SIMILAR PATTERNS OF AMINO ACIDS FOR 2X7H_B_PFNB1374

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 TYR A 143
LEU A 139
LEU A 122
HIS A 253
 None
 1.43A 2x7hB-1a0pA:
undetectable		 2x7hB-1a0pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 TYR A 323
LEU A 321
LEU A 320
HIS A 244
 None
 1.17A 2x7hB-1c4oA:
3.2		 2x7hB-1c4oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		4 TYR A  95
LEU A  98
LEU A  41
HIS A 143
 None
 1.37A 2x7hB-1fewA:
undetectable		 2x7hB-1fewA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		4 TYR A  54
LEU A  44
LEU A  45
HIS A  84
 None
 1.38A 2x7hB-1gpjA:
9.0		 2x7hB-1gpjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 TYR A  37
LEU A 111
LEU A 197
HIS A 119
 None
 1.47A 2x7hB-1jqoA:
undetectable		 2x7hB-1jqoA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 TYR A 698
LEU A 701
LEU A 664
HIS A 687
 None
 1.44A 2x7hB-1mt0A:
undetectable		 2x7hB-1mt0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 TYR A   2
LEU A  54
LEU A 130
HIS A   4
 None
 1.42A 2x7hB-1nr9A:
undetectable		 2x7hB-1nr9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pex COLLAGENASE-3

(Homo sapiens) 		PF00045
(Hemopexin) 		4 TYR A 400
LEU A 370
LEU A 368
HIS A 405
 None
 1.47A 2x7hB-1pexA:
undetectable		 2x7hB-1pexA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srq GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF02145
(Rap_GAP) 		4 TYR A 398
LEU A 112
LEU A 105
HIS A 402
 None
 1.37A 2x7hB-1srqA:
undetectable		 2x7hB-1srqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		4 TYR A  52
LEU A  49
LEU A  33
HIS A 115
 None
 1.28A 2x7hB-1x0aA:
undetectable		 2x7hB-1x0aA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 TYR A 156
LEU A 195
LEU A 164
HIS A 179
 None
 1.24A 2x7hB-1yvpA:
2.8		 2x7hB-1yvpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 TYR A 162
LEU A 171
LEU A 169
HIS A 152
 None
 1.42A 2x7hB-2b2nA:
undetectable		 2x7hB-2b2nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR A 532
LEU A 650
LEU A 644
HIS A  47
 None
 1.50A 2x7hB-2b39A:
undetectable		 2x7hB-2b39A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 TYR A 328
LEU A 326
LEU A 325
HIS A 248
 None
 1.24A 2x7hB-2d7dA:
2.9		 2x7hB-2d7dA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A  84
LEU A  86
LEU A  79
HIS A  51
 None
 1.12A 2x7hB-2e6kA:
2.6		 2x7hB-2e6kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 TYR A 136
LEU A 137
LEU A 158
HIS A  71
 None
 1.42A 2x7hB-2hihA:
undetectable		 2x7hB-2hihA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf6 EFFECTOR PROTEIN
HOPAB1

(Pseudomonas
savastanoi) 		PF16847
(AvrPtoB_bdg) 		4 TYR A 266
LEU A 277
LEU A 263
HIS A 299
 None
 1.33A 2x7hB-2lf6A:
undetectable		 2x7hB-2lf6A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0y HYPOTHETICAL PROTEIN
LP_0780

(Lactobacillus
plantarum) 		PF01933
(UPF0052) 		4 TYR A 225
LEU A 194
LEU A 248
HIS A 244
 None
 1.37A 2x7hB-2p0yA:
4.1		 2x7hB-2p0yA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 298
LEU A 300
LEU A 320
HIS A 133
 None
 1.45A 2x7hB-2r9zA:
2.8		 2x7hB-2r9zA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 TYR A 556
LEU A 557
LEU A 538
HIS A 505
 None
 1.46A 2x7hB-2rfoA:
undetectable		 2x7hB-2rfoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 TYR A 209
LEU A 239
LEU A 242
HIS A 212
 None
 1.49A 2x7hB-2zq5A:
undetectable		 2x7hB-2zq5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 TYR A 202
LEU A 200
LEU A 199
HIS A 169
 None
 1.50A 2x7hB-2zvbA:
undetectable		 2x7hB-2zvbA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 TYR A 144
LEU A 103
LEU A 104
HIS A 207
 MLI  A 701 ( 4.0A)
None
MLI  A 701 ( 4.9A)
ZN  A1003 ( 3.4A)
 1.36A 2x7hB-3bleA:
undetectable		 2x7hB-3bleA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		4 TYR A 204
LEU A 125
LEU A 127
HIS A 197
 None
 1.22A 2x7hB-3cjtA:
9.7		 2x7hB-3cjtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		4 TYR A 204
LEU A 208
LEU A 188
HIS A 197
 None
 1.27A 2x7hB-3cjtA:
9.7		 2x7hB-3cjtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		4 TYR A 248
LEU A 260
LEU A 246
HIS A  52
 TLA  A 999 (-4.7A)
None
None
TLA  A 999 ( 3.7A)
 1.34A 2x7hB-3dmeA:
2.7		 2x7hB-3dmeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		4 TYR A 125
LEU A 161
LEU A 120
HIS A 136
 None
None
None
ACT  A 711 (-3.9A)
 1.24A 2x7hB-3eo7A:
undetectable		 2x7hB-3eo7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 186
LEU A 149
LEU A 146
HIS A 178
 None
 1.45A 2x7hB-3glqA:
4.2		 2x7hB-3glqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 TYR A 188
LEU A  81
LEU A  62
HIS A  60
 None
 1.49A 2x7hB-3hr6A:
undetectable		 2x7hB-3hr6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 TYR A 135
LEU A 131
LEU A 256
HIS A 139
 None
 1.47A 2x7hB-3i7aA:
undetectable		 2x7hB-3i7aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		4 TYR A  85
LEU A  77
LEU A  16
HIS A  83
 None
None
None
NI  A 292 ( 3.4A)
 1.17A 2x7hB-3k4zA:
undetectable		 2x7hB-3k4zA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A  82
LEU A  84
LEU A  77
HIS A  49
 None
 1.16A 2x7hB-3komA:
2.0		 2x7hB-3komA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 303
LEU A 306
LEU A 288
HIS A 295
 None
 1.46A 2x7hB-3na0A:
undetectable		 2x7hB-3na0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 TYR A 163
LEU A 160
LEU A 150
HIS A 145
 None
 1.48A 2x7hB-3p3lA:
undetectable		 2x7hB-3p3lA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n COA BINDING PROTEIN

(Escherichia
coli) 		PF13380
(CoA_binding_2) 		4 TYR A  47
LEU A  43
LEU A  42
HIS A 134
 None
 1.46A 2x7hB-3q9nA:
5.9		 2x7hB-3q9nA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 100
LEU A 102
LEU A  95
HIS A  67
 None
 1.16A 2x7hB-3uk1A:
2.0		 2x7hB-3uk1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 TYR B 136
LEU B 135
LEU B 216
HIS B 212
 None
 1.46A 2x7hB-3v4vB:
undetectable		 2x7hB-3v4vB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 379
LEU A 382
LEU A 326
HIS A 273
 None
 1.45A 2x7hB-3vu2A:
undetectable		 2x7hB-3vu2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		4 TYR A  93
LEU A  70
LEU A  95
HIS A  91
 None
 1.36A 2x7hB-4k2xA:
2.3		 2x7hB-4k2xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		4 TYR A  47
LEU A  43
LEU A 225
HIS A 210
 None
 1.40A 2x7hB-4kdrA:
9.4		 2x7hB-4kdrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 TYR A 272
LEU A 311
LEU A 253
HIS A 203
 None
 1.48A 2x7hB-4ksaA:
undetectable		 2x7hB-4ksaA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		4 TYR A  32
LEU A  43
LEU A  44
HIS A  64
 None
 1.23A 2x7hB-4rg6A:
undetectable		 2x7hB-4rg6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		4 TYR A 645
LEU A 677
LEU A 678
HIS A 714
 None
 1.44A 2x7hB-4rg6A:
undetectable		 2x7hB-4rg6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		4 TYR A 162
LEU A 180
LEU A 183
HIS A 146
 None
None
None
GOL  A 302 (-4.1A)
 1.46A 2x7hB-4rzmA:
undetectable		 2x7hB-4rzmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 TYR B 119
LEU B 155
LEU B 199
HIS B 195
 None
 1.34A 2x7hB-4um8B:
undetectable		 2x7hB-4um8B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A  80
LEU A  82
LEU A  75
HIS A  47
 None
 1.16A 2x7hB-4xeuA:
undetectable		 2x7hB-4xeuA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcf TYROSINE RECOMBINASE
XERD,DNA TRANSLOCASE
FTSK

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF09397
(Ftsk_gamma) 		4 TYR A  34
LEU A  30
LEU A  13
HIS A 144
 None
 1.42A 2x7hB-5dcfA:
undetectable		 2x7hB-5dcfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 478
LEU A 475
LEU A 420
HIS A  84
 None
 1.08A 2x7hB-5gr1A:
undetectable		 2x7hB-5gr1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 TYR A  62
LEU A  72
LEU A  71
HIS A  60
 None
 1.11A 2x7hB-5gw8A:
2.0		 2x7hB-5gw8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt)
PF07307
(HEPPP_synt_1) 		4 TYR C  82
LEU C  84
LEU C  85
HIS A 130
 None
 1.41A 2x7hB-5h9dC:
undetectable		 2x7hB-5h9dC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 TYR A 797
LEU A 798
LEU A 779
HIS A 739
 None
 1.49A 2x7hB-5hb3A:
undetectable		 2x7hB-5hb3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		4 TYR A1024
LEU A 983
LEU A 982
HIS A1030
 None
 1.45A 2x7hB-5hccA:
undetectable		 2x7hB-5hccA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jff PROBABLE ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FIC

(Escherichia
coli) 		PF02661
(Fic) 		4 TYR A  14
LEU A  13
LEU A  17
HIS A  27
 None
 1.47A 2x7hB-5jffA:
undetectable		 2x7hB-5jffA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kck ANTHRANILATE
SYNTHASE COMPONENT I

(Streptococcus
pneumoniae) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 TYR A  73
LEU A  72
LEU A 395
HIS A  77
 None
 1.46A 2x7hB-5kckA:
undetectable		 2x7hB-5kckA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, B14.5B
SUBUNIT
MITOCHONDRIAL
COMPLEX I, KFYI
SUBUNIT

(Ovis aries) 		PF00550
(PP-binding)
no annotation 		4 TYR o  73
LEU o  76
LEU o  31
HIS x  35
 None
 1.14A 2x7hB-5lnko:
undetectable		 2x7hB-5lnko:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1

(Arabidopsis
thaliana) 		PF00719
(Pyrophosphatase) 		4 TYR A 202
LEU A 201
LEU A  95
HIS A  37
 None
 1.44A 2x7hB-5ls0A:
undetectable		 2x7hB-5ls0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw6 DDB_G0293866

(Dictyostelium
discoideum) 		no annotation 4 TYR A  50
LEU A 214
LEU A 218
HIS A  54
 None
 1.36A 2x7hB-5lw6A:
undetectable		 2x7hB-5lw6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 TYR B 116
LEU B 115
LEU B 196
HIS B 192
 None
 1.42A 2x7hB-5nemB:
undetectable		 2x7hB-5nemB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 TYR B 116
LEU B 152
LEU B 196
HIS B 192
 None
 1.22A 2x7hB-5nemB:
undetectable		 2x7hB-5nemB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 TYR A  11
LEU A   8
LEU A   7
HIS A  74
 None
 0.90A 2x7hB-5tvtA:
undetectable		 2x7hB-5tvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 299
LEU A 301
LEU A 321
HIS A 134
 None
 1.47A 2x7hB-5v36A:
3.7		 2x7hB-5v36A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A  77
LEU A  79
LEU A  72
HIS A  44
 None
 1.12A 2x7hB-5vrbA:
2.0		 2x7hB-5vrbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7l TSRD

(Streptomyces
laurentii) 		no annotation 4 TYR A  33
LEU A 113
LEU A  29
HIS A 117
 None
None
None
IPA  A 202 (-3.5A)
 1.48A 2x7hB-5x7lA:
undetectable		 2x7hB-5x7lA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A 368
LEU A 394
LEU A 393
HIS A  68
 None
 1.50A 2x7hB-5xh9A:
undetectable		 2x7hB-5xh9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4e ANKYRIN-2,ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 TYR A 886
LEU A1396
LEU A1366
HIS A1374
 None
None
None
SO4  A1508 (-4.6A)
 1.46A 2x7hB-5y4eA:
undetectable		 2x7hB-5y4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 TYR A 399
LEU A 401
LEU A 394
HIS A 478
 None
 1.39A 2x7hB-6cczA:
4.8		 2x7hB-6cczA:
11.88