SIMILAR PATTERNS OF AMINO ACIDS FOR 2WUZ_B_TPFB1460
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bry | BRYODIN I (Bryonia dioica) |
PF00161(RIP) | 5 | TYR Y 14ALA Y 162ALA Y 159LEU Y 154VAL Y 62 | None | 1.36A | 2wuzB-1bryY:undetectable | 2wuzB-1bryY:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cf5 | PROTEIN(BETA-MOMORCHARIN) (Momordicacharantia) |
PF00161(RIP) | 5 | TYR A 14ALA A 160ALA A 157LEU A 152VAL A 62 | None | 1.28A | 2wuzB-1cf5A:undetectable | 2wuzB-1cf5A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fzd | FIBRINOGEN-420 (Homo sapiens) |
PF00147(Fibrinogen_C) | 5 | ALA A 795ALA A 746LEU A 709MET A 839VAL A 707 | None | 1.16A | 2wuzB-1fzdA:undetectable | 2wuzB-1fzdA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gt9 | KUMAMOLYSIN (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | PHE 1 17ALA 1 286ALA 1 285THR 1 157LEU 1 188 | None | 1.43A | 2wuzB-1gt91:0.0 | 2wuzB-1gt91:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3n | 3-OXOACYL-(ACYL-CARRIER PROTEIN)SYNTHASE II (Thermusthermophilus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | MET A 281ALA A 404ALA A 389LEU A 327VAL A 329 | None | 1.34A | 2wuzB-1j3nA:0.0 | 2wuzB-1j3nA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ka9 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF00977(His_biosynth) | 5 | PHE F 228ALA F 224ALA F 222LEU F 242VAL F 249 | None | 1.31A | 2wuzB-1ka9F:undetectable | 2wuzB-1ka9F:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mo2 | ERYTHRONOLIDESYNTHASE, MODULES 5AND 6 (Saccharopolysporaerythraea) |
PF00975(Thioesterase) | 5 | ALA A 148ALA A 139LEU A 88MET A 61VAL A 98 | None | 1.35A | 2wuzB-1mo2A:undetectable | 2wuzB-1mo2A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 5 | PHE A 114ALA A 294THR A 298LEU A 359VAL A 474 | DIF A 501 (-4.5A)DIF A 501 ( 3.3A)HEM A 500 ( 3.6A)DIF A 501 (-4.4A)None | 0.93A | 2wuzB-1nr6A:33.6 | 2wuzB-1nr6A:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qxy | METHIONYLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00557(Peptidase_M24) | 5 | ALA A 96ALA A 103THR A 235MET A 1VAL A 198 | None | 1.38A | 2wuzB-1qxyA:0.0 | 2wuzB-1qxyA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | ALA A 371ALA A 368LEU A 417MET A 356VAL A 361 | None | 1.32A | 2wuzB-1r20A:undetectable | 2wuzB-1r20A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r9j | TRANSKETOLASE (Leishmaniamexicana) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | TYR A 205MET A 208PHE A 210ALA A 170ALA A 166 | None | 1.25A | 2wuzB-1r9jA:undetectable | 2wuzB-1r9jA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru3 | ACETYL-COA SYNTHASE (Carboxydothermushydrogenoformans) |
PF03598(CdhC) | 5 | MET A 185PHE A 187ALA A 221ALA A 225VAL A 152 | None | 1.44A | 2wuzB-1ru3A:undetectable | 2wuzB-1ru3A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASEMEDIUM SUBUNIT (Pseudomonasputida) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | MET C 124ALA C 148ALA C 133LEU C 69VAL C 90 | None | 1.44A | 2wuzB-1t3qC:undetectable | 2wuzB-1t3qC:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w07 | ACYL-COA OXIDASE (Arabidopsisthaliana) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 5 | MET A 21PHE A 16ALA A 14THR A 304LEU A 338 | None | 1.36A | 2wuzB-1w07A:2.2 | 2wuzB-1w07A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wc8 | TRAFFICKING PROTEINPARTICLE COMPLEXSUBUNIT3 (Mus musculus) |
PF04051(TRAPP) | 5 | MET A 165PHE A 103ALA A 75ALA A 79LEU A 107 | None | 1.18A | 2wuzB-1wc8A:undetectable | 2wuzB-1wc8A:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzo | HPCE (Thermusthermophilus) |
PF01557(FAA_hydrolase) | 5 | MET A 108ALA A 113ALA A 193LEU A 211VAL A 102 | None | 1.44A | 2wuzB-1wzoA:undetectable | 2wuzB-1wzoA:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | MET A 79PHE A 83ALA A 256THR A 260LEU A 321 | ESL A 471 ( 4.4A)NoneESL A 471 ( 3.4A)HEM A 470 (-3.6A)HEM A 470 (-4.1A) | 1.07A | 2wuzB-1x8vA:39.6 | 2wuzB-1x8vA:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xl8 | PEROXISOMALCARNITINEO-OCTANOYLTRANSFERASE (Mus musculus) |
PF00755(Carn_acyltransf) | 5 | PHE A 294TYR A 290ALA A 577MET A 335VAL A 336 | None | 1.19A | 2wuzB-1xl8A:undetectable | 2wuzB-1xl8A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yqe | HYPOTHETICAL UPF0204PROTEIN AF0625 (Archaeoglobusfulgidus) |
PF04414(tRNA_deacylase) | 5 | ALA A 196ALA A 215THR A 218LEU A 222VAL A 93 | None | 1.41A | 2wuzB-1yqeA:undetectable | 2wuzB-1yqeA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvs | MHC CLASS I ANTIGEN (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.36A | 2wuzB-1zvsA:undetectable | 2wuzB-1zvsA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ahn | THAUMATIN-LIKEPROTEIN (Prunus avium) |
PF00314(Thaumatin) | 5 | ALA A 84ALA A 70THR A 55LEU A 114VAL A 13 | None | 1.38A | 2wuzB-2ahnA:undetectable | 2wuzB-2ahnA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ek8 | AMINOPEPTIDASE (Aneurinibacillussp. AM-1) |
PF02225(PA)PF04389(Peptidase_M28) | 5 | ALA A 330THR A 13LEU A 251MET A 255VAL A 254 | None ZN A1004 (-3.2A)NoneNoneNone | 1.17A | 2wuzB-2ek8A:undetectable | 2wuzB-2ek8A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2faq | PROBABLEATP-DEPENDENT DNALIGASE (Pseudomonasaeruginosa) |
no annotation | 5 | MET A 833ALA A 730ALA A 728LEU A 715VAL A 713 | None | 1.32A | 2wuzB-2faqA:undetectable | 2wuzB-2faqA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g29 | NITRATE TRANSPORTPROTEIN NRTA (Synechocystissp.) |
PF13379(NMT1_2) | 5 | MET A 209ALA A 180ALA A 178LEU A 159VAL A 168 | None | 1.24A | 2wuzB-2g29A:undetectable | 2wuzB-2g29A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gpj | SIDEROPHORE-INTERACTING PROTEIN (Shewanellaputrefaciens) |
PF04954(SIP)PF08021(FAD_binding_9) | 5 | PHE A 48ALA A 83ALA A 87LEU A 27VAL A 12 | NoneFAD A 500 (-3.3A)NoneNoneNone | 1.39A | 2wuzB-2gpjA:undetectable | 2wuzB-2gpjA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfl | PUTATIVEPHOSPHOHISTIDINEPHOSPHATASE SIXA (Agrobacteriumfabrum) |
PF00300(His_Phos_1) | 5 | ALA A 74ALA A 70THR A 67LEU A 12VAL A 111 | None | 1.41A | 2wuzB-2rflA:undetectable | 2wuzB-2rflA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj8 | PUTATIVE SKI2-TYPEHELICASE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C)PF14520(HHH_5) | 5 | PHE A 316ALA A 338ALA A 240LEU A 257VAL A 261 | None | 1.41A | 2wuzB-2zj8A:undetectable | 2wuzB-2zj8A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayt | PUTATIVEUNCHARACTERIZEDPROTEIN TTHB071 (Thermusthermophilus) |
PF01261(AP_endonuc_2) | 5 | ALA A 237ALA A 233LEU A 222MET A 220VAL A 3 | None | 1.27A | 2wuzB-3aytA:undetectable | 2wuzB-3aytA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvh | FIBRINOGEN GAMMACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | ALA C 341ALA C 289LEU C 250MET C 384VAL C 248 | None | 1.07A | 2wuzB-3bvhC:undetectable | 2wuzB-3bvhC:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjy | PUTATIVETHIOESTERASE (Novosphingobiumaromaticivorans) |
PF13622(4HBT_3) | 5 | PHE A 35ALA A 38ALA A 181LEU A 239VAL A 237 | NoneNoneNoneNoneGOL A 261 ( 4.5A) | 1.23A | 2wuzB-3cjyA:undetectable | 2wuzB-3cjyA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjy | PUTATIVETHIOESTERASE (Novosphingobiumaromaticivorans) |
PF13622(4HBT_3) | 5 | PHE A 35ALA A 181LEU A 239MET A 223VAL A 237 | NoneNoneNoneNoneGOL A 261 ( 4.5A) | 1.16A | 2wuzB-3cjyA:undetectable | 2wuzB-3cjyA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjy | PUTATIVETHIOESTERASE (Novosphingobiumaromaticivorans) |
PF13622(4HBT_3) | 5 | TYR A 144ALA A 181LEU A 239MET A 223VAL A 237 | NoneNoneNoneNoneGOL A 261 ( 4.5A) | 1.44A | 2wuzB-3cjyA:undetectable | 2wuzB-3cjyA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clm | TRANSALDOLASE (Neisseriagonorrhoeae) |
PF00923(TAL_FSA) | 5 | PHE A 237TYR A 236ALA A 198LEU A 149VAL A 159 | None | 1.42A | 2wuzB-3clmA:undetectable | 2wuzB-3clmA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fib | FIBRINOGEN GAMMACHAIN RESIDUES (Homo sapiens) |
PF00147(Fibrinogen_C) | 5 | ALA A 341ALA A 289LEU A 250MET A 384VAL A 248 | None | 1.07A | 2wuzB-3fibA:undetectable | 2wuzB-3fibA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghg | FIBRINOGEN GAMMACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | ALA C 341ALA C 289LEU C 250MET C 384VAL C 248 | ALA C 341 ( 0.0A)ALA C 289 ( 0.0A)LEU C 250 ( 0.6A)MET C 384 ( 0.0A)VAL C 248 ( 0.6A) | 1.07A | 2wuzB-3ghgC:undetectable | 2wuzB-3ghgC:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gk0 | PYRIDOXINE5'-PHOSPHATESYNTHASE (Burkholderiapseudomallei) |
PF03740(PdxJ) | 5 | ALA A 146ALA A 150THR A 154LEU A 139VAL A 123 | None | 1.31A | 2wuzB-3gk0A:undetectable | 2wuzB-3gk0A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4y | PUTATIVE CHEMOTAXISPROTEIN (Desulfovibriovulgaris) |
PF13690(CheX) | 5 | ALA A 47THR A 16LEU A 20MET A 23VAL A 19 | None | 1.41A | 2wuzB-3h4yA:undetectable | 2wuzB-3h4yA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdx | SUSD SUPERFAMILYPROTEIN (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | TYR A 208ALA A 146ALA A 150LEU A 293VAL A 236 | NoneNoneNoneEDO A 608 (-4.1A)None | 1.38A | 2wuzB-3hdxA:undetectable | 2wuzB-3hdxA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ivr | PUTATIVELONG-CHAIN-FATTY-ACID COA LIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding) | 5 | MET A 208PHE A 236ALA A 242LEU A 275VAL A 250 | None | 1.29A | 2wuzB-3ivrA:undetectable | 2wuzB-3ivrA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krv | HYDROLASE (Geobacillusstearothermophilus) |
PF04199(Cyclase) | 5 | ALA A 196ALA A 194THR A 191MET A 56VAL A 57 | None | 1.22A | 2wuzB-3krvA:undetectable | 2wuzB-3krvA:20.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 6 | MET A 106PHE A 110ALA A 287ALA A 291THR A 295VAL A 461 | VNF A 490 ( 3.8A)NoneVNF A 490 ( 3.9A)VNF A 490 ( 4.0A)VNF A 490 ( 4.0A)None | 0.98A | 2wuzB-3kswA:44.7 | 2wuzB-3kswA:97.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 6 | PHE A 110ALA A 287ALA A 291THR A 295MET A 460VAL A 461 | NoneVNF A 490 ( 3.9A)VNF A 490 ( 4.0A)VNF A 490 ( 4.0A)NoneNone | 0.83A | 2wuzB-3kswA:44.7 | 2wuzB-3kswA:97.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 6 | TYR A 116ALA A 287ALA A 291THR A 295MET A 460VAL A 461 | VNF A 490 (-4.6A)VNF A 490 ( 3.9A)VNF A 490 ( 4.0A)VNF A 490 ( 4.0A)NoneNone | 0.83A | 2wuzB-3kswA:44.7 | 2wuzB-3kswA:97.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyo | MHC CLASS I ANTIGEN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.34A | 2wuzB-3kyoA:undetectable | 2wuzB-3kyoA:18.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 6 | ALA A 287ALA A 290THR A 294LEU A 355MET A 459VAL A 460 | HEM A 481 (-3.3A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A)TPF A 490 (-4.7A)None | 1.16A | 2wuzB-3l4dA:57.1 | 2wuzB-3l4dA:74.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 9 | MET A 105PHE A 109TYR A 115ALA A 286ALA A 290THR A 294LEU A 355MET A 459VAL A 460 | TPF A 490 ( 4.0A)TPF A 490 (-4.5A)HEM A 481 ( 4.9A)TPF A 490 (-3.4A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A)TPF A 490 (-4.7A)None | 0.66A | 2wuzB-3l4dA:57.1 | 2wuzB-3l4dA:74.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 9 | TYR A 102MET A 105TYR A 115ALA A 286ALA A 290THR A 294LEU A 355MET A 459VAL A 460 | HEM A 481 (-4.7A)TPF A 490 ( 4.0A)HEM A 481 ( 4.9A)TPF A 490 (-3.4A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A)TPF A 490 (-4.7A)None | 0.86A | 2wuzB-3l4dA:57.1 | 2wuzB-3l4dA:74.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 5 | TYR A 115ALA A 287ALA A 290THR A 294MET A 459 | HEM A 481 ( 4.9A)HEM A 481 (-3.3A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.7A) | 1.41A | 2wuzB-3l4dA:57.1 | 2wuzB-3l4dA:74.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 7 | TYR A 115MET A 105PHE A 109ALA A 286ALA A 290THR A 294MET A 459 | HEM A 481 ( 4.9A)TPF A 490 ( 4.0A)TPF A 490 (-4.5A)TPF A 490 (-3.4A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.7A) | 1.15A | 2wuzB-3l4dA:57.1 | 2wuzB-3l4dA:74.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqk | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF14274(DUF4361)PF16343(DUF4973) | 5 | TYR A 295PHE A 293ALA A 186THR A 206LEU A 225 | None | 1.19A | 2wuzB-3nqkA:undetectable | 2wuzB-3nqkA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ou6 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptomycesluridus) |
PF13649(Methyltransf_25) | 5 | ALA A 82ALA A 84THR A 61LEU A 89VAL A 92 | None | 1.38A | 2wuzB-3ou6A:undetectable | 2wuzB-3ou6A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3l | CYTOCHROME P450 (Streptomycesthioluteus) |
PF00067(p450) | 5 | PHE A 89ALA A 243THR A 247LEU A 290VAL A 393 | NoneHEM A 501 (-3.5A)HEM A 501 (-3.6A)HEM A 501 (-4.5A)None | 0.67A | 2wuzB-3p3lA:29.9 | 2wuzB-3p3lA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 5 | PHE B1058ALA B1062THR B1009LEU B 904VAL B 900 | None | 1.03A | 2wuzB-3p8cB:undetectable | 2wuzB-3p8cB:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc2 | SUGAR3-KETOREDUCTASE (Actinomadurakijaniata) |
PF01408(GFO_IDH_MocA) | 5 | ALA A 298ALA A 296THR A 35LEU A 29VAL A 12 | None | 1.24A | 2wuzB-3rc2A:undetectable | 2wuzB-3rc2A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwg | MAJORHISTOCOMPATIBILITYCOMPLEX CLASS I (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.39A | 2wuzB-3rwgA:undetectable | 2wuzB-3rwgA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA C 811ALA C 815THR C 819LEU C 603VAL C 632 | None | 1.29A | 2wuzB-3sr6C:undetectable | 2wuzB-3sr6C:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6c | PUTATIVE MAND FAMILYDEHYDRATASE (Pantoeaananatis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 199ALA A 233ALA A 237THR A 269LEU A 245 | None | 1.44A | 2wuzB-3t6cA:undetectable | 2wuzB-3t6cA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzu | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 5 | MET A 335PHE A 309ALA A 311THR A 326LEU A 380 | None | 1.31A | 2wuzB-3zzuA:undetectable | 2wuzB-3zzuA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5w | COMPLEMENT C5 (Homo sapiens) |
PF00207(A2M)PF01759(NTR)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2) | 5 | PHE A1147ALA A1080ALA A1082LEU A1012VAL A1016 | None | 1.15A | 2wuzB-4a5wA:undetectable | 2wuzB-4a5wA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3y | LEGUMAIN (Cricetulusgriseus) |
PF01650(Peptidase_C13) | 5 | TYR A 149ALA A 193ALA A 214THR A 267VAL A 263 | NoneCSX A 194 ( 3.1A)NoneNoneNone | 1.44A | 2wuzB-4d3yA:undetectable | 2wuzB-4d3yA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evz | HISF-LUCA (syntheticconstruct) |
PF00977(His_biosynth) | 5 | PHE A 228ALA A 224ALA A 222LEU A 242VAL A 249 | None PI A 301 (-3.8A)NoneNoneNone | 1.29A | 2wuzB-4evzA:undetectable | 2wuzB-4evzA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdd | TRANSPORTIN-1 (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | MET A 676ALA A 728ALA A 731THR A 695VAL A 702 | None | 1.31A | 2wuzB-4fddA:undetectable | 2wuzB-4fddA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzw | 1,2-EPOXYPHENYLACETYL-COA ISOMERASE (Escherichiacoli) |
PF00378(ECH_1) | 5 | MET C 134ALA C 110ALA C 118LEU C 150VAL C 154 | None | 1.42A | 2wuzB-4fzwC:undetectable | 2wuzB-4fzwC:18.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 6 | ALA A 288ALA A 291THR A 295LEU A 356MET A 460VAL A 461 | HEM A 501 (-4.4A)HEM A 501 ( 3.5A)VNT A 502 ( 3.2A)VNT A 502 ( 4.5A)VNT A 502 (-4.9A)VNT A 502 ( 4.9A) | 1.18A | 2wuzB-4g3jA:59.0 | 2wuzB-4g3jA:82.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 10 | TYR A 103MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356MET A 460VAL A 461 | VNT A 502 ( 4.8A)VNT A 502 ( 3.9A)VNT A 502 (-4.4A)HEM A 501 ( 4.5A)VNT A 502 ( 3.9A)HEM A 501 ( 3.5A)VNT A 502 ( 3.2A)VNT A 502 ( 4.5A)VNT A 502 (-4.9A)VNT A 502 ( 4.9A) | 0.63A | 2wuzB-4g3jA:59.0 | 2wuzB-4g3jA:82.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnl | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Enterococcusgallinarum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 181ALA A 215ALA A 219THR A 251LEU A 227 | None | 1.43A | 2wuzB-4hnlA:undetectable | 2wuzB-4hnlA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhp | X-LINKED RETINITISPIGMENTOSA GTPASEREGULATOR (Homo sapiens) |
PF00415(RCC1) | 5 | MET C 316ALA C 365LEU C 40MET C 361VAL C 362 | None | 1.41A | 2wuzB-4jhpC:undetectable | 2wuzB-4jhpC:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.35A | 2wuzB-4lcyA:undetectable | 2wuzB-4lcyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qaw | XYN30D (Paenibacillusbarcinonensis) |
PF03422(CBM_6)PF17189(Glyco_hydro_30C) | 5 | TYR A 112PHE A 156ALA A 161THR A 167VAL A 120 | None | 1.41A | 2wuzB-4qawA:undetectable | 2wuzB-4qawA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u28 | PHOSPHORIBOSYLISOMERASE A (Streptomycessviceus) |
PF00977(His_biosynth) | 5 | ALA A 92ALA A 96THR A 100LEU A 84VAL A 71 | None | 1.34A | 2wuzB-4u28A:undetectable | 2wuzB-4u28A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wnz | CRISPR SYSTEM CMRSUBUNIT CMR4 (Pyrococcusfuriosus) |
PF03787(RAMPs) | 5 | TYR A 237PHE A 176ALA A 175ALA A 171LEU A 110 | None | 1.32A | 2wuzB-4wnzA:undetectable | 2wuzB-4wnzA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9s | PHOSPHORIBOSYLISOMERASE A (Streptomycessp. Mg1) |
PF00977(His_biosynth) | 5 | ALA A 90ALA A 94THR A 98LEU A 82VAL A 69 | None | 1.35A | 2wuzB-4x9sA:undetectable | 2wuzB-4x9sA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdi | CHLAMYDOMONASREINHARDTII THB1 (Chlamydomonasreinhardtii) |
PF01152(Bac_globin) | 5 | TYR A 12ALA A 20ALA A 24THR A 101LEU A 98 | None | 1.32A | 2wuzB-4xdiA:undetectable | 2wuzB-4xdiA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ALA A 811ALA A 815THR A 819LEU A 603VAL A 632 | None | 1.28A | 2wuzB-4yswA:undetectable | 2wuzB-4yswA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv7 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 5 | TYR A 75ALA A 78ALA A 48LEU A 58VAL A 127 | None | 1.43A | 2wuzB-4yv7A:undetectable | 2wuzB-4yv7A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfz | MAJORHISTOCOMPATIBILITYCOMPLEX CLASS I (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | NoneNoneNoneEDO A 307 ( 3.9A)None | 1.36A | 2wuzB-4zfzA:undetectable | 2wuzB-4zfzA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zut | CLASSICAL MHC CLASSI ANTIGEN (Equus caballus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.36A | 2wuzB-4zutA:undetectable | 2wuzB-4zutA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahk | ACETOLACTATESYNTHASE II, LARGESUBUNIT (Pseudomonasprotegens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 6ALA A 8THR A 40LEU A 69VAL A 16 | None | 1.17A | 2wuzB-5ahkA:undetectable | 2wuzB-5ahkA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5z | PTLCIB4 H88A MUTANT (Phaeodactylumtricornutum) |
no annotation | 5 | PHE A 74ALA A 72ALA A 129LEU A 186VAL A 136 | None | 1.10A | 2wuzB-5b5zA:undetectable | 2wuzB-5b5zA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 5 | ALA A 221ALA A 225THR A 229LEU A 104VAL A 27 | None | 1.38A | 2wuzB-5dm3A:undetectable | 2wuzB-5dm3A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | MET A 376ALA A 320ALA A 358LEU A 171VAL A 66 | None | 1.23A | 2wuzB-5eefA:undetectable | 2wuzB-5eefA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5et1 | ESPINMYOSIN-IIIB (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5)no annotation | 5 | TYR C1267TYR C1268ALA A 78ALA A 74VAL A 40 | None | 1.24A | 2wuzB-5et1C:undetectable | 2wuzB-5et1C:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 5 | TYR A 126TYR A 140THR A 318LEU A 380VAL A 510 | VOR A 602 ( 3.8A)HEM A 601 (-4.3A)HEM A 601 (-3.4A)VOR A 602 (-4.0A)None | 0.92A | 2wuzB-5hs1A:40.0 | 2wuzB-5hs1A:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6g | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, Q10 ALPHACHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | None | 1.31A | 2wuzB-5j6gA:undetectable | 2wuzB-5j6gA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6s | ENDOPLASMICRETICULUMAMINOPEPTIDASE 2 (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | TYR A 344ALA A 299ALA A 302THR A 407VAL A 404 | None | 1.31A | 2wuzB-5j6sA:2.5 | 2wuzB-5j6sA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 5 | PHE A 135THR A 319LEU A 381MET A 512VAL A 513 | 1YN A 602 ( 4.6A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A)1YN A 602 (-3.5A)None | 1.12A | 2wuzB-5jlcA:39.5 | 2wuzB-5jlcA:29.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 5 | PHE A 135TYR A 141THR A 319LEU A 381VAL A 513 | 1YN A 602 ( 4.6A)HEM A 601 (-4.2A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A)None | 0.96A | 2wuzB-5jlcA:39.5 | 2wuzB-5jlcA:29.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 5 | TYR A 127TYR A 141THR A 319LEU A 381VAL A 513 | 1YN A 602 ( 3.8A)HEM A 601 (-4.2A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A)None | 0.94A | 2wuzB-5jlcA:39.5 | 2wuzB-5jlcA:29.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz9 | - (-) |
no annotation | 5 | TYR A 322MET A 312THR A 573LEU A 345VAL A 543 | None | 1.34A | 2wuzB-5mz9A:undetectable | 2wuzB-5mz9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5unc | PHOSPHOENOLPYRUVATEPHOSPHOMUTASE (Streptomycesplatensis) |
PF13714(PEP_mutase) | 5 | MET A 167ALA A 22ALA A 26MET A 246VAL A 34 | None | 1.35A | 2wuzB-5uncA:undetectable | 2wuzB-5uncA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vld | HISTIDINOLDEHYDROGENASE,CHLOROPLASTIC (Medicagotruncatula) |
PF00815(Histidinol_dh) | 5 | ALA A 196ALA A 224THR A 93LEU A 101VAL A 99 | None | 1.26A | 2wuzB-5vldA:undetectable | 2wuzB-5vldA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ya1 | AUTOINDUCER-2 KINASE (Escherichiacoli) |
no annotation | 5 | ALA A 464ALA A 86THR A 245LEU A 241VAL A 231 | None | 1.30A | 2wuzB-5ya1A:undetectable | 2wuzB-5ya1A:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbq | NEUROPEPTIDE YRECEPTOR TYPE 1,T4LYSOZYME (Escherichiavirus T4;Homo sapiens) |
no annotation | 5 | PHE A 302ALA A 309THR A 313LEU A 94VAL A 89 | 9AO A1301 (-4.0A)NoneNoneNoneNone | 1.41A | 2wuzB-5zbqA:undetectable | 2wuzB-5zbqA:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvt | CORE PROTEIN VP6 (Aquareovirus C) |
no annotation | 5 | TYR U 359TYR U 362ALA U 237ALA U 246LEU U 219 | None | 1.39A | 2wuzB-5zvtU:undetectable | 2wuzB-5zvtU:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6avf | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-7 ALPHACHAIN (Homo sapiens) |
no annotation | 5 | ALA H 49THR H 31LEU H 179MET H 5VAL H 28 | None | 1.33A | 2wuzB-6avfH:undetectable | 2wuzB-6avfH:10.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 6 | PHE A 114TYR A 120ALA A 289ALA A 293THR A 297LEU A 358 | TPF A 506 (-4.4A)NoneTPF A 506 (-3.5A)TPF A 506 ( 3.2A)HEM A 501 (-3.4A)TPF A 506 ( 4.4A) | 0.91A | 2wuzB-6ay4A:46.3 | 2wuzB-6ay4A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 8 | TYR A 120MET A 110PHE A 114ALA A 289ALA A 293THR A 297LEU A 358VAL A 468 | NoneTPF A 506 (-4.6A)TPF A 506 (-4.4A)TPF A 506 (-3.5A)TPF A 506 ( 3.2A)HEM A 501 (-3.4A)TPF A 506 ( 4.4A)EDO A 503 (-4.0A) | 0.95A | 2wuzB-6ay4A:46.3 | 2wuzB-6ay4A:36.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 5 | PHE A 227ALA A 223ALA A 221LEU A 241VAL A 248 | None | 1.18A | 2wuzB-6c7vA:undetectable | 2wuzB-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8v | COENZYME PQQSYNTHESIS PROTEIN E (Methylobacteriumextorquens) |
no annotation | 5 | ALA A 107ALA A 105THR A 99LEU A 97VAL A 120 | None | 1.20A | 2wuzB-6c8vA:undetectable | 2wuzB-6c8vA:10.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccb | GLYCOPROTEIN 120 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | PHE C 317ALA C 319ALA C 174LEU C 129VAL C 181 | None | 1.35A | 2wuzB-6ccbC:undetectable | 2wuzB-6ccbC:9.73 |