SIMILAR PATTERNS OF AMINO ACIDS FOR 2X2I_D_QPSD1050_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 LEU A 367
TYR A 189
ARG A 358
TRP A 360
 None
None
ACR  A 405 (-2.5A)
None
 1.48A 2x2iD-3jzjA:
0.0		 2x2iD-3jzjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 LEU A 233
TRP A 470
ARG A 555
TRP A 568
 None
None
TRS  A6001 ( 4.6A)
None
 0.80A 2x2iD-3lppA:
33.5		 2x2iD-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		4 LEU A  85
TYR A 114
ARG A  84
TRP A  55
 None
 1.47A 2x2iD-4zn2A:
2.0		 2x2iD-4zn2A:
17.29