SIMILAR PATTERNS OF AMINO ACIDS FOR 2X0P_A_ADNA1607_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 GLY A  39
HIS A  40
ILE A 127
ALA A  42
 None
None
CAS  A 128 ( 3.9A)
None
 0.91A 2x0pA-1fu1A:
2.1		 2x0pA-1fu1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		4 GLY A 133
HIS A 178
ILE A 153
ALA A  87
 None
 0.88A 2x0pA-1hjqA:
0.0		 2x0pA-1hjqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 GLY A 133
HIS A 178
ILE A 153
ALA A  87
 None
 0.92A 2x0pA-1hjuA:
0.6		 2x0pA-1hjuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 GLY A 332
HIS A 333
ILE A 105
ALA A 280
 None
 0.92A 2x0pA-1kcxA:
0.0		 2x0pA-1kcxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A 144
ILE A 152
ALA A 178
HIS A 180
 None
 0.92A 2x0pA-1pgpA:
0.0		 2x0pA-1pgpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 GLY A 166
ASN A 125
HIS A 169
GLU A 281
 None
 0.89A 2x0pA-1q33A:
undetectable		 2x0pA-1q33A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		4 GLY A 160
HIS A 161
ILE A 281
ALA A 100
 None
GOL  A1000 (-3.9A)
None
None
 0.81A 2x0pA-1qy9A:
0.0		 2x0pA-1qy9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		4 GLY A 209
ILE A 266
MET A 238
ALA A 147
 None
 0.85A 2x0pA-1u60A:
undetectable		 2x0pA-1u60A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 GLY A  67
HIS A  65
ILE A  17
GLU A  62
 None
 0.91A 2x0pA-1un9A:
0.0		 2x0pA-1un9A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		4 GLY A  98
HIS A  70
ILE A  93
ALA A 133
 None
 0.92A 2x0pA-1uxoA:
undetectable		 2x0pA-1uxoA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4p ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		no annotation 4 GLY A  40
ILE A  43
ALA A  11
HIS A   9
 None
None
None
ZN  A1001 (-3.2A)
 0.90A 2x0pA-1v4pA:
undetectable		 2x0pA-1v4pA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		4 GLY A  84
ILE A  93
ASN A  43
ALA A  13
 None
 0.73A 2x0pA-1v6cA:
undetectable		 2x0pA-1v6cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8y ADP-RIBOSE
PYROPHOSPHATASE

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 GLY A  67
ILE A  19
ALA A  78
GLU A  70
 ZN  A 300 ( 4.5A)
APR  A 619 (-4.5A)
None
ZN  A 301 (-2.3A)
 0.93A 2x0pA-1v8yA:
undetectable		 2x0pA-1v8yA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 GLY A 163
ILE A 454
ASN A 458
ALA A 167
GLU A 164
 None
 1.49A 2x0pA-1w8jA:
undetectable		 2x0pA-1w8jA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 196
ILE A 283
ASN A 280
ALA A 189
 None
 0.79A 2x0pA-1wacA:
undetectable		 2x0pA-1wacA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 GLY 1 354
HIS 1 427
ILE 1 424
ASN 1 269
 None
MN  1 601 (-3.4A)
None
None
 0.87A 2x0pA-1wao1:
undetectable		 2x0pA-1wao1:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		4 GLY A 179
HIS A 150
ILE A 158
ASN A  98
 SAH  A4261 (-3.3A)
SAH  A4261 (-3.6A)
None
None
 0.94A 2x0pA-1x1bA:
undetectable		 2x0pA-1x1bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 GLY A 322
ILE A 338
ASN A 132
MET A 128
 None
 0.92A 2x0pA-1xl8A:
1.4		 2x0pA-1xl8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 GLY A  99
HIS A 139
ILE A 144
ALA A  96
 None
POP  A3000 (-4.3A)
None
None
 0.93A 2x0pA-1yqeA:
undetectable		 2x0pA-1yqeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLY I 283
HIS I 284
ILE I 232
ALA I 539
 None
 0.64A 2x0pA-1zo1I:
undetectable		 2x0pA-1zo1I:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 419
HIS A 418
ILE A 470
HIS A  83
 None
CU1  A1002 ( 3.3A)
None
CU1  A1003 ( 3.0A)
 0.93A 2x0pA-1zpuA:
undetectable		 2x0pA-1zpuA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 GLY A 328
HIS A 330
ILE A 506
ALA A 352
 None
 0.75A 2x0pA-2bllA:
undetectable		 2x0pA-2bllA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eix NADH-CYTOCHROME B5
REDUCTASE

(Physarum
polycephalum) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A 165
ILE A 280
ASN A 261
MET A 260
 None
 0.80A 2x0pA-2eixA:
undetectable		 2x0pA-2eixA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLY A 220
ILE A 186
ASN A 192
GLU A 217
 None
 0.90A 2x0pA-2fpgA:
undetectable		 2x0pA-2fpgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT

(Sphingobium
yanoikuyae) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 148
ILE A 313
ASN A 301
ALA A  75
 None
 0.86A 2x0pA-2gbxA:
undetectable		 2x0pA-2gbxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhg HYPOTHETICAL PROTEIN
RPA3614

(Rhodopseudomonas
palustris) 		PF00581
(Rhodanese) 		4 GLY A  95
ASN A  17
ALA A 122
GLU A 117
 PO4  A4285 (-4.0A)
None
None
None
 0.93A 2x0pA-2hhgA:
undetectable		 2x0pA-2hhgA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		5 GLY A 530
ILE A 533
ASN A 478
ALA A 571
HIS A 559
 GOL  A 605 ( 3.2A)
None
None
None
None
 1.26A 2x0pA-2iwbA:
undetectable		 2x0pA-2iwbA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Bacillus
subtilis) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 HIS A 142
ILE A 170
MET A 115
GLU A 140
 None
 0.93A 2x0pA-2vt2A:
undetectable		 2x0pA-2vt2A:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		8 GLY A 161
HIS A 162
ILE A 285
ASN A 307
MET A 308
ALA A 396
HIS A 449
GLU A 451
 ATP  A1607 (-3.4A)
ATP  A1607 (-4.4A)
None
ATP  A1607 (-3.7A)
ATP  A1607 (-3.3A)
ATP  A1607 (-3.5A)
ATP  A1607 (-3.6A)
ATP  A1607 ( 2.6A)
 0.60A 2x0pA-2x0qA:
57.6		 2x0pA-2x0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 GLY A 169
HIS A 170
ILE A 280
HIS A 444
 AMP  A1588 ( 4.5A)
AMP  A1588 (-3.8A)
None
AMP  A1588 (-3.3A)
 0.90A 2x0pA-2x3kA:
30.3		 2x0pA-2x3kA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 GLY A 154
ILE A 108
HIS A 181
GLU A 144
 None
None
ZN  A1289 ( 3.3A)
ZN  A1287 ( 2.4A)
 0.94A 2x0pA-2x7vA:
undetectable		 2x0pA-2x7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 502
ILE A 219
ALA A 507
GLU A 224
 None
 0.88A 2x0pA-2y8nA:
1.0		 2x0pA-2y8nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 GLY A 164
ILE A  83
ASN A 205
ALA A 116
 None
 0.94A 2x0pA-2yevA:
undetectable		 2x0pA-2yevA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		4 GLY A  75
ILE A 184
ALA A 108
HIS A  87
 None
 0.93A 2x0pA-2zdsA:
undetectable		 2x0pA-2zdsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		4 GLY A 277
HIS A 317
ILE A 327
ALA A 283
 C5P  A   1 (-4.0A)
C5P  A   1 (-4.0A)
None
None
 0.94A 2x0pA-2zwiA:
undetectable		 2x0pA-2zwiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 GLY A 375
ILE A 229
ALA A 351
HIS A 250
 ADP  A 411 ( 4.4A)
None
None
None
 0.89A 2x0pA-3c4nA:
undetectable		 2x0pA-3c4nA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 GLY A  52
ILE A 262
ASN A 215
GLU A  56
 None
 0.89A 2x0pA-3d0cA:
undetectable		 2x0pA-3d0cA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6i MONOTHIOL
GLUTAREDOXIN-3

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 GLY A 122
HIS A 120
ILE A 117
ALA A  55
 None
 0.93A 2x0pA-3d6iA:
undetectable		 2x0pA-3d6iA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		4 GLY A  45
ILE A 253
ASN A 211
GLU A  49
 GOL  A 296 (-3.2A)
None
None
None
 0.90A 2x0pA-3daqA:
undetectable		 2x0pA-3daqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		4 GLY A  54
ILE A 264
ASN A 217
GLU A  58
 None
 0.89A 2x0pA-3e96A:
undetectable		 2x0pA-3e96A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 GLY A 168
HIS A 164
ILE A 134
MET A 231
 None
 0.79A 2x0pA-3ee4A:
undetectable		 2x0pA-3ee4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 GLY A 354
HIS A 427
ILE A 424
ASN A 269
 None
ZN  A 500 ( 3.2A)
None
None
 0.93A 2x0pA-3h68A:
undetectable		 2x0pA-3h68A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 655
ASN B 661
ALA B 929
GLU B 926
 None
 0.93A 2x0pA-3hkzB:
undetectable		 2x0pA-3hkzB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii7 KELCH-LIKE PROTEIN 7

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 487
HIS A 474
ASN A 490
GLU A 499
 None
None
EDO  A 961 (-3.7A)
None
 0.94A 2x0pA-3ii7A:
undetectable		 2x0pA-3ii7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLY A 394
HIS A 377
ILE A 430
GLU A 390
 None
None
None
CA  A   1 (-2.1A)
 0.94A 2x0pA-3lijA:
2.1		 2x0pA-3lijA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		4 GLY A 231
ILE A 239
ASN A 288
ALA A 191
 None
 0.87A 2x0pA-3lunA:
undetectable		 2x0pA-3lunA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLY A  75
HIS A  77
ILE A  43
ASN A 361
 None
 0.94A 2x0pA-3mq4A:
undetectable		 2x0pA-3mq4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 GLY A  55
ILE A 269
ASN A 224
GLU A  59
 MCL  A 174 ( 3.2A)
None
None
None
 0.84A 2x0pA-3n2xA:
undetectable		 2x0pA-3n2xA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A  19
ILE A   6
MET A   1
HIS A 500
 None
 0.90A 2x0pA-3nzpA:
undetectable		 2x0pA-3nzpA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 GLY A 174
HIS A 177
ILE A 190
ALA A 211
 None
 0.92A 2x0pA-3opsA:
undetectable		 2x0pA-3opsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 401
HIS A 400
ILE A 439
HIS A  66
 None
CU  A1500 ( 3.2A)
None
CU  A1501 ( 3.0A)
 0.92A 2x0pA-3pxlA:
undetectable		 2x0pA-3pxlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		4 GLY A 528
ILE A 531
ALA A 568
HIS A 557
 BOU  A 584 (-3.7A)
BOU  A 584 (-3.8A)
None
None
 0.92A 2x0pA-3q7zA:
undetectable		 2x0pA-3q7zA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C  86
HIS C  93
ALA C  98
HIS C 110
 None
 0.89A 2x0pA-3qgkC:
undetectable		 2x0pA-3qgkC:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 GLY A 125
HIS A 128
ILE A 172
ALA A 136
 None
 0.92A 2x0pA-3t8lA:
undetectable		 2x0pA-3t8lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A 102
HIS A  90
ILE A  77
ALA A 147
HIS A 144
 None
 1.45A 2x0pA-3t9wA:
undetectable		 2x0pA-3t9wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 ILE A  26
ALA A 232
HIS A  46
GLU A 233
 None
 0.92A 2x0pA-3tg9A:
undetectable		 2x0pA-3tg9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 HIS A  76
ILE A  39
ALA A  15
GLU A  12
 None
 0.91A 2x0pA-3tm5A:
undetectable		 2x0pA-3tm5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLY A 227
ASN A 410
MET A 409
GLU A 221
 GLY  A 227 ( 0.0A)
ASN  A 410 ( 0.6A)
MET  A 409 ( 0.0A)
GLU  A 221 (-0.6A)
 0.80A 2x0pA-3ulkA:
0.5		 2x0pA-3ulkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Plasmodium
falciparum) 		PF00579
(tRNA-synt_1b) 		4 GLY A  62
ILE A 196
ASN A 214
ALA A  96
 TYR  A 401 ( 3.3A)
None
None
TYR  A 401 (-3.6A)
 0.88A 2x0pA-3vgjA:
undetectable		 2x0pA-3vgjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT
FLAVOCYTOCHROME C
HEME SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		4 HIS B 389
ILE B 395
MET B  44
ALA A  25
 None
 0.90A 2x0pA-3vrdB:
undetectable		 2x0pA-3vrdB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLY A 213
HIS A 244
ILE A 232
ALA A 521
 None
 0.83A 2x0pA-3vtrA:
undetectable		 2x0pA-3vtrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w03 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 GLY C  39
HIS C  40
ILE C 127
ALA C  42
 None
 0.91A 2x0pA-3w03C:
2.6		 2x0pA-3w03C:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 GLY D 271
ILE D 232
ALA A 346
GLU D 269
 None
 0.89A 2x0pA-3w3aD:
undetectable		 2x0pA-3w3aD:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 GLY A 164
HIS A 165
ILE A 159
ALA A 221
 None
 0.92A 2x0pA-3wo8A:
undetectable		 2x0pA-3wo8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		4 GLY A 467
ILE A 309
MET A 455
HIS A 474
 FAD  A 601 (-3.4A)
None
None
None
 0.89A 2x0pA-3x0vA:
undetectable		 2x0pA-3x0vA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		4 GLY A 206
HIS A 207
ILE A  59
HIS A 194
 None
ZN  A1257 ( 3.2A)
None
ZN  A1257 ( 3.3A)
 0.93A 2x0pA-4bt6A:
undetectable		 2x0pA-4bt6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		5 GLY A 138
HIS A 135
ILE A 165
ASN A 160
HIS A 306
 None
 1.26A 2x0pA-4bvlA:
undetectable		 2x0pA-4bvlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 GLY A 577
ILE A 561
MET A 543
ALA A 575
 None
 0.84A 2x0pA-4ccdA:
undetectable		 2x0pA-4ccdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		4 HIS A  89
ASN A 235
MET A 237
GLU A 120
 FE  A 301 (-3.4A)
None
OH  A 303 (-4.0A)
None
 0.71A 2x0pA-4d4zA:
undetectable		 2x0pA-4d4zA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 257
HIS A 259
ILE A 302
ASN A 299
 None
 0.88A 2x0pA-4e0bA:
undetectable		 2x0pA-4e0bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 GLY A 304
ILE A 381
ALA A 297
HIS A 301
 None
 0.89A 2x0pA-4g9iA:
1.4		 2x0pA-4g9iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		4 GLY A  83
ILE A  90
MET A 282
ALA A  66
 None
 0.81A 2x0pA-4gl3A:
undetectable		 2x0pA-4gl3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i04 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 GLY A 244
HIS A 270
ILE A 145
GLU A 242
 None
 0.93A 2x0pA-4i04A:
undetectable		 2x0pA-4i04A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 GLY A 244
HIS A 270
ILE A 145
GLU A 242
 None
CSO  A 100 ( 4.2A)
None
CSO  A 100 ( 4.8A)
 0.93A 2x0pA-4i05A:
undetectable		 2x0pA-4i05A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipn 6-PHOSPHO-BETA-GLUCO
SIDASE

(Streptococcus
pneumoniae) 		PF00232
(Glyco_hydro_1) 		4 HIS B 202
ILE B 185
ALA B 207
GLU B 204
 None
 0.85A 2x0pA-4ipnB:
undetectable		 2x0pA-4ipnB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 GLY A 128
HIS A 127
ILE A 131
GLU A 125
 None
 0.93A 2x0pA-4j7qA:
undetectable		 2x0pA-4j7qA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		4 HIS A 397
ILE A 391
ASN A 392
ALA A 402
 None
 0.87A 2x0pA-4kq7A:
undetectable		 2x0pA-4kq7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 GLY A 176
ILE A 141
HIS A 206
GLU A 204
 None
None
TRS  A 401 ( 4.8A)
None
 0.93A 2x0pA-4lx4A:
undetectable		 2x0pA-4lx4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 GLY A  55
ILE A 269
ASN A 224
GLU A  59
 PYR  A 410 (-3.2A)
None
None
None
 0.82A 2x0pA-4oe7A:
undetectable		 2x0pA-4oe7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION

(Lama glama) 		PF07686
(V-set) 		4 GLY G 108
ASN G  96
ALA G 101
GLU G 100
 None
 0.94A 2x0pA-4p2cG:
undetectable		 2x0pA-4p2cG:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		4 GLY A 154
HIS A 153
ILE A  52
HIS A 203
 GCS  A 301 (-3.3A)
None
None
GCS  A 303 ( 4.9A)
 0.94A 2x0pA-4qwpA:
undetectable		 2x0pA-4qwpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd7 ATP SYNTHASE GAMMA
CHAIN

(Bacillus sp.
PS3) 		PF00231
(ATP-synt) 		4 ILE G 118
ALA G 239
HIS G 237
GLU G 236
 None
 0.87A 2x0pA-4xd7G:
0.7		 2x0pA-4xd7G:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 MET A 632
ALA A 639
HIS A 647
GLU A 637
 None
 0.88A 2x0pA-4xeuA:
undetectable		 2x0pA-4xeuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Burkholderia
multivorans) 		PF13407
(Peripla_BP_4) 		4 GLY A 154
ILE A 169
MET A 195
ALA A 273
 None
 0.88A 2x0pA-4yleA:
undetectable		 2x0pA-4yleA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 144
HIS A 145
ILE A 221
ASN A 166
 None
 0.78A 2x0pA-4z2aA:
undetectable		 2x0pA-4z2aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLY A 164
HIS A 165
ILE A 159
ALA A 221
 None
 0.89A 2x0pA-5bzaA:
undetectable		 2x0pA-5bzaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 GLY A 741
HIS A 780
ASN A 798
ALA A 784
 None
BCO  A1103 ( 3.8A)
None
B12  A1101 (-3.7A)
 0.83A 2x0pA-5cjuA:
undetectable		 2x0pA-5cjuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		4 GLY A 294
ILE A 284
ALA A 134
HIS A 314
 None
 0.94A 2x0pA-5d95A:
undetectable		 2x0pA-5d95A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		4 GLY A 204
ILE A 165
ALA A   7
HIS A  10
 None
None
None
MG  A 401 (-3.5A)
 0.90A 2x0pA-5dnyA:
undetectable		 2x0pA-5dnyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		4 GLY A 115
HIS A 116
ILE A 110
GLU A 112
 None
 0.89A 2x0pA-5eywA:
undetectable		 2x0pA-5eywA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 GLY A 343
HIS A 342
ASN A 265
ALA A 250
 None
 0.94A 2x0pA-5fqlA:
2.8		 2x0pA-5fqlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt NETRIN RECEPTOR
UNC5D

(Rattus
norvegicus) 		PF00090
(TSP_1)
PF07679
(I-set) 		4 HIS A 212
ILE A 198
ALA A 232
GLU A 190
 None
 0.91A 2x0pA-5fttA:
undetectable		 2x0pA-5fttA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hop LMO0182 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ILE A  22
ASN A  19
ALA A 233
GLU A  16
 None
 0.90A 2x0pA-5hopA:
undetectable		 2x0pA-5hopA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 GLY A 236
HIS A 231
MET A 197
GLU A 233
 None
 0.94A 2x0pA-5infA:
undetectable		 2x0pA-5infA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jea SUPERKILLER PROTEIN
7,ENDOLYSIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme) 		4 GLY K 253
HIS K 256
ILE K 242
ALA K 288
 None
 0.79A 2x0pA-5jeaK:
undetectable		 2x0pA-5jeaK:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		4 GLY A 477
ILE A 508
ALA A 482
GLU A 479
 None
 0.83A 2x0pA-5jp3A:
undetectable		 2x0pA-5jp3A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 GLY A  65
HIS A  52
ILE A  62
MET A 496
ALA A 128
 GLY  A  65 ( 0.0A)
HIS  A  52 ( 1.0A)
ILE  A  62 ( 0.6A)
MET  A 496 ( 0.0A)
ALA  A 128 ( 0.0A)
 1.10A 2x0pA-5l5nA:
undetectable		 2x0pA-5l5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 149
HIS A 150
ILE A 162
ALA A 119
 None
 0.94A 2x0pA-5lx8A:
undetectable		 2x0pA-5lx8A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 403
HIS A 402
ILE A 439
HIS A  67
 None
CU  A 501 (-3.2A)
None
CU  A 502 ( 2.9A)
 0.93A 2x0pA-5mewA:
undetectable		 2x0pA-5mewA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A 171
ILE A 191
ALA A 140
HIS A 111
 None
 0.92A 2x0pA-5mp2A:
undetectable		 2x0pA-5mp2A:
8.51