SIMILAR PATTERNS OF AMINO ACIDS FOR 2WUZ_A_TPFA1460_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica)
PF00161
(RIP)
5 TYR Y  14
ALA Y 162
ALA Y 159
LEU Y 154
VAL Y  62
None
1.39A 2wuzA-1bryY:
undetectable
2wuzA-1bryY:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)


(Momordica
charantia)
PF00161
(RIP)
5 TYR A  14
ALA A 160
ALA A 157
LEU A 152
VAL A  62
None
1.30A 2wuzA-1cf5A:
0.3
2wuzA-1cf5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzd FIBRINOGEN-420

(Homo sapiens)
PF00147
(Fibrinogen_C)
5 ALA A 795
ALA A 746
LEU A 709
MET A 839
VAL A 707
None
1.19A 2wuzA-1fzdA:
undetectable
2wuzA-1fzdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 PHE 1  17
ALA 1 286
ALA 1 285
THR 1 157
LEU 1 188
None
1.43A 2wuzA-1gt91:
undetectable
2wuzA-1gt91:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 MET A 281
ALA A 404
ALA A 389
LEU A 327
VAL A 329
None
1.36A 2wuzA-1j3nA:
undetectable
2wuzA-1j3nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE


(Thermus
thermophilus)
PF00977
(His_biosynth)
5 PHE F 228
ALA F 224
ALA F 222
LEU F 242
VAL F 249
None
1.36A 2wuzA-1ka9F:
undetectable
2wuzA-1ka9F:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
5 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
None
1.16A 2wuzA-1mhyB:
0.4
2wuzA-1mhyB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6


(Saccharopolyspora
erythraea)
PF00975
(Thioesterase)
5 ALA A 148
ALA A 139
LEU A  88
MET A  61
VAL A  98
None
1.37A 2wuzA-1mo2A:
undetectable
2wuzA-1mo2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ALA A 811
ALA A 815
THR A 819
LEU A 603
VAL A 632
None
1.33A 2wuzA-1n5xA:
undetectable
2wuzA-1n5xA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus)
PF00067
(p450)
5 PHE A 114
ALA A 294
THR A 298
LEU A 359
VAL A 474
DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
None
0.94A 2wuzA-1nr6A:
33.7
2wuzA-1nr6A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00557
(Peptidase_M24)
5 ALA A  96
ALA A 103
THR A 235
MET A   1
VAL A 198
None
1.36A 2wuzA-1qxyA:
undetectable
2wuzA-1qxyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN


(Heliothis
virescens)
PF00104
(Hormone_recep)
5 ALA A 371
ALA A 368
LEU A 417
MET A 356
VAL A 361
None
1.34A 2wuzA-1r20A:
undetectable
2wuzA-1r20A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 TYR A 205
MET A 208
PHE A 210
ALA A 170
ALA A 166
None
1.27A 2wuzA-1r9jA:
undetectable
2wuzA-1r9jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
5 MET A  21
PHE A  16
ALA A  14
THR A 304
LEU A 338
None
1.35A 2wuzA-1w07A:
undetectable
2wuzA-1w07A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
5 PHE C 485
TYR C 481
ALA C 433
ALA C 431
THR C 382
None
1.36A 2wuzA-1wa5C:
undetectable
2wuzA-1wa5C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3


(Mus musculus)
PF04051
(TRAPP)
5 MET A 165
PHE A 103
ALA A  75
ALA A  79
LEU A 107
None
1.17A 2wuzA-1wc8A:
undetectable
2wuzA-1wc8A:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A  79
PHE A  83
ALA A 256
THR A 260
LEU A 321
ESL  A 471 ( 4.4A)
None
ESL  A 471 ( 3.4A)
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
1.06A 2wuzA-1x8vA:
39.7
2wuzA-1x8vA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E


(Mus musculus)
PF00755
(Carn_acyltransf)
5 PHE A 294
TYR A 290
ALA A 577
MET A 335
VAL A 336
None
1.20A 2wuzA-1xl8A:
undetectable
2wuzA-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625


(Archaeoglobus
fulgidus)
PF04414
(tRNA_deacylase)
5 ALA A 196
ALA A 215
THR A 218
LEU A 222
VAL A  93
None
1.41A 2wuzA-1yqeA:
undetectable
2wuzA-1yqeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyh NOTCH 1, ANKYRIN
DOMAIN


(Homo sapiens)
PF12796
(Ank_2)
5 ALA A 160
ALA A 164
THR A 205
LEU A 209
VAL A 208
None
1.35A 2wuzA-1yyhA:
undetectable
2wuzA-1yyhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvs MHC CLASS I ANTIGEN

(Macaca mulatta)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.39A 2wuzA-1zvsA:
undetectable
2wuzA-1zvsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahn THAUMATIN-LIKE
PROTEIN


(Prunus avium)
PF00314
(Thaumatin)
5 ALA A  84
ALA A  70
THR A  55
LEU A 114
VAL A  13
None
1.41A 2wuzA-2ahnA:
undetectable
2wuzA-2ahnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE


(Pseudomonas
aeruginosa)
no annotation 5 MET A 833
ALA A 730
ALA A 728
LEU A 715
VAL A 713
None
1.31A 2wuzA-2faqA:
undetectable
2wuzA-2faqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA


(Synechocystis
sp.)
PF13379
(NMT1_2)
5 MET A 209
ALA A 180
ALA A 178
LEU A 159
VAL A 168
None
1.24A 2wuzA-2g29A:
undetectable
2wuzA-2g29A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpj SIDEROPHORE-INTERACT
ING PROTEIN


(Shewanella
putrefaciens)
PF04954
(SIP)
PF08021
(FAD_binding_9)
5 PHE A  48
ALA A  83
ALA A  87
LEU A  27
VAL A  12
None
FAD  A 500 (-3.3A)
None
None
None
1.41A 2wuzA-2gpjA:
undetectable
2wuzA-2gpjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens)
PF11563
(Protoglobin)
5 TYR A  78
ALA A 134
THR A 114
MET A 107
VAL A 110
None
None
None
HEM  A 200 (-3.9A)
None
1.28A 2wuzA-2w31A:
undetectable
2wuzA-2w31A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
5 PHE A 316
ALA A 338
ALA A 240
LEU A 257
VAL A 261
None
1.42A 2wuzA-2zj8A:
undetectable
2wuzA-2zj8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071


(Thermus
thermophilus)
PF01261
(AP_endonuc_2)
5 ALA A 237
ALA A 233
LEU A 222
MET A 220
VAL A   3
None
1.27A 2wuzA-3aytA:
undetectable
2wuzA-3aytA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN


(Homo sapiens)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
None
1.09A 2wuzA-3bvhC:
undetectable
2wuzA-3bvhC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE


(Novosphingobium
aromaticivorans)
PF13622
(4HBT_3)
5 PHE A  35
ALA A  38
ALA A 181
LEU A 239
VAL A 237
None
None
None
None
GOL  A 261 ( 4.5A)
1.24A 2wuzA-3cjyA:
undetectable
2wuzA-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE


(Novosphingobium
aromaticivorans)
PF13622
(4HBT_3)
5 PHE A  35
ALA A 181
LEU A 239
MET A 223
VAL A 237
None
None
None
None
GOL  A 261 ( 4.5A)
1.17A 2wuzA-3cjyA:
undetectable
2wuzA-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES


(Homo sapiens)
PF00147
(Fibrinogen_C)
5 ALA A 341
ALA A 289
LEU A 250
MET A 384
VAL A 248
None
1.09A 2wuzA-3fibA:
undetectable
2wuzA-3fibA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN


(Homo sapiens)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
5 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
ALA  C 341 ( 0.0A)
ALA  C 289 ( 0.0A)
LEU  C 250 ( 0.6A)
MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
1.09A 2wuzA-3ghgC:
undetectable
2wuzA-3ghgC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Burkholderia
pseudomallei)
PF03740
(PdxJ)
5 ALA A 146
ALA A 150
THR A 154
LEU A 139
VAL A 123
None
1.32A 2wuzA-3gk0A:
undetectable
2wuzA-3gk0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN


(Desulfovibrio
vulgaris)
PF13690
(CheX)
5 ALA A  47
THR A  16
LEU A  20
MET A  23
VAL A  19
None
1.41A 2wuzA-3h4yA:
undetectable
2wuzA-3h4yA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 TYR A 208
ALA A 146
ALA A 150
LEU A 293
VAL A 236
None
None
None
EDO  A 608 (-4.1A)
None
1.35A 2wuzA-3hdxA:
undetectable
2wuzA-3hdxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpg INTEGRASE

(Visna-maedi
virus)
PF00665
(rve)
PF02022
(Integrase_Zn)
5 MET A 132
ALA A 125
ALA A 122
LEU A  76
VAL A  65
None
1.25A 2wuzA-3hpgA:
undetectable
2wuzA-3hpgA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
5 MET A 208
PHE A 236
ALA A 242
LEU A 275
VAL A 250
None
1.30A 2wuzA-3ivrA:
undetectable
2wuzA-3ivrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus)
PF04199
(Cyclase)
5 ALA A 196
ALA A 194
THR A 191
MET A  56
VAL A  57
None
1.26A 2wuzA-3krvA:
undetectable
2wuzA-3krvA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE


(Trypanosoma
cruzi)
PF00067
(p450)
6 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
VAL A 461
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
0.98A 2wuzA-3kswA:
44.9
2wuzA-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE


(Trypanosoma
cruzi)
PF00067
(p450)
6 PHE A 110
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
0.84A 2wuzA-3kswA:
44.9
2wuzA-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE


(Trypanosoma
cruzi)
PF00067
(p450)
6 TYR A 116
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
0.85A 2wuzA-3kswA:
44.9
2wuzA-3kswA:
97.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.37A 2wuzA-3kyoA:
undetectable
2wuzA-3kyoA:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE


(Leishmania
infantum)
PF00067
(p450)
6 ALA A 287
ALA A 290
THR A 294
LEU A 355
MET A 459
VAL A 460
HEM  A 481 (-3.3A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
TPF  A 490 (-4.7A)
None
1.13A 2wuzA-3l4dA:
57.3
2wuzA-3l4dA:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE


(Leishmania
infantum)
PF00067
(p450)
9 MET A 105
PHE A 109
TYR A 115
ALA A 286
ALA A 290
THR A 294
LEU A 355
MET A 459
VAL A 460
TPF  A 490 ( 4.0A)
TPF  A 490 (-4.5A)
HEM  A 481 ( 4.9A)
TPF  A 490 (-3.4A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
TPF  A 490 (-4.7A)
None
0.64A 2wuzA-3l4dA:
57.3
2wuzA-3l4dA:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE


(Leishmania
infantum)
PF00067
(p450)
9 TYR A 102
MET A 105
TYR A 115
ALA A 286
ALA A 290
THR A 294
LEU A 355
MET A 459
VAL A 460
HEM  A 481 (-4.7A)
TPF  A 490 ( 4.0A)
HEM  A 481 ( 4.9A)
TPF  A 490 (-3.4A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
TPF  A 490 (-4.7A)
None
0.85A 2wuzA-3l4dA:
57.3
2wuzA-3l4dA:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE


(Leishmania
infantum)
PF00067
(p450)
5 TYR A 115
ALA A 287
ALA A 290
THR A 294
MET A 459
HEM  A 481 ( 4.9A)
HEM  A 481 (-3.3A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.7A)
1.39A 2wuzA-3l4dA:
57.3
2wuzA-3l4dA:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l4d STEROL 14-ALPHA
DEMETHYLASE


(Leishmania
infantum)
PF00067
(p450)
7 TYR A 115
MET A 105
PHE A 109
ALA A 286
ALA A 290
THR A 294
MET A 459
HEM  A 481 ( 4.9A)
TPF  A 490 ( 4.0A)
TPF  A 490 (-4.5A)
TPF  A 490 (-3.4A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.7A)
1.14A 2wuzA-3l4dA:
57.3
2wuzA-3l4dA:
74.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS


(Bordetella
pertussis)
PF00497
(SBP_bac_3)
5 TYR A 390
ALA A 335
ALA A 334
MET A 370
VAL A 311
None
1.29A 2wuzA-3mplA:
undetectable
2wuzA-3mplA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqk UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF14274
(DUF4361)
PF16343
(DUF4973)
5 TYR A 295
PHE A 293
ALA A 186
THR A 206
LEU A 225
None
1.19A 2wuzA-3nqkA:
undetectable
2wuzA-3nqkA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN


(Caenorhabditis
elegans)
PF02136
(NTF2)
5 MET B  65
PHE B  64
ALA B  48
LEU B 117
VAL B 128
None
1.40A 2wuzA-3nv0B:
undetectable
2wuzA-3nv0B:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptomyces
luridus)
PF13649
(Methyltransf_25)
5 ALA A  82
ALA A  84
THR A  61
LEU A  89
VAL A  92
None
1.38A 2wuzA-3ou6A:
undetectable
2wuzA-3ou6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus)
PF00067
(p450)
5 PHE A  89
ALA A 243
THR A 247
LEU A 290
VAL A 393
None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
None
0.66A 2wuzA-3p3lA:
30.6
2wuzA-3p3lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1


(Homo sapiens)
PF09735
(Nckap1)
5 PHE B1058
ALA B1062
THR B1009
LEU B 904
VAL B 900
None
1.04A 2wuzA-3p8cB:
undetectable
2wuzA-3p8cB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE


(Actinomadura
kijaniata)
PF01408
(GFO_IDH_MocA)
5 ALA A 298
ALA A 296
THR A  35
LEU A  29
VAL A  12
None
1.23A 2wuzA-3rc2A:
undetectable
2wuzA-3rc2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I


(Macaca mulatta)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.42A 2wuzA-3rwgA:
undetectable
2wuzA-3rwgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E


(Bos taurus)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA C 811
ALA C 815
THR C 819
LEU C 603
VAL C 632
None
1.29A 2wuzA-3sr6C:
undetectable
2wuzA-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE


(Pantoea
ananatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 199
ALA A 233
ALA A 237
THR A 269
LEU A 245
None
1.43A 2wuzA-3t6cA:
undetectable
2wuzA-3t6cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE


(Pyrococcus
horikoshii)
no annotation 5 ALA A  66
ALA A 303
THR A 307
LEU A 279
VAL A 320
None
1.36A 2wuzA-3u4gA:
undetectable
2wuzA-3u4gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
5 MET A 335
PHE A 309
ALA A 311
THR A 326
LEU A 380
None
1.31A 2wuzA-3zzuA:
undetectable
2wuzA-3zzuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
5 PHE A1147
ALA A1080
ALA A1082
LEU A1012
VAL A1016
None
1.16A 2wuzA-4a5wA:
undetectable
2wuzA-4a5wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
None
1.15A 2wuzA-4cgrA:
1.2
2wuzA-4cgrA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct)
PF00977
(His_biosynth)
5 PHE A 228
ALA A 224
ALA A 222
LEU A 242
VAL A 249
None
PI  A 301 (-3.8A)
None
None
None
1.33A 2wuzA-4evzA:
undetectable
2wuzA-4evzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 MET A 676
ALA A 728
ALA A 731
THR A 695
VAL A 702
None
1.34A 2wuzA-4fddA:
undetectable
2wuzA-4fddA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE


(Trypanosoma
brucei)
PF00067
(p450)
6 ALA A 288
ALA A 291
THR A 295
LEU A 356
MET A 460
VAL A 461
HEM  A 501 (-4.4A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
VNT  A 502 ( 4.9A)
1.15A 2wuzA-4g3jA:
59.1
2wuzA-4g3jA:
82.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE


(Trypanosoma
brucei)
PF00067
(p450)
10 TYR A 103
MET A 106
PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
LEU A 356
MET A 460
VAL A 461
VNT  A 502 ( 4.8A)
VNT  A 502 ( 3.9A)
VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
VNT  A 502 ( 4.9A)
0.62A 2wuzA-4g3jA:
59.1
2wuzA-4g3jA:
82.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Enterococcus
gallinarum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 181
ALA A 215
ALA A 219
THR A 251
LEU A 227
None
1.41A 2wuzA-4hnlA:
undetectable
2wuzA-4hnlA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR


(Homo sapiens)
PF00415
(RCC1)
5 MET C 316
ALA C 365
LEU C  40
MET C 361
VAL C 362
None
1.43A 2wuzA-4jhpC:
undetectable
2wuzA-4jhpC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN


(Homo sapiens)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.38A 2wuzA-4lcyA:
undetectable
2wuzA-4lcyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis)
PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C)
5 TYR A 112
PHE A 156
ALA A 161
THR A 167
VAL A 120
None
1.41A 2wuzA-4qawA:
undetectable
2wuzA-4qawA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sviceus)
PF00977
(His_biosynth)
5 ALA A  92
ALA A  96
THR A 100
LEU A  84
VAL A  71
None
1.34A 2wuzA-4u28A:
undetectable
2wuzA-4u28A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4


(Pyrococcus
furiosus)
PF03787
(RAMPs)
5 TYR A 237
PHE A 176
ALA A 175
ALA A 171
LEU A 110
None
1.34A 2wuzA-4wnzA:
undetectable
2wuzA-4wnzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sp. Mg1)
PF00977
(His_biosynth)
5 ALA A  90
ALA A  94
THR A  98
LEU A  82
VAL A  69
None
1.35A 2wuzA-4x9sA:
undetectable
2wuzA-4x9sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdi CHLAMYDOMONAS
REINHARDTII THB1


(Chlamydomonas
reinhardtii)
PF01152
(Bac_globin)
5 TYR A  12
ALA A  20
ALA A  24
THR A 101
LEU A  98
None
1.31A 2wuzA-4xdiA:
undetectable
2wuzA-4xdiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E


(Rattus
norvegicus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ALA A 811
ALA A 815
THR A 819
LEU A 603
VAL A 632
None
1.28A 2wuzA-4yswA:
undetectable
2wuzA-4yswA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I


(Macaca mulatta)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
None
None
EDO  A 307 ( 3.9A)
None
1.39A 2wuzA-4zfzA:
undetectable
2wuzA-4zfzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN


(Equus caballus)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.38A 2wuzA-4zutA:
undetectable
2wuzA-4zutA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT


(Pseudomonas
protegens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A   6
ALA A   8
THR A  40
LEU A  69
VAL A  16
None
1.19A 2wuzA-5ahkA:
undetectable
2wuzA-5ahkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum)
no annotation 5 PHE A  74
ALA A  72
ALA A 129
LEU A 186
VAL A 136
None
1.12A 2wuzA-5b5zA:
undetectable
2wuzA-5b5zA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE


(Chromohalobacter
salexigens)
PF00120
(Gln-synt_C)
5 ALA A 221
ALA A 225
THR A 229
LEU A 104
VAL A  27
None
1.37A 2wuzA-5dm3A:
undetectable
2wuzA-5dm3A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio)
PF00850
(Hist_deacetyl)
5 MET A 376
ALA A 320
ALA A 358
LEU A 171
VAL A  66
None
1.24A 2wuzA-5eefA:
undetectable
2wuzA-5eefA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN
MYOSIN-IIIB


(Mus musculus)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5)
no annotation
5 TYR C1267
TYR C1268
ALA A  78
ALA A  74
VAL A  40
None
1.26A 2wuzA-5et1C:
undetectable
2wuzA-5et1C:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 TYR A 126
TYR A 140
THR A 318
LEU A 380
VAL A 510
VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
0.92A 2wuzA-5hs1A:
40.0
2wuzA-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6g H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
5 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
None
1.34A 2wuzA-5j6gA:
undetectable
2wuzA-5j6gA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 TYR A 344
ALA A 299
ALA A 302
THR A 407
VAL A 404
None
1.33A 2wuzA-5j6sA:
undetectable
2wuzA-5j6sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 PHE A 135
THR A 319
LEU A 381
MET A 512
VAL A 513
1YN  A 602 ( 4.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
None
1.08A 2wuzA-5jlcA:
39.6
2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 PHE A 135
TYR A 141
THR A 319
LEU A 381
VAL A 513
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
0.95A 2wuzA-5jlcA:
39.6
2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
5 TYR A 127
TYR A 141
THR A 319
LEU A 381
VAL A 513
1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
0.93A 2wuzA-5jlcA:
39.6
2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-)
no annotation 5 TYR A 322
MET A 312
THR A 573
LEU A 345
VAL A 543
None
1.35A 2wuzA-5mz9A:
undetectable
2wuzA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE


(Streptomyces
platensis)
PF13714
(PEP_mutase)
5 MET A 167
ALA A  22
ALA A  26
MET A 246
VAL A  34
None
1.34A 2wuzA-5uncA:
undetectable
2wuzA-5uncA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC


(Medicago
truncatula)
PF00815
(Histidinol_dh)
5 ALA A 196
ALA A 224
THR A  93
LEU A 101
VAL A  99
None
1.26A 2wuzA-5vldA:
undetectable
2wuzA-5vldA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME


(Escherichia
virus T4;
Homo sapiens)
no annotation 5 PHE A 302
ALA A 309
THR A 313
LEU A  94
VAL A  89
9AO  A1301 (-4.0A)
None
None
None
None
1.43A 2wuzA-5zbqA:
undetectable
2wuzA-5zbqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C)
no annotation 5 TYR U 359
TYR U 362
ALA U 237
ALA U 246
LEU U 219
None
1.41A 2wuzA-5zvtU:
undetectable
2wuzA-5zvtU:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avf HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-7 ALPHA
CHAIN


(Homo sapiens)
no annotation 5 ALA H  49
THR H  31
LEU H 179
MET H   5
VAL H  28
None
1.36A 2wuzA-6avfH:
undetectable
2wuzA-6avfH:
10.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE


(Naegleria
fowleri)
no annotation 6 PHE A 114
TYR A 120
ALA A 289
ALA A 293
THR A 297
LEU A 358
TPF  A 506 (-4.4A)
None
TPF  A 506 (-3.5A)
TPF  A 506 ( 3.2A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
0.92A 2wuzA-6ay4A:
46.4
2wuzA-6ay4A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE


(Naegleria
fowleri)
no annotation 8 TYR A 120
MET A 110
PHE A 114
ALA A 289
ALA A 293
THR A 297
LEU A 358
VAL A 468
None
TPF  A 506 (-4.6A)
TPF  A 506 (-4.4A)
TPF  A 506 (-3.5A)
TPF  A 506 ( 3.2A)
HEM  A 501 (-3.4A)
TPF  A 506 ( 4.4A)
EDO  A 503 (-4.0A)
0.92A 2wuzA-6ay4A:
46.4
2wuzA-6ay4A:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 5 PHE A 227
ALA A 223
ALA A 221
LEU A 241
VAL A 248
None
1.22A 2wuzA-6c7vA:
undetectable
2wuzA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8v COENZYME PQQ
SYNTHESIS PROTEIN E


(Methylobacterium
extorquens)
no annotation 5 ALA A 107
ALA A 105
THR A  99
LEU A  97
VAL A 120
None
1.23A 2wuzA-6c8vA:
undetectable
2wuzA-6c8vA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN


(Homo sapiens)
no annotation 5 MET A  31
PHE A  62
ALA A 169
LEU A 147
MET A 182
None
1.21A 2wuzA-6co1A:
undetectable
2wuzA-6co1A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-)
no annotation 5 TYR D 224
PHE D 221
ALA D 184
THR D 101
VAL D 105
None
1.35A 2wuzA-6h25D:
undetectable
2wuzA-6h25D:
undetectable