SIMILAR PATTERNS OF AMINO ACIDS FOR 2XDC_B_DVAB6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 TRP A 211
TRP A 130
TRP A 136
VAL A 204
 None
 1.38A 2xdcA-2vowA:
undetectable
2xdcB-2vowA:
undetectable		 2xdcA-2vowA:
3.65
2xdcB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 TRP A 246
TRP A 207
ALA A 205
VAL A 224
 None
EDO  A 490 (-3.5A)
None
None
 1.40A 2xdcA-3b9tA:
undetectable
2xdcB-3b9tA:
undetectable		 2xdcA-3b9tA:
3.02
2xdcB-3b9tA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TRP A  23
TRP A 339
ALA A 317
VAL A 315
 None
 1.43A 2xdcA-4e4uA:
undetectable
2xdcB-4e4uA:
undetectable		 2xdcA-4e4uA:
4.02
2xdcB-4e4uA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 TRP A 188
TRP A 174
ALA A 176
VAL A 171
 None
 1.43A 2xdcA-4pxnA:
undetectable
2xdcB-4pxnA:
undetectable		 2xdcA-4pxnA:
2.60
2xdcB-4pxnA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 TRP A 407
TRP A  66
ALA A 103
VAL A 105
 None
 1.45A 2xdcA-5xd0A:
undetectable
2xdcB-5xd0A:
undetectable		 2xdcA-5xd0A:
2.49
2xdcB-5xd0A:
2.49