SIMILAR PATTERNS OF AMINO ACIDS FOR 2WQ5_A_MIYA1120_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
TRP A  19
ALA A  23
GLY A  30
 None
None
None
NA  A 121 (-4.4A)
 0.72A 2wq5A-1bunA:
20.1		 2wq5A-1bunA:
53.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 433
ALA A 411
GLY A 413
PHE A 429
 None
 0.91A 2wq5A-1eovA:
0.0		 2wq5A-1eovA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 LEU A  76
ALA A 176
GLY A 180
PHE A  72
 IN0  A 991 ( 4.6A)
IN0  A 991 (-4.1A)
IN0  A 991 (-3.2A)
IN0  A 991 ( 4.7A)
 0.92A 2wq5A-1ezfA:
0.0		 2wq5A-1ezfA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 LEU A 665
ALA A 659
GLY A 661
PHE A 707
 None
 0.96A 2wq5A-1h7wA:
0.0		 2wq5A-1h7wA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 LEU A 165
ALA A 235
GLY A 239
PHE A  12
 None
 0.98A 2wq5A-1j0aA:
0.0		 2wq5A-1j0aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 LEU A 356
ALA A 242
GLY A 244
PHE A 355
 None
 0.94A 2wq5A-1j2bA:
0.0		 2wq5A-1j2bA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 143
ALA A  98
GLY A  97
PHE A 117
PHE A 150
 None
None
NAD  A 352 (-4.2A)
None
None
 1.48A 2wq5A-1ldnA:
0.4		 2wq5A-1ldnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 327
ALA A 348
GLY A 347
ARG A  36
 None
GLA  A 400 ( 3.6A)
PO4  A 401 ( 3.9A)
PO4  A 401 ( 3.5A)
 0.94A 2wq5A-1pieA:
undetectable		 2wq5A-1pieA:
16.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
TRP A  18
ALA A  22
PHE A  64
 None
 0.69A 2wq5A-1pshA:
23.7		 2wq5A-1pshA:
96.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 TRP A  18
ALA A  22
GLY A  29
PHE A  64
 None
None
CA  A 120 (-4.4A)
None
 0.78A 2wq5A-1pshA:
23.7		 2wq5A-1pshA:
96.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 LEU A 291
ALA A 378
GLY A 380
ARG A 384
 None
 0.95A 2wq5A-1q5dA:
undetectable		 2wq5A-1q5dA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re0 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 1

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 LEU B 142
ALA B 117
GLY B 120
PHE B 141
 None
 0.87A 2wq5A-1re0B:
undetectable		 2wq5A-1re0B:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 285
ALA A 305
GLY A 304
ARG A  11
PHE A 288
 None
GLA  A 500 (-3.7A)
GLA  A 500 (-4.0A)
GLA  A 500 (-4.3A)
None
 1.36A 2wq5A-1s4eA:
undetectable		 2wq5A-1s4eA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		4 LEU A 134
ALA A  67
GLY A  69
PHE A 130
 None
HEM  A 144 (-3.4A)
None
None
 0.75A 2wq5A-1spgA:
undetectable		 2wq5A-1spgA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ubd PROTEIN (YY1 ZINC
FINGER DOMAIN)

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 LEU C 340
ALA C 328
GLY C 331
PHE C 334
 None
 0.94A 2wq5A-1ubdC:
undetectable		 2wq5A-1ubdC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  24
ALA A  76
GLY A 109
PHE A  28
 None
 0.95A 2wq5A-1wl1A:
1.2		 2wq5A-1wl1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A 132
ALA A 114
GLY A 112
PHE A 144
 None
 0.88A 2wq5A-1xt8A:
undetectable		 2wq5A-1xt8A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 LEU A 365
TRP A 299
ALA A 298
GLY A 296
 None
 0.97A 2wq5A-1yiqA:
undetectable		 2wq5A-1yiqA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LEU A 370
ALA A 301
GLY A 303
PHE A 374
 None
 0.97A 2wq5A-2b4vA:
undetectable		 2wq5A-2b4vA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 283
ALA A 303
GLY A 302
ARG A   9
PHE A 286
 None
GLA  A 401 (-3.7A)
GLA  A 401 ( 4.1A)
GLA  A 401 (-4.1A)
None
 1.30A 2wq5A-2dejA:
undetectable		 2wq5A-2dejA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 4 LEU L  45
ALA L 532
GLY L 534
PHE L 480
 None
 0.90A 2wq5A-2frvL:
undetectable		 2wq5A-2frvL:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h28 HYPOTHETICAL PROTEIN
YEEU

(Escherichia
coli) 		PF06154
(CbeA_antitoxin) 		4 LEU A  62
ALA A  32
GLY A  49
ARG A  17
 None
 0.96A 2wq5A-2h28A:
undetectable		 2wq5A-2h28A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		4 LEU A 199
ALA A  40
GLY A  35
PHE A 103
 None
 0.90A 2wq5A-2j92A:
undetectable		 2wq5A-2j92A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jek RV1873

(Mycobacterium
tuberculosis) 		PF08837
(DUF1810) 		4 LEU A 111
GLY A  58
ARG A  12
PHE A 122
 None
 0.91A 2wq5A-2jekA:
undetectable		 2wq5A-2jekA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfs EP-AMP1

(synthetic
construct) 		no annotation 4 LEU A  26
ALA A  34
GLY A   5
PHE A  28
 None
 0.73A 2wq5A-2mfsA:
undetectable		 2wq5A-2mfsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7v REGULATOR OF SIGMA D

(Escherichia
coli) 		PF04353
(Rsd_AlgQ) 		4 LEU A  61
ALA A 133
GLY A 131
PHE A  57
 None
 0.94A 2wq5A-2p7vA:
undetectable		 2wq5A-2p7vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A  40
ALA A  44
GLY A 197
PHE A 151
 None
 0.87A 2wq5A-2psyA:
undetectable		 2wq5A-2psyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 LEU A 163
ALA A 118
GLY A 111
ARG A  89
PHE A  35
 None
 1.47A 2wq5A-2r8wA:
undetectable		 2wq5A-2r8wA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		4 LEU A 348
ALA A 340
GLY A 338
PHE A 489
 None
 0.85A 2wq5A-2rchA:
undetectable		 2wq5A-2rchA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 LEU C 293
ALA C  41
GLY C 256
PHE C 289
 None
 0.93A 2wq5A-2v3cC:
undetectable		 2wq5A-2v3cC:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK

(Escherichia
coli) 		PF02678
(Pirin) 		4 LEU A  43
GLY A 205
ARG A   8
PHE A  24
 None
 0.68A 2wq5A-2vecA:
undetectable		 2wq5A-2vecA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		5 LEU A 234
TRP A 165
ALA A 170
GLY A 172
PHE A 237
 None
 1.35A 2wq5A-2wa5A:
undetectable		 2wq5A-2wa5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		4 LEU A   6
ALA A 161
GLY A 159
PHE A   7
 None
 0.98A 2wq5A-2wf7A:
1.2		 2wq5A-2wf7A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  90
ALA A 108
GLY A  68
PHE A  91
 None
 0.96A 2wq5A-2yxzA:
undetectable		 2wq5A-2yxzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 LEU A  35
ALA A 227
GLY A 206
PHE A  33
 None
CA  A1001 (-4.9A)
CA  A1003 ( 4.3A)
None
 0.89A 2wq5A-2z2zA:
undetectable		 2wq5A-2z2zA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 LEU A 284
ALA A 177
PHE A 250
PHE A 249
 None
 0.95A 2wq5A-2zy2A:
undetectable		 2wq5A-2zy2A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 LEU A 303
ALA A 295
GLY A 293
PHE A 444
 None
 0.90A 2wq5A-3danA:
undetectable		 2wq5A-3danA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima) 		PF00344
(SecY)
PF00584
(SecE) 		4 LEU D  37
ALA C 398
GLY C 400
PHE D  30
 None
 0.88A 2wq5A-3dinD:
undetectable		 2wq5A-3dinD:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 ALA A 189
GLY A 193
ARG A 283
PHE A 308
 None
 0.90A 2wq5A-3dlaA:
undetectable		 2wq5A-3dlaA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 LEU A 284
ALA A 177
PHE A 250
PHE A 249
 None
 0.97A 2wq5A-3fddA:
undetectable		 2wq5A-3fddA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 129
ALA A  84
GLY A  83
PHE A 103
PHE A 136
 None
None
NAD  A 500 (-4.1A)
None
None
 1.44A 2wq5A-3h3jA:
undetectable		 2wq5A-3h3jA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 930
TRP A 871
ALA A 885
GLY A 887
 None
 0.96A 2wq5A-3hmjA:
undetectable		 2wq5A-3hmjA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 ALA A 198
ARG A 141
PHE A 256
PHE A 457
 None
 0.97A 2wq5A-3i5gA:
undetectable		 2wq5A-3i5gA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN

(Anaplasma
phagocytophilum) 		PF00132
(Hexapep) 		4 LEU A 135
GLY A 138
ARG A 139
PHE A  99
 None
 0.86A 2wq5A-3ixcA:
undetectable		 2wq5A-3ixcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		PF01381
(HTH_3) 		4 LEU A  79
ALA A 109
GLY A 113
PHE A  74
 None
None
None
CL  A 134 ( 4.5A)
 0.84A 2wq5A-3kxaA:
undetectable		 2wq5A-3kxaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 LEU A  38
TRP A  94
ALA A 116
GLY A  69
 None
None
GOL  A 262 (-2.8A)
None
 0.85A 2wq5A-3laoA:
undetectable		 2wq5A-3laoA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 LEU B 449
GLY B 414
ARG B 418
PHE B 150
 None
 0.89A 2wq5A-3nwaB:
undetectable		 2wq5A-3nwaB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 468
GLY A 470
ARG A 286
PHE A 308
 None
 0.77A 2wq5A-3p4xA:
undetectable		 2wq5A-3p4xA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 LEU A 489
ALA A 352
GLY A 354
PHE A 492
 None
 0.91A 2wq5A-3qfkA:
undetectable		 2wq5A-3qfkA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 LEU A 206
ALA A 177
GLY A 107
PHE A 231
 None
 0.96A 2wq5A-3swgA:
undetectable		 2wq5A-3swgA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13

(Homo sapiens) 		PF00090
(TSP_1) 		4 LEU A 374
TRP A 365
ALA A 417
GLY A 420
 None
 0.97A 2wq5A-3vn4A:
undetectable		 2wq5A-3vn4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 4 LEU B 206
ALA B 235
GLY B 238
PHE B 191
 None
 0.95A 2wq5A-3wlxB:
undetectable		 2wq5A-3wlxB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 258
TRP A 273
GLY A 289
PHE A 248
 None
 0.86A 2wq5A-4a3rA:
undetectable		 2wq5A-4a3rA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		4 LEU A 175
ALA A  46
GLY A 123
PHE A 135
 None
 0.95A 2wq5A-4asyA:
undetectable		 2wq5A-4asyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		5 LEU A 234
TRP A 165
ALA A 170
GLY A 172
PHE A 237
 None
 1.32A 2wq5A-4b7lA:
undetectable		 2wq5A-4b7lA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ALA A 468
GLY A 470
ARG A 286
PHE A 308
 None
 0.75A 2wq5A-4ddwA:
undetectable		 2wq5A-4ddwA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE

(Drosophila
melanogaster) 		PF07859
(Abhydrolase_3) 		4 LEU A 193
TRP A  90
ALA A 158
GLY A 189
 None
None
SEB  A 157 ( 3.3A)
SEB  A 157 ( 3.3A)
 0.91A 2wq5A-4e14A:
undetectable		 2wq5A-4e14A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 160
GLY A 189
ARG A 193
PHE A 157
 None
 0.87A 2wq5A-4eudA:
undetectable		 2wq5A-4eudA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020) 		PF04227
(Indigoidine_A) 		4 LEU A 224
ALA A 158
GLY A 127
PHE A 146
 None
None
5RP  A 402 ( 4.2A)
None
 0.93A 2wq5A-4ex9A:
undetectable		 2wq5A-4ex9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		4 LEU A  37
ALA A  63
GLY A  66
ARG A  70
 None
 0.94A 2wq5A-4fqdA:
undetectable		 2wq5A-4fqdA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 LEU A 235
ALA A 338
GLY A 336
PHE A 238
 None
 0.97A 2wq5A-4fusA:
undetectable		 2wq5A-4fusA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		4 LEU A 178
ALA A 165
GLY A 134
PHE A 181
 None
None
SO4  A 400 ( 4.4A)
None
 0.98A 2wq5A-4gijA:
0.7		 2wq5A-4gijA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME

(Aquifex
aeolicus;
Escherichia
virus T4) 		PF00902
(TatC) 		4 ALA A 115
GLY A 161
PHE A  73
PHE A  21
 None
 0.99A 2wq5A-4httA:
undetectable		 2wq5A-4httA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  17
ALA A  55
GLY A  52
PHE A  21
 None
 0.90A 2wq5A-4isbA:
undetectable		 2wq5A-4isbA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 LEU A 275
ALA A 209
GLY A 211
PHE A 107
 None
 0.77A 2wq5A-4j72A:
0.9		 2wq5A-4j72A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		4 LEU A  36
TRP A  63
ALA A  48
PHE A 103
 None
 0.96A 2wq5A-4lgcA:
undetectable		 2wq5A-4lgcA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 ALA A  88
GLY A  82
PHE A 139
PHE A 136
 None
 0.86A 2wq5A-4n6dA:
undetectable		 2wq5A-4n6dA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1k CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		4 LEU A 214
ALA A 184
GLY A 187
PHE A 210
 None
 0.92A 2wq5A-4o1kA:
undetectable		 2wq5A-4o1kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LEU A 189
ALA A 153
GLY A 151
PHE A 192
 None
 0.92A 2wq5A-4pqiA:
undetectable		 2wq5A-4pqiA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		4 LEU B 223
ALA B 180
GLY B 186
PHE B 219
 None
 0.96A 2wq5A-4r8uB:
undetectable		 2wq5A-4r8uB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU L  61
ALA L 548
GLY L 550
PHE L 496
 None
 0.98A 2wq5A-4u9iL:
0.8		 2wq5A-4u9iL:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 LEU A 903
ALA A 972
GLY A 975
PHE A 810
 None
 0.91A 2wq5A-4um2A:
2.0		 2wq5A-4um2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 LEU Q  52
ALA Q 545
GLY Q 547
PHE Q 493
 None
 0.92A 2wq5A-4upeQ:
undetectable		 2wq5A-4upeQ:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 LEU A 170
ALA A 126
GLY A 122
PHE A 166
 None
 0.97A 2wq5A-4weoA:
undetectable		 2wq5A-4weoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wkz AUTONOMOUS COHESIN

(Ruminococcus
flavefaciens) 		no annotation 4 ALA B  95
GLY B 134
PHE B 168
PHE B 182
 None
 0.97A 2wq5A-4wkzB:
undetectable		 2wq5A-4wkzB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		4 LEU A   9
ALA A  26
GLY A  29
ARG A  33
 None
 0.94A 2wq5A-4wrwA:
undetectable		 2wq5A-4wrwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab4 SCP2-THIOLASE LIKE
PROTEIN

(Trypanosoma
brucei) 		no annotation 5 LEU A 389
ALA A 310
GLY A 312
PHE A 294
PHE A 293
 None
 1.48A 2wq5A-5ab4A:
undetectable		 2wq5A-5ab4A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3p NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus) 		PF00329
(Complex1_30kDa) 		4 LEU A 101
ALA A  69
GLY A  54
PHE A 126
 None
 0.89A 2wq5A-5b3pA:
undetectable		 2wq5A-5b3pA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		4 LEU A 322
ALA A 295
GLY A 299
PHE A 321
 None
 0.97A 2wq5A-5ey7A:
undetectable		 2wq5A-5ey7A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU B  40
ALA B 148
GLY B 146
ARG B  89
 None
 0.97A 2wq5A-5fq6B:
undetectable		 2wq5A-5fq6B:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		4 LEU A  35
ALA A  21
GLY A  19
PHE A  41
 None
 0.91A 2wq5A-5gmbA:
undetectable		 2wq5A-5gmbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 ALA A 317
GLY A 315
PHE A 292
PHE A 295
 None
7BV  A 500 ( 3.6A)
None
None
 0.97A 2wq5A-5gyzA:
undetectable		 2wq5A-5gyzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 LEU A 987
ALA A 960
GLY A 963
ARG A 967
 None
 0.88A 2wq5A-5hb3A:
undetectable		 2wq5A-5hb3A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm2 3C PROTEINASE

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		4 LEU A 199
ALA A  40
GLY A  35
PHE A 103
 None
 0.97A 2wq5A-5hm2A:
undetectable		 2wq5A-5hm2A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 LEU A 387
ALA A 273
GLY A 314
ARG A 302
 None
 0.88A 2wq5A-5iobA:
undetectable		 2wq5A-5iobA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 203
TRP A 100
ALA A 170
GLY A 199
 None
None
OAS  A 169 ( 3.6A)
OAS  A 169 ( 3.4A)
 0.92A 2wq5A-5jd5A:
undetectable		 2wq5A-5jd5A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 4 GLY B 842
ARG B 846
PHE B 780
PHE B 781
 None
 0.96A 2wq5A-5kdjB:
undetectable		 2wq5A-5kdjB:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgo FLAGELLAR BRAKE
PROTEIN YCGR

(Klebsiella
pneumoniae) 		no annotation 4 LEU D 148
ALA D 167
GLY D 126
PHE D 136
 None
 0.91A 2wq5A-5kgoD:
undetectable		 2wq5A-5kgoD:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 LEU A  52
ALA A 315
GLY A 319
PHE A 684
 None
NAG  A1121 ( 4.0A)
None
None
 0.92A 2wq5A-5nbsA:
undetectable		 2wq5A-5nbsA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		4 LEU A 324
ALA A 235
GLY A 231
PHE A 320
 None
 0.93A 2wq5A-5nsqA:
undetectable		 2wq5A-5nsqA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 LEU A 164
ALA A 182
GLY A 185
PHE A 161
 None
 0.89A 2wq5A-5sy1A:
undetectable		 2wq5A-5sy1A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l C5 ANTIBODY VARIABLE
LIGHT DOMAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU G  33
ALA G  72
GLY G  64
PHE G  91
 None
 0.94A 2wq5A-5w3lG:
undetectable		 2wq5A-5w3lG:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 LEU A 165
TRP A 162
ALA A 122
GLY A 130
 None
 0.98A 2wq5A-5wx1A:
undetectable		 2wq5A-5wx1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 LEU A1270
ALA A1221
GLY A1259
PHE A1180
 None
 0.86A 2wq5A-5x7sA:
undetectable		 2wq5A-5x7sA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 4 LEU A 372
ALA A 350
GLY A 352
PHE A 398
 None
 0.94A 2wq5A-5xt3A:
undetectable		 2wq5A-5xt3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y16 DUAL SPECIFICITY
PHOSPHATASE 28

(Homo sapiens) 		no annotation 4 LEU A  19
ALA A  41
GLY A  44
PHE A  27
 None
 0.87A 2wq5A-5y16A:
undetectable		 2wq5A-5y16A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A  99
ALA A 550
GLY A 554
PHE A 104
 None
 0.93A 2wq5A-6ao8A:
undetectable		 2wq5A-6ao8A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 4 LEU A  76
TRP A 130
ALA A 184
GLY A 186
 None
 0.90A 2wq5A-6byqA:
undetectable		 2wq5A-6byqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 LEU A 332
ALA A 324
GLY A 326
PHE A 337
 None
 0.94A 2wq5A-6cc4A:
4.1		 2wq5A-6cc4A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 ALA A 134
GLY A 118
ARG A  63
PHE A 107
 None
 0.87A 2wq5A-6en4A:
undetectable		 2wq5A-6en4A:
20.35