TRP A 479
 GOL  A1823 (-4.9A)
None
PQQ  A1800 (-4.8A)
 1.22A 2xdcE-1kb0A:
undetectable
2xdcF-1kb0A:
undetectable		 2xdcE-1kb0A:
2.73
2xdcF-1kb0A:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		3 TRP N  31
VAL N  37
TRP N 128
 None
 1.35A 2xdcE-1kc8N:
undetectable
2xdcF-1kc8N:
undetectable		 2xdcE-1kc8N:
5.82
2xdcF-1kc8N:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz7 ECHICETIN B-CHAIN

(Echis carinatus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.29A 2xdcE-1oz7B:
undetectable
2xdcF-1oz7B:
undetectable		 2xdcE-1oz7B:
26.67
2xdcF-1oz7B:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz7 ECHICETIN B-CHAIN

(Echis carinatus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.13A 2xdcE-1oz7B:
undetectable
2xdcF-1oz7B:
undetectable		 2xdcE-1oz7B:
26.67
2xdcF-1oz7B:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdd LITHOSTATHINE

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A  77
VAL A 139
TRP A  35
 None
 0.99A 2xdcE-1qddA:
undetectable
2xdcF-1qddA:
undetectable		 2xdcE-1qddA:
17.54
2xdcF-1qddA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		3 TRP A 160
VAL A 167
TRP A 162
 None
 1.16A 2xdcE-1qotA:
undetectable
2xdcF-1qotA:
undetectable		 2xdcE-1qotA:
5.58
2xdcF-1qotA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 TRP A  96
VAL A 150
TRP A 120
 None
 1.25A 2xdcE-1rcqA:
undetectable
2xdcF-1rcqA:
undetectable		 2xdcE-1rcqA:
4.32
2xdcF-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s72 50S RIBOSOMAL
PROTEIN L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		3 TRP M  31
VAL M  37
TRP M 128
 None
 1.32A 2xdcE-1s72M:
undetectable
2xdcF-1s72M:
undetectable		 2xdcE-1s72M:
5.33
2xdcF-1s72M:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 TRP A 323
VAL A 345
TRP A 327
 None
 1.30A 2xdcE-1sxjA:
undetectable
2xdcF-1sxjA:
undetectable		 2xdcE-1sxjA:
3.27
2xdcF-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 TRP A 248
VAL A 252
TRP A 180
 None
 1.05A 2xdcE-1te5A:
undetectable
2xdcF-1te5A:
undetectable		 2xdcE-1te5A:
7.88
2xdcF-1te5A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o BOTROCETIN

(Bothrops
jararaca) 		PF00059
(Lectin_C) 		3 TRP B 265
VAL B 320
TRP B 223
 None
 1.15A 2xdcE-1u0oB:
undetectable
2xdcF-1u0oB:
undetectable		 2xdcE-1u0oB:
9.17
2xdcF-1u0oB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A 128
TRP A  25
 None
 1.02A 2xdcE-1ukmA:
undetectable
2xdcF-1ukmA:
undetectable		 2xdcE-1ukmA:
9.91
2xdcF-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 B CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		3 TRP B  64
VAL B 119
TRP B  22
 None
 1.16A 2xdcE-1ukmB:
undetectable
2xdcF-1ukmB:
undetectable		 2xdcE-1ukmB:
23.33
2xdcF-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		3 TRP C 267
VAL C 320
TRP C 225
 None
 1.06A 2xdcE-1umrC:
undetectable
2xdcF-1umrC:
undetectable		 2xdcE-1umrC:
10.19
2xdcF-1umrC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 0.93A 2xdcE-1v0zA:
undetectable
2xdcF-1v0zA:
undetectable		 2xdcE-1v0zA:
4.31
2xdcF-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4l MUCROCETIN BETA
CHAIN

(Protobothrops
mucrosquamatus) 		PF00059
(Lectin_C) 		3 TRP B 267
VAL B 320
TRP B 225
 None
 1.29A 2xdcE-1v4lB:
undetectable
2xdcF-1v4lB:
undetectable		 2xdcE-1v4lB:
8.00
2xdcF-1v4lB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 TRP A 224
VAL A 193
TRP A 228
 None
 1.30A 2xdcE-1v9lA:
undetectable
2xdcF-1v9lA:
undetectable		 2xdcE-1v9lA:
3.64
2xdcF-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt9 ANTICOAGULANT
PROTEIN-B

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.10A 2xdcE-1wt9B:
undetectable
2xdcF-1wt9B:
undetectable		 2xdcE-1wt9B:
13.75
2xdcF-1wt9B:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/FACTOR X-BINDING
PROTEIN B CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.13A 2xdcE-1x2wB:
undetectable
2xdcF-1x2wB:
undetectable		 2xdcE-1x2wB:
13.75
2xdcF-1x2wB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/X-BINDING PROTEIN
A CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  23
 None
 1.08A 2xdcE-1x2wA:
undetectable
2xdcF-1x2wA:
undetectable		 2xdcE-1x2wA:
10.43
2xdcF-1x2wA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  23
 None
 1.08A 2xdcE-1y17A:
undetectable
2xdcF-1y17A:
undetectable		 2xdcE-1y17A:
9.57
2xdcF-1y17A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 TRP A1603
VAL A1605
TRP A1625
 None
 1.25A 2xdcE-2b39A:
undetectable
2xdcF-2b39A:
undetectable		 2xdcE-2b39A:
1.03
2xdcF-2b39A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE

(Streptococcus
pneumoniae) 		PF01288
(HPPK)
PF02152
(FolB) 		3 TRP A  63
VAL A  75
TRP A  60
 None
 1.27A 2xdcE-2cg8A:
undetectable
2xdcF-2cg8A:
undetectable		 2xdcE-2cg8A:
4.56
2xdcF-2cg8A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqa LYSOZYME

(Ruditapes
philippinarum) 		PF05497
(Destabilase) 		3 TRP A  46
VAL A  70
TRP A  56
 None
 1.32A 2xdcE-2dqaA:
undetectable
2xdcF-2dqaA:
undetectable		 2xdcE-2dqaA:
6.25
2xdcF-2dqaA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1

(Daboia
siamensis) 		PF00059
(Lectin_C) 		3 TRP C  67
VAL C 120
TRP C  25
 None
 1.14A 2xdcE-2e3xC:
undetectable
2xdcF-2e3xC:
undetectable		 2xdcE-2e3xC:
13.51
2xdcF-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2

(Daboia
siamensis) 		PF00059
(Lectin_C) 		3 TRP B  67
VAL B 126
TRP B  23
 None
 1.14A 2xdcE-2e3xB:
undetectable
2xdcF-2e3xB:
undetectable		 2xdcE-2e3xB:
10.00
2xdcF-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go0 REGENERATING
ISLET-DERIVED
PROTEIN 3 ALPHA

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A  65
VAL A 132
TRP A  23
 None
 0.90A 2xdcE-2go0A:
undetectable
2xdcF-2go0A:
undetectable		 2xdcE-2go0A:
9.41
2xdcF-2go0A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP B 220
VAL B 281
TRP B 184
 None
 1.04A 2xdcE-2h2tB:
undetectable
2xdcF-2h2tB:
undetectable		 2xdcE-2h2tB:
4.38
2xdcF-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o30 NUCLEAR MOVEMENT
PROTEIN

(Encephalitozoon
cuniculi) 		PF04969
(CS) 		3 TRP A  64
VAL A  76
TRP A  65
 None
 1.12A 2xdcE-2o30A:
undetectable
2xdcF-2o30A:
undetectable		 2xdcE-2o30A:
14.29
2xdcF-2o30A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 TRP A  96
VAL A 150
TRP A 120
 None
 1.22A 2xdcE-2odoA:
undetectable
2xdcF-2odoA:
undetectable		 2xdcE-2odoA:
4.64
2xdcF-2odoA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo2 HYPOTHETICAL PROTEIN
AF_1782

(Archaeoglobus
fulgidus) 		PF04010
(DUF357) 		3 TRP A  58
VAL A  56
TRP A  62
 None
 1.33A 2xdcE-2oo2A:
undetectable
2xdcF-2oo2A:
undetectable		 2xdcE-2oo2A:
22.86
2xdcF-2oo2A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 TRP A 111
VAL A 107
TRP A 298
 None
 1.33A 2xdcE-2p3xA:
undetectable
2xdcF-2p3xA:
undetectable		 2xdcE-2p3xA:
4.02
2xdcF-2p3xA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		3 TRP A 166
VAL A 115
TRP A 162
 None
 0.97A 2xdcE-2r1fA:
undetectable
2xdcF-2r1fA:
undetectable		 2xdcE-2r1fA:
11.59
2xdcF-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 TRP A 145
VAL A 258
TRP A 261
 None
 0.79A 2xdcE-2r4jA:
undetectable
2xdcF-2r4jA:
undetectable		 2xdcE-2r4jA:
2.63
2xdcF-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw NRFC PROTEIN
HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF13247
(Fer4_11)
PF14589
(NrfD_2) 		3 TRP C  90
VAL B  69
TRP C  91
 None
 1.32A 2xdcE-2vpwC:
undetectable
2xdcF-2vpwC:
undetectable		 2xdcE-2vpwC:
4.80
2xdcF-2vpwC:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrp AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.09A 2xdcE-2vrpB:
undetectable
2xdcF-2vrpB:
undetectable		 2xdcE-2vrpB:
12.50
2xdcF-2vrpB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		3 TRP A 148
VAL A 143
TRP A 179
 None
 1.10A 2xdcE-3b12A:
undetectable
2xdcF-3b12A:
undetectable		 2xdcE-3b12A:
4.66
2xdcF-3b12A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx4 AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.09A 2xdcE-3bx4B:
undetectable
2xdcF-3bx4B:
undetectable		 2xdcE-3bx4B:
9.71
2xdcF-3bx4B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 3 TRP A 243
VAL A 246
TRP A 225
 None
 1.29A 2xdcE-3csqA:
undetectable
2xdcF-3csqA:
undetectable		 2xdcE-3csqA:
3.45
2xdcF-3csqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew2 RHIZAVIDIN

(Rhizobium etli) 		PF01382
(Avidin) 		3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.17A 2xdcE-3ew2A:
undetectable
2xdcF-3ew2A:
undetectable		 2xdcE-3ew2A:
13.64
2xdcF-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 TRP A 463
VAL A 522
TRP A 484
 None
 0.92A 2xdcE-3fahA:
undetectable
2xdcF-3fahA:
undetectable		 2xdcE-3fahA:
1.49
2xdcF-3fahA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff7 KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY G MEMBER 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP C 132
VAL C 183
TRP C  96
 None
 1.05A 2xdcE-3ff7C:
undetectable
2xdcF-3ff7C:
undetectable		 2xdcE-3ff7C:
9.17
2xdcF-3ff7C:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		3 TRP A 121
VAL A 116
TRP A 360
 None
 1.13A 2xdcE-3k40A:
undetectable
2xdcF-3k40A:
undetectable		 2xdcE-3k40A:
7.87
2xdcF-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		3 TRP A 193
VAL A 101
TRP A 105
 SAH  A 216 (-3.7A)
None
SAH  A 216 (-4.5A)
 0.88A 2xdcE-3mq2A:
undetectable
2xdcF-3mq2A:
undetectable		 2xdcE-3mq2A:
7.06
2xdcF-3mq2A:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 TRP A 252
VAL A 256
TRP A 253
 None
 1.32A 2xdcE-3pwzA:
undetectable
2xdcF-3pwzA:
undetectable		 2xdcE-3pwzA:
3.01
2xdcF-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 TRP A  13
VAL A 239
TRP A   6
 None
None
SO4  A 353 (-4.8A)
 1.28A 2xdcE-3raoA:
undetectable
2xdcF-3raoA:
undetectable		 2xdcE-3raoA:
2.96
2xdcF-3raoA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		3 TRP A 146
VAL A 141
TRP A  87
 None
 1.15A 2xdcE-3rjyA:
undetectable
2xdcF-3rjyA:
undetectable		 2xdcE-3rjyA:
2.85
2xdcF-3rjyA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		3 TRP A 251
VAL A 249
TRP A 298
 None
 1.31A 2xdcE-3rjyA:
undetectable
2xdcF-3rjyA:
undetectable		 2xdcE-3rjyA:
2.85
2xdcF-3rjyA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
ALPHA-1

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  25
 None
 1.06A 2xdcE-3ubuA:
undetectable
2xdcF-3ubuA:
undetectable		 2xdcE-3ubuA:
9.23
2xdcF-3ubuA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
BETA-2

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP B  67
VAL B 121
TRP B  25
 None
 0.94A 2xdcE-3ubuB:
undetectable
2xdcF-3ubuB:
undetectable		 2xdcE-3ubuB:
9.17
2xdcF-3ubuB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		3 TRP A 300
VAL A 298
TRP A 292
 XYP  A 402 (-4.1A)
None
XYP  A 401 (-4.2A)
 1.33A 2xdcE-3w25A:
undetectable
2xdcF-3w25A:
undetectable		 2xdcE-3w25A:
3.79
2xdcF-3w25A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwk SNACLEC RHODOCYTIN
SUBUNIT ALPHA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP A  71
VAL A 130
TRP A  26
 None
 1.03A 2xdcE-3wwkA:
undetectable
2xdcF-3wwkA:
undetectable		 2xdcE-3wwkA:
8.09
2xdcF-3wwkA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.16A 2xdcE-4d7eA:
undetectable
2xdcF-4d7eA:
undetectable		 2xdcE-4d7eA:
4.17
2xdcF-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.28A 2xdcE-4hr3A:
undetectable
2xdcF-4hr3A:
undetectable		 2xdcE-4hr3A:
4.10
2xdcF-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		3 TRP A 438
VAL A 432
TRP A 430
 GOL  A 502 (-4.0A)
None
GOL  A 502 ( 4.4A)
 1.23A 2xdcE-4hu8A:
undetectable
2xdcF-4hu8A:
undetectable		 2xdcE-4hu8A:
6.59
2xdcF-4hu8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6p LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 220
VAL A 281
TRP A 184
 None
 1.03A 2xdcE-4j6pA:
undetectable
2xdcF-4j6pA:
undetectable		 2xdcE-4j6pA:
10.00
2xdcF-4j6pA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 TRP A 193
VAL A 170
TRP A 194
 None
 1.34A 2xdcE-4jsoA:
undetectable
2xdcF-4jsoA:
undetectable		 2xdcE-4jsoA:
2.43
2xdcF-4jsoA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.32A 2xdcE-4lypA:
undetectable
2xdcF-4lypA:
undetectable		 2xdcE-4lypA:
2.99
2xdcF-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		3 TRP A 246
VAL A 219
TRP A 244
 None
 1.26A 2xdcE-4mx8A:
undetectable
2xdcF-4mx8A:
undetectable		 2xdcE-4mx8A:
6.48
2xdcF-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orz PROTEIN NEF

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 TRP B 187
VAL B 150
TRP B 106
 None
 1.02A 2xdcE-4orzB:
undetectable
2xdcF-4orzB:
undetectable		 2xdcE-4orzB:
18.37
2xdcF-4orzB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 TRP A 238
VAL A 427
TRP A 432
 None
 1.04A 2xdcE-4q2cA:
undetectable
2xdcF-4q2cA:
undetectable		 2xdcE-4q2cA:
1.96
2xdcF-4q2cA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		3 TRP A 153
VAL A 160
TRP A 155
 None
 1.09A 2xdcE-4u36A:
undetectable
2xdcF-4u36A:
undetectable		 2xdcE-4u36A:
5.47
2xdcF-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		3 TRP A 188
VAL A 208
TRP A 211
 None
 1.28A 2xdcE-4yryA:
undetectable
2xdcF-4yryA:
undetectable		 2xdcE-4yryA:
4.33
2xdcF-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 TRP A 180
VAL A 184
TRP A 181
 None
 1.33A 2xdcE-4zmhA:
undetectable
2xdcF-4zmhA:
undetectable		 2xdcE-4zmhA:
2.77
2xdcF-4zmhA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 TRP B 251
VAL B 335
TRP B 255
 None
 1.33A 2xdcE-4ztuB:
undetectable
2xdcF-4ztuB:
undetectable		 2xdcE-4ztuB:
4.63
2xdcF-4ztuB:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		3 TRP A 297
VAL A 358
TRP A 259
 None
 1.11A 2xdcE-5ao5A:
undetectable
2xdcF-5ao5A:
undetectable		 2xdcE-5ao5A:
3.25
2xdcF-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H  47
VAL H 100
TRP H  50
 None
 0.74A 2xdcE-5awnH:
undetectable
2xdcF-5awnH:
undetectable		 2xdcE-5awnH:
8.47
2xdcF-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TRP B 429
VAL B 471
TRP B 455
 None
 1.27A 2xdcE-5b4xB:
undetectable
2xdcF-5b4xB:
undetectable		 2xdcE-5b4xB:
2.23
2xdcF-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		3 TRP A 134
VAL A 138
TRP A 135
 None
 1.26A 2xdcE-5by3A:
undetectable
2xdcF-5by3A:
undetectable		 2xdcE-5by3A:
3.31
2xdcF-5by3A:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 TRP B 251
VAL B 335
TRP B 255
 None
 1.30A 2xdcE-5c53B:
undetectable
2xdcF-5c53B:
undetectable		 2xdcE-5c53B:
2.09
2xdcF-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 TRP A 638
VAL A 635
TRP A 121
 None
NAG  A1471 (-4.5A)
None
 1.28A 2xdcE-5fkcA:
undetectable
2xdcF-5fkcA:
undetectable		 2xdcE-5fkcA:
16.92
2xdcF-5fkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 TRP A 138
VAL A 141
TRP A 164
 None
 1.09A 2xdcE-5gjeA:
undetectable
2xdcF-5gjeA:
undetectable		 2xdcE-5gjeA:
8.50
2xdcF-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		3 TRP B  71
VAL B  75
TRP B  68
 None
 1.00A 2xdcE-5gqrB:
undetectable
2xdcF-5gqrB:
undetectable		 2xdcE-5gqrB:
3.21
2xdcF-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		3 TRP A 237
VAL A 232
TRP A 185
 None
 1.23A 2xdcE-5i6sA:
undetectable
2xdcF-5i6sA:
undetectable		 2xdcE-5i6sA:
5.60
2xdcF-5i6sA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpv ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 275
TRP A 174
 None
 1.07A 2xdcE-5jpvA:
undetectable
2xdcF-5jpvA:
undetectable		 2xdcE-5jpvA:
12.82
2xdcF-5jpvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgk LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP E 220
VAL E 281
TRP E 184
 None
 1.07A 2xdcE-5lgkE:
undetectable
2xdcF-5lgkE:
undetectable		 2xdcE-5lgkE:
8.25
2xdcF-5lgkE:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 3 TRP A 127
VAL A 192
TRP A  36
 None
 1.26A 2xdcE-5oq3A:
undetectable
2xdcF-5oq3A:
undetectable		 2xdcE-5oq3A:
4.88
2xdcF-5oq3A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tod TRANSMEMBRANE
PROTEIN 24

(Homo sapiens) 		no annotation 3 TRP F 106
VAL F 128
TRP F 102
 None
 1.21A 2xdcE-5todF:
undetectable
2xdcF-5todF:
undetectable		 2xdcE-5todF:
9.73
2xdcF-5todF:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 3 TRP A 146
VAL A 109
TRP A  61
 None
 1.24A 2xdcE-5txfA:
undetectable
2xdcF-5txfA:
undetectable		 2xdcE-5txfA:
2.78
2xdcF-5txfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE

(Tribolium
castaneum) 		no annotation 3 TRP A 218
VAL A 213
TRP A 215
 None
 1.27A 2xdcE-5vg9A:
undetectable
2xdcF-5vg9A:
undetectable		 2xdcE-5vg9A:
undetectable
2xdcF-5vg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wze AMINOPEPTIDASE P

(Pseudomonas
aeruginosa) 		no annotation 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.17A 2xdcE-5wzeA:
undetectable
2xdcF-5wzeA:
undetectable		 2xdcE-5wzeA:
undetectable
2xdcF-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 3 TRP A  29
VAL A  27
TRP A  32
 None
 1.09A 2xdcE-6aqfA:
undetectable
2xdcF-6aqfA:
undetectable		 2xdcE-6aqfA:
undetectable
2xdcF-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		no annotation
no annotation 		3 TRP F 341
VAL F 353
TRP B 743
 None
 1.16A 2xdcE-6btmF:
undetectable
2xdcF-6btmF:
undetectable		 2xdcE-6btmF:
undetectable
2xdcF-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.75A 2xdcE-6cxhB:
undetectable
2xdcF-6cxhB:
undetectable		 2xdcE-6cxhB:
undetectable
2xdcF-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 TRP A 202
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.35A 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable		 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 3 TRP A 154
VAL A 168
TRP A 300
 None
 1.19A 2xdcE-6gqdA:
undetectable
2xdcF-6gqdA:
undetectable		 2xdcE-6gqdA:
undetectable
2xdcF-6gqdA:
undetectable